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•Guanosine-based pathway evaluation in different matrices.•Simultaneous HPLC-DAD quantification of guanosine and pterins molecules.•Human extracellular vesicles isolated from different human parts.

Rare side-effects of fluoroquinolone therapy are tendinitis and tendon rupture. Many reports have demonstrated that the concomitant use of corticosteroids, in patients aged 60 years or older, increase the risk substantially. We present a case of spontaneous bilateral Achilles tendon rupture induced by ciprofloxacin and methylprednisolone. A 61-year-old woman was diagnosed with Bronchiolitis Obliterans with Organizing Pneumonia (BOOP) and was started on oral ciprofloxacin 500 mg twice daily for 3 weeks and on oral methylprednisolone 16 mg twice daily for 2 weeks. The diagnosis was made after doctors, rather than stop drug therapy and advise complete rest, had mistakenly prescribed for the woman to undergo physiotherapy and local NSAIDs, thus favoring the onset of tendon ruptures and resulting in surgical and legal implications. Inspired by this case, we also submit a brief review on professional liability in Orthopaedics.

•Fast LC–MS/MS screening method for compounds in biological matrices•Blood, urine, and post mortem blood analyses•Bioactive compounds, drugs and illicit drugs fast screening analyses•Innovative configurations to maximize the instrumental performances•Green Analytical Procedure Index (GAPI) evaluation