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3. Physical exercise and cognitive function across the life span: Results of a nationwide population-based study.

Author

Gaertner, Beate, Buttery, Amanda K., Finger, Jonas D., Wolfsgruber, Steffen, Wagner, Michael, and Busch, Markus A.

Abstract

Objectives: To examine cross-sectional and longitudinal associations between physical exercise and cognitive function across different age groups in a nationwide population-based sample of adults aged 18-79 years in Germany.Design: Cross-sectional/prospective.Methods: Cognitive function was assessed in the mental health module of the German Health Interview and Examination Survey for Adults (DEGS1-MH, 2009-2012, n=3535), using a comprehensive neuropsychological test battery. Cognitive domain scores for executive function and memory were derived from confirmatory factor analysis. Regular physical exercise in the last three months was assessed by self-report and defined as no exercise, <2 and ≥2h (hours) of exercise per week. A subgroup of DEGS1-MH participants who previously participated in the German National Health Interview and Examination Survey 1998 (GNHIES98, 1997-1999, n=1624) enabled longitudinal analyses with a mean follow-up of 12.4 years.Results: Compared to no exercise, more weekly physical exercise was associated with better executive function in cross-sectional (<2h: β=0.12; ≥2h: β=0.17; all p<0.001) and longitudinal analyses (<2h: β=0.14, p<0.001; ≥2h: β=0.15, p=0.001) using linear regression models adjusted for age, sex, education, smoking, alcohol consumption, fruit and vegetable consumption and obesity. Slightly weaker associations were found for memory in cross-sectional (<2h: β=0.08, p=0.009; ≥2h: β=0.08, p=0.026) and longitudinal analysis (<2h: β=0.09, p=0.036; ≥2h: β=0.08, p=0.114). There was no evidence of interaction between physical exercise and age.Conclusions: Higher levels of physical exercise were associated with better executive function and memory in cross-sectional and longitudinal analyses with no evidence for differential effects by age. [ABSTRACT FROM AUTHOR]

Published
2018
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5. Do in-person and computer-based brief alcohol interventions reduce tobacco smoking among general hospital patients? Secondary outcomes from a randomized controlled trial

Author

Krolo-Wicovsky, Filipa, Baumann, Sophie, Tiede, Anika, Bischof, Gallus, John, Ulrich, Gaertner, Beate, and Freyer-Adam, Jennis

Abstract

Background: At-risk alcohol use and tobacco smoking often co-occur. We investigated whether brief alcohol interventions (BAIs) among general hospital patients with at-risk alcohol use may also reduce tobacco smoking over 2 years. We also investigated whether such effects vary by delivery mode; i.e. in-person versus computer-based BAI. Methods: A proactively recruited sample of 961 general hospital patients with at-risk alcohol use aged 18 to 64 years was allocated to three BAI study groups: in-person BAI, computer-based BAI, and assessment only. In-person- and computer-based BAI included motivation-enhancing intervention contacts to reduce alcohol use at baseline and 1 and 3 months later. Follow-ups were conducted after 6, 12, 18 and 24 months. A two-part latent growth model, with self-reported smoking status (current smoking: yes/no) and number of cigarettes in smoking participants as outcomes, was estimated. Results: Smoking participants in computer-based BAI smoked fewer cigarettes per day than those assigned to assessment only at month 6 (meannet change= − 0.02; 95% confidence interval = − 0.08–0.00). After 2 years, neither in-person- nor computer-based BAI significantly changed smoking status or number of cigarettes per day in comparison to assessment only or to each other (ps ≥ 0.23). Conclusions: While computer-based BAI also resulted in short-term reductions of number of cigarettes in smoking participants, none of the two BAIs were sufficient to evoke spill-over effects on tobacco smoking over 2 years. For long-term smoking cessation effects, multibehavioural interventions simultaneously targeting tobacco smoking along with at-risk alcohol use may be more effective.

