123 results on '"Ding, Xu"'
Search Results
2. Multidisciplinary and multiscale nanoscience research roadmap based on large scientific facilities
- Author
-
Zeng, Yuan, Zhang, Shuhan, Guo, Yuecong, Cong, Yalin, Ding, Xu, Li, Peihua, Lin, Yunxiang, Ren, Wenzhi, Su, Hui, Sun, Weigang, Xu, Liuxin, Zhang, Guikai, Chen, Shihua, Chen, Yu, Cheng, Weiren, Chu, Shengqi, Guan, Yong, Han, Jinru, Lin, Jie, Liu, Hengjie, Liu, Zheyi, Luo, Pan, Meng, Fanchun, Qiao, Sicong, Song, Zongyin, Wang, Ying, Wu, Zhao, Yang, Chenyu, Yang, Meng, Yang, Shirui, Yin, Zi, Yin, Zhibin, Zhang, Pengjun, Zhang, Hongyu, Zheng, Pingping, Zhou, Jia, Zhou, Wanlin, An, Pengfei, Cheng, He, Fan, Chunhai, Huang, Xingjiu, Lei, Yong, Li, Lina, Li, Mu, Liu, Qinghua, Peng, Shuming, Song, Li, Sun, Zhihu, Tian, Yangchao, Wang, Fangjun, Wang, Lihua, Wang, Liming, Wei, Shiqiang, Wu, Aiguo, Xiao, Chunlei, Yang, Xueming, Yin, Panchao, Zhang, Jing, Zhang, Mingxin, Wang, Yaling, and Chen, Chunying
- Abstract
With the advancement of modern science and technology, large scientific facilities are increasingly oriented toward demand and application, and can be used for basic research as well as serving multiple disciplines. Developing large scientific facilities and related analytical technologies enhances understanding of large scientific facilities and popularizes their application in research across multiple disciplines. The combination of light or neutron sources from large scientific facilities and advanced analytical technologies can be achieved for materials structure information, dynamics study of chemical reactions, high dissociation of biomolecules, 3D visualization of energy materials or biological samples, etc. We first introduce the progress of domestic large scientific facilities of synchrotron radiation (SR) and free electron lasers (FELs) with different wavelengths and neutron sources. We further discuss the comparison between Chinese and typical foreign facilities in X-ray radiation from X-ray tubes, synchrotrons, X-ray FELs, and neutron sources based on physical parameters of light and neutron sources. In addition, we focus on the technological progress and perspectives combined with advanced X-ray radiation and neutron sources of large scientific facilities in China, especially in the nanoscience fields of energy catalysis and biological science. We hope that this roadmap will provide references on technology and methods to experimental users, as well as prospects for future development of technologies based on large research infrastructure facilities. Comprehensive studies and guidelines for basic research to practical application in various disciplines can be made with the assistance of large scientific facilities.
- Published
- 2024
- Full Text
- View/download PDF
3. Multiscale structural engineering of cobalt single-atom catalyst for highly efficient photocatalytic CO2reduction
- Author
-
Wang, Yuhui, Zheng, Tianyu, Jin, Yucheng, Sun, Tingting, Ding, Xu, Wang, Xiao, Xu, Qingmei, Li, Tongxuan, Zhang, Shaolong, and Jiang, Jianzhuang
- Abstract
Artificial photosynthesis, which converts CO2into value-added chemicals and fuels, is of enormous potential in overcoming both global environmental problems and energy crisis. However, the development of CO2photoconversion catalysts with high efficiency remains a great challenge due to the thermodynamic stability and dynamics sluggishness of CO2. Herein, a superior hierarchical porous cobalt single-atom photocatalyst featuring highly dispersed Co isolated single atomic sites on micro-mesoporous nitrogen-doped carbon (0.8-Co-ISAS/MMNC-900) is developed and characterized, which significantly boosts the photoreduction of CO2-to-CO. The 0.8-Co-ISAS/MMNC-900 catalyst achieves a high 7261 µmol g−1h−1CO formation rate, an impressive 90.1% CO selectivity, as well as an decent stability during four times cycling test, indicating a boosted CO2photoconversion property. Experimental data and theoretical results reveal that the hierarchically porous structure can promote the formation of exterior local electric field caused by charge separation as well as the synergic role of Co ISASs and micro-mesoporous configuration can facilitate photo-excited electron accumulation, CO2adsorption and activation, and *COOH intermediate formation. This work develops a novel strategy to synthesize superior photocatalysts for CO2reduction through multiscale porous structural engineering.
- Published
- 2024
- Full Text
- View/download PDF
4. Single Cobalt Ion-Immobilized Covalent Organic Framework for Lithium–Sulfur Batteries with Enhanced Rate Capabilities.
- Author
-
Liu, Xiaolin, Ding, Xu, Zheng, Tianyu, Jin, Yucheng, Wang, Hailong, Yang, Xiya, Yu, Baoqiu, and Jiang, Jianzhuang
- Published
- 2024
- Full Text
- View/download PDF
5. Rim plate fixation for a rare fracture pattern of the lateral femoral condyle: A case report.
- Author
-
Hanrong Xu, Ding Xu, Yinjiang Lu, and Jiong Lin
- Published
- 2024
- Full Text
- View/download PDF
6. Two-Dimensional Kagome Covalent Organic Frameworks with Single Atomic Co Sites for Superior Photocatalytic CO2 Reduction.
- Author
-
Wang, Yuhui, Sun, Tingting, Zheng, Tianyu, Ding, Xu, Zhang, Pianpian, Xu, Qingmei, Li, Tongxuan, Zhang, Shaolong, Wang, Kang, Xu, Lianbin, and Jiang, Jianzhuang
- Published
- 2024
- Full Text
- View/download PDF
7. Green Synthesis of PtPdNiFeCu High-Entropy Alloy Nanoparticles for Glucose Detection.
- Author
-
Wang, Fengxia, Feng, Xin, Gao, Yanting, Ding, Xu, Wang, Wei, and Zhang, Ji
- Published
- 2023
- Full Text
- View/download PDF
8. An Intelligent Fault Diagnosis Framework for Rolling Bearings With Integrated Feature Extraction and Ordering-Based Causal Discovery
- Author
-
Ding, Xu, Wang, Junlong, Wu, Hao, Xu, Juan, and Xin, Miao
- Abstract
Recent advancements in data-driven deep-learning methods have significantly improved rolling bearing fault diagnosis. However, these frameworks face limitations due to data defects and inadequate feature extraction. To overcome these obstacles, this article proposes a novel feature extraction and causal model-based diagnosis framework. This framework leverages causal discovery to derive causal models from real data, accurately estimate causal effects, and enhance fault diagnosis performance. Specifically, the proposed framework utilizes the time-reassigned synchrosqueezing transform (TSST) to process collected rolling bearing signals, transforming them from the time domain to the time–frequency (TF) domain. This transformation enables the extraction of energy distribution and frequency components of vibration signals at different frequencies, effectively reducing noise interference. Subsequently, a directed acyclic graph (DAG) is constructed using an ordering-based causal discovery method to identify potential interfering factors that may impact vibration signals, facilitating causal effects estimation. Furthermore, by integrating the vision transformer (ViT) network with causal effects estimation techniques, the framework achieves end-to-end rolling bearing fault diagnosis. Experimental results on laboratory-bearing datasets demonstrate the superior performance of this proposed fault diagnosis framework compared to existing methods.
