61 results on '"Hu, Chunyan"'
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2. An analog circuit soft fault diagnosis method based on Boruta feature selection and LightGBM model
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Jabbar, M. A., Lorenz, Pascal, Chen, Hongyang, Hu, Chunyan, Han, Bo, and Miao, Keqiang
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- 2024
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3. Pathogenic Somatic Mutation of DICER1 and Clinicopathological Features in Nasal Chondromesenchymal Hamartomas
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Hu, Chunyan, Liu, Yifeng, Lin, Lan, Yuan, Cuncun, Ma, Duan, and Huang, Qiang
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Nasal chondromesenchymal hamartoma (NCMH) is a rare benign polypoid mesenchymal tumor arising in the nasal cavity and/or paranasal sinuses. Recognizing these sporadic, rare lesions is crucial, as surgical complete removal of the mass is the common treatment approach. This retrospective study analyzed the demographics, symptoms, and imaging data of 9 patients diagnosed with NCMH between January 2017 and June 2023, possibly representing the largest single-center adult case cohort to date. Diagnostic techniques included nasal endoscopy, CT/MRI scan, immunohistological studies, and morphologic comparisons. Pathologic specimens were subjected to Sanger sequencing of exons 24 and 25 of DICER1. The average age of 9 cases was 24.4 years, and the oldest was 55 years. Four of the patients were children, ranging from 1 year old to 11 years old, with an average of 4.5 years. Nasal congestion is the most common registered symptom. Endoscopic findings showed that most patients had smooth pink neoplasms or polypoid masses in the nasal meatus. Radiologic scanning revealed soft-tissue density masses that occupied the nasal cavity. Histologically, the characteristic structure of NCMHs is immature cellular cartilage nodules and mature cartilage nodules distributed in a loose mucoid matrix. Five of the 9 patients had somatic DICER1 missense mutations. Four of the patients with DICER1-mutated NCMH exhibited a p.E1813 missense hotspot mutation. We also report a case of a rare p.P1836H missense mutation. The detected DICER1 somatic mutations provide compelling evidence of an association with the DICER1 tumor family. We emphasize the importance of pathologic consultation and the need for pathologists to accumulate experience in NCMH diagnosis to avoid misdiagnosis.
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- 2024
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4. Inspired by Plant Transpiration: Fabrication of a Unique Micro–Nano-Structured Janus Evaporator Using Waste Cotton Fabric for Enhanced Efficiency and Salt Resistance.
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Xiao, Junhai, Chen, Yunfei, Hu, Chunyan, Zhu, Zhijia, and Liu, Baojiang
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- 2024
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5. Development of new dehydrocostuslactone derivatives for treatment of atopic dermatitis viainhibition of the NF-κB signaling pathwayElectronic supplementary information (ESI) available: NMR and HRMS spectra. See DOI: https://doi.org/10.1039/d4md00301b
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Li, Xiaoyi, Lu, Cheng, Du, Wenxia, Zou, Qiuping, Wang, Ruirui, Hu, Chunyan, Li, Yanping, Zhang, Yi, and Mao, Zewei
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Atopic dermatitis (AD), a recurrent inflammatory systemic skin disease, is difficult to cure. In the present study, several ethylenediamine-derived dehydrocostuslactone (DHCL) derivatives were prepared to assess their in vitroand in vivoanti-inflammatory activities. The results indicated that DHCL derivatives inhibited NO generation with low cytotoxicity. In particular, compound 5dexhibited the best anti-inflammatory activity. Subsequent experiments revealed that 5dnot only inhibited the LPS-induced inflammatory response in RAW264.7 cells viathe MAPK–NF-κB signaling pathway inhibition but also significantly decreased Th2-type cytokine levels and inhibited the NF-κB signaling pathway activation in mice with MC903-induced AD. Therefore, DHCL derivatives may be considered as new agents for the treatment of AD.
