273 results on '"Feng Qian"'
Search Results
2. Nonswellable Hydrogel Patch with Tissue-Mimetic Mechanical Characteristics Remodeling In Vivo Microenvironment for Effective Adhesion Prevention.
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Liu, Xuezhe, Qiu, Xingan, Nie, Linxia, Zhou, Bikun, Bu, Pengzhen, Li, Yang, Xue, Xinwen, Tang, Bo, Feng, Qian, and Cai, Kaiyong
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- 2024
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3. Performance Enhancement of NiOx/β-Ga₂O₃ Heterojunction Diodes by Synergistic Interface Engineering
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Liu, Dinghe, Zhang, Zeyulin, Chen, Hao, Tian, Xusheng, Wang, Yao, Yan, Yiru, Zeng, Liru, Liu, Xinke, Chen, Dazheng, Feng, Qian, Zhou, Hong, Liu, Zhihong, Zhang, Jincheng, Zhang, Chunfu, and Hao, Yue
- Abstract
In this work, we report on achieving enhanced performance NiOx/beta gallium oxide (
$\beta $ $\beta $ $\Omega \cdot $ - Published
- 2024
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4. Regulation of metabolic microenvironment with a nanocomposite hydrogel for improved bone fracture healing
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Zha, Kangkang, Tan, Meijun, Hu, Yiqiang, Hu, Weixian, Zhang, Shengming, Zhao, Yanzhi, Lin, Ze, Zhang, Wenqian, Xue, Hang, Mi, Bobin, Zhou, Wu, Feng, Qian, Cao, Faqi, and Liu, Guohui
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Bone nonunion poses an urgent clinical challenge that needs to be addressed. Recent studies have revealed that the metabolic microenvironment plays a vital role in fracture healing. Macrophages and bone marrow-derived mesenchymal stromal cells (BMSCs) are important targets for therapeutic interventions in bone fractures. Itaconate is a TCA cycle metabolite that has emerged as a potent macrophage immunomodulator that limits the inflammatory response. During osteogenic differentiation, BMSCs tend to undergo aerobic glycolysis and metabolize glucose to lactate. Copper ion (Cu2+) is an essential trace element that participates in glucose metabolism and may stimulate glycolysis in BMSCs and promote osteogenesis. In this study, we develop a 4-octyl itaconate (4-OI)@Cu@Gel nanocomposite hydrogel that can effectively deliver and release 4-OI and Cu2+to modulate the metabolic microenvironment and improve the functions of cells involved in the fracture healing process. The findings reveal that burst release of 4-OI reduces the inflammatory response, promotes M2 macrophage polarization, and alleviates oxidative stress, while sustained release of Cu2+stimulates BMSC glycolysis and osteogenic differentiation and enhances endothelial cell angiogenesis. Consequently, the 4-OI@Cu@Gel system achieves rapid fracture healing in mice. Thus, this study proposes a promising regenerative strategy to expedite bone fracture healing through metabolic reprogramming of macrophages and BMSCs.
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- 2024
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5. Multi-modal imaging for dynamic visualization of osteogenesis and implant degradation in 3D bioprinted scaffolds
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Feng, Qian, Fatima, Kanwal, Yang, Ai, Li, Chenglin, Chen, Shuo, Yang, Guang, Zhou, Xiaojun, and He, Chuanglong
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In situmonitoring of bone regeneration enables timely diagnosis and intervention by acquiring vital biological parameters. However, an existing gap exists in the availability of effective methodologies for continuous and dynamic monitoring of the bone tissue regeneration process, encompassing the concurrent visualization of bone formation and implant degradation. Here, we present an integrated scaffold designed to facilitate real-time monitoring of both bone formation and implant degradation during the repair of bone defects. Laponite (Lap), CyP-loaded mesoporous silica (CyP@MSNs) and ultrasmall superparamagnetic iron oxide nanoparticles (USPIO@SiO2) were incorporated into a bioink containing bone marrow mesenchymal stem cells (BMSCs) to fabricate functional scaffolds denoted as C@M/GLU using 3D bioprinting technology. In both in vivoand in vitroexperiments, the composite scaffold has demonstrated a significant enhancement of bone regeneration through the controlled release of silicon (Si) and magnesium (Mg) ions. Employing near-infrared fluorescence (NIR-FL) imaging, the composite scaffold facilitates the monitoring of alkaline phosphate (ALP) expression, providing an accurate reflection of the scaffold's initial osteogenic activity. Meanwhile, the degradation of scaffolds was monitored by tracking the changes in the magnetic resonance (MR) signals at various time points. These findings indicate that the designed scaffold holds potential as an in situbone implant for combined visualization of osteogenesis and implant degradation throughout the bone repair process.
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- 2024
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6. Regulation of rheumatoid arthritis microenvironment viaa self-healing injectable hydrogel for improved inflammation elimination and bone repair
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Geng, Wenbo, Zhao, Jie, Tao, Bailong, Yang, Yulu, Duan, Qiaojian, Gao, Pengfei, He, Tingting, Liu, Shaopeng, Feng, Qian, Zhao, Peng, and Cai, Kaiyong
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The rheumatoid arthritis (RA) microenvironment is often followed by a vicious circle of high inflammation, endogenous gas levels imbalance, and poor treatment. To break the circle, we develop a dual-gas-mediated injectable hydrogel for modulating the immune microenvironment of RA and simultaneously releasing therapeutic drugs. The hydrogel (DNRS gel) could be broken down on-demand by consuming excessive nitric oxide (NO) and releasing therapeutic hydrogen sulfide (H2S), resulting in endogenous gas restoration, inflammation alleviation, and macrophage polarization to M2 type. Additionally, the hydrogel could suppress osteoclastogenesis and enhance osteogenesis. Furthermore, the intra-articularly injected hydrogel with methotrexate (MTX/DNRS gel) significantly alleviated inflammation and clinical symptoms and promoted the repair of bone erosion in the collagen-induced arthritis rat model. As a result, in vivoresults demonstrated that MTX/DNRS gel restored the microenvironment and improved the therapeutic effect of MTX. This study provides a novel understanding of developing versatile smart delivery platforms for RA treatment.
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- 2024
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7. New α‑Glucosidase Inhibitors from the Whole Plant of Hypericum beanii Based on Ligand Fishing and Molecular Networking Analysis.
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Hu, Rui-Dan, Lin, Wei-Yao, Feng, Qian, Liu, Jinru, Chen, Yidi, Ji, Aijia, Wang, Caiyan, Cao, Liping, Zhang, Rong, Liu, Zhongqiu, Cui, Hui, Liang, Qi, and Zhang, Rong-Rong
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- 2024
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8. Glutathione-Responsive and Hydrogen Sulfide Self-Generating Nanocages Based on Self-Weaving Technology To Optimize Cancer Immunotherapy.