- Published
- 2024
- Full Text
- View/download PDF
9. Generative Zero-Shot Compound Fault Diagnosis Based on Semantic Alignment
- Author
-
Xu, Juan, Kong, Hui, Li, Kang, and Ding, Xu
- Abstract
Fault diagnosis of bearings plays a critical role in the predictive maintenance and health management of mechanical equipment. However, compound faults diagnosis of bearings remains a challenging task, because compound faults are coupled together by multiple single faults, which are difficult to decouple and identify. In addition, in industrial scenarios, collecting sufficient compound fault samples for model training is unrealistic. To address these issues, we propose a generative zero-shot compound fault diagnosis model based on semantic alignment. The model includes a semantic alignment module, feature extraction module, generative adversarial module, and classification module. First, we propose a feature extractor that combines channel and spatial attention mechanisms to extract fault features from the original vibration signals. Second, we designed a novel fault semantic construction method that combines interpretable priori fault semantics in time–frequency domain and hidden feature distribution alignment. Third, in the generative adversarial module, we combine supervised contrastive loss and comparator into the improved Wasserstein generative adversarial networks with gradient penalty (WGANs_GP) to learn the mapping relationship between fault semantics and fault features. Finally, we use the pseudocompound faults features generated by the generator to train a classifier for classifying ground-truth unseen compound fault. The effectiveness of the proposed method is verified on a self-built bearing test bench, and the results show that the proposed model can achieve classification accuracy of 89.25% for compound faults under the condition of only using single-fault samples for training.
- Published
- 2024
- Full Text
- View/download PDF
10. The effect of the third component on high performance ternary organic solar cells: A review
- Author
-
Ding, Xu and Li, Zhenye
- Abstract
In recent years, with the continuous development of photoactive layer material, the power conversion efficiency (PCE) of bulk heterojunction (BHJ) binary organic solar cells (BOSCs) has been significantly improved. However, it is difficult for BOSCs to maximize the effective utilization of the wide spectrum of solar energy, limiting the further improvement of PCE. Adding a third component to BOSCs that constructing ternary organic solar cells (TOSCs) is an effective method to broaden the absorption spectrum of BOSC, match the gradient energy level, and regulate the morphology of the active layer. Constructing TOSCs can not only effectively improve the device performance, but also maintain the advantages of easy‐to‐fabricate single‐junction device structures. In this review, we first introduced the basic working mechanism of TOSCs. Then based on the working mechanism, we comprehensively reviewed the latest research results of TOSCs, and analyzed the effects of the third component on the microscopic morphology of the active layer, photovoltaic performance and device stability. Finally, we systematically summarized the role of the third component in TOSCs and proposed some future development trends of TOSCs, such as designing and synthesizing more economical, green, and environmentally friendly TOSCs that towards the commercial application in the future.
- Published
- 2023
- Full Text
- View/download PDF
11. Quantifying the Growth and Evolution of Particle Cracking in Mo2C Anode with Different Cycles Using Soft X‑ray Imaging.
- Author
-
Ding, Xu, Zhu, Shuang, Tao, Xia-Yu, Chu, WangSheng, Wu, Zhao, Liu, Gang, Guan, Yong, and Tian, YangChao
- Published
- 2023
- Full Text
- View/download PDF
12. Observation of Interpenetrated Topology Isomerism for Covalent Organic Frameworks with Atom-Resolution Single Crystal Structures.
- Author
-
Yu, Baoqiu, Li, Wenliang, Wang, Xiao, Li, Jing-Hong, Lin, Rui-Biao, Wang, Hailong, Ding, Xu, Jin, Yucheng, Yang, Xiya, Wu, Hui, Zhou, Wei, Zhang, Jingping, and Jiang, Jianzhuang
- Published
- 2023
- Full Text
- View/download PDF
13. Quantifying the Growth and Evolution of Particle Cracking in Mo2C Anode with Different Cycles Using Soft X-ray Imaging
- Author
-
Ding, Xu, Zhu, Shuang, Tao, Xia-Yu, Chu, WangSheng, Wu, Zhao, Liu, Gang, Guan, Yong, and Tian, YangChao
- Abstract
Mechanical properties play a crucial role in the degradation of battery performance, and a comprehensive understanding of particle crack formation is vital for optimizing battery materials. Here, we focus on Mo2C, a promising anode material for lithium-ion batteries, and we employ soft X-ray tomography to observe the internal structure of Mo2C particles at different cycle numbers. The growth and evolution of cracking have been quantified by analyzing the porosity and morphological complexity of the particles based on the reconstruction images. Furthermore, considering the tendency for hole formation during particle preparation, we investigate the impact of such defects on crack propagation and the evolution of cracking. Irreversible cracking during cell operation can significantly contribute to the degradation of the Mo2C anode performance. In addition, the presence of internal defects in the particles influences the direction of crack propagation and intensifies the evolution of cracking. This study offers valuable insights into the synthesis and modification strategies for Mo2C materials, which can help enhance battery performance.
- Published
- 2023
- Full Text
- View/download PDF
14. Observation of Interpenetrated Topology Isomerism for Covalent Organic Frameworks with Atom-Resolution Single Crystal Structures
- Author
-
Yu, Baoqiu, Li, Wenliang, Wang, Xiao, Li, Jing-Hong, Lin, Rui-Biao, Wang, Hailong, Ding, Xu, Jin, Yucheng, Yang, Xiya, Wu, Hui, Zhou, Wei, Zhang, Jingping, and Jiang, Jianzhuang
- Abstract
Rational control and understanding of isomerism are of significance but still remain a great challenge in reticular frameworks, in particular, for covalent organic frameworks (COFs) due to the complicated synthesis and energy factors. Herein, reaction of 3,3′,5,5′-tetra(4-formylphenyl)-2,2′,6,6′-tetramethoxy-1,1′-biphenyl (TFTB) with 3,3′,5,5′-tetrakis(4-aminophenyl)bimesityl (TAPB) under different reaction conditions affords single crystals of two 3D COF isomers, namely, USTB-20-dia and USTB-20-qtz. Their structures with resolutions up to 0.9–1.1 Å have been directly solved by three-dimensional electron diffraction (3D ED) and synchrotron single crystal X-ray diffraction, respectively. USTB-20-dia and USTB-20-qtz show rare 2 × 2-fold interpenetrated dia-bnets and 3-fold interpenetrated qtz-bframeworks. Comparative studies of the crystal structures of these COFs and theoretical simulation results indicate the crucial role of the flexible molecular configurations of building blocks in the present interpenetrated topology isomerism. This work not only presents the rare COF isomers but also gains an understanding of the formation of framework isomerism from both single crystal structures and theoretical simulation perspectives.
- Published
- 2023
- Full Text
- View/download PDF
15. Effect of simulated digestion in vitro on the rheology and biological activity of Lilium davidii var.unicolor SalisbPolysaccharide
- Author
-
Tian, Wenjing, Ding, Xu, Shi, Jinhan, Jiang, Feifei, Ding, Ling, Zhao, Baotang, Wang, Fengxia, and Zhang, Ji
- Abstract
Graphical abstract:
- Published
- 2023
- Full Text
- View/download PDF
16. Intraoral versus transcervical approaches in mandibular reconstruction with free flaps: A retrospective study.
- Author
-
Wang, Zhuo, Miao, Dongqing, Wan, Jinbo, Ding, Xu, Song, Xiaomeng, Wu, Heming, Yuan, Hua, Du, Yifei, and Wang, Yuli
- Subjects
MANDIBLE surgery ,FREE flaps ,SURGICAL blood loss ,BODY mass index - Abstract
This study aims to investigate the clinical and functional differences between intraoral and transcervical approaches for segmental mandible resection and reconstruction with free flaps. Patients diagnosed as benign and low-grade mandibular malignant tumors without neck dissections were retrospectively reviewed and divided into intraoral and transcervical groups. Patients of intraoral group underwent intraoral mandibulectomy and vascular anastomosis was performed through a 2-cm submandibular incision, while traditional submandibular approach was used in transcervical group. Clinical characteristics of two groups were assessed including body mass index (BMI), defect types and number of fibular segments, as well as perioperative variables such as operation time, blood loss, drainage volume. The score of appearance, swallowing and speech using the University of Washington Quality of Life Questionnaire (UW-QOL) was recorded and analyzed 6-month postoperatively. A total of 14 patients in intraoral group and 21 patients in transcervical group was collected, respectively. In intraoral group, intraoperative blood loss and postoperative drainage volume were significantly reduced in comparison with transcervical group (p = 0.0146, p = 0.0017; respectively). The score of appearance was 87.50 ± 12.97 in intraoral group, which was significantly higher than 64.29 ± 12.68 in transcervical group (p < 0.0001). Similar results were found in patients of subtype Class II mandibular defect between two groups. However, patients of intraoral group had a significant increase in operative time and a comparable amount of intraoperative blood loss (p = 0.0472, p = 0.1434; respectively). Within the limitations of the study it seems that an intraoral approach combined with a 2-cm submandibular incision should be preferred over a transcervical approach for segmental mandibulectomy and free flap reconstruction whenever appropriate. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
17. Two-Dimensional Porphyrin-Based Covalent Organic Framework with Enlarged Inter-layer Spacing for Tunable Photocatalytic CO2 Reduction.