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- 2024
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6. Fixed-Time Antidisturbance Consensus Tracking for Nonlinear Multiagent Systems with Matching and Mismatching Disturbances
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Tan, Xiangmin, Hu, Chunyan, Cao, Guanzhen, Wei, Qinglai, Li, Wei, and Han, Bo
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In this paper, fixed-time consensus tracking for multiagent systems (MASs) with dynamics in the form of strict feedback affine nonlinearity is addressed. A fixed-time antidisturbance consensus tracking protocol is proposed, which consists of a distributed fixed-time observer, a fixed-time disturbance observer, a nonsmooth antidisturbance backstepping controller, and the fixed-time stability analysis is conducted by using the Lyapunov theory correspondingly. This paper includes three main improvements. First, a distributed fixed-time observer is developed for each follower to obtain an estimate of the leader's output by utilizing the topology of the communication network. Second, a fixed-time disturbance observer is given to estimate the lumped disturbances for feedforward compensation. Finally, a nonsmooth antidisturbance backstepping tracking controller with feedforward compensation for lumped disturbances is designed. In order to mitigate the “explosion of complexity” in the traditional backstepping approach, we have implemented a modified nonsmooth command filter to enhance the performance of the closed-loop system. The simulation results show that the proposed method is effective.
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- 2024
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7. Synthesis and Antifungal Evaluation of New Azole Derivatives against Candida albicans.
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Hu, Chunyan, Xu, Zhichang, Huang, Zhengxiao, Wang, Ruirui, Zhang, Yi, and Mao, Zewei
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- 2023
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8. Prediction of acoustic pressure of thermoacoustic combustion instability based on Elman neural network
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Zeng, Qingwen, Hu, Chunyan, Xu, Hanling, Sun, Jiaxian, Tan, Xiangmin, and Zhu, Junqiang
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Accurate prediction of thermoacoustic instability is a prerequisite for thermoacoustic control to avoid the damage of combustion chamber, however, this problem has not been completely solved yet. This paper proposes a data-driven method based on the Elman neural network (ENN) to predict the value of acoustic pressure of combustion instability. As a comparison, a model based on support vector machine (SVM) was built. It is proved that ENN has better prediction performance with a certain predicted time horizon compared to the SVM method. What is more, the prediction model based on ENN can adapt to time-varying characteristics of the transition scenario which is characterized by amplitude modulation, multiple frequencies, and irregular bursts. ENN model still maintains enough prediction accuracy for various input training sets, indicating that ENN can fully mine the features of data and has a strong feature extraction ability in combustion oscillation prediction. Hence, it is demonstrated that ENN is a promising prediction tool for thermoacoustic instability under various combustion conditions. These findings are of great significance for the accurate prediction and control of thermoacoustic instability.
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- 2023
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9. NEF-Induced HIV-Associated Nephropathy Through HCK/LYN Tyrosine Kinases
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Hu, Chunyan, Priceputu, Elena, Cool, Marc, Chrobak, Pavel, Bouchard, Nathalie, Forestier, Clara, Lowell, Clifford A., Bénichou, Serge, Hanna, Zaher, Royal, Virginie, and Jolicoeur, Paul
- Abstract
HIV-1–associated nephropathy (HIVAN) is a severe complication of HIV-1 infection. To gain insight into the pathogenesis of kidney disease in the setting of HIV, a transgenic (Tg) mouse model [CD4C/HIV-negative regulator factor (Nef)] was used in which HIV-1 nefexpression is under control of regulatory sequences (CD4C) of the human CD4gene, thus allowing expression in target cells of the virus. These Tg mice develop a collapsing focal segmental glomerulosclerosis associated with microcystic dilatation, similar to human HIVAN. To identify kidney cells permissive to the CD4C promoter, CD4C reporter Tg lines were used. They showed preferential expression in glomeruli, mainly in mesangial cells. Breeding CD4C/HIV Tg mice on 10 different mouse backgrounds showed that HIVAN was modulated by host genetic factors. Studies of gene-deficient Tg mice revealed that the presence of B and T cells and that of several genes was dispensable for the development of HIVAN: those involved in apoptosis (Trp53, Tnfsf10, Tnf, Tnfrsf1b, and Bax), in immune cell recruitment (Ccl3, Ccl2, Ccr2, Ccr5, and Cx3cr1), in nitric oxide (NO) formation (Nos3and Nos2), or in cell signaling (Fyn, Lck, and Hck/Fgr). However, deletion of Srcpartially and that of Hck/Lynlargely abrogated its development. These data suggest that Nef expression in mesangial cells through hematopoietic cell kinase (Hck)/Lck/Yes novel tyrosine kinase (Lyn) represents important cellular and molecular events for the development of HIVAN in these Tg mice.
