6 results on '"Dimitrova, Desislava"'
Search Results
2. Interprofessionelles und interkulturelles Arbeiten und Kommunikation in der Gesundheitsversorgung
- Author
-
Dimitrova, Desislava, Siebert, Ute, Borde, Theda, and Sehouli, Jalid
- Abstract
Zunehmende globale Migration und Flucht aufgrund neuer Konflikte und Krisensituationen führen zu einer deutlichen Zunahme der ethnischen und soziokulturellen Diversität unserer Gesellschaft. Diese Veränderungen und Einflüsse finden sich auch im Gesundheitssystem wieder und stellen neue Herausforderung für das gesamte Gesundheitswesen dar. Im Folgenden berichten wir von einem Projekt, das aus der klinischen Routine heraus entstanden ist, im Gespräch mit dem Angehörigen einer Patientin 2014 begann und inzwischen als Regelfortbildung an der Fortbildungsakademie der Charité etabliert ist. Das IPIKA-Projekt startete zunächst als Pilotmodell für ein interkulturelles und interprofessionelles Fortbildungsprogramm. 2016 wurde das Programm mit der Bezeichnung „IPIKA – Interprofessionelles und Interkulturelles Arbeiten in Medizin, Pflege und Sozialdienst“ in Kooperation der Klinik für Gynäkologie, dem Comprehensive Cancer Center der Charité und der Alice-Salomon-Hochschule (ASH) durch die Robert-Bosch-Stiftung gefördert. In einer zweiten Förderphase (2018–2019) konnte das IPIKA-Curriculum im Bildungsprogramm der Charité-Fortbildungsakademie etabliert und ein IPIKA-Zertifikatkurs im Weiterbildungsprogramm der ASH aufgenommen werden. Die IPIKA-Fortbildung ist transprofessionell aufgestellt und richtet sich an verschiedene Berufsgruppen aus Pflege, Medizin, Psychoonkologie, Sozialdienst und an Hebammen. Es vermittelt berufsübergreifend praxisnahe interkulturelle Kompetenzen und Kommunikationsfähigkeit.
- Published
- 2022
- Full Text
- View/download PDF
3. PROMOTING EDEN DESTINATIONS IN BULGARIA – THE WAY FOR SUSTAINABLE DEVELOPMENT OF TOURISM.
- Author
-
Yancheva, Krasimira and Dimitrova, Desislava
- Subjects
SUSTAINABLE tourism ,SUSTAINABLE development ,TOURIST attractions ,TOURIST attitudes ,TOURISM websites ,FOOD tourism ,PRODUCT advertising - Abstract
The European Destinations of ExcelleNce (EDEN) initiative provides the opportunity to enhance the visibility and recognition of emerging European tourist destinations, to create a platform for exchanging good practices at European level and to promote a network between award-winning destinations that could lead other destinations to adopt the model for sustainable development of tourism. The EDEN project is an excellent option for destinations that do not have the necessary financial funds but want to develop tourism. It provides a chance for every tourist product to be advertised free of charge in the other EU Member States. [ABSTRACT FROM AUTHOR]
- Published
- 2018
4. Genetic Versus Epigenetic BRCA1 Silencing Pathways: Clinical Effects in Primary Ovarian Cancer Patients: A Study of the Tumor Bank Ovarian Cancer Consortium.