- Author
-
Wang, Xinxin, Ding, Xu, Wang, Tianyu, Wang, Kang, Jin, Yucheng, Han, Yuesheng, Zhang, Pianpian, Li, Ning, Wang, Hailong, and Jiang, Jianzhuang
- Published
- 2022
- Full Text
- View/download PDF
18. ARID2 mitigates hepatic steatosis via promoting the ubiquitination of JAK2
- Author
-
Cao, Hui-Jun, Jiang, Hao, Ding, Kai, Qiu, Xiao-Song, Ma, Ning, Zhang, Feng-Kun, Wang, Yi-Kang, Zheng, Qian-Wen, Xia, Ji, Ni, Qian-Zhi, Xu, Sheng, Zhu, Bing, Ding, Xu-Fen, Chen, Tian-Wei, Qiu, Lin, Chen, Wei, Li, Zhi-Gang, Zhou, Bin, Feng, Wen-Ming, Xie, Dong, and Li, Jing-Jing
- Abstract
Non-alcoholic fatty liver disease (NAFLD) has become a growing public health problem. However, the complicated pathogenesis of NAFLD contributes to the deficiency of effective clinical treatment. Here, we demonstrated that liver-specific loss of Arid2induced hepatic steatosis and this progression could be exacerbated by HFD. Mechanistic study revealed that ARID2 repressed JAK2-STAT5-PPARγ signaling pathway by promoting the ubiquitination of JAK2, which was mediated by NEDD4L, a novel E3 ligase for JAK2. ChIP assay revealed that ARID2 recruited CARM1 to increase H3R17me2a level at the NEDD4L promoter and activated the transcription of NEDD4L. Moreover, inhibition of Jak2 by Fedratinib in liver-specific Arid2knockout mice alleviated HFD-induced hepatic steatosis. Downregulation of ARID2 and the reverse correlation between ARID2 and JAK2 were also observed in clinical samples. Therefore, our study has revealed an important role of ARID2 in the development of NAFLD and provided a potential therapeutic strategy for NAFLD.
- Published
- 2023
- Full Text
- View/download PDF
19. Topochemical polymerization of hydrogen-bonded organic framework for supporting ultrafine palladium nanoparticles
- Author
-
Ding, Xu, Han, Bin, Yu, Baoqiu, Wang, Hailong, and Jiang, Jianzhuang
- Abstract
Topochemical polymerization of molecular crystals into porous materials is of significance due to their promising applications in the field of adsorption and catalysis, yet rarely reported due to the synthesis difficulty. Herein, a hydrogen-bonded organic framework (HOF-45) has been fabricated by the crystallization of a cage-like building block containing three alkynyl groups. It exhibits almost mesoporous structure demonstrated by single crystal X-ray diffraction study. Light-driven topochemical polymerization of HOF-45 with ethanedithiol covalently links alkynyl groups in HOF-45, generating a hydrogen-bond and covalent-bond cross-linked material (HOF-45C). In contrast to HOF-45, cross-linked HOF-45C retains the crystalline nature and displays improved solution resistence according to the powder X-ray diffraction data. In particular, HOF-45C is able to support the growth of ultrafine palladium nanoparticles with the average size of ca. 1.9 nm for rapidly promoting the degradation of nitrophenol, methyl orange, and congo red with the help of NaBH4as well as Suzuki-Miyaura coupling reaction. This work inputs a new idea on the HOFs application in preparing covalent-linked porous organic materials.
- Published
- 2023
- Full Text
- View/download PDF
20. Coordinated planning transmission tasks in heterogeneous space networks: A semi-distributed approach
- Author
-
Liu, Runzi, Wu, Weihua, Zhao, Zhongyuan, Ding, Xu, Zhou, Di, and Zhang, Yan
- Abstract
This paper studies the coordinated planning of transmission tasks in the heterogeneous space networks to enable efficient sharing of ground stations cross satellite systems. Specifically, we first formulate the coordinated planning problem into a mixed integer liner programming (MILP) problem based on time expanded graph. Then, the problem is transferred and reformulated into a consensus optimization framework which can be solved by satellite systems parallelly. With alternating direction method of multipliers (ADMM), a semi-distributed coordinated transmission task planning algorithm is proposed, in which each satellite system plans its own tasks based on local information and limited communication with the coordination center. Simulation results demonstrate that compared with the centralized and fully-distributed methods, the proposed semi-distributed coordinated method can strike a better balance among task complete rate, complexity, and the amount of information required to be exchanged.
- Published
- 2023
- Full Text
- View/download PDF
21. Data sharing based on conflict graph and clustering in VANET
- Author
-
Ding, Xu, Zheng, Xiang, Zhang, Bixun, Xu, Pengfei, and Shi, Lei
- Abstract
Efficient data sharing in autonomous driving is expected to improve road safety. However, time-varying network topologies, limited roadside unit (RSU) coverage, and communication limitations make efficient data sharing challenging. Therefore, we propose an RSU-assisted hybrid scheduling (RAHC) scheme, including centralised scheduling within the RSU and self-organised scheduling in the RSU blind zone. For centralised scheduling, we model data transmission and transmission conflicts as conflict graph based on real-time network topology, and solve for optimal transmission paths while satisfying communication constraints, and increase the chance for vehicles in RSU blind areas to obtain data by carrying and forwarding data. For self-organised scheduling, we use degree of link similarity (DLS) to cluster vehicles and select the vehicle with the largest service capacity (SC) in the cluster to serve the opposite vehicle. This reduces duplication and redundancy of data transmission and improves sharing efficiency. Simulation results demonstrate the superiority of the solution.
- Published
- 2023
- Full Text
- View/download PDF
22. Tau suppresses microtubule-regulated pancreatic insulin secretion
- Author
-
Mangiafico, Salvatore P., Tuo, Qing-Zhang, Li, Xiao-Lan, Liu, Yu, Haralambous, Christian, Ding, Xu-Long, Ayton, Scott, Wang, Qing, Laybutt, D. Ross, Chan, Jeng Yie, Zhang, Xiang, Kos, Cameron, Thomas, Helen E., Loudovaris, Thomas, Yang, Chieh-Hsin, Joannides, Christos N., Lamont, Benjamin J., Dai, Lunzhi, He, Hai-Huai, Dong, Biao, Andrikopoulos, Sofianos, Bush, Ashley I., and Lei, Peng
- Abstract
Tau protein is implicated in the pathogenesis of Alzheimer’s disease (AD) and other tauopathies, but its physiological function is in debate. Mostly explored in the brain, tau is also expressed in the pancreas. We further explored the mechanism of tau’s involvement in the regulation of glucose-stimulated insulin secretion (GSIS) in islet β-cells, and established a potential relationship between type 2 diabetes mellitus (T2DM) and AD. We demonstrate that pancreatic tau is crucial for insulin secretion regulation and glucose homeostasis. Tau levels were found to be elevated in β-islet cells of patients with T2DM, and loss of tau enhanced insulin secretion in cell lines, drosophila, and mice. Pharmacological or genetic suppression of tau in the db/dbdiabetic mouse model normalized glucose levels by promoting insulin secretion and was recapitulated by pharmacological inhibition of microtubule assembly. Clinical studies further showed that serum tau protein was positively correlated with blood glucose levels in healthy controls, which was lost in AD. These findings present tau as a common therapeutic target between AD and T2DM.