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Gou, Shuangquan, Geng, Wenbo, Zou, Yanan, Chen, Fangye, He, Tingting, Duan, Qiaojian, Qin, Zizhen, Li, Liangsheng, Xia, Jiang, Yu, Yongsheng, Feng, Qian, and Cai, Kaiyong
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- 2024
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9. New α-Glucosidase Inhibitors from the Whole Plant of Hypericum beaniiBased on Ligand Fishing and Molecular Networking Analysis
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Hu, Rui-Dan, Lin, Wei-Yao, Feng, Qian, Liu, Jinru, Chen, Yidi, Ji, Aijia, Wang, Caiyan, Cao, Liping, Zhang, Rong, Liu, Zhongqiu, Cui, Hui, Liang, Qi, and Zhang, Rong-Rong
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In this work, a new rapid and targeted method for screening α-glucosidase inhibitors from Hypericum beaniiwas developed and verified. Ten new polycyclic polyprenylated acylphloroglucinols (PPAPs), hyperlagarol A–J (1–10), and nine known PPAPs (11–19) were obtained from H. beanii. Their structures were identified by using comprehensive analyses involving mass spectrometry, ultraviolet spectroscopy, infrared spectroscopy, nuclear magnetic resonance spectroscopy, and electron capture dissociation calculations. 1and 2are two new rare 2,3-seco-spirocyclic PPAPs, 3and 4are two novel 12,13-seco-spirocyclic PPAPs, 5and 6are two novel spirocyclic PPAPs, 7and 8are two new unusual spirocyclic PPAPs with complex bridged ring systems, and 9and 10are two novel nonspirocyclic PPAPs. α-GC inhibitory activities of all isolated compounds were tested. Most of them displayed inhibitory activities against α-glucosidase, with the IC50values ranging from 6.85 ± 0.65 to 112.5 ± 9.03 μM. Moreover, the inhibitory type and mechanism of the active compounds were further analyzed using kinetic studies and molecular docking.
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- 2024
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10. High-quality crystalline NiO/β-Ga2O3p–n heterojunctions grown by the low-cost and vacuum-free mist-CVD for device applications
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Zhang, Zeyulin, Song, Qingwen, Liu, Dinghe, Yan, Yiru, Chen, Hao, Mu, Changgen, Chen, Dazheng, Feng, Qian, Zhang, Jincheng, Zhang, Yuming, Hao, Yue, and Zhang, Chunfu
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Gallium oxide (Ga2O3) p–n heterojunctions play an important role in addressing the difficulties in Ga2O3p-type doping. Therefore, an efficient and economical fabrication method needs to be established to create single-crystal Ga2O3heterojunctions for device applications. In this work, we successfully achieved epitaxial growth of single-crystal nickel oxide (NiO) and β-Ga2O3heterojunctions based on the low-cost and vacuum-free mist chemical-vapor deposition. The full width at half maximum of the X-ray diffraction rocking curves of NiO (111) and β-Ga2O3(−201) reached 0.077° and 0.807°, respectively. The energy band between NiO and β-Ga2O3has a Type II heterojunction. Finally, we prepared a quasi-vertical diode based on the NiO/β-Ga2O3heterojunction, which exhibits obvious rectification characteristics of the p–n junction and provides a reverse breakdown voltage of 117 V. This work proposes a low-cost fabrication method for β-Ga2O3p–n heterojunctions.
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- 2024
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11. Orientational Bamboo Veneer Evaporator for Enhanced Interfacial Solar Steam Generation.
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Feng, Qian, Tan, Sicong, Lu, Jiarui, Li, Jiatian, Wang, Jinze, Chen, Chuchu, Wu, Weibing, and Xu, Zhaoyang
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- 2024
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12. Uniform Micronano Network Affords All-Chitin Films with Water Resistance, Biodegradability, and High Strength.
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Ma, Jieru, Zao, Yamei, Feng, Qian, Liu, Lihui, Jin, Yongcan, Li, Dagang, Xu, Zhaoyang, and Chen, Chuchu
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- 2024
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13. A Strategy of End Anchoring to Poly(N‑isopropylacrylamide) Chains for the Thermo-Driven Controllable Oil–Water Separation.
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Zhou, Yuze, Feng, Qian, Huang, Ruipeng, Liu, Zhigang, Lei, Jiaying, Wang, Yumeng, and Tang, Dongyan
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- 2024
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14. Influence of Oxygen on Ga2O3 Deposition at Low Temperature by MOCVD.
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Li, Wenji, Li, Jiale, Wang, Yao, Zhang, Tao, Wang, Wentao, Gao, Huhu, Tian, Xusheng, Zhang, Yachao, Cheng, Qian, Feng, Qian, Zhang, Jincheng, and Hao, Yue
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- 2024
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15. Score a goal with buckyballs: Hypoxia-sensitive [70]fullerene nanotherapeutics
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Krzykawska-Serda, Martyna, Feng, Qian, and Serda, Maciej
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Li et al. reported the development and application of a novel hypoxia-sensitive fullerene-based nanotherapeutic system for photodynamic therapy in cancer treatment. This system integrates a [70]fullerene scaffold with amino-modified cyclodextrin and the hypoxia-activatable anticancer prodrug tirapazamine, enhanced with tumor-targeting peptides and disulfide bond donors. The created fullerene nanomaterial exhibits selective accumulation in tumor tissues, facilitated by its enhanced water solubility and targeted specificity.
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- 2024
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16. Dielectric and Magnetic Composites of Fe3O4@APNs for Superior Microwave Thermal Effect
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Zhan, Yan-lei, Wen, Kai-chao, Li, Zheng-an, Sun, Ping, and Li, Feng-qian
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As for the deep tissue infections of chronic osteomyelitis, antibiotics are hard to deliver into the infected bone tissue, which makes it difficult to be cured completely in clinic. Microwave has strong penetration, and the medium can produce a good bactericidal effect through the microwave thermal effect (MTE). Here, a new microwave sensitizer (Fe3O4@APNs) was prepared and evaluated. Black phosphorus nanosheets modified with phytic acid dodecasodium (APNs) were fabricated by a liquid-phase exfoliation method that exhibited good water oxygen stability. A complex with Fe3O4compound and APNs (Fe3O4@APNs) was formed by an ultrasonic mixing process, which showed excellent MTE (quickly increased to 53.5 °C in 5 min at 2.45 GHz, 10 W/cm2) via dielectric versus magnetic loss (reflect loss value of −5.94 dB at 2.45 GHz). The Fe3O4@APNs microwave sensitizer developed in this study has an outstanding in vitro antibacterial effect and might show promise for the treatment of chronic osteomyelitis enabled by local tissue heating via the MTE.
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- 2024
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17. Identifying Station Importance in Urban Rail Transit Networks Using a Combination of Centrality and Time Reliability Measures: A Case Study in Beijing, China
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Xu, Xiaohan, Shalaby, Amer, Feng, Qian, and Huang, Ailing
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Time reliability (TR) is a critical factor that affects the efficiency and service quality of the urban rail transit network (URTN). However, previous studies have not incorporated TR into the evaluation of URTN station importance, focusing instead on basic centrality measures. Therefore, this paper proposes a new metric of station-based TR for evaluating and ranking URTN station importance. The new metric in combination with traditional centrality measures was used by the weighted Technique for Order of Preference by Similarity to Ideal Solution (weighted TOPSIS) to identify the combined significance level of individual URTN station importance and rank them accordingly. To investigate the performance of this method, we exploit deliberate attacks on the top-ranked stations through different methods. A case study of Beijing’s URTN during the morning peak hour showed that the proposed method is generally a better indicator for identifying station importance in maintaining network connectivity. The case study also demonstrated the feasibility and validity of the model. This study can provide recommendations for the planning and operation of rail transit systems and can inform the effective design of station protection strategies.