Published
2023
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6. In-person alcohol counseling versus computer-generated feedback: Results from a randomized controlled trial.

Author

Freyer-Adam, Jennis, Baumann, Sophie, Haberecht, Katja, Tobschall, Stefanie, Bischof, Gallus, John, Ulrich, and Gaertner, Beate

Abstract

Objective: To investigate the comparative 2-year efficacy of brief alcohol interventions delivered in-person versus through computer-generated feedback letters among general hospital inpatients with at-risk alcohol use. Methods: In 2011-2012, all general hospital inpatients aged 18-64 years on 13 wards at 4 medical departments in 1 general hospital were systematically screened for at-risk alcohol use. Nine-hundred sixty-one inpatients who screened positive for at-risk alcohol use and negative for more severe alcohol problems were randomized by timeframe to in-person counseling (PE), computer-generated feedback letters (CO) and assessment only (AO). Both interventions included 3 contacts: on the ward and 1 and 3 months later and were based on the transtheoretical model (TTM). After 6, 12, 18, and 24 months computer-assisted telephone interviews assessed self-report outcomes: gram alcohol per week (primary), at-risk alcohol use and highest blood alcohol concentration (both secondary). Latent growth models were used. Results: After 24 months, CO resulted in a greater reduction of self-reported gram alcohol per week than AO (p = .027); PE did not differ significantly from AO (p = .503) and CO (p = .088); and group differences concerning secondary outcomes were not statistically significant (ps > 0.07). After 6 months, the odds of at-risk alcohol use were reduced by half in PE versus AO (odds ratio = 0.50, 95% confidence interval: 0.25-0.98). Conclusions: No significant group differences between in-person counseling and computer-generated feedback letters were found. TTM-based computer-generated feedback letters reduced self-reported gram alcohol over 2 years and can be considered a long-term effective alternative in medical settings when addressing at-risk alcohol use. [ABSTRACT FROM AUTHOR]

Published
2018
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7. Does Impaired Mental Health Interfere With the Outcome of Brief Alcohol Intervention at General Hospitals?

Author

Baumann, Sophie, Haberecht, Katja, Meyer, Christian, John, Ulrich, Gaertner, Beate, Rumpf, Hans-Jiirgen, and Freyer-Adam, Jennis

Subjects
MENTAL health, ALCOHOL, HOSPITALS
Abstract

Objective: The aim of this study was to test whether the efficacy of in-person and computer delivered brief alcohol intervention (BAI) is moderated by mental health status. Method: General hospital inpatients with at-risk alcohol use aged 18 to 64 years (N = 961, 75% men) were allocated to in-person BAI, computer-based BAI, and assessment only. In-person BAI contained counseling by research staff. Computer-based BAI contained computer-generated individualized feedback letters. BAIs were designed to be delivered at baseline and 1 and 3 months later. Outcome was reduction in alcohol use per day after 6, 12, 18, and 24 months. Latent growth curve models were estimated. Two mental health indicators, the 5-item mental health inventory and routine care diagnosis of mental and behavioral disorders assessed by general hospital physicians, were tested as moderators of BAI efficacy. Results: In all groups, inpatients with better mental health reduced alcohol use after hospitalization (ps < 0.01). While inpatients with impaired mental health did not reduce their drinking significantly following assessment only, those who received any of the 2 BAIs did (ps < 0.05). Conclusions: BAI was particularly efficacious in reducing alcohol use among general hospital inpatients with at-risk alcohol use and impaired mental health, with computer-based delivery being at least as efficacious as in-person delivery. [ABSTRACT FROM AUTHOR]

Published
2017
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8. Proceedings of the 13th annual conference of INEBRIA