- Published
- 2023
- Full Text
- View/download PDF
23. Lithospheric thinning of the North China craton: Insights from Early Cretaceous intermediate–mafic dyke swarms in Jiaodong peninsula.
- Author
-
Ji, Lei, Liu, Junlai, Ding, Xu, Luo, Zhiming, Ni, Jinlong, Shi, Xiaoxiao, and Nam Dao, Hai
- Abstract
[Display omitted] • Intermediate–mafic dyke swarms in Jiaodong peninsula are dated (122–121 Ma). • The dykes were formed in a WNW-ESE oriented extensional stress field. • Tectono-magmatic processes at crust–mantle depths were decoupled along the Moho. • Destruction of the lithospheric keel in southeastern NCC occurred at 122–120 Ma. • Tectonic extension acted as the major driving force for destruction of the craton. The coupling/decoupling relationships between shallow crustal deformation and deep mantle tectono-magmatic activities, during lithospheric thinning and destruction of cratons, remain hotly debated in the last decades. Multidisciplinary studies were done on intermediate–mafic dyke swarms diffusively located in southern Jiaodong peninsula, southeastern North China craton (NCC) to explore the crustal and lithospheric mantle responses to regional tectonic extension. Uniform ages (122–121 Ma) of the dykes indicate intensive magma generation at the mantle depth around 122 Ma related to large-scale tectonic extension of regional lithospheric mantle. Systemic anisotropy of magnetic susceptibility (AMS), geochemical, and Sr-Nd isotope analyses suggest that the dykes were originated from enriched lithospheric mantle sources and emplaced along crustal fractures formed in a WNW-ESE oriented extensional stress field. We show that the Jiaodong lithosphere experienced two stages of Early Cretaceous tectonic evolution, i.e., an early stage (135–122 Ma) lithospheric thinning characterized by large-scale tectonic extension of the crust and limited magmatic activities of crustal sources, and a late stage (122–108 Ma) lithospheric root collapse dominated by intensive tectonic extension and magmatism in the lithospheric mantle level. The decoupling crust-mantle evolution during lithospheric thinning and destruction of the NCC is ascribed to continuous tectonic extension in WNW-ESE direction. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
24. Two-Dimensional Porphyrin-Based Covalent Organic Framework with Enlarged Inter-layer Spacing for Tunable Photocatalytic CO2Reduction
- Author
-
Wang, Xinxin, Ding, Xu, Wang, Tianyu, Wang, Kang, Jin, Yucheng, Han, Yuesheng, Zhang, Pianpian, Li, Ning, Wang, Hailong, and Jiang, Jianzhuang
- Abstract
Two-dimensional (2D) porphyrin-based covalent organic frameworks (COFs) are one of the most promising candidates for photocatalytic carbon dioxide reduction reaction (CO2RR), which however still suffer from the hindered mass transfer during the catalysis procedure associated with the close packing of 2D COF layers due to the strong axial π–π stacking. Herein, condensation between the porphyrinic aldehydes p-MPor-CHO (M = H2, Co, and Ni) and 3,8-diamino-6-phenyl-phenanthridine (DPP) affords new porphyrin-based 2D COF architecture MPor-DPP-COFs (M = H2, Co, and Ni). The bulky phenyl substituent at the phenanthridine periphery of the linking unit reduces the axial π–π stacking, providing an enlarged inter-layer spacing of 6.0 Å according to high-resolution transmission electron microscopy. This, in combination with the large surface area (1021 m2g–1) revealed by nitrogen sorption measurements at 77 K for CoPor-DPP-COF possessing electroactive Co ions, endows it with excellent photocatalytic activity for CO2RR with a CO generation rate of 10 200 μmol g–1h–1and a CO selectivity up to 82%. This work affords new ideas for achieving efficient photocatalytic CO2RR upon fine-tuning the inter-layer spacing of 2D COFs.
- Published
- 2022
- Full Text
- View/download PDF
25. Dark-Exciton Driven Energy Funneling into Dielectric Inhomogeneities in Two-Dimensional Semiconductors.
- Author
-
Haowen Su, Ding Xu, Shan-Wen Cheng, Baichang Li, Song Liu, Kenji Watanabe, Takashi Taniguchi, Berkelbach, Timothy C., Hone, James C., and Delor, Milan
- Published
- 2022
- Full Text
- View/download PDF
26. Online Task Scheduling Algorithm with Complex Dependencies in Edge Computing.
- Author
-
Shi, Lei, Ma, Zhaoxing, Fan, Yuqi, Shi, Yi, Ding, Xu, and Li, Zhehao
- Subjects
EDGE computing ,ALGORITHMS ,TASKS ,SCHEDULING ,PROBLEM solving ,ONLINE algorithms - Abstract
In the edge computing network environment, our applications can be deployed on edge servers. The request to execute the application can be produced on the edge device and transmitted to the edge server for calculation. A complex request may be divided into multiple computing tasks and transmitted to different servers and then parallel calculated before obtaining the final result. How to schedule computing tasks in multiple requests so that all requests can be completed faster is a difficult problem, especially in the edge computing environment where we should consider the communicating work and the calculating work simultaneously. In this paper, we first build a task dependency model of the computing tasks included in the request based on the idea of dividing the method components of the application. The dependencies include sequence, selection and parallel. Then we propose an online scheduling algorithm MCOS based on optimizing the task with the maximum amount of calculation to solve the problem of the minimum sum of the completion time of all requests. In simulations, we show the algorithm MCOS has a better completion time. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
27. Spacer Side-wall Processed 0.15 μm GaN HEMT for Ka-band Application
- Author
-
Zhang, Lixing, Lv, Beibei, Ding, Xu, Yu, Faxin, Wang, Zhiyu, and Mo, Jiongjiong
- Abstract
In this paper, we have effectively demonstrated 150 nm-gate-length AlGaN/GaN high electron mobility transistors (HEMTs) on 4-inch SiC substrate. The 150 nm gate-length was accomplished by utilizing traditional I-line stepper photolithography, together with a nitride spacer side-wall. This method offers superior processing efficiency compared to E-beam lithography with high wafer uniformity. The devices processed with this spacer side-wall aided method demonstrated comparable electrical performances as that of E-beam processed one with fTof 45 GHz, fMAXof 80 GHz, Pout of 31 dBm and PAE of 45% at 29 GHz, which can be imported to large scale manufacturing.
- Published
- 2024
- Full Text
- View/download PDF
28. Porphyrin Coordination Polymer with Dual Photocatalytic Sites for Efficient Carbon Dioxide Reduction.
- Author
-
Ding, Xu, Yu, Baoqiu, Han, Bin, Wang, Hailong, Zheng, Tianyu, Chen, Baotong, Wang, Jian, Yu, Zonghua, Sun, Tingting, Fu, Xianzhang, Qi, Dongdong, and Jiang, Jianzhuang
- Published
- 2022
- Full Text
- View/download PDF
29. Asymmetric Reductive Amination of Structurally Diverse Ketones with Ammonia Using a Spectrum-Extended Amine Dehydrogenase.
