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The increasing temperatures and changing precipitation patterns have affected both crop yields and water requirements challenging agricultural systems in sustaining high crop yields and ensuring water and food security. In the present study, we evaluated the impact of climate change on the corn production under irrigated and rainfed cropping systems in Nebraska considering four climate zones until 2100 as a case study for the US Corn Belt. Additionally, suggests ways to reduce the impact of climate change on corn yield and water resources. Five global circulation model datasets from the sixth phase of the Coupled Model Intercomparison Project (CMIP6) interconnected to Shared Socioeconomic Pathways (SSPs), were selected. Three future periods: near (2020–2039), mid (2040–2069), and far future (2070–2100) under SSP226, SSP370, and SSP585 scenarios were used to predict the climate changes, crop cycle length, crop yield, and crop water requirement. Additionally, we input annual CO2concentration scenarios for each SSP scenario to model changes from 2015 to 2100 using the CERES-Maize model. Temperatures are forecasted to rise, precipitation to decline, and crop cycle length to decrease, particularly for SSP370 (up to 49% yield decrease) and SSP585 (up to 67% yield decrease) by 2070–2100. Yields are expected to decline across all scenarios and periods for irrigated and rainfed fields due to the reduction in crop cycle length. Crop water demand is projected to increase, with rainfed systems facing heightened impact due to reduced precipitation. Addressing climate change in Nebraska requires actions like developing new corn varieties to longer the crop season, transitioning to efficient irrigation systems, improving irrigation management for water and food security, and reducing the risk of conflicts over its use. These results open possibilities for discussion about the actions that can be taken to cope with climate change and guarantee water and food security in the US Corn Belt.