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- 2023
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10. Comparative susceptibility of SARS-CoV-2, SARS-CoV, and MERS-CoV across mammals
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Li, Meng, Du, Juan, Liu, Weiqiang, Li, Zihao, Lv, Fei, Hu, Chunyan, Dai, Yichen, Zhang, Xiaoxiao, Zhang, Zhan, Liu, Gaoming, Pan, Qi, Yu, Yang, Wang, Xiao, Zhu, Pingfen, Tan, Xu, Garber, Paul A, and Zhou, Xuming
- Abstract
Exploring wild reservoirs of pathogenic viruses is critical for their long-term control and for predicting future pandemic scenarios. Here, a comparative in vitro infection analysis was first performed on 83 cell cultures derived from 55 mammalian species using pseudotyped viruses bearing S proteins from SARS-CoV-2, SARS-CoV, and MERS-CoV. Cell cultures from Thomas’s horseshoe bats, king horseshoe bats, green monkeys, and ferrets were found to be highly susceptible to SARS-CoV-2, SARS-CoV, and MERS-CoV pseudotyped viruses. Moreover, five variants (del69-70, D80Y, S98F, T572I, and Q675H), that beside spike receptor-binding domain can significantly alter the host tropism of SARS-CoV-2. An examination of phylogenetic signals of transduction rates revealed that closely related taxa generally have similar susceptibility to MERS-CoV but not to SARS-CoV and SARS-CoV-2 pseudotyped viruses. Additionally, we discovered that the expression of 95 genes, e.g., PZDK1and APOBEC3, were commonly associated with the transduction rates of SARS-CoV, MERS-CoV, and SARS-CoV-2 pseudotyped viruses. This study provides basic documentation of the susceptibility, variants, and molecules that underlie the cross-species transmission of these coronaviruses.
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- 2023
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11. Insight into enhanced dehydrogenation of LiBH4 modified by Ti and O from first-principles calculations.
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Hu, Chunyan, Mo, Xiaohua, Zhou, Haojie, Li, Xiulan, Zuo, Xiaoli, Ma, Yu, and Jiang, Weiqing
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DEHYDROGENATION ,LITHIUM borohydride ,HYDROGEN as fuel ,ELECTRONIC structure ,DOPING agents (Chemistry) - Abstract
• Ti + O co-doped LiBH 4 are introduced by Ti substitution for Li and O for B/H. • Modification of Ti + O on enhanced dehydrogenation of LiBH 4 depends on occupation sites. • Decrease of Li − B/H and B − H interactions leads to destabilized LiBH 4 for favorable H-desorption. • Formation of Ti − H and O − H bonds acts as thermodynamic force for LiBH 4 destabilization. The present work gives the occupation energies, hydrogen dissociation energies and electronic structures of pure (Li 8 B 8 H 32 /Li 16 B 16 H 64), Ti-doped (Li 7 TiB 8 H 32 /Li 15 TiB 16 H 64) and Ti + O co-doped LiBH 4 (Li 7 TiB 7 OH 32 /Li 15 TiB 15 OH 64 and Li 7 TiB 8 OH 31 /Li 15 TiB 16 OH 63) using first-principles calculations, with the aim of providing new insights into the enhanced dehydrogenation of LiBH 4 modified by Ti and O. The results show that Ti + O incorporation in LiBH 4 lattice is energetically favorable in terms of occupation energy, relative to Ti adding. Ti and Ti + O modification not only suppresses B 2 H 6 formation upon H-desorption, but also destabilizes LiBH 4 for favorable H-desorption. The decreased B − H and Li − B/H interactions contributes to LiBH 4 destabilization, and the formed Ti − H and O H bonds acts as thermodynamic driving force for this destabilization. In our studies, Ti + O enable hydrogen dissociation energy to reach the minimum at Li 7 TiB 7 OH 32 /Li 15 TiB 15 OH 64 not at Li 7 TiB 8 OH 31 /Li 15 TiB 16 OH 63. Thus, suitable Ti + O co-substitution is needed to achieve significant enhancement in LiBH 4 dehydrogenation. [ABSTRACT FROM AUTHOR]