Author

Watson, Rod, Morris, James, Isitt, John, Barrio, Pablo, Ortega, Lluisa, Gual, Antoni, Conner, Kenneth, Stecker, Tracy, Maisto, Stephen, Paroz, Sophie, Graap, Caroline, Grazioli, Véronique, Daeppen, Jean-Bernard, Collins, Susan, Bertholet, Nicolas, McNeely, Jennifer, Kushnir, Vlad, Cunningham, John, Crombie, Iain, Cunningham, Kathryn, Irvine, Linda, Williams, Brian, Sniehotta, Falko, Norrie, John, Melson, Ambrose, Jones, Claire, Briggs, Andrew, Rice, Peter, Achison, Marcus, McKenzie, Andrew, Dimova, Elena, Slane, Peter, Grazioli, Véronique, Collins, Susan, Paroz, Sophie, Graap, Caroline, Daeppen, Jean-Bernard, Baggio, Stéphanie, Dupuis, Marc, Studer, Joseph, Gmel, Gerhard, Magill, Molly, Grazioli, Véronique, Tait, Robert, Teoh, Lucinda, Kelty, Erin, Geelhoed, Elizabeth, Mountain, David, Hulse, Gary, Renko, Elina, Mitchell, Shannon, Lounsbury, David, Li, Zhi, Schwartz, Robert, Gryczynski, Jan, Kirk, Arethusa, Oros, Marla, Hosler, Colleen, Dusek, Kristi, Brown, Barry, Finnell, Deborah, Holloway, Aisha, Wu, Li-Tzy, Subramaniam, Geetha, Sharma, Gaurav, Wallhed Finn, Sara, Andreasson, Sven, Dvorak, Robert, Kramer, Matthew, Stevenson, Brittany, Sargent, Emily, Kilwein, Tess, Harris, Sion, Sherritt, Lon, Copelas, Sarah, Knight, John, Mdege, Noreen, McCambridge, Jim, Bischof, Gallus, Bischof, Anja, Freyer-Adam, Jennis, Rumpf, Hans-Juergen, Fitzgerald, Niamh, Schölin, Lisa, Toner, Paul, Böhnke, Jan, Veach, Laura, Currin, Olivia, Dongre, Leigh, Miller, Preston, White, Elizabeth, Williams, Emily, Lapham, Gwen, Bobb, Jennifer, Rubinsky, Anna, Catz, Sheryl, Shortreed, Susan, Bensley, Kara, Bradley, Katharine, Milward, Joanna, Deluca, Paolo, Khadjesari, Zarnie, Watson, Rod, Fincham-Campbell, Stephanie, Drummond, Colin, Angus, Kathryn, Bauld, Linda, Baumann, Sophie, Haberecht, Katja, Schnuerer, Inga, Meyer, Christian, Rumpf, Hans-Jürgen, John, Ulrich, Gaertner, Beate, Barrault-Couchouron, Marion, Béracochéa, Marion, Allafort, Vincent, Barthélémy, Valérie, Bonnefoi, Hervé, Bussières, Emmanuel, Garguil, Véronique, Auriacombe, Marc, Saint-Jacques, Marianne, Dorval, Michel, M’Bailara, Katia, Segura-Garcia, Lidia, Ibañez-Martinez, Nuria, Mendive-Arbeloa, Juan, Anoro-Perminger, Manel, Diaz-Gallego, Pako, Piñar-Mateos, Mª, Colom-Farran, Joan, Deligianni, Marianthi, Yersin, Bertrand, Adam, Angeline, Weisner, Constance, Chi, Felicia, Lu, Wendy, Sterling, Stacy, Kraemer, Kevin, McGinnis, Kathleen, Fiellin, David, Skanderson, Melissa, Gordon, Adam, Robbins, Jonathan, Zickmund, Susan, Korthuis, P., Edelman, E., Hansen, Nathan, Cutter, Christopher, Dziura, James, Fiellin, Lynn, O’Connor, Patrick, Maisto, Stephen, Bedimo, Roger, Gilbert, Cynthia, Marconi, Vincent, Rimland, David, Rodriguez-Barradas, Maria, Simberkoff, Michael, Justice, Amy, Bryant, Kendall, Berman, Anne, Shorter, Gillian, Bray, Jeremy, Barbosa, Carolina, Johansson, Magnus, Hester, Reid, Campbell, William, Souza Formigoni, Maria, Andrade, André, Sartes, Laisa, Sundström, Christopher, Eék, Niels, Kraepelien, Martin, Kaldo, Viktor, Fahlke, Claudia, Hernandez, Lynn, Becker, Sara, Jones, Richard, Graves, Hannah, Spirito, Anthony, Diestelkamp, Silke, Wartberg, Lutz, Arnaud, Nicolas, Thomasius, Rainer, Gaume, Jacques, Grazioli, Véronique, Fortini, Cristiana, Malan, Zelra, Mash, Bob, Everett-Murphy, Katherine, Grazioli, Véronique, Studer, Joseph, Mohler-Kuo, M., Bertholet, Nicolas, Gmel, Gerhard, Doi, Lawrence, Cheyne, Helen, Jepson, Ruth, Luna, Vanesa, Echeverria, Leticia, Morales, Silvia, Barroso, Teresa, Abreu, Ângela, Aguiar, Cosma, Stewart, Duncan, Abreu, Angela, Brites, Riany, Jomar, Rafael, Marinho, Gerson, Parreira, Pedro, Seale, J., Johnson, J., Henry, Dena, Chalmers, Sharon, Payne, Freida, Tuck, Linda, Morris, Akula, Gonçalves, Cátia, Besser, Bettina, Casajuana, Cristina, López-Pelayo, Hugo, Balcells, María, Teixidó, Lídia, Miquel, Laia, Colom, Joan, Hepner, Kimberly, Hoggatt, Katherine., Bogart, Andy, Paddock, Susan., Hardoon, Sarah, Petersen, Irene, Hamilton, Fiona, Nazareth, Irwin, White, Ian, Marston, Louise, Wallace, Paul, Godfrey, Christine, Murray, Elizabeth, Sovinová, Hana, and Csémy, Ladislav