- Author
-
Wang, Dong-Hao, Chen, Qi, Yin, Sai-Nan, Ding, Xu-Wei, Zheng, Yu-Cong, Zhang, Zhi, Zhang, Yu-Hui, Chen, Fei-Fei, Xu, Jian-He, and Zheng, Gao-Wei
- Published
- 2021
- Full Text
- View/download PDF
30. A tetraaldehyde-derived porous organic cage and covalent organic frameworks: Syntheses, structures, and iodine vapor capture
- Author
-
Cao, Xinyi, Jin, Yucheng, Wang, Hailong, Ding, Xu, Liu, Xiaolin, Yu, Baoqiu, Zhan, Xiaoning, and Jiang, Jianzhuang
- Abstract
Dynamic covalent imine reactions between 2′,3′-dimethoxy-[1,1′:4′,1″-terphenyl]-3,3″,5,5″-tetracarbaldehyde (DMTT) and cyclohexanediamine, p-phenylenediamine, and benzidine, respectively, generate a porous organic cage (DMPOC) and two covalent organic frameworks (COFs), USTB-29, and USTB-30. DMPOC shows a [3 + 6] topological cage-like structure according to single crystal X-ray diffraction result. In contrast, both microcrystalline USTB-29 and USTB-30 exhibit two-dimensional monoporous structures in an eclipsed AA stacking style based on powder X-ray diffraction and theoretical simulations. In addition, DMPOC is capable of efficiently absorbing the iodine vapor with an outstanding uptake of 5.10 g/g, much higher than that of USTB-29 (3.07 g/g) and USTB-30 (3.16 g/g). Cage to COFs transformations have been realized from DMPOC to USTB-29 and USTB-30 viathe imine bond exchange with slightly increased iodine vapor uptake. Mechanism investigations uncover that both nitrogen and oxygen atoms of POC and COFs contribute to iodine vapor capture due to the formation of charge transfer matter, and loose interaction introducing adaptive expanding voids of DMPOC is suggested to capture more iodine vapor than that of COFs with strong π-πinteractions.
- Published
- 2024
- Full Text
- View/download PDF
31. Postoperative morbidity and mortality after anterior resection with preventive diverting loop ileostomy versus loop colostomy for rectal cancer: A updated systematic review and meta-analysis.
- Author
-
Du, Rui, Zhou, Jiajie, Tong, Guifan, Chang, Yue, Li, Dongliang, Wang, Feng, Ding, Xu, Zhang, Qi, Wang, Wei, Wang, Liuhua, and Wang, Daorong
- Subjects
RECTAL cancer ,COLOSTOMY ,ILEOSTOMY ,SURGICAL site infections ,RANDOMIZED controlled trials ,DATABASE searching - Abstract
The purpose of this meta-analysis was to evaluate the perioperative morbidity after anterior resection with diverting loop ileostomy (LI) versus colostomy (LC) and its reversal for rectal cancer. The studies on the application of loop ileostomy versus loop colostomy in anterior resection published from January 2000 to January 2020 were searched in the databases of Pubmed, Embase, Cochrane library, and Clinical trials. All randomized controlled trials (RCTs) and cohort studies were included according to inclusion criteria. Eight studies (2 RCTs and 6 cohort studies) totaling 1451 patients (821 LI and 630 LC) were included in the meta-analysis. The morbidity related to stoma formation and closure did not demonstrate significant differences. Significantly more LCs were complicated by stoma prolapse & retraction (OR:0.26,95%CI:0.11–0.60,P = 0.001), parastomal hernia (OR = 0.52,95%CI:0.30–0.88, P = 0.01), surgical site infection (SSI) (OR = 0.24,95%CI:0.11–0.49,P < 0.0001) and incisional hernias (OR = 0.39,95%CI:0.19–0.83,P = 0.01) than by LIs. Patients with LI demonstrated significantly more complications related to the stoma, such as dehydration (OR = 0.52,95%CI:0.30–0.88, P = 0.01) and ileus (OR = 2.23,95%CI:1.12–4.43, P = 0.02) than patients with LC. While after the subgroup analysis of different publication years, LI could reduce the risk of the morbidity after stoma formation in previous years group (P = 0.04) with a lower heterogeneity (I
2 = 37%); LC could reduce the incidence of parastomal dermatitis in recent years group (P < 0.0001) without heterogeneity in each subgroup (I2 = 0%). Cumulative meta-analysis detected significant turning points in dehydration, SSI, and ileus. This meta-analysis recommends diverting LI in the anterior resection for rectal cancer, but there is a risk of dehydration, irritant dermatitis, and ileus. [ABSTRACT FROM AUTHOR]- Published
- 2021
- Full Text
- View/download PDF
32. Porphyrin Coordination Polymer with Dual Photocatalytic Sites for Efficient Carbon Dioxide Reduction
- Author
-
Ding, Xu, Yu, Baoqiu, Han, Bin, Wang, Hailong, Zheng, Tianyu, Chen, Baotong, Wang, Jian, Yu, Zonghua, Sun, Tingting, Fu, Xianzhang, Qi, Dongdong, and Jiang, Jianzhuang
- Abstract
The resurgence of visible light photocatalysis for carbon dioxide reduction reaction (CO2RR) has resulted in the generation of various homogeneous and heterogeneous paradigms. Herein, a new system has been established by incorporating dual catalytic sites into porous coordination polymer toward the photocatalysis of CO2RR. A functional ligand, 5,10,15,20-tetrakis[4′-(terpyridinyl)phenyl]porphyrin (TTPP), has been used to assemble discrete divalent nickel ions into the coordination polymer (TTPP-Ni) through metal bis(terpyridine) nodes. Both the porphyrin and terpyridine moieties prefer to bind with nickel ions, giving rise to TTPP-Ni with dual active catalytic sites. By controlling different molar ratios of ligand and metal and the reaction temperature, four samples including TTPP-Ni-n(n= 1, 2, 3, and 4) with different molar ratios of nickel porphyrin and nickel bis(terpyridine) subunits have been fabricated. The predesigned two-dimensional chemical structures of TTPP-Ni samples have been fully characterized using powder X-ray diffraction, X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and IR and UV–vis spectroscopies. The photocatalytic activities of these coordination polymers have been screened using [Ru(bpy)3]Cl2·6H2O as a photosensitizer together with triisopropanolamine as the sacrificial electron donor in CH3CN and H2O. Among these photocatalysts, TTPP-Ni-3 and TTPP-Ni-4 with almost saturated metal sites are able to display extraordinary photocatalytic performance including a CO generation rate of ca. 3900 μmol g–1h–1and 98% selectivity. The mechanism associated with dual active sites has been rationalized on the basis of theoretical simulations.
- Published
- 2022
- Full Text
- View/download PDF
33. PPDPF promotes lung adenocarcinoma progression via inhibiting apoptosis and NK cell-mediated cytotoxicity through STAT3
- Author
-
Zheng, Qian-Wen, Ni, Qian-Zhi, Zhu, Bing, Liang, Xin, Ma, Ning, Wang, Yi-Kang, Xu, Sheng, Cao, Hui-Jun, Xia, Ji, Zhang, Feng-Kun, Zhang, Er-Bin, Qiu, Xiao-Song, Ding, Xu-Fen, Qiu, Lin, Zhang, Xi-Lin, Dong, Zhao-Hui, Li, Zhi-Gang, Zhang, Xue-Li, Xie, Dong, and Li, Jing-Jing
- Abstract
Lung cancer is the most common malignancy and the leading cause of cancer death worldwide, and lung adenocarcinoma (LUAD) is the most prevalent subtype. Considering the emergence of resistance to therapies, it is urgent to develop more effective therapies to improve the prognosis. Here we reported that pancreatic progenitor cell differentiation and proliferation factor (PPDPF) deficiency inhibited LUAD development both in vitro and in vivo. Mechanistically, PPDPF induces hyperactive STAT3 by interfering STAT3-PTPN1 interaction. Activated STAT3 promoted BMPR2 transcription, which further inhibited apoptosis. Moreover, PPDPF reduced NK cell infiltration and activation to develop an immunosuppressive microenvironment, which was also mediated by STAT3. Furthermore, we identified that the expression of PPDPF was positively correlated with the malignant features of LUAD, as well as BMPR2 and p-STAT3 level in clinical samples. Therefore, our study suggests that PPDPF positively regulates BMPR2 expression and facilitates immune escape via regulating STAT3 activity, providing a potential therapy target for LUAD.
- Published
- 2022
- Full Text
- View/download PDF
34. Regulation of Semaphorin3A in the process of cutaneous wound healing
- Author
-
Zheng, Yang, Jiang, Feng, Wang, Chao, Dong, Mengjie, Wang, Chundi, Yan, Enshi, Wang, Yi, Zhu, Zaiou, Xiong, Xianbin, Ding, Xu, Ye, Jinhai, He, Yue, Zhang, Hongchuang, Zhou, Junbo, Zhang, Wei, Wu, Yunong, and Song, Xiaomeng
- Abstract
Semaphorin 3A (Sema3A) has been recognized as a crucial regulator of morphogenesis and homeostasis over a wide range of organ systems. However, its function in cutaneous wound healing is poorly understood. In our study, we demonstrated that Sema3A adenovirus plasmids transfection limited keratinocyte proliferation and decreased migrative capacity as assessed by in vitro wound healing assay. Sema3A transduction inhibited TGF-β1-mediated keratinocyte migration and EMT process. Besides, we applied mice with K14-Cre-mediated deletion of Sema3A and found that Sema3A depletion postponed wound closure with decreased re-epithelialization and matrix growth. Contrary to the results obtained with full-length Sema3A plasmids transfection, increased keratinocyte migration with recombinant Sema3A proteins resulted in quicker closure of the wounding area after a scratch. Further, exogenously applied recombinant Sema3A worked with EGF to maintain the activation of EGFR by interacting with NRP1 and thereby regulated the internalization of the EGFR-NRP1 complex. Taken together, these results indicated a paradoxical role of autonomous and non-autonomous Sema3A expression during wound healing. Combined administration of recombinant EGF and Sema3A proteins could accelerate the process of wound repair, thus providing promising treatment prospects in the future.
- Published
- 2022
- Full Text
- View/download PDF
35. Fundamental parameters for 30 faint open clusters with Gaia EDR3 based on the more reliable members
- Author
-
Ding, Xu, Ji, Kai-Fan, Li, Xu-Zhi, Cheng, Qi-Yuan, Wang, Jin-Liang, Yu, Xiao-Guang, and Liu, Hui
- Abstract
An open cluster is an ideal region to study the evolution of stars. In this work, we use Gaia Early Data Release 3 (Gaia EDR3) to derive the fundamental parameters of 30 faint open clusters listed in the catalogue given by Cantat-Gaudin et al. (2018, A&A, 618, A93), but the Gmagnitude of all of the member stars of that catalogue is brighter than ∼18 mag. This catalogue does not provide isochrone fitting parameters and spatial structure parameters. We acquired the member stars of 30 open clusters using the Density-Based Spatial Clustering of Applications with Noise algorithm in Gaia EDR3. The Gmagnitude of the member stars using our method can be found down to ∼21 mag. The G-band, GBP-band, and GRP-band data of the member stars construct a good color–magnitude diagram, which can further ensure the precision of isochrone fitting. We also calculated the spatial structure parameters, which are the core radius and the limiting radius, using Markov chain Monte Carlo algorithm.
- Published
- 2021
- Full Text
- View/download PDF
36. Adiabatic terminator for fermionic hierarchical equations of motion†
- Author
-
Zhang, Daochi, Ding, Xu, Zhang, Hou-Dao, Zheng, Xiao, and Yan, YiJing
- Published
- 2021
- Full Text
- View/download PDF
37. A machine-learning method to derive the parameters of contact binaries
- Author
-
Ding, Xu, Ji, Kai-Fan, and Li, Xu-Zhi
- Abstract
Contact binary stars are important research objects in astrophysics. The calculation speed of deriving the parameters of contact binaries with the Wilson–Devinney program and the Phoebe with Markov chain Monte Carlo (MCMC) program is relatively slow. It is unrealistic to derive the parameters in batches with the program for sky survey data. We obtain a neural network model of supervised learning with the training of synthetic light curves with Phoebe. We calculate the parameters of eight special targets from the simulated data and the Kepler data. Then, we generate the new light curve to fit the light curve of the special target base on these parameters. The correlation index R2of the fitting result is more than 0.98. The method can be used to fit the target which has orbital inclinations greater than 50°. By fitting the Kepler data and the observed data on the ground, the method has a good generalization ability to these targets, which have some noise and some starspots. The calculation speed of one light curve with this method is less than seconds. We can derive the parameters quickly in batches to undertake some statistical work for sky survey data with the method.
- Published
- 2021
- Full Text
- View/download PDF
38. Effects of Medication Use on Small Airway Function and Airway Inflammation in Patients with Clinically Controlled Asthma
- Author
-
Li, Yun, Yu, Hong-ying, Zhao, Kao-chuang, Ding, Xu-hong, Huang, Yi, Hu, Su-ping, and Nie, Han-xiang
- Abstract
Objective: To observe effects of medication use on small airway function, airway inflammation and acute exacerbations in patients with clinically controlled asthma. Methods: Forced expiratory flow over the middle half of the forced expiratory curve (FEF
25%–75% ), percentage of eosinophil, concentrations of eosinophil cationic protein (ECP) and interleukin (IL)-5 in induced sputum were assessed in patients with clinically controlled asthma who were given oral anti-inflammatory agents alone or in combination with inhaled therapy and inhaled therapy alone. Subsequently, acute exacerbations were compared between two groups during the 24-week follow-up period. Results: FEF25%–75% in 43 patients with clinically controlled asthma given oral anti-inflammatory agents alone or in combination with inhaled therapy was significantly higher than that in 49 patients given inhaled therapy alone. Meanwhile, the percentage of eosinophils and levels of IL-5 and ECP in patients with clinically controlled asthma given oral anti-inflammatory agents alone or in combination with inhaled therapy were significantly lower than those in patients given inhaled therapy alone. Additionally, the patients with clinically controlled asthma given inhaled therapy were likely to have more acute exacerbation than the patients given oral anti-inflammatory agents alone or in combination with inhaled therapy during the 24-week follow-up period. Conclusion: Systemic anti-inflammatory agents may have a greater effect on parameters reflecting small airway patency and reducing acute exacerbations, presumably secondary to reduction in airway inflammation.- Published
- 2021
- Full Text
- View/download PDF
39. Enhanced Safety and Antitumor Efficacy of Switchable Dual Chimeric Antigen Receptor-Engineered T Cells against Solid Tumors through a Synthetic Bifunctional PD-L1-Blocking Peptide.
- Author
-
Yang, Peiwei, Wang, Ying, Yao, Zheng, Gao, Xinmei, Liu, Chen, Wang, Xinmin, Wu, Heming, Ding, Xu, Hu, Jialiang, Lin, Bingjing, Li, Qian, Li, Mengwei, Li, Xin, Chen, Xiangying, Qi, Weiyan, Li, Weiguang, Xue, Jianpeng, and Xu, Hanmei
- Published
- 2020
- Full Text
- View/download PDF
40. The accumulation of ascorbic acid and lignin, and differential expression of ascorbic acid and lignin related-genes in yellow celery.
