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INSEL provides an integrated simulation environment based on a block-diagram approach. Due to its flexible structure INSEL can easily be used for a wide range of simulation applications. It has been extended towards the simulation of the performance of the components of a parabolic trough plant including models for reflector, absorber, thermal storage, heat exchanger and steam turbine stage.

We report the cloning and molecular analysis of the Leishmania donovani clpB gene. The protein-coding region is highly conserved compared with its L. major homologue, while 5'- and 3'-flanking DNA sequences display considerable divergence. The encoded mRNA has an unusually long 5'-leader sequence typical for RNAs, which are translated preferentially under heat stress. The gene product, a 100-kDa heat shock protein, Hsp100, becomes abundant only during sustained heat stress, but not under common chemical stresses. Hsp100 associates into trimeric complexes and is found mostly in a cytoplasmic, possibly membrane-associated, localization as determined by immune electron microscopy. Hsp100 shows immediate early expression kinetics during axenic amastigote development. In its absence, expression of at least one amastigote stage-specific protein family is impaired.

Bugscope is a new educational project in the World Wide Laboratory. The World Wide Laboratory provides Web browser based control of scientific imaging instrumentation using the Internet [1]. Providing K-12 classrooms with web based remote access to sophisticated scientific imaging systems was initially demonstrated by us in 1996 in the Chickscope project [2,3]. Chickscope allowed students to study chicken embryo development using a remotely controlled magnetic resonance imaging (MRI) system from their classrooms. While the Chickscope project was highly successful, the resources required to provide operational support for the remote imaging aspects of the project for a small number of classrooms were enormous and the project was not sustainable. The Bugscope project builds on the methods developed and the lessons learned from the Chickscope project. The primary goal is to demonstrate that relatively low cost, sustainable access to an environmental scanning electron microscope (ESEM) can be made available to K-12 classrooms to examine arthropods.Methods: Classrooms use a standard web browser over the Internet to control and acquire images from a Philips XL-30FEG ESEM. The architecture to support remote acquisition is shown in fig. 1. The client/server control architecture for the ESEM remote control server is based on the emScope control library [4].