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- 2024
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18. Influence of Oxygen on Ga2O3Deposition at Low Temperature by MOCVD
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Li, Wenji, Li, Jiale, Wang, Yao, Zhang, Tao, Wang, Wentao, Gao, Huhu, Tian, Xusheng, Zhang, Yachao, Cheng, Qian, Feng, Qian, Zhang, Jincheng, and Hao, Yue
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In this study, thin films of Ga2O3were fabricated on sapphire substrates utilizing metal–organic chemical vapor deposition technology, with deposition conducted at a temperature of 400 °C. The investigation focused on examining the influence of oxygen on the surface morphology, phase transition, and optical characteristics of Ga2O3films synthesized at relatively low temperatures. X-ray diffraction tests indicated that all films were polycrystalline and had mixed β and ε phases. With an increase in oxygen flow rate from 1400 to 1800 sccm, β-Ga2O3became the dominant material. Atomic force microscope analysis showed that the root-mean-square roughness had decreased. Film thicknesses, as measured by scanning electron microscopy, were 285.3, 257.6, 243.2, and 254.2 nm, respectively. The high-resolution transmission electron microscope confirmed a mixed-phase structure at an oxygen rate of 2100 sccm. Moreover, the X-ray photoelectron spectroscopy results show that increasing the oxygen flow rate from 1400 to 1800 sccm is effective in reducing the oxygen vacancies and defects in the films. However, excessive oxygen flow (2100 sccm) leads to the exacerbation of prereaction and the deterioration of the film’s crystalline quality.
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- 2024
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19. All-in-One Engineering Multifunctional Nanoplatforms for Sensitizing Tumor Low-Temperature Photothermal Therapy In Vivo.
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Li, Ke, Xu, Kun, Liu, Shaopeng, He, Ye, Tan, Meijun, Mao, Yulan, Yang, Yulu, Wu, Jing, Feng, Qian, Luo, Zhong, and Cai, Kaiyong
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- 2023
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20. Functionalized human umbilical cord mesenchymal stem cells and injectable HA/Gel hydrogel synergy in endometrial repair and fertility recovery.
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Zhang, Donghai, Du, Qianqian, Li, Cong, Ding, Chuanfeng, Chen, Junfeng, He, Yun, Duan, Tao, Feng, Qian, Yu, Yongsheng, and Zhou, Qian
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ENDOMETRIUM ,MESENCHYMAL stem cells ,FETUS ,FROZEN human embryos ,UMBILICAL cord ,HYDROGELS ,EMBRYO implantation ,TISSUE adhesions - Abstract
Intrauterine adhesions (IUA) caused by endometrial injury are one of the main causes of female infertility. The current treatments for endometrial injury offer limited clinical benefits and cannot improve endometrial receptivity and pregnancy outcomes. Tissue engineering and regenerative medicine are considered potential solutions to address this concern and may offer effective treatment methods for the regeneration of injured human endometrium. Herein, we prepared an injectable hydrogel based on oxidized hyaluronic acid (HA-CHO) and hydrazide-grafted gelatin (Gel-ADH). The injectable hydrogel showed satisfactory biocompatibility when mixed with human umbilical cord mesenchymal stem cells (hUCMSCs). In an endometrial injury rat model, the treatment with hUCMSCs-loaded injectable hydrogel significantly enhanced the thickness of the endometrium and increased the abundance of blood vessels and glands in the injured endometrium compared to the control group. The hUCMSCs-loaded injectable hydrogel treatment significantly reduced endometrial fibrosis, decreased the expression of the pro-inflammatory factors (IL-1β and IL-6) and increased the expression of the anti-inflammatory factor (IL-10). This treatment induced endometrial VEGF expression by activating the MEK/ERK1/2 signaling pathway. Moreover, this treatment improved endometrial receptivity to the embryo and restored the embryo implantation rate similar to the sham group (48% in the sham group vs 46% in the treatment group), and this treatment achieved pregnancy and live birth in rats with endometrial injury. In addition, we also preliminarily validated the safety of this treatment in the maternal rats and fetuses. Collectively, our study showed that the hUCMSCs-loaded injectable hydrogel hold potential as an effective treatment strategy promoting rapid recovery of endometrial injury, and this hydrogel is a promising biomaterial for regenerative medicine applications. 1. Oxidized hyaluronic acid (HA-CHO)/hydrazide-grafted gelatin (Gel-ADH) hydrogel combined with human umbilical cord mesenchymal stem cells (hUCMSCs) are effective in improving the regeneration of endometrium in the endometrial injury rat model. 2. The hUCMSCs-loaded hydrogel treatment promotes the expression of endometrial VEGF through MEK/ERK1/2 signaling pathway and regulates the balance of inflammatory factors. 3. The embryo implantation and live birth rates restore to normal level in the endometrial injury rat model, and the hydrogel has no adverse effects on maternal rats, fetuses, and offspring development after the treatments. [Display omitted] [ABSTRACT FROM AUTHOR]
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- 2023
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21. A comparative study on a firm’s optimal production decision considering risk aversion and carbon policies
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Qi, Qi, Bai, Qingguo, Xu, Jianteng, Feng, Qian, Qi, Qi, Bai, Qingguo, Xu, Jianteng, and Feng, Qian
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To cope with global warming and achieve the goal of carbon emission reduction, various carbon policies have been implemented in many countries and regions. Some studies have indicated that with the popularity of low carbon, a small proportion of consumers show a green purchasing tendency. However, for firms, it is still difficult to predict the green purchase preferences of most consumers, and firms may face greater market demand uncertainty, which will bring profit risks. We assume that a firm’s decision is subject to its behavioral considerations, that is, its risk attitude. Considering the risk preferences of decision-makers and carbon emission policies, this paper addresses decision optimization in operations management. Our purpose is to analyze the optimal production decisions of risk-averse firms under carbon cap and carbon tax policies. Adopting the CVaR (conditional value-at-risk) criterion, we construct an optimization model with the constraints of carbon policies and obtain the analytic formula of optimal solutions. Then, we compare the optimal operational decisions for risk-averse firms and risk-neutral firms and further explore the impact of risk aversion on production and the parameters of carbon policy. Finally, some numerical studies are presented to analyze the carbon policies and risk aversion on firms’ operational decisions and give some managerial insights based on the analysis results.
