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7 results on '"Garret, Charlotte"'

1. Continued enteral nutrition until extubation compared with fasting before extubation in patients in the intensive care unit: an open-label, cluster-randomised, parallel-group, non-inferiority trial

Author

Landais, Mickaël, Nay, Mai-Anh, Auchabie, Johann, Hubert, Noemie, Frerou, Aurélien, Yehia, Aihem, Mercat, Alain, Jonas, Maud, Martino, Frédéric, Moriconi, Mikael, Courte, Anne, Robert-Edan, Vincent, Conia, Alexandre, Bavozet, Florent, Egreteau, Pierre-Yves, Bruel, Cédric, Renault, Anne, Huet, Olivier, Feller, Marc, Chudeau, Nicolas, Ferrandiere, Martine, Rebion, Anne, Robert, Alain, Giraudeau, Bruno, Reignier, Jean, Thille, Arnaud W, Tavernier, Elsa, Ehrmann, Stephan, MORTAZA, Satar, DEMISELLE, Julien, SASSI, Taoufik, DELALE, Charles, GROUILLE, Julien, DE TINTENIAC, Anne, GESLAIN, Marie, FLOCH, Herve, BAILLY, Pierre, BODENES, Laetitia, PRAT, Gwenaël, KALFON, Pierre, BADRE, Gaetan, JOURDAIN, Cecile, MAZZONI, Thierry, LE MEUR, Anthony, FAYOLLE, Pierre Marie, HERON, Anne, MAILLET, Odile, LEDOUX, Nelly, ROLLE, Amélie, RICHARD, Régine, VALETTE, Marc, AZAIS, Marie-Ange, POUPLET, Caroline, BACHOUMAS, Konstantinos, CALLAHAN, Jean Christophe, GUITTON, Christophe, DARREAU, Cedric, LEFEVRE, Montaine, LELOUP, Guillaume, BERTEL, Mélanie, DAUVERGNE, Jerome, PACAUD, Laurence, LAKHAL, Karim, MARTIN, Maelle, GARRET, Charlotte, LASCARROU, Jean-Baptiste, BOULAIN, Thierry, MATHONNET, Armelle, MULLER, Grégoire, PHILIPPART, François, TRAN, Marc, FOURNIER, Julien, FRAT, Jean-Pierre, COUDROY, Remi, CHATELLIER, Delphine, HALLEY, Guillaume, GACOUIN, Arnaud, HOFF, Jerome, VASTAL, Servane, TELLIER, Anne-Charlotte, BARBAZ, Mathilde, SALMON GANDONNIERE, Charlotte, MERCIER, Emmanuelle, and DARWICHE, Walid

Abstract

Fasting is frequently imposed before extubation in patients in intensive care units, with the aim to reduce risk of aspiration. This unevaluated practice might delay extubation, increase workload, and reduce caloric intake. We aimed to compare continued enteral nutrition until extubation with fasting before extubation in patients in the intensive care unit.

Published
2023
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2. High-flow nasal oxygen alone or alternating with non-invasive ventilation in critically ill immunocompromised patients with acute respiratory failure: a randomised controlled trial.

Author

Coudroy, Rémi, Frat, Jean-Pierre, Ehrmann, Stephan, Pène, Frédéric, Decavèle, Maxens, Terzi, Nicolas, Prat, Gwenaël, Garret, Charlotte, Contou, Damien, Gacouin, Arnaud, Bourenne, Jeremy, Girault, Christophe, Vinsonneau, Christophe, Dellamonica, Jean, Labro, Guylaine, Jochmans, Sébastien, Herbland, Alexandre, Quenot, Jean-Pierre, Devaquet, Jérôme, and Benzekri, Dalila

Subjects
NONINVASIVE ventilation, ADULT respiratory distress syndrome, RANDOMIZED controlled trials, IMMUNOCOMPROMISED patients, CRITICALLY ill, PULMONARY edema
Abstract