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- 2024
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12. Comparative susceptibility of SARS-CoV-2, SARS-CoV, and MERS-CoV across mammals
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Li, Meng, Du, Juan, Liu, Weiqiang, Li, Zihao, Lv, Fei, Hu, Chunyan, Dai, Yichen, Zhang, Xiaoxiao, Zhang, Zhan, Liu, Gaoming, Pan, Qi, Yu, Yang, Wang, Xiao, Zhu, Pingfen, Tan, Xu, Garber, Paul A., and Zhou, Xuming
- Abstract
Exploring wild reservoirs of pathogenic viruses is critical for their long-term control and for predicting future pandemic scenarios. Here, a comparative in vitro infection analysis was first performed on 83 cell cultures derived from 55 mammalian species using pseudotyped viruses bearing S proteins from SARS-CoV-2, SARS-CoV, and MERS-CoV. Cell cultures from Thomas’s horseshoe bats, king horseshoe bats, green monkeys, and ferrets were found to be highly susceptible to SARS-CoV-2, SARS-CoV, and MERS-CoV pseudotyped viruses. Moreover, five variants (del69-70, D80Y, S98F, T572I, and Q675H), that beside spike receptor-binding domain can significantly alter the host tropism of SARS-CoV-2. An examination of phylogenetic signals of transduction rates revealed that closely related taxa generally have similar susceptibility to MERS-CoV but not to SARS-CoV and SARS-CoV-2 pseudotyped viruses. Additionally, we discovered that the expression of 95 genes, e.g., PZDK1and APOBEC3, were commonly associated with the transduction rates of SARS-CoV, MERS-CoV, and SARS-CoV-2 pseudotyped viruses. This study provides basic documentation of the susceptibility, variants, and molecules that underlie the cross-species transmission of these coronaviruses.
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- 2023
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13. A New Methodology for Early Detection of Thermoacoustic Combustion Oscillations Based on Permutation Entropy
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Li, Yao, Hu, Chunyan, Shen, Youhao, Han, Bo, Yang, Jinhu, and Xu, Gang
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We carry out a series of experimental investigations in a model combustor to detect a precursor of thermoacoustic combustion oscillations based on permutation entropy, which can amplify the subtle changes effected in the time sequence to identify the anomaly. By changing the flame’s location or the fuel flow to a value, an abrupt switch from aperiodic small-amplitude oscillations to periodic large-amplitude oscillations would occur in pressure fluctuations. The characteristic frequency of combustion oscillation is obtained by spectral analysis, with which a modified algorithm of the permutation entropy is proposed. The impact evaluation on key parameters such as moving step sizes and window sizes reveals that the moving data permutation entropy has strong robustness, and can accurately detect the onset of thermoacoustic oscillations. Further nonlinear analysis exhibits peculiar dynamics of the combustion system, which result in specific patterns in the time series and provide a theoretical basis for anomaly detection. Our results suggest that the permutation entropy has a certain potential in early warning and detection of combustion oscillations.
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- 2023
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14. The association between early-life famine exposure and adulthood obesity on the risk of dyslipidemia.
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Hu, Chunyan, Du, Rui, Lin, Lin, Zheng, Ruizhi, Qi, Hongyan, Zhu, Yuanyue, Wei, Ran, Wu, Xueyan, Zhang, Yi, Li, Mian, Wang, Tiange, Zhao, Zhiyun, Xu, Min, Xu, Yu, Bi, Yufang, Ning, Guang, Wang, Weiqