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The article analyzes the genetic structure and phylogenetics of Alpha-synuclein as well as the factors for gene mutations, variable splicing to synuclein protein hydrophobicity and hydrophilicity, spatial structure and aggregation. Alpha-synuclein is predominantly expressed in brain tissues as a major component of Lewy bodies, the hallmark of Parkinson's disease. The article suggests that alpha-synuclein may contribute to Parkinson's disease formation and progression and its structure is influenced genetically and cytologically.