Although non-invasive ventilation (NIV) is recommended for immunocompromised patients with acute respiratory failure in the intensive care unit (ICU), it might have deleterious effects in the most severe patients. High-flow nasal oxygen (HFNO) alone might be an alternative method to reduce mortality. We aimed to determine whether HFNO alone could reduce the rate of mortality at day 28 compared with HFNO alternated with NIV. FLORALI-IM is a multicentre, open-label, randomised clinical trial conducted in 29 ICUs (28 in France and one in Italy). Adult immunocompromised patients with acute respiratory failure, defined as respiratory rate of 25 breaths per min or more and a partial pressure of arterial oxygen to inspired fraction of oxygen ratio of 300 mm Hg or lower, were randomly assigned (1:1) to HFNO alone (HFNO alone group) or NIV alternating with HFNO (NIV group). Key exclusion criteria were severe hypercapnia above 50 mm Hg, patients who could strongly benefit from NIV (ie, those with underlying chronic lung disease, with cardiogenic pulmonary oedema, or who were postoperative), severe shock, impaired consciousness defined as Glasgow coma score ≤12, urgent need for intubation, do not intubate order, and contraindication to NIV. Patients were assigned using computer-generated permuted blocks and were stratified according to centre and to the type of immunosuppression using a centralised web-based management system. In the HFNO alone group, patients were continuously treated by HFNO with a gas flow rate of 60 L/min or the highest tolerated. In the NIV group, patients were treated with NIV with a first session of at least 4 h, and then by sessions for a minimal duration of 12 h a day, with a dedicated ventilator, targeting a tidal volume below 8 mL/kg of predicted bodyweight, and with a positive end-expiratory level of at least 8 cm H 2 O. NIV sessions were interspaced with HFNO delivered as in the HFNO alone group. The primary outcome was mortality at day 28 and was assessed in the intention-to-treat population. Secondary outcomes were mortality in the ICU, in hospital, at day 90 and at day 180, intubation at day 28, length of stay in the ICU and in hospital, number of ventilator-free days at day 28, number of oxygenation technique-free days at day 28, and efficacy and tolerance of oxygenation techniques. The trial is registered with ClinicalTrials.gov , NCT02978300 , and is complete. Between Jan 21, 2017 to March 4, 2019, of 497 eligible patients, 300 were randomly assigned but one patient withdrew consent, leaving 299 patients included in the intention-to-treat analysis (154 assigned to the HFNO alone group and 145 assigned to NIV group). Mortality rate at day 28 was 36% (95% CI 29·2 to 44·2; 56 of 154 patients) in the HFNO alone group and 35% (27·9 to 43·2; 51 of 145 patients) in the NIV group (absolute difference 1·2% [95% CI −9·6 to 11·9]; p=0·83). None of the other prespecified secondary outcomes were different between groups except for greater decreased discomfort after initiation of HFNO than with NIV (−4 mm on visual analogic scale [IQR −18 to 4] vs 0 mm [–16 to 17]; p=0·040). In critically ill immunocompromised patients with acute respiratory failure, the mortality rate did not differ between HFNO alone and NIV alternating with HFNO. However, study power was limited, so results should be interpreted with caution. French Ministry of Health. [ABSTRACT FROM AUTHOR]

Published
2022
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3. High-flow nasal oxygen alone or alternating with non-invasive ventilation in critically ill immunocompromised patients with acute respiratory failure: a randomised controlled trial

Author

Coudroy, Rémi, Frat, Jean-Pierre, Ehrmann, Stephan, Pène, Frédéric, Decavèle, Maxens, Terzi, Nicolas, Prat, Gwenaël, Garret, Charlotte, Contou, Damien, Gacouin, Arnaud, Bourenne, Jeremy, Girault, Christophe, Vinsonneau, Christophe, Dellamonica, Jean, Labro, Guylaine, Jochmans, Sébastien, Herbland, Alexandre, Quenot, Jean-Pierre, Devaquet, Jérôme, Benzekri, Dalila, Vivier, Emmanuel, Nseir, Saad, Colin, Gwenhaël, Thevenin, Didier, Grasselli, Giacomo, Bougon, David, Assefi, Mona, Guérin, Claude, Lherm, Thierry, Kouatchet, Achille, Ragot, Stephanie, Thille, Arnaud W, Delphine, Chatellier, Anne, Veinstein, Florence, Boissier, Faustine, Reynaud, Maeva, Rodriguez, Florent, Joly, François, Arrivé, Victor, De Roubin, René, Robert, Laetitia, Bodet-Contentin, Charlotte, Salmon Gandonnière, Emmanuelle, Mercier, Paul, Jaubert, Nathalie, Marin, Marine, Paul, Morgane, Faure, Suela, Demiri, Alexandre, Demoule, Clara, Candille, Anaïs, Dartevel, Florian, Sigaud, Vanessa, Jean Michel, Raphaël, Le Mao, Pierre, Bailly, Amélie, Seguin, Jean-Baptiste, Lascarrou, Emmanuel, Canet, Gaëtan, Plantefève, Radj, Cally, Joanna, Tirolien, Adel, Maamar, Benoit, Painvin, Julien, Carvelli, Marc, Gainnier, Gaëtan, Béduneau, Dorothée, Carpentier, Dominique, Malacrino, Mehdi, Marzouk, Clément, Saccheri, Nicolas, Mahr, Pauline, Soulier, Quentin, Levrat, Pascal, Andreu, David, Cortier, and Mai Anh, Nay

Abstract

Although non-invasive ventilation (NIV) is recommended for immunocompromised patients with acute respiratory failure in the intensive care unit (ICU), it might have deleterious effects in the most severe patients. High-flow nasal oxygen (HFNO) alone might be an alternative method to reduce mortality. We aimed to determine whether HFNO alone could reduce the rate of mortality at day 28 compared with HFNO alternated with NIV.

Published
2022
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4. Pressure-Support Ventilation vs T-Piece During Spontaneous Breathing Trials Before Extubation Among Patients at High Risk of Extubation Failure

Author

Thille, Arnaud W., Coudroy, Rémi, Nay, Mai-Anh, Gacouin, Arnaud, Demoule, Alexandre, Sonneville, Romain, Beloncle, François, Girault, Christophe, Dangers, Laurence, Lautrette, Alexandre, Levrat, Quentin, Rouzé, Anahita, Vivier, Emmanuel, Lascarrou, Jean-Baptiste, Ricard, Jean-Damien, Razazi, Keyvan, Barberet, Guillaume, Lebert, Christine, Ehrmann, Stephan, Massri, Alexandre, Bourenne, Jeremy, Pradel, Gael, Bailly, Pierre, Terzi, Nicolas, Dellamonica, Jean, Lacave, Guillaume, Robert, René, Ragot, Stéphanie, Frat, Jean-Pierre, Boissier, Florence, Chatellier, Delphine, Deletage, Céline, Guignon, Carole, Joly, Florent, Olivry, Morgane, Veinstein, Anne, Benzekri-Lefevre, Dalila, Boulain, Thierry, Muller, Grégoire, Le Tulzo, Yves, Tadié, Jean-Marc, Maamar, Adel, Demiri, Suela, Mayaux, Julien, Decavèle, Maxens, Bouadma, Lila, Dupuis, Claire, Asfar, Pierre, Pierrot, Marc, Béduneau, Gaëtan, Boyer, Déborah, Delmas, Benjamin, Puech, Bérénice, Bachoumas, Konstantinos, Soum, Edouard, Cabasson, Séverin, Hoppe, Marie-Anne, Nseir, Saad, Pouly, Olivier, Bourdin, Gaël, Rosselli, Sylvène, Le Meur, Anthony, Garret, Charlotte, Martin, Maelle, Berquier, Guillaume, Thiagarajah, Abirami, Carteaux, Guillaume, Mekontso-Dessap, Armand, Poidevin, Antoine, Dureau, Anne-Florence, Azais, Marie-Ange, Colin, Gwenhaël, Mercier, Emmanuelle, Morisseau, Marlène, Sabatier, Caroline, Picard, Walter, Gainnier, Marc, Nguyen, Thi-My-Hue, Prat, Gwenaël, Schwebel, Carole, and Buscot, Matthieu

Abstract

Spontaneous breathing trial (SBT) using a T-piece remains the most frequently performed trial before extubation in ICUs.