- Author
-
Ding, Xu, Liu, Jie-Xia, Xing, Guo-Ming, Chen, Long-Zheng, Sun, Sheng, Li, Sen, Feng, Kai, Duan, Ao-Qi, Yin, Lian, Shen, Di, Xu, Zhi-Sheng, and Xiong, Ai-Sheng
- Subjects
VITAMIN C ,CELERY ,LIGNINS ,GENETIC engineering ,GENE expression ,LIGNIN structure ,GENETIC regulation - Abstract
Increasing the level of AsA and maintaining proper lignin content will improve the quality of celery (Apium graveolens L.). However, the study on the regulation mechanism of genes related to AsA and lignin metabolism in celery was limited, especially in yellow celery. In this study, the accumulation of AsA and lignin and the expression profiles of related-genes were detected in three kinds of yellow celery. The results showed that the content of AsA was higher in the leaf blades of 'Huangtaiji' and the petioles of 'Jinhuangqincai'. The content of lignin was the highest in 'Jinhuangqincai' leaves, followed by 'Liuhehuangxinqin' and 'Huangtaiji'. The expression levels of AgAO (r = −0.032) and AgDHAR1 (r = −0.193) genes involved in AsA recycling and degradation showed negatively correlated with AsA content. AgCCoAOMT (r = 0.692) and AgF5 H (r = 0.733) genes expression were positively correlated with lignin content, while the expression of AgCAD (r = −0.694) and AgC3ʹH (r = −0.722) genes were negatively correlated with lignin content. Our current work provided potential theoretical basis for effectively changing accumulation of AsA and lignin by genetic engineering in celery. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
41. Two-Dimensional Covalent Organic Frameworks with Cobalt(II)-Phthalocyanine Sites for Efficient Electrocatalytic Carbon Dioxide Reduction
- Author
-
Han, Bin, Ding, Xu, Yu, Baoqiu, Wu, Hui, Zhou, Wei, Liu, Wenping, Wei, Chuangyu, Chen, Baotong, Qi, Dongdong, Wang, Hailong, Wang, Kang, Chen, Yanli, Chen, Banglin, and Jiang, Jianzhuang
- Abstract
The rapid development in synthesis methodology and applications for covalent organic frameworks (COFs) has been witnessed in recent years. However, the synthesis of highly stable functional COFs still remains a great challenge. Herein two-dimensional polyimide-linked phthalocyanine COFs (denoted as CoPc-PI-COF-1 and CoPc-PI-COF-2) have been devised and prepared through the solvothermal reaction of the tetraanhydrides of 2,3,9,10,16,17,23,24-octacarboxyphthalocyaninato cobalt(II) with 1,4-phenylenediamine and 4,4′-biphenyldiamine, respectively. The resultant CoPc-PI-COFs with a four-connected sql net exhibit AA stacking configurations according to powder X-ray diffraction studies, showing permanent porosity, thermal stability above 300 °C, and excellent resistance to a 12 M HCl aqueous solution for 20 days. Current–voltage curves reveal the conductivity of CoPc-PI-COF-1 and CoPc-PI-COF-2 with the value of 3.7 × 10–3and 1.6 × 10–3S m–1, respectively. Due to the same Co(II) electroactive sites together with similar permanent porosity and CO2adsorption capacity for CoPc-PI-COFs, the cathodes made up of COFs and carbon black display a similar CO2-to-CO Faradaic efficiency of 87–97% at applied potentials between −0.60 and −0.90 V (vs RHE) in 0.5 M KHCO3solution. However, in comparison with the CoPc-PI-COF-2&carbon black electrode, the CoPc-PI-COF-1 counterpart provides a larger current density (jCO) of −21.2 mA cm–2at −0.90 V associated with its higher conductivity. This cathode also has a high turnover number and turnover frequency, amounting to 277 000 and 2.2 s–1at −0.70 V during 40 h of measurement. The present result clearly discloses the great potential of 2D porous crystalline solids in electrocatalysis.
- Published
- 2021
- Full Text
- View/download PDF
42. EZH2 is associated with cartilage degeneration in osteoarthritis by promoting SDC1 expression viahistone methylation of the microRNA-138 promoter
- Author
-
Wang, Jian, Wang, Xiang, Ding, Xu, Huang, Tao, Song, Dengxin, and Tao, Hairong
- Abstract
Cartilage degeneration has been reported to deteriorate osteoarthritis (OA), a prevalent joint disease caused by intrinsic and epigenetic factors. This study aimed to examine the molecular mechanism of enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2)/microRNA-138 (miR-138)/syndecan 1 (SDC1) and its epigenetic regulation in cartilage degeneration in OA. An OA cell model was induced by stimulating chondrocytes with interleukin (IL)-1β at a final concentration of 10 ng/mL, followed by alterations in EZH2 and miR-138 expression. Afterwards, cell apoptosis was analyzed using flow cytometry. The expression patterns of cartilage catabolism-related factors (MMP-13, ADAMTS-4, and ADAMTS-5) were determined using RT-qPCR and western blot analyses. The EZH2 and H3K27me3 enrichment at the miR-138 promoter region were determined using ChIP-qPCR. Finally, an OA mouse model was constructed to verify the function of EZH2 in vivo. EZH2 was expressed at high levels in OA models. EZH2 depletion ameliorated OA, as evidenced by reduced cell apoptosis in IL-1β-treated chondrocytes and decreased levels of cartilage catabolism-related factors. Moreover, EZH2 promoted histone methylation at the miR-138 promoter to suppress miR-138 expression, thereby upregulating the expression of SDC1, a target gene of miR-138. Changes in this pathway increased the expression of cartilage catabolism-related factors in vitro while promoting cartilage degeneration in vivo. Our data provided evidence that EZH2 inhibits miR-138 expression by promoting the histone methylation of its promoter, which induces cartilage degeneration in OA models by upregulating SDC1 expression, suggesting a novel mechanistic strategy for OA treatment.
- Published
- 2021
- Full Text
- View/download PDF
43. Single Cobalt Ion-Immobilized Covalent Organic Framework for Lithium–Sulfur Batteries with Enhanced Rate Capabilities
- Author
-
Liu, Xiaolin, Ding, Xu, Zheng, Tianyu, Jin, Yucheng, Wang, Hailong, Yang, Xiya, Yu, Baoqiu, and Jiang, Jianzhuang
- Abstract
Covalent organic frameworks (COFs) are notable for their remarkable structure, function designability, and tailorability, as well as stability, and the introduction of “open metal sites” ensures the efficient binding of small molecules and activation of substrates for heterogeneous catalysis and energy storage. Herein, we use the postsynthetic metal sites to catalyze polysulfide conversion and to boost the binding affinity to active matter for lithium–sulfur batteries (LSBs). A dual-pore COF, USTB-27, with hxltopology has been successfully assembled from the imine chemical reaction between 2,3,8,9,14,15-hexa(4-formylphenyl)diquinoxalino [2,3-a:2′,3′-c]phenazine and [2,2′-bipyridine]-5,5′-diamine. The chelating nitrogen sites of both modules are able to postsynthetically functionalize with single cobalt sites to generate USTB-27-Co. The discharge capacity of the sulfur-loaded S@USTB-27-Co composite in a LSB is 1063, 945, 836, 765, 696, and 644 mA h g–1at current densities of 0.1, 0.2, 0.5, 1.0, 2.0, and 5.0 C, respectively, much superior to that of non-cobalt-functionalized species S@USTB-27. Following the increased current densities, the rate performance of S@USTB-27-Co is much better than that of S@USTB-27. In particular, the capacity retention at 5.0 C has a magnificent increase from 19% for the latter species to 61% for the former one. Moreover, S@USTB-27-Co exhibits a higher specific capacity of 543 mA h g–1than that of S@USTB-27 (402 mA h g–1) at a current density of 1.0 C after electrochemical cycling for 500 runs. This work illustrates the “open metal sites” strategy to engineer the active chemical component conversion in COF channels as well as their binding strength for specific applications.
- Published
- 2024
- Full Text
- View/download PDF
44. Optimizing Wireless Sensor Networks Based on Collaborative Beamforming.
- Author
-
Shi, Lei, Li, Zhehao, Ding, Xu, Xu, Juan, and Lv, Zengwei
- Subjects
DATA transmission systems ,WIRELESS sensor networks ,BEAMFORMING ,ANTENNA arrays ,INTERNET of things - Abstract
With the expansion of the scale of the Internet of Things, the transmission distance and speed of wireless networks need to be improved. Due to the limitation of power and energy of sensor nodes, data transmission is basically carried out by multi-hop relay. Collaborative beamforming is a technology that uses multiple sensor nodes to form a virtual antenna array to transmit high-gain and directional beams, which greatly enhances the transmission range. Compared with the muilt-hop network, collaborative beamforming can reduce the numbers of hop or even transmit data to the target node at one time, thus reducing the time required for routing and forwarding. This means that collaborative beamforming can transmit data more quickly and improve data throughput. In this paper, a brief introduction of cooperative beamforming is given. Then we propose an algorithm based on Collaborative beamforming. Simulation results show that the Collaborative beamforming wireless sensor networks can achieve better throughput compared with multi-hop networks. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
45. Low-Velocity Impact and Compression after Impact (CAI) Behaviors of Carbon-Aramid/Epoxy Hybrid Braided Composite Laminates.
