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Selecting the best embryos to transfer is essential in any in vitro fertilization treatment. For years, embryo morphology supported this selection. Now, the field is seeking more accurate and non-invasive methods for selection. Recent studies show that embryos that do not result in successful pregnancy exhibit different metabolomic profiles from those embryos that result in successful pregnancy, opening a new possibility in the field. Metabolomic profiling and analysis of the cell-free DNA released by the embryo to the culture media are the most promising techniques for embryo selection developed so far.