Published
2020
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5. Risk factors and outcomes of infected pancreatic necrosis: Retrospective cohort of 148 patients admitted to the ICU for acute pancreatitis

Author

Garret, Charlotte, Péron, Matthieu, Reignier, Jean, Le Thuaut, Aurélie, Lascarrou, Jean-Baptiste, Douane, Frédéric, Lerhun, Marc, Archambeaud, Isabelle, Brulé, Noëlle, Bretonnière, Cédric, Zambon, Olivier, Nicolet, Laurent, Regenet, Nicolas, Guitton, Christophe, and Coron, Emmanuel

Abstract

The primary objective of this article is to identify risk factors for infected pancreatic necrosis (IPN) in patients admitted to the intensive care unit (ICU) for severe acute pancreatitis. We also described outcomes of IPN. Acute pancreatitis is common and associated with multiple, potentially life-threatening complications. Over the last decade, minimally invasive procedures have been developed to treat IPN. We retrospectively studied consecutive patients admitted for severe acute pancreatitis to the ICUs of the Nantes University Hospital in France, between 2012 and 2015. Logistic regression was used to evaluate potential associations linking IPN to baseline patient characteristics and outcomes. Of the 148 included patients, 26 (17.6%) died. IPN developed in 62 (43%) patients and consistently required radiological, endoscopic, and/or surgical intervention. By multivariate analysis, factors associated with IPN were number of organ failure (OF) (for?=?3: OR, 28.67 (6.23–131.96), p?

Published
2018
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6. Risk factors and outcomes of infected pancreatic necrosis: Retrospective cohort of 148 patients admitted to the ICU for acute pancreatitis

Author

Garret, Charlotte, Péron, Matthieu, Reignier, Jean, Le Thuaut, Aurélie, Lascarrou, Jean-Baptiste, Douane, Frédéric, Lerhun, Marc, Archambeaud, Isabelle, Brulé, Noëlle, Bretonnière, Cédric, Zambon, Olivier, Nicolet, Laurent, Regenet, Nicolas, Guitton, Christophe, and Coron, Emmanuel

Abstract

Objective The primary objective of this article is to identify risk factors for infected pancreatic necrosis (IPN) in patients admitted to the intensive care unit (ICU) for severe acute pancreatitis. We also described outcomes of IPN.Background Acute pancreatitis is common and associated with multiple, potentially life-threatening complications. Over the last decade, minimally invasive procedures have been developed to treat IPN.Methods We retrospectively studied consecutive patients admitted for severe acute pancreatitis to the ICUs of the Nantes University Hospital in France, between 2012 and 2015. Logistic regression was used to evaluate potential associations linking IPN to baseline patient characteristics and outcomes.Results Of the 148 included patients, 26 (17.6%) died. IPN developed in 62 (43%) patients and consistently required radiological, endoscopic, and/or surgical intervention. By multivariate analysis, factors associated with IPN were number of organ failure (OF) (for ≥ 3: OR, 28.67 (6.23–131.96), p< 0.001) and portosplenomesenteric venous thrombosis (OR, 8.16 (3.06–21.76)).Conclusion IPN occurred in nearly half our ICU patients with acute pancreatitis and consistently required interventional therapy. Number of OFs and portosplenomesenteric venous thrombosis were significantly associated with IPN. Early management of OF may reduce IPN incidence, and management of portosplenomesenteric venous thrombosis should be investigated.

Published
2018
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7. Intoxication fatale à l’oxycodone dans les suites d’une leuco-encéphalopathie

Author

Le Carpentier, Edouard, Garret, Charlotte, Pineau, Alain, Deslandes, Guillaume, Monteil-Ganière, Catherine, and Boels, David

Abstract

L’oxycodone est un morphinique de plus en plus prescrit dans la prise en charge de douleurs aigues et chroniques. Nous décrivons un cas mortel d’intoxication aiguë volontaire à l’oxycodone chez un patient souffrant d’un syndrome douloureux chronique.

Published
2020
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