- Author
-
CAO Hongxue, SUN Ying, TANG Mengyun, DING Xu, and CHEN Li
- Subjects
IMPACT (Mechanics) ,LAMINATED materials ,EPOXY coatings ,PEAK load ,COMPOSITE materials - Abstract
Low-velocity impact and in-plane axial compression after impact (CAI) behaviors of carbonaramid/epoxy hybrid braided composite laminates were investigated experimentally. The following three different types of carbon-aramid/epoxy hybrid braided composite laminates were produced and tested : (a) inter-hybrid laminates, (b) sandwich-like inter-hybrid laminates, and (c) unsymmetric-hybrid laminates. At the same time, carbon/epoxy braided composite laminates were used for comparisons. Impact properties and impact resistance were studied. Internal damages and damage mechanisms of laminates were detected by ultrasonic C-scan and B-scan methods. The results show that the ductility index (DI) values of three kinds of hybrid laminates aforementioned are 37%, 4% and 120% higher than those of carbon/epoxy laminates, respectively. The peak load of inter-hybrid laminates is higher than that of sandwich-like inter-hybrid laminates and unsymmetric-hybrid laminates. The average damage area and dent depths of inter-hybrid laminates are 64% and 69% smaller than those of carbon/epoxy laminates. Those results show that carbon-aramid/epoxy hybrid braided composite laminates could significantly improve the impact properties and toughness of non-hybrid braided composite laminates. [ABSTRACT FROM AUTHOR]
- Published
- 2020
46. Effect of mi-138 targeting PLD2 gene on proliferation and migration of oral cancer cells.
- Author
-
LI Huai-qi, YE Jin-hai, DING Xu, and WU He-ming
- Published
- 2020
- Full Text
- View/download PDF
47. Resource allocation in downlink SWIPT-based cooperative NOMA systems.
- Author
-
Longqi Wang and Ding Xu
- Subjects
WIRELESS power transmission ,RESOURCE allocation ,TIME management ,ENERGY harvesting ,POWER transmission ,QUALITY of service - Abstract
This paper considers a downlink multi-carrier cooperative non-orthogonal multiple access (NOMA) transmission, where no direct link exists between the far user and the base station (BS), and the communication between them only relies on the assist of the near user. Firstly, the BS sends a superimposed signal of the far and the near user to the near user, and then the near user adopts simultaneous wireless information and power transfer (SWIPT) to split the received superimposed signal into two portions for energy harvesting and information decoding respectively. Afterwards, the near user forwards the signal of the far user by utilizing the harvested energy. A minimum data is required to ensure the quality of service (QoS) of the far user. We jointly optimize power allocation, subcarrier allocation, time allocation, the power allocation (PA) coefficient and the power splitting (PS) ratio to maximize the number of data bits received at the near user under the energy causality constraint, the minimum data constraint and the transmission power constraint. The block-coordinate descent method and the Lagrange duality method are used to obtain a suboptimal solution of this optimization problem. In the final simulation results, the superiority of the proposed NOMA scheme is confirmed compared with the benchmark NOMA schemes and the orthogonal multiple access (OMA) scheme. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
48. Correction to: PPDPF promotes lung adenocarcinoma progression via inhibiting apoptosis and NK cell-mediated cytotoxicity through STAT3
- Author
-
Zheng, Qian-Wen, Ni, Qian-Zhi, Zhu, Bing, Liang, Xin, Ma, Ning, Wang, Yi-Kang, Xu, Sheng, Cao, Hui-Jun, Xia, Ji, Zhang, Feng-Kun, Zhang, Er-Bin, Qiu, Xiao-Song, Ding, Xu-Fen, Qiu, Lin, Zhang, Xi-Lin, Dong, Zhao-Hui, Li, Zhi-Gang, Zhang, Xue-Li, Xie, Dong, and Li, Jing-Jing
- Published
- 2023
- Full Text
- View/download PDF
49. Enhanced Safety and Antitumor Efficacy of Switchable Dual Chimeric Antigen Receptor-Engineered T Cells against Solid Tumors through a Synthetic Bifunctional PD-L1-Blocking Peptide
- Author
-
Yang, Peiwei, Wang, Ying, Yao, Zheng, Gao, Xinmei, Liu, Chen, Wang, Xinmin, Wu, Heming, Ding, Xu, Hu, Jialiang, Lin, Bingjing, Li, Qian, Li, Mengwei, Li, Xin, Chen, Xiangying, Qi, Weiyan, Li, Weiguang, Xue, Jianpeng, and Xu, Hanmei
- Abstract
Chimeric antigen receptor (CAR)-engineered T cells (CAR-Ts) therapy has an excellent efficacy in cancer treatment, especially its impressive results in hematological malignancies. Unfortunately, its application on solid tumors is challenged by the off-target effects caused by lacking of tumor specific antigens and the immunosuppression caused by the tumor microenvironment. We constructed a switchable dual receptor CAR-T cell (sdCAR-T) whose activity relied upon double antigens (mesothelin and fluorescein isothiocyanate) and was strictly controlled by a “switch” (FPBM) consisting of a PD-L1 blocking peptide conjugated to fluorescein isothiocyanate. SdCAR-T cells were activated only when FPBM and cognate tumor cells expressing both PD-L1 and mesothelin coexist. Importantly, long-term proliferation experiments in vitroand the pharmacodynamic study in vivoshowed a stronger antitumor activity of this system compared to the second generation mesothelin CAR-T cells. In view of this novel treatment paradigm being safer and more effective than traditional CAR-T cells, it may become a new strategy for the treatment of solid tumors.
- Published
- 2020
- Full Text
- View/download PDF
50. The accumulation of ascorbic acid and lignin, and differential expression of ascorbic acid and lignin related-genes in yellow celery
- Author
-
Ding, Xu, Liu, Jie-Xia, Xing, Guo-Ming, Chen, Long-Zheng, Sun, Sheng, Li, Sen, Feng, Kai, Duan, Ao-Qi, Yin, Lian, Shen, Di, Xu, Zhi-Sheng, and Xiong, Ai-Sheng
- Abstract
ABSTRACTIncreasing the level of AsA and maintaining proper lignin content will improve the quality of celery (Apium graveolens L.). However, the study on the regulation mechanism of genes related to AsA and lignin metabolism in celery was limited, especially in yellow celery. In this study, the accumulation of AsA and lignin and the expression profiles of related-genes were detected in three kinds of yellow celery. The results showed that the content of AsA was higher in the leaf blades of ‘Huangtaiji’ and the petioles of ‘Jinhuangqincai’. The content of lignin was the highest in ‘Jinhuangqincai’ leaves, followed by ‘Liuhehuangxinqin’ and ‘Huangtaiji’. The expression levels of AgAO(r= −0.032) and AgDHAR1(r= −0.193) genes involved in AsA recycling and degradation showed negatively correlated with AsA content. AgCCoAOMT(r= 0.692) and AgF5 H(r= 0.733) genes expression were positively correlated with lignin content, while the expression of AgCAD(r= −0.694) and AgC3ʹH(r= −0.722) genes were negatively correlated with lignin content. Our current work provided potential theoretical basis for effectively changing accumulation of AsA and lignin by genetic engineering in celery.
- Published
- 2020
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.