Published
2016
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9. MRI in acute cerebral ischemia of the young: the Stroke in Young Fabry Patients (sifap1) Study.

Author

Fazekas, Franz, Enzinger, Christian, Schmidt, Reinhold, Dichgans, Martin, Gaertner, Beate, Jungehulsing, Gerhard J, Hennerici, Michael G, Heuschmann, Peter, Holzhausen, Martin, Kaps, Manfred, Kessler, Christof, Martus, Peter, Putaala, Jukka, Ropele, Stefan, Tanislav, Christian, Tatlisumak, Turgut, Norrving, Bo, Rolfs, Arndt, and sifap1 Investigators

Published
2013
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10. MRI in acute cerebral ischemia of the young.

Author

Fazekas, Franz, Enzinger, Christian, Schmidt, Reinhold, Dichgans, Martin, Gaertner, Beate, Jungehulsing, Gerhard J., Hennerici, Michael G., Heuschmann, Peter, Holzhausen, Martin, Kaps, Manfred, Kessler, Christof, Martus, Peter, Putaala, Jukka, Ropele, Stefan, Tanislav, Christian, Tatlisumak, Turgut, Norrving, Bo, and Rolfs, Arndt

Published
2013
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11. How Well Do TTM Measures Work Among a Sample of Individuals With Unhealthy Alcohol Use That Is Characterized by Low Readiness to Change?

Author

Baumann, Sophie, Schmierer, Inga, Gaertner, Beate, Bischof, Gallus, John, Ulrich, and Freyer-Adam, Jennis

Abstract

The article offers information on a study related to the transtheoretical model (TTM) of intentional behavioral change in alcoholics. It mentions that the study was conducted on individuals with unhealthy alcohol use characterized by low readiness to change. It reports that the psychometric properties weer assessed by three constructs of TTM including the 20-item Processes of Change (POC-20), the Alcohol Decisional Balance Scale (ADBS) and the Alcohol Abstinence Self-Efficacy (AASE) scale.

