1. Benign mixed mammary tumor with sebaceous differentiation in a dog.
- Author
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Ying MA, Junchao SHI, Huijun LU, Jing ZHANG, Zheng LIU, Jianwei WEI, Kui ZHAO, Feng GAO, and Wenqi HE
- Subjects
FEMALE dogs ,MAMMARY glands ,DOGS ,CARTILAGE cells ,BENIGN tumors ,MAST cell tumors - Abstract
We describe here a case of canine mammary benign mixed tumor with sebaceous metaplasia in the right fifth mammary gland of an eight-year-old, intact female Poodle dog. Grossly, the mass was firm with off-white, poorly lobulated cut surfaces. Histologically, the luminal epithelial cells and myoepithelial cells proliferated with cartilage formation and focal squamous metaplasia. Moreover, a large number of nests of various sizes, which were filled with foamy cells in the center and associated with basaloid reserve-like cells in the periphery, showed sebaceous gland-like structures. Immunohistochemically, myoepithelial cells and reserve-like cells in the metaplastic sebaceous gland-like structures were CK14, α-smooth muscle actin (α-SMA) and p63 positive, suggesting a possibility that these two components may have a common cell of origin. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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