- Author
-
Tingting Sun, Ruscito, Ilary, Dimitrova, Desislava, Chekerov, Radoslav, Kulbe, Hagen, Baron, Udo, Blanchard, Véronique, Panici, Pierluigi Benedetti, Darb-Esfahani, Silvia, Sehouli, Jalid, Olek, Sven, and Braicu, Elena Ioana
- Abstract
Objectives: The aim of the present study was to assess in a large cohort of primary epithelial ovarian cancer patients the incidence and the clinical effect of BRCA1 genetic and epigenetic silencing mechanisms. Methods: A total of 188 primary epithelial ovarian cancer patients, treated between 2000 and 2011 at the Charité University Hospital of Berlin, were included. The patients' tumor and blood samples were obtained from the Tumor Bank Ovarian Cancer Network (www.toc-network.de). Direct sequencing of BRCA1 exon 11 was performed to detect germline mutations, whereas tumor samples were assessed for BRCA1 promoter hypermethylation by bisulphite-converted methylation-specific polymerase chain reaction. Basing on their BRCA1 status, patients were compared regarding clinicopathological variables and survival. Results: Twenty-one patients (11.2%) showed hypermethylation in BRCA1 promoter (HMB), and 18 patients (9.6%) presented germline mutations in BRCA1 exon 11 (GMB). Patients with HMB showed a significantly younger age at diagnosis compared with BRCA1 wild type (BWT) patients (54 vs 61 years, P = 0.045), and both GMB and HMB patients were more likely to have high-grade serous ovarian cancer (76.2% and 77.8% vs 52.7%, P = 0.043 and P = 0.043). Positive family history of breast or ovarian cancer (OC) was more frequently reported among GMB patients with respect to BWT patients (44.4% vs 13.5%, P = 0.003); GMB, HMB, and BWT patients did not show significant differences in terms of tumor dissemination pattern, surgical outcomes, platinum response or survival; neither mutational nor hypermethylation BRCA1 status was found to be an independent prognostic factor for OC patients. Conclusions: Hypermethylation in BRCA1 is associated with earlier occurrence of OC. In addition, the coexistence of both GBM and HMB is an infrequent event, occurring in 0.5% of OC cases. Silencing of BRCA1 through mutation and hypermethylation confers to distinct clinical characteristics of OC patients but similar clinical outcome with respect to BWT patients. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
5. Expression of Epithelial Cell Adhesion Molecule in Paired Tumor Samples of Patients With Primary and Recurrent Serous Ovarian Cancer.
- Author
-
Pietzner, Klaus, Woopen, Hannah, Richter, Rolf, Joens, Thomas, Braicu, Elena Ioana, Dimitrova, Desislava, Mellstedt, Håkan, Darb-Esfahani, Silvia, Denkert, Carsten, Lindhofer, Horst, Fotopoulou, Christina, and Sehouli, Jalid
- Abstract
Ovarian cancer (OC) recurrence constitutes a therapeutic dilemma with various novel targeted agents emerging that offer alternative treatment options. The aim of the present study was to evaluate and compare epithelial cell adhesion molecule (EpCAM) expression profiles in paired tumor samples of patients with OC relapse.EpCAM expression was analyzed by immunohistochemistry using the avidin-biotin-complex method on paraffin-embedded OC tissues obtained at primary surgery as well as on corresponding tumor samples of the same patients at relapse. The EpCAM overexpression was defined as 76% to 100% of tumor cells positively stained for EpCAM. Clinical data were collected within the Tumorbank Ovarian Cancer Network.Nineteen patients with serous OC histology were included in the study (median age at primary diagnosis, 50 years; range, 40-74 years). The majority of the patients (95%) presented with International Federation of Gynecology and Obstetrics stage III/IV, and 68.4% of the tumors were poorly differentiated. A complete macroscopic tumor resection could be achieved in 15 patients (78.9%) at diagnosis. Epithelial cell adhesion molecule overexpression was detected in 17 (89%) of the primary and 16 (84%) of the recurrent tumors (P = 1.0); hence, no significant change of the EpCAM expression profile could be identified over time.Epithelial cell adhesion molecule expression profile appears to remain stable during the course from the primary throughout the relapse of serous OC. The results indicate that EpCAM might be an interesting therapeutic target structure in serous OC. [ABSTRACT FROM AUTHOR]
- Published
- 2013
- Full Text
- View/download PDF
6. Archaeal Diversity at Two Hot Springs, Rupi Basin, Bulgaria
- Author
-
Tomova, Iva, Dimitrova, Desislava, Stoilova-Disheva, Margarita, Lyutskanova, Dimitrina, and Kambourova, Margarita
- Abstract
ABSTRACTArchaea is the newest and the least understood domain which diversity and physiology are predominantly suggested after investigation of natural ecosystems. Recently many new archaeal groups have been detected by molecular phylogenetic methods. Diversity of thermophilic archaea in two hot springs at Rupi basin was studied by a culture-independent approach and high degree of covering biological diversity was reached in both clone libraries (RB and RB2). The 16S rRNA gene analysis of 379 clones grouped in 33 restriction profiles for each library showed presence of eleven groups from the domain Archaea, five of them being common for both springs. The retrieved sequences grouped together predominantly with environmental sequences and a small number of already known culturable Archaea was detected. A strong domination of HWCG III (Hot Water Crenarcheotic Group) was observed in both springs revealing strong domination of ammonia oxidizing metabolism. Although the difference in temperature between the two springs was only seven degrees, presence of hyperthermophiles was registered in the warmer spring. Four of the RB and nine of the RB2 sequences showed less than 97% similarity to the closest neighbour and were referred as representing new phylogenetic units.
- Published
- 2011
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.