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1. Orthogonal Sulfation Strategy for Synthetic Heparan Sulfate Ligands

Author

Fan, R.-H., Achkar, J., Hernandez-Torres, J. M., and Wei, A.

Abstract

An orthogonal sulfation strategy involving six different protecting groups has been developed for generating sulfated carbohydrate libraries based on heparan. Chemoselective cleavage conditions (optimized for a heparan disaccharide) can be performed in the presence of sulfate esters as well as the remaining protecting groups.

Published
2005

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