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- 2023
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22. Unraveling the effects of Cr interface segregation on precipitation mechanism and mechanical properties of MC carbides in high carbon chromium bearing steels
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Feng, Qian, Wang, Yajun, Zeng, Yanan, Li, Junguo, Liu, Bao, Zhang, Xi, Tang, Guozhang, and Wang, Yitong
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This study explored the influence of Cr interfacial segregation on the precipitation mechanism and mechanical properties of MC carbides in high-carbon chromium bearing steels. The precipitation of Cr-doped MC carbides at different concentrations was investigated using microscopic morphological characterization (SEM, EDS and HR-TEM) alongside first principles calculations. The results indicated that both the austenite matrix and MC carbides exhibited, FCC structures, and the following orientation relationships of crystal planes in high-carbon chromium bearing steels were as follows: MC (010)//FCC-Fe (100) and MC (111)//FCC-Fe (111). Initially, Cr atoms adsorbed on the Fe-top site of the MC carbide (010) crystal plane, maintaining a distance of 2.5 Å from the Fe atom. Notably, when the Cr atom doping amount was 0.5, the Cr–Fe metallic bond exhibited a long bond length, large bond angle and low bond strength in the MC transition state (TS), resulting in a reduced, reaction barrier (908.08 kcal/mol), thus promoting the precipitation of MC carbide in bearing steel. However, at a Cr atom doping amount level of 1, the shorter bond length, small bond angle, and higher bonding strength of the Cr–Fe metallic bond in the MC TS, elevated the reaction barrier (49709.72 kcal/mol), inhibiting the precipitation of MC carbide in bearing steel. Additionally, this study quantitatively analyzed the effect of Cr atom content on the brittle plastic properties and hardness of MC carbides. At Cr atom contents of 0.23 and 1, the MC carbide hardness reached a minimum value of 3.0 GPa and a maximum value of 17.1 GPa, respectively. This investigation not only elucidated the atomic scale effects of Cr interfacial segregation on the precipitation mechanism and mechanical properties of MC carbides but also provided new ideas for controlling carbide precipitation in high-carbon chromium bearing steels.
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- 2023
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23. All-in-One Engineering Multifunctional Nanoplatforms for Sensitizing Tumor Low-Temperature Photothermal Therapy In Vivo
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Li, Ke, Xu, Kun, Liu, Shaopeng, He, Ye, Tan, Meijun, Mao, Yulan, Yang, Yulu, Wu, Jing, Feng, Qian, Luo, Zhong, and Cai, Kaiyong
- Abstract
Low-temperature photothermal therapy (PTT) is a noninvasive method that harnesses the photothermal effect at low temperatures to selectively eliminate tumor cells, while safeguarding normal tissues, minimizing thermal damage, and enhancing treatment safety. First we evaluated the transcriptome of tumor cells at the gene level following low-temperature treatment and observed significant enrichment of genes involved in cell cycle and heat response-related signaling pathways. To address this challenge, we have developed an engineering multifunctional nanoplatform that offered an all-in-one strategy for efficient sensitization of low-temperature PTT. Specifically, we utilized MoS2nanoparticles as the photothermal core to generate low temperature (40–48 °C). The nanoplatform was coated with DPA to load CPT-11 and Fe2+and was further modified with PEG and iRGD to enhance tumor specificity (MoS2/Fe@CPT-11-PEG-iRGD). Laser- and acid-triggered release of CPT-11 can significantly increase intracellular H2O2content, cooperate with Fe2+ions to increase intracellular lipid ROS content, and activate ferroptosis. Furthermore, CPT-11 induced cell cycle arrest in the temperature-sensitive S-phase, and increased lipid ROS levels contributed to the degradation of HSPs protein expression. This synergistic approach could effectively induce tumor cell death by the sensitized low-temperature PTT and the combination of ferroptosis and chemotherapy. Our nanoplatform can also maximize tumor cell eradication and prolong the survival time of tumor-bearing mice in vivo. The multifunctional approach will provide more possibilities for clinical applications of low-temperature PTT and potential avenues for the development of multiple tumor treatments.
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- 2023
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24. Emissive metallacages for biomedical applications
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Feng, Qian, Li, Rongrong, Gao, Tingting, Chu, Dake, and Zhang, Mingming
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Owing to their appealing three-dimensional structures and tunable photophysical properties, emissive metallacages have been widely applied in recognition and sensing, adsorption and separation, catalysis, etc. Recently, the application of emissive metallacages in biomedical fields has emerged as a hot research topic, because multiple biological functionalities can be facilely integrated into metallacage-based platforms to deliver different functions. In this review, the applications of emissive metallacages in bio-imaging, delivery and cancer theranostics are systematically summarized. The dilemmas and challenges of metallacage-based biomedical materials are also raised at the end of this review. We hope this review would provide some guidance for the construction of novel emissive metallacages with biological functions, and further advance the development of emissive metallacages as biomedical materials.
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- 2023
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25. Oxygen Self-Generating Nanoreactor Mediated Ferroptosis Activation and Immunotherapy in Triple-Negative Breast Cancer.
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Li, Ke, Xu, Kun, He, Ye, Yang, Yulu, Tan, Meijun, Mao, Yulan, Zou, Yanan, Feng, Qian, Luo, Zhong, and Cai, Kaiyong
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- 2023
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26. Information fields of written texts protect cells from oxidative damage and accelerate repair.
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Feng, Qian, Chen, Yu, Teng, Jie, Wang, Lin, Cai, Zhong-zhen, Li, Meng-mei, Rein, Glen, Yang, Qiao-li, Shao, Xiao-qian, and Bai, Xue-mei
- Abstract
• Texts with positive meaning and the word "Buddha" in Chinese showed effect on specific biochemical measures in oxidation-damaged human embryonic kidney cell line HEK293T. • Words with positive meaning such as love and compassion enhanced the adenosine triphosphate (ATP) production, reduced reactive oxygen species (ROS) levels, accompanied by the cell growth rate improved significantly in the cell oxidation and repair after injury. • The word "Buddha" enhanced the ATP production and the cell growth rate in the cell oxidation and repair after injury. Written words demonstrated specific effects on biochemical measures and cell growth in cultured mammalian cells in previous study. We examined the protection and reparative effects of Chinese texts with positive meaning and the word "Buddha" on oxidative-damaged cells, with the goal of exploring the therapeutic effect of such characters. The human embryonic kidney cell line HEK293T was utilized, with the oxidative- damaged cell model produced by hydrogen peroxide (H 2 O 2). Double-blind experiments were set up to ensure all operators involved in the experiments did not know the contents of the texts in envelopes. Petri-dishes (9 plates) containing oxidative-damaged cells were selected randomly for three controls, three treatments by texts with positive meaning, and another three treatment by the word "Buddha". Cells were sub-sampled at 3 h and 24 h to examine growth and mitochondrial functions. All data are expressed relative to the controls. Compared with the control group, mitochondrial functions were enhanced as evidenced by increased adenosine triphosphate (ATP) levels, accompanied by the significant improvement in cell growth rate for the groups treated by positive texts and the word "Buddha". Reactive oxygen species (ROS) levels were decreased significantly in positive texts treatment, which suggested that the antioxidant capacity of cells was also improved. This study revealed that certain texts can potentially offer protection and accelerate the cellular repair for oxidative-damaged cells. [ABSTRACT FROM AUTHOR]
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- 2023
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27. Multifunctional hydrogel enhances bone regeneration through sustained release of Stromal Cell-Derived Factor-1α and exosomes
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Chen, Lang, Yu, Chenyan, Xiong, Yuan, Chen, Kai, Liu, Pei, Panayi, Adriana C., Xiao, Xiufeng, Feng, Qian, Mi, Bobin, and Liu, Guohui
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Fracture nonunion remains a great challenge for orthopedic surgeons. Fracture repair comprises of three phases, the inflammatory, repair and remodeling stage. Extensive advancements have been made in the field of bone repair, including development of strategies to balance the M1/M2 macrophage populations, and to improve osteogenesis and angiogenesis. However, such developments focused on only one or the latter two phases, while ignoring the inflammatory phase during which cell recruitment occurs. In this study, we combined Stromal Cell-Derived Factor-1α (SDF-1α) and M2 macrophage derived exosomes (M2D-Exos) with a hyaluronic acid (HA)-based hydrogel precursor solution to synthesize an injectable, self-healing, adhesive HA@SDF-1α/M2D-Exos hydrogel. The HA hydrogel demonstrated good biocompatibility and hemostatic ability, with the 4% HA hydrogels displaying great antibacterial activity against gram-negative E. coliand gram-positive S. aureusand Methicillin-resistant Staphylococcus aureus(MRSA). Synchronously and sustainably released SDF-1α and M2D-Exos from the HA@SDF-1α/M2D-Exos hydrogel enhanced proliferation and migration of human bone marrow mesenchymal stem cell (HMSCs) and Human Umbilical Vein Endothelial Cells (HUVECs), promoting osteogenesis and angiogenesis both in vivo and in vitro. Overall, the developed HA@ SDF-1α/M2D-Exos hydrogel was compatible with the natural healing process of fractures and provides a new modality for accelerating bone repair by coupling osteogenesis, angiogenesis, and resisting infection at all stages.
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- 2023
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28. Effects of different music on HEK293T cell growth and mitochondrial functions.
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Feng, Qian, Wang, Lin, Chen, Yu, Teng, Jie, Li, Mengmei, Cai, Zhongzhen, Niu, Xiaoguo, Rein, Glen, Yang, Qiaoli, Shao, Xiaoqian, Zhang, Chao, and Bai, Xuemei
- Abstract
Background: Mitochondria are considered a portal to receive, process and integrate external energy and information to maintain cellular homeostasis. Previous studies demonstrated that mitochondrial function and antioxidant capacity of in-vitro cultured mammalian cells is modified by different energetic stimuli including electromagnetic energy, acoustic energy, external Qi and subtle energy emitted by written texts in relatively short time frames. Thus, individual cells can act as a rapid and sensitive biological sensor and act as a platform to evaluate and understand the subtle effect of different biophysical stimuli. Regarding acoustic energy, several different types of music have been reported to produce beneficial effects on human health.Objective: To compare eastern and western music styles on cell function at the biochemical level to understand the underlying mechanisms involved. Methods In this study, we compared the effects of Chinese five-element music with two types of western music (heavy-metal and classical) on mitochondrial function, oxidative capacity and growth using HEK293T cells (human embryonic kidney cells).Results: Unlike rock and classical music, exposing cells to five-element music produced several beneficial physiological effects, including statistically significant increases in the production of adenosine triphosphate (ATP) by 17%, glutathione (GSH) by 21% and cell growth rates (14%), as well as a significant reduction in the reactive oxygen species (ROS) by 13%. For the group treated with classical music, there was only a trend toward increased GSH (8%), although the increased growth rates (14%) did reach significance. In sharp contrast, the cells treated with heavy-metal music responded with an opposite and significant 16% increase in ROS and a significant 11% reduction in cell viability.Conclusions: This study revealed the dramatically different and even opposite effects of different styles of music on specific biochemical measures in cultured human cells. These results help explain the underlying biochemical mechanisms of the effects of the different types of music. [ABSTRACT FROM AUTHOR]- Published
- 2022
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29. Elevated remnant cholesterol is a risk factor for acute ischemic stroke.
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Feng, Qian, Li, Hao, Zhang, Ru-Yang, Sun, Li, Zhang, Shi-Yu, Chen, Yue, Zhang, Yue, Shan, Bao-Shuai, Zhao, Zhong, Zhou, Hua, and Xu, Xingshun
- Abstract
Remnant cholesterol (RC) is thought to be an important pathogenic risk factor for atherosclerosis, however, the relationship between RC and acute ischemic stroke (AIS) is still unclear. This study aimed to determine whether fasting blood RC level is an independent risk factor for AIS. A retrospective analysis was performed on 650 patients with AIS and 598 healthy controls during the same time period. The association between RC and AIS was investigated using binary logistic regression, and the relationship between RC and AIS risk was demonstrated using Restricted Cubic Splines (RCS). RC was significantly higher in the AIS group compared with control group, and was an independent risk factor for AIS when the covariates were not adjusted;After adjusting some covariates, RC was still an independent risk factor for AIS. The RCS analysis found the risk was non-linear: when RC concentration was less than 0.69 mol/L, the risk of AIS increased with the elevation of RC, and when RC concentration was more than or equal to 0.69 mol/L, the risk of AIS was insignificant with the elevation of RC. Correlation analysis revealed that RC was associated with diabetes and fasting glucose. Further analysis revealed that the incidence of AIS in diabetic patients increased significantly with the increase of RC, and RCS analysis revealed that the risk of AIS in diabetic patients increased with the increase of RC when RC was more than 1.15 mol/L. This study confirms RC as an independent risk factor for AIS, which highlights a distinct non-linear association between RC levels and AIS risk. These findings suggest the need for targeted AIS risk assessment strategies, especially in diabetic patients, and underscore the relevance of RC as a biomarker in AIS risk stratification. [ABSTRACT FROM AUTHOR]
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- 2024
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30. Efficient Grasp Detection Network With Gaussian-Based Grasp Representation for Robotic Manipulation
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Cao, Hu, Chen, Guang, Li, Zhijun, Feng, Qian, Lin, Jianjie, and Knoll, Alois
- Abstract
Deep learning methods have achieved excellent results in the field of grasp detection. However, deep learning-based models for general object detection lack the proper balance of accuracy and inference speed, resulting in poor performance in real-time grasp tasks. This work proposes an efficient grasp detection network with n-channel images as inputs for robotic grasp. The proposed network is a lightweight generative structure for grasp detection in one stage. Specifically, a Gaussian kernel-based grasp representation is introduced to encode the training samples, embodying the maximum center that possesses the highest grasp confidence. A receptive field block is plugged into the bottleneck to improve the model's feature discriminability. In addition, pixel-based and channel-based attention mechanisms are used to construct a multidimensional attention fusion network to fuse valuable semantic information, achieved by suppressing noisy features and highlighting object features. The proposed method is evaluated on the Cornell, Jacquard, and extended OCID grasp datasets. The experimental results show that our method achieves excellent balancing accuracy and running speed performance. The network gets a running speed of
, achieving better performance on the Cornell, Jacquard, and extended OCID grasp datasets with 97.8, 95.6, and 76.4% accuracy, respectively. Subsequently, an excellent grasp success rate in a physical environment is obtained using the UR5 robot arm.$\text{6}\,\text{ms}$ - Published
- 2023
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31. Immune homeostasis modulation by hydrogel-guided delivery systems: a tool for accelerated bone regeneration
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Mi, Bobin, Xiong, Yuan, Zha, Kangkang, Cao, Faqi, Zhou, Wu, Abbaszadeh, Samin, Ouyang, Lizhi, Liao, Yuheng, Hu, Weixian, Dai, Guandong, Zhao, Zhiming, Feng, Qian, Shahbazi, Mohammad-Ali, and Liu, Guohui
- Abstract
Immune homeostasis is delicately mediated by the dynamic balance between effector immune cells and regulatory immune cells. Local deviations from immune homeostasis in the microenvironment of bone fractures, caused by an increased ratio of effector to regulatory cues, can lead to excessive inflammatory conditions and hinder bone regeneration. Therefore, achieving effective and localized immunomodulation of bone fractures is crucial for successful bone regeneration. Recent research has focused on developing localized and specific immunomodulatory strategies using local hydrogel-based delivery systems. In this review, we aim to emphasize the significant role of immune homeostasis in bone regeneration, explore local hydrogel-based delivery systems, discuss emerging trends in immunomodulation for enhancing bone regeneration, and address the limitations of current delivery strategies along with the challenges of clinical translation.
