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HIV/AIDS is a global and national epidemic that affects college-aged individuals, a significant group that can be reached through prevention programs. The goal of this study was to determine whether an association between sensation seeking and sexual risk behavior exists and, if so, to assess whether HIV knowledge and sexual risk behaviors are predictors of sensation seeking among undergraduate students. Students at a Midwestern university (N = 719) were surveyed. Results indicated that sensation seeking was associated with sexual risk behaviors; however, knowledge was not a predictor of these variables. Therefore, developing university programs that not only address knowledge but also better decision making is suggested. [ABSTRACT FROM AUTHOR]