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3 results on '"Esteve Reyner, Jordi"'

1. Varnimcabtagene Autoleucel (ARI-0001) for Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL) and Richter Transformation (RT)

Author

Ortiz-Maldonado, Valentin, Martinez-Cibrian, Nuria, Del Campo Balguerías, Gonzalo, Español-Rego, Marta, Navarro, Sergio, Lopez-Oreja, Irene, Nadeu, Ferran, Cobo, Amparo, Brillembourg, Helena, Alserawan, Leticia, Castella, Maria, Benitez-Ribas, Daniel, Magnano, Laura, Correa, Juan Gonzalo, Rivero, Andrea, Mozas, Pablo, Gine, Eva, Rodríguez-Lobato, Luis Gerardo, Martínez-Roca, Alexandra, Montoro-Lorite, Mercedes, Ayora, Pilar, Fernández de Larrea, Carlos, Pascal, Mariona, Setoain, Xavier, Esteve Reyner, Jordi, Urbano-Ispizua, Alvaro, Juan, Manel, and Delgado, Julio

Abstract

Background:The prognosis of CLL patients that do not respond to targeted therapy is unfavourable, especially in the case of adverse genomic aberrations (e.g. TP53 alterations or complex karyotype) or after transformation to aggressive B lymphoma (Richter transformation, RT). In patients with refractory CLL, anti-CD19 CAR-T (CART19) therapy has achieved complete response (CR) rates of 19-45%, with RT usually excluded from pivotal trials. However, long-term remission in CLL patients still remains a challenge with CART19 therapy.

Published
2023
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2. Impact of Salvage and Bridging Therapy in Adult Patients with Refractory B-Cell Acute Lymphoblastic Leukemia (B-ALL) Referred for Anti-CD19 CAR T-Cell Therapy: An Intention to Treat Analysis

Author

Ortiz-Maldonado, Valentin, Martinez-Cibrian, Nuria, Del Campo Balguerías, Gonzalo, Español-Rego, Marta, Navarro, Sergio, Brillembourg, Helena, Alserawan, Leticia, Castella, Maria, Benitez-Ribas, Daniel, Magnano, Laura, Correa, Juan Gonzalo, Rivero, Andrea, Mozas, Pablo, Oliver-Caldes, Aina, Gine, Eva, Rodríguez-Lobato, Luis Gerardo, Martínez-Roca, Alexandra, Montoro-Lorite, Mercedes, Ayora, Pilar, Fernández de Larrea, Carlos, Pascal, Mariona, Esteve Reyner, Jordi, Urbano-Ispizua, Alvaro, Juan, Manel, and Delgado, Julio

Abstract

Background:Prognosis of relapsed/refractory (R/R) B-cell acute lymphoblastic leukemia (ALL) is poor, particularly after allogeneic hematopoietic cell transplantation (alloHCT). In this setting, several CAR T-cell products targeting CD19 (CART19) have been able to achieve complete response (CR) rates of 70 to 90%. However, a significant proportion of these patients still relapse. Several studies focus on the effect of the CART19 product on efficacy, however, information on how salvage therapy (ST) and bridging therapy (BT) can modulate the outcomes of CART19 therapy is scarce.

Published
2023
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3. Inherited Thrombocytopenias Predisposing to Hematologic Neoplasms. Experience of the Spanish Group for Inherited Platelet Disorders (GEAPC)

Author

Bastida, Jose Maria, Marín-Quílez, Ana, Zamora, Ana, Benito Sanchez, Maria Rocio, Rodriguez Alen, Agustín, Sevivas, Teresa, Gómez-González, Pedro Luis, Díaz-Ajenjo, Lorena, Butta, Nora, Campos, Rosa M., Escribano, Paola, Huertas-Aragoneses, Jorge, Lopez-Duarte, Monica, León, Antonio, Mompel, Angela, De Oña Navarrete, Raquel, Peláez-Pleguezuelos, Irene, Ramos-Ortega, Fernando Jesús, Sebastian, Elena, Serrano, Claudia, Sierra-Aisa, Cristina, Velasco, Pablo, Murillo, Laura, Vidal-Laso, Rosa, Nomdedeu, Meritxell, Esteve Reyner, Jordi, Hernández-Rivas, Jesús María, Rivera Pozo, Jose, and Lozano, Maria Luisa

Abstract

Introduction

Published
2023
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