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- 2023
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32. Morpholine-Functionalized Multicomponent Metallacage as a Vector for Lysosome-Targeted Cell Imaging.
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Feng, Qian, Yang, Tianfeng, Ma, Lingzhi, Li, Xiaopeng, Yuan, Hongye, Zhang, Mingming, Zhang, Yanmin, and Fan, Lihong
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- 2022
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33. Development of a fully human anti-GITR antibody with potent antitumor activity using H2L2 mice.
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Qiuli Tong, Hu Liu, Qianqian Qi, Chaohui Dai, Teddy Yang, and Feng Qian
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IMMUNOGLOBULINS ,ANTINEOPLASTIC agents ,IMMUNE checkpoint inhibitors ,ANTIBODY-dependent cell cytotoxicity ,T cells ,REGULATORY T cells ,TRANSGENIC mice ,POST-translational modification - Abstract
Glucocorticoid-induced TNF receptor-related (GITR) can act as a costimulatory receptor, representing a potential target for safely enhancing immunotherapy efficacy. GITR is triggered by a GITR ligand or an agonist antibody and activates CD8
+ and CD4+ effector T cells, reducing tumor-infiltrating Treg numbers and resulting in activation of immune responses and tumor cell destruction by effector T cells. GITR is an attractive target for immunotherapy, especially in combination therapy with immune checkpoint inhibitors, as is being explored in clinical trials. Using H2L2 transgenic mice encoding the human immunoglobulin variable region and hybridoma technology, we generated a panel of fully human antibodies that showed excellent specific affinity and strong activation of human T cells. After conversion to fully human antibodies and engineering modification, we obtained an anti-GITR antibody hab019e2 with enhanced antitumor activity in a B-hGITR MC38 mouse model compared to Tab9H6V3, an anti-GITR antibody that activates T cells and inhibits Treg suppression from XenoMouse. As a fully human antibody with its posttranslational modification hot spot removed, the hab019e2 antibody exerted more potent therapeutic effects, and may have potential as a novel and developable antibody targeting GITR for follow-up drug studies. [ABSTRACT FROM AUTHOR]- Published
- 2022
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34. Heterogrowth of β‑(AlxGa1–x)2O3 Thin Films on Sapphire Substrates.
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Zhang, Tao, Cheng, Qian, Li, Yifan, Hu, Zhiguo, Zhang, Yuxuan, Ma, Jinbang, Yao, Yixin, Zuo, Yan, Feng, Qian, Zhang, Yachao, Zhou, Hong, Ning, Jing, Zhang, Chunfu, Zhang, Jincheng, and Hao, Yue
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- 2022
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35. Fabrication of silica-based ceramic cores with internal lattice structures by stereolithography
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Hu, Ke-hui, Wang, Hao-yuan, Lu, Kuan, Feng, Qian, Yang, Dao-ding, Cao, Jian, Zhang, Bo, Lü, Zhi-gang, and Ran, Xing
- Abstract
Ceramic cores are widely used in investment casting, and ideal properties of cores are essential for high-quality castings. Under the circumstances requiring thick cores, solid cores are likely to encounter deformation and cracking defects due to the accumulation of shrinkage. Therefore, with the superiority of ceramic stereolithography in producing complex ceramic parts, hollow cores with lattice structures were designed and fabricated. The dimensional accuracy and properties of the green and sintered bodies were evaluated. Results show the dimensional accuracy of sintered cores is controlled within ±0.25 mm benefited from the precise green bodies. The mechanical properties are not obviously deteriorated. The bending strength reaches 11.94 MPa at room temperature and 12.87 MPa at 1,500 °C with a creep deformation of 0.345 mm. Furthermore, casting verifications prove that the hollow cores meet the requirements of investment casting. Smooth casting surfaces are obtained, at the same time, the core-removal efficiency is improved by over 3 times.
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- 2022
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36. Data-Driven Stochastic Robust Optimization for Industrial Energy System Considering Renewable Energy Penetration.
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Feifei Shen, Liang Zhao, Wenli Du, Weimin Zhong, Xin Peng, and Feng Qian
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- 2022
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37. Tough, Flexible, and Bioactive Amphoteric Copolymer-Based Hydrogel for Bone Regeneration without Encapsulation of Seed Cells/Simulating Cues.
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Wang, Rong, Che, Lingbin, Feng, Qian, and Cai, Kaiyong
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- 2022
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38. Highly Stretchable, Sensitive, and Durable Ag/Tannic Acid@Graphene Oxide-Composite Hydrogel for Wearable Strain Sensors.
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Chen, Kai, Wang, Feng, Hu, Yunping, Liu, Mingxiang, Liu, Pei, Yu, Yongsheng, Feng, Qian, and Xiao, Xiufeng
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- 2022
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39. Effect of information fields from written texts on cell growth and mitochondrial functions in-vitro: An exploratory study.