Published
2013
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12. Lifestyle Risk Factors for Ischemic Stroke and Transient Ischemic Attack in Young Adults in the Stroke in Young Fabry Patients Study.

Author

von Sarnowski, Bettina, Putaala, Jukka, Grittner, Ulrike, Gaertner, Beate, Schminke, Ulf, Curtze, Sami, Huber, Roman, Tanislav, Christian, Lichy, Christoph, Demarin, Vida, Basic-Kes, Vanja, Ringelstein, E. Bernd, Neumann-Haefelin, Tobias, Enzinger, Christian, Fazekas, Franz, Rothwell, Peter M., Dichgans, Martin, Jungehulsing, Gerhard J., Heuschmann, Peter U., and Kaps, Manfred

Published
2013
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13. Kidney Function and White Matter Disease in Young Stroke Patients: Analysis of the Stroke in Young Fabry Patients Study Population.

Author

Steinicke, Robert, Gaertner, Beate, Grittner, Ulrike, Schmidt, Wolf, Dichgans, Martin, Heuschmann, Peter U., Tanislav, Christian, Putaala, Jukka, Kaps, Manfred, Endres, Matthias, Schmidt, Reinhold, Fazekas, Franz, Norrving, Bo, Rolfs, Arndt, Martus, Peter, Tatlisumak, Turgut, Enzinger, Christian, and Jungehulsing, Gerhard Jan

Published
2012
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14. MRI in acute cerebral ischemia of the young

Author

Fazekas, Franz, Enzinger, Christian, Schmidt, Reinhold, Dichgans, Martin, Gaertner, Beate, Jungehulsing, Gerhard J., Hennerici, Michael G., Heuschmann, Peter, Holzhausen, Martin, Kaps, Manfred, Kessler, Christof, Martus, Peter, Putaala, Jukka, Ropele, Stefan, Tanislav, Christian, Tatlisumak, Turgut, Norrving, Bo, and Rolfs, Arndt

Abstract

We focused on cerebral imaging findings in a large cohort of young patients with a symptomatic ischemic cerebrovascular event (CVE) to extract relevant pathophysiologic and clinical information.

Published
2013
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15. Lifestyle Risk Factors for Ischemic Stroke and Transient Ischemic Attack in Young Adults in the Stroke in Young Fabry Patients Study

Author

von Sarnowski, Bettina, Putaala, Jukka, Grittner, Ulrike, Gaertner, Beate, Schminke, Ulf, Curtze, Sami, Huber, Roman, Tanislav, Christian, Lichy, Christoph, Demarin, Vida, Basic-Kes, Vanja, Ringelstein, E. Bernd, Neumann-Haefelin, Tobias, Enzinger, Christian, Fazekas, Franz, Rothwell, Peter M., Dichgans, Martin, Jungehulsing, Gerhard J., Heuschmann, Peter U., Kaps, Manfred, Norrving, Bo, Rolfs, Arndt, Kessler, Christof, and Tatlisumak, Turgut

Abstract

Although many stroke patients are young or middle-aged, risk factor profiles in these age groups are poorly understood.

Published
2013
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16. Kidney Function and White Matter Disease in Young Stroke Patients

Author

Steinicke, Robert, Gaertner, Beate, Grittner, Ulrike, Schmidt, Wolf, Dichgans, Martin, Heuschmann, Peter U., Tanislav, Christian, Putaala, Jukka, Kaps, Manfred, Endres, Matthias, Schmidt, Reinhold, Fazekas, Franz, Norrving, Bo, Rolfs, Arndt, Martus, Peter, Tatlisumak, Turgut, Enzinger, Christian, and Jungehulsing, Gerhard Jan

Abstract

Impaired kidney function is thought to be associated with small vessel disease, outcome, and mortality in the general stroke population. Data are limited regarding young patients. The aim of this study was to investigate the association of kidney function and white matter hyperintensities (WMHs) in young patients with first ischemic stroke.

Published
2012
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