1. Rare disease research resources at the Rat Genome Database
- Author
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Kaldunski, Mary L, Smith, Jennifer R, Brodie, Kent C, De Pons, Jeffrey L, Demos, Wendy M, Gibson, Adam C, Hayman, G Thomas, Lamers, Logan, Laulederkind, Stanley J F, Thorat, Ketaki, Thota, Jyothi, Tutaj, Marek A, Tutaj, Monika, Vedi, Mahima, Wang, Shur-Jen, Zacher, Stacy, Dwinell, Melinda R, and Kwitek, Anne E
- Abstract
Rare diseases individually affect relatively few people, but as a group they impact considerable numbers of people. The Rat Genome Database (https://rgd.mcw.edu) is a knowledgebase that offers resources for rare disease research. This includes disease definitions, genes, quantitative trail loci (QTLs), genetic variants, annotations to published literature, links to external resources, and more. One important resource is identifying relevant cell lines and rat strains that serve as models for disease research. Diseases, genes, and strains have report pages with consolidated data, and links to analysis tools. Utilizing these globally accessible resources for rare disease research, potentiating discovery of mechanisms and new treatments, can point researchers toward solutions to alleviate the suffering of those afflicted with these diseases.At the Rat Genome Database (RGD), the disease research community can find a wealth of rare disease information, relevant strains, disease, gene, and strain report pages with consolidated data, and an arsenal of analysis tools with which to further biomedical research. Leveraging these resources for rare disease mechanism discovery, and potentially the discovery of new treatment modalities, will help further clinical progress for those afflicted with these diseases. RGD’s data and tools are globally accessible.
- Published
- 2023
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