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Feng, Qian, Chen, Yu, Wang, Lin, Li, Mengmei, Teng, Jie, Chen, Yuming, Cai, Zhongzhen, Rein, Glen, Tang, B. Qing, and Bai, Xuemei
- Abstract
Objective: Mitochondria are considered a portal to receive, process and integrate external energy and information to maintain cellular homeostasis. We examined the effect of Chinese texts with positive and negative meaning on the growth and mitochondrial functions using a mouse kidney collecting duct cell line called M1 cells.Methods: To avoid skewing the results due to differential handling of the cells or analyzing the results, we conducted experiments by keeping the texts and blanks covered in brown opaque envelopes, exposed the cells to randomly selected envelopes and examined the differences over time. All operators involved in the experiments did not know the contents of the envelopes until the end of the experiments, and all data are expressed relative to the controls.Results: Cell growth rate was not affected for the group treated with positive information but was significantly reduced by 18% when treated with negative information. At the biochemical level, positive texts significantly increased whole cell adenosine triphosphate (ATP) and glutathione (GSH) by 22% and 21% respectively.Conclusions: This study for the first time demonstrated the effect of written words on specific biochemical measures in cultured mammalian cells. [ABSTRACT FROM AUTHOR]- Published
- 2022
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40. Preparation and characterization of PLGA nano-drug delivery system co-loaded with tranilast/gallium phytate for stent coating
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Wen, Kai-chao, Li, Zheng-an, Liu, Ji-heng, Zhang, Chuan, Zhang, Feng, and Li, Feng-qian
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The implantation of bare metal ureteral stents may lead to bacterial colonization and scar hyperplasia. To effectively address these issues, PLGA nanoparticles co-loaded with tranilast and gallium phytate (PG-TRL-PLGA-NPs) were prepared using an emulsifying solvent volatilization technique. The PG-TRL-PLGA-NPs possess a dual function of antibacterial and proliferation inhibition, which could be used for stent functional coating. The PG-TRL-PLGA-NPs displayed a regular spherical morphology with a smooth surface, and average particle size of 163 ± 1.37 nm, Zeta potential of −16.09 mV, drug loading capacity of 9.4 ± 0.6%, and encapsulation efficiency of 97.5 ± 0.4% could be achieved. FTIR, XRD, and DSC analysis demonstrated that PG-TRL-PLGA-NPS was successfully nano-encapsulated without chemical reaction among TRL, PG, and PLGA. In vitro release profiles of TRL and gallium ions from PG-TRL-PLGA-NPs exhibited a sustained-release effect, with 89.7 ± 0.9% and 3.2 ± 0.15 mg/L released in 14 days, respectively. Furthermore, it was observed the potent antibacterial activity (against S. aureusand E. coli.) of PG-TRL-PLGA-NPs, also significantly inhibited SV-HUC-1 cell proliferation through experiments involving cell migration, cell cycle, and apoptosis studies. These results provide valuable insights into the stent coatings of PG-TRL-PGLA NPs with potential functions of antibacterial and proliferative inhibitory.
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- 2024
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41. Passive stress-strain model and ultimate strength prediction for short steel tube confined concrete (STCC) columns allowing for size effect
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Hao, Xin-Kai, Zheng, Jian-Jun, Fu, Chuanqing, Wang, Yetao, and Feng, Qian
- Abstract
Steel tubes can significantly enhance the strength and ductility of concrete-filled steel tube (CFST) and steel tube confined concrete (STCC) columns. Existing research work have mainly focused on the former type while the later type of members not only avoid longitudinal steel bulking but also provide better ductility performance to resist seismic loads which is further investigated in this paper. Based on partial-interaction shear-friction mechanics, a passive stress-strain model for short steel tube confined concrete columns is proposed. The main benefit of the proposed model is that it is based on mechanics for rectangular and circular cross-sections which could allow for the size effect. Besides, this model also gives the ultimate strength of steel tube confined concrete columns and is further simplified as a design-oriented approach. The proposed passive stress-strain model and the simplified model for the ultimate strength of concrete columns show good correlation with experimental data. Compared with three other existing approaches, the simplified model could enhance the computing efficiency to a new level. Then a parametric study is conducted to investigate the effect of specimen size on the behaviour of steel tube confined concrete columns.
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- 2024
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42. Failure mechanism analysis and partial-interaction numerical simulation of Grouted Sleeve Connections (GSC) in tensile behavior
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Feng, Qian, Zheng, Shicheng, Wang, Yun, Xiang, Huawei, Wang, Jinfeng, and Xu, Rongqiao
- Abstract
Grouted Sleeve Connections (GSC) play an important role in assembly of structural members for precast concrete structures. With many experimental work and parametric study have been done on the tension load-slip behavior of GSC, the mechanical behavior for the tension load-slip responses of GSC should also be studied and explained. The failure modes for GSC in tensile tests with different material properties are firstly analyzed here by investigations on 326 GSC specimens. To study the mechanism of the failure modes, a partial-interaction numerical model is introduced to simulate the load-slip responses of GSC with provided bond-slip characteristics. The different boundary conditions for long and short embedment lengths are described respectively. More than 400 data points in load-slip responses are collected from tensile tests of GSC. The verification between theoretical results with test results shows good agreement. Hence, with the partial-interaction numerical model, the corresponding GSC load-slip responses could be obtained by given material and dimensional properties. Furthermore, parametric study shows that load-slip responses of GSC in tensile behavior change with embedment lengths of reinforcing bars. The CT scan results also show that embedment lengths for reinforcement are suggested to be longer than the designed size by considering the original defects of the sleeves and the eccentricity of reinforcement in construction.
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- 2024
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43. How network structures affect the 2D-3D registration of cardiovascular images.
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Ma, Limei, Nie, Yang, Feng, Qian, Cao, Jianshu, and Guan, Shaoya
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IMAGE registration ,DEEP learning ,VASCULAR surgery ,CARDIOVASCULAR diseases - Abstract
Pre-operative and intra-operative vascular image registration plays an important role in the navigation of minimally invasive vascular interventional surgery (MIVI). Deep learning methods perform excellently in the balance of time consumption and registration accuracy. Optimal network structure is hard to construct due to the indirect correlation between convolution operation and vascular characteristics. In this paper, we compare the performance of various CNN models to find the most suitable network structure for vascular image registration. The effects of different convolution submodules are also discussed to optimize the network structures. Experiments on patients suffering from different cardiovascular diseases are conducted to evaluate the robustness of CNN models. Networks covered in this paper are all suitable for vascular image registration with the registration error within 1 mm or 1 degree, while Alex-reg outperforms the others and achieves the best registration result. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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44. Application of transparent casting moulds prepared by additive manufacturing technology in hydraulic simulation
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Feng, Qian, Ran, Xing, Hu, Ke-hui, Wang, Hao-yuan, and Lü, Zhi-gang
- Abstract
Hydraulic simulation is one of the critical methods to research the filling mechanism of molten metal in the casting process. However, it only performs on test pieces with relatively simple structures due to the limitation of the preparation method. In this study, the method of photocuring additive manufacturing was used to prepare the complex casting mould from transparent photosensitive resin. The pouring test was carried out under different centrifugal conditions, and the filling process of the gating system, support bars and other positions in the vertical direction was recorded and analyzed. The experimental results show that the internal liquid level and the filling process of the test piece prepared by this method can be observed clearly. The angle between the liquid surface and the horizontal plane in the test piece gradually increases as the centrifugal rotational speed increases, which means the filling process is carried out from outside to inside at high rotational speed. The velocity of the fluid entering the runner increases with the increase of rotational speed, but the filling speeds is less affected by the centrifugal speed at other positions. The liquid flow is continuous and stable during the forward filling process, without splashing or interruption of liquid droplets.
- Published
- 2022
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45. Exosomal PD-L1 induces osteogenic differentiation and promotes fracture healing by acting as an immunosuppressant
- Author
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Lin, Ze, Xiong, Yuan, Meng, Weilin, Hu, Yiqiang, Chen, Lili, Chen, Lang, Xue, Hang, Panayi, Adriana C., Zhou, Wu, Sun, Yun, Cao, Faqi, Liu, Guodong, Hu, Liangcong, Yan, Chenchen, Xie, Xudong, Lin, Chuanchuan, Cai, Kaiyong, Feng, Qian, Mi, Bobin, and Liu, Guohui
- Abstract
A moderate inflammatory response at the early stages of fracture healing is necessary for callus formation. Over-active and continuous inflammation, however, impairs fracture healing and leads to excessive tissue damage. Adequate fracture healing could be promoted through suppression of local over-active immune cells in the fracture site. In the present study, we achieved an enriched concentration of PD-L1 from exosomes (Exos) of a genetically engineered Human Umbilical Vein Endothelial Cell (HUVECs), and demonstrated that exosomes overexpressing PD-L1 specifically bind to PD-1 on the T cell surface, suppressing the activation of T cells. Furthermore, exosomal PD-L1 induced Mesenchymal Stem Cells (MSCs) towards osteogenic differentiation when pre-cultured with T cells. Moreover, embedding of Exos into an injectable hydrogel allowed Exos delivery to the surrounding microenvironment in a time-released manner. Additionally, exosomal PD-L1, embedded in a hydrogel, markedly promoted callus formation and fracture healing in a murine model at the early over-active inflammation phase. Importantly, our results suggested that activation of T cells in the peripheral lymphatic tissues was inhibited after local administration of PD-L1-enriched Exos to the fracture sites, while T cells in distant immune organs such as the spleen were not affected. In summary, this study provides the first example of using PD-L1-enriched Exos for bone fracture repair, and highlights the potential of Hydrogel@Exos systems for bone fracture therapy through immune inhibitory effects.
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- 2022
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46. Surface Enrichment of Surfactants in Amorphous Drugs: An X-ray Photoelectron Spectroscopy Study.
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Junguang Yu, Yuhui Li, Xin Yao, Chailu Que, Lian Huang, Ho-Wah Hui, Yuchuan Gong, Feng Qian, and Lian Yu
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- 2022
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47. Osteoblast/Osteoclast and Immune Cocktail Therapy of an Exosome/Drug Delivery Multifunctional Hydrogel Accelerates Fracture Repair.
- Author
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Mi, Bobin, Chen, Lang, Xiong, Yuan, Yang, Yayan, Panayi, Adriana C., Xue, Hang, Hu, Yiqiang, Yan, Chenchen, Hu, Liangcong, Xie, Xudong, Lin, Ze, Zhou, Wu, Cao, Faqi, Xiao, Xiufeng, Feng, Qian, and Liu, Guohui
- Published
- 2022
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48. #293 : Trends of Statistical Significance Reporting in Abstracts of Reproductive Medicine Studies from 1990 to 2022
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Feng, Qian, Li, Wentao, and Mol, Ben
- Abstract
Background and Aims: Despite efforts to minimize publication reporting bias in medical research, it remains unclear whether the magnitude and patterns of the bias have changed over time. We aim to assess the frequency in which the statistical information is presented in forms other than P-values and evaluate how statistical significance was reported in the abstracts of reproductive medicine studies.Method: We studied reproductive medicine studies published in 23 Q1 journals in reproductive medicine, and five top medical journals, including JAMA, Lancet, BMJ, NEJM, and PLOS Medicine. We text-mined abstracts from 1990 to 2022 to extract P-value, confidence interval (CI), and text description in statistical significance; the presence of effect size metrics and Bayes factors were searched. One thousand abstracts were randomly selected and manually checked. The extracted statistical significance information was then analysed for temporal trends and distribution.Results: We identified 24,550 reproductive medicine abstracts. The proportion of abstracts reporting isolated P-values was 13.9% in 1990 and 18.8% in 2021 (Figure 1); reporting isolated P-values was 3.0% (95% CI, 0.5%-11.3%) in meta-analyses, 20.8% (95% CI, 11.3%-34.5%) in randomized controlled trials, and 33.3% (95% CI, 23.8%-44.3%) in basic research in 2021. By contrast, the proportion of abstracts in reporting effect measures without P-value surged from 4.1% to 23.3% from 1990 to 2021. The reported P-values (n = 18,132) mainly clustered at 0.001 (20.0%) and 0.05 (16.2%). Of the 14,689 abstracts containing at least one statement describing statistical significance, 74.9% of abstracts made at least one statistically significant statement; this proportion had merely changed over time (Figure 2).Conclusion: Despite the increasing adoption of effect measures to convey statistical significance, reporting isolated P-values remains common. Publication reporting bias is pervasive and persisting in reproductive medicine abstracts; the inflated treatment could mislead all types of patient care and policy decisions.
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- 2023
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49. Six Unusual Meroterpenoids from the Leaves of Psidium guajavaL. and Their PTP1B Inhibitory Activities
- Author
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Xiao, Xianfeng, Zhang, Xuerong, Yang, Zhenkun, Ji, Aijia, Wang, Caiyan, Feng, Qian, Liu, Zhongqiu, and Zhang, Rong-Rong
- Abstract
Six unusual meroterpenoids, psidiguajadiol A–J (1–6), and three known meroterpenoids (7–9) were isolated from the leaves of Psidium guajavaL. Compounds 2–6represent the first examples of 6/8-formyl-5,7-dihydroxy-4-phenylchromane-coupled sesquiterpenoids. The structures of the undescribed compounds, including their absolute configurations, were elucidated by spectroscopic analyses, X-ray diffraction, and computational calculations. Compounds 3, 4, and 6exhibited inhibitory activities against PTP1B with IC50values of 9.83, 18.52, and 16.87 μM, respectively. In light of these findings, we performed molecular docking studies to predict their inhibition mechanisms at the atomic level.
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- 2022
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50. Tough, Flexible, and Bioactive Amphoteric Copolymer-Based Hydrogel for Bone Regeneration without Encapsulation of Seed Cells/Simulating Cues
- Author
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Wang, Rong, Che, Lingbin, Feng, Qian, and Cai, Kaiyong
- Abstract
Bone tissue scaffolds with good bulk or surface osteoconductivity are always pursued by biomaterial scientists. In this paper, we design a tough and flexible amphoteric copolymer-based (AC) hydrogel with bioactive groups for bone regeneration. In detail, our hydrogels are copolymerized with N-acyl glycinamide (NAGA), anionic acrylate alendronate (AcAln), and cationic (2-(acryloyloxy)ethyl) trimethyl ammonium chloride (DMAEA-Q) by free radical polymerization. There are three kinds of synergetic physical cross-links among our polyamphion hydrogels: (1) double hydrogen bonds between amide groups in NAGA to provide toughness, (2) hydrogen bonds between dual bisphosphite groups in AcAln, and (3) weak ionic pairs between the anionic bisphosphite groups and the cationic quaternary ammonium groups in DMAEA-Q to offer flexibility. The AC hydrogel shows osteoid-like viscoelasticity, which makes the AC hydrogel osteogenesis inductive. During the repairing process, the bioactive bisphosphite groups accelerate the calcium fixation to expedite the mineralization of the new-formed bone. At the same time, the surface charge property of AC hydrogels also prevents fibrous cyst formation, thus guaranteeing osseointegration. Our in vitro data strongly demonstrate that the AC hydrogel is an excellent matrix to induce osteogenesis of rat bone marrow mesenchymal stem cells. More importantly, the following in vivo experiments further prove that the AC hydrogel can reach satisfactory bone regeneration without encapsulation of seed cells or application of external simulating cues. These exciting results demonstrate that our AC hydrogel is a promising scaffold for bone regeneration. Our work can also inspire the constituent and structure design of biomaterial scaffolds for tissue regeneration.
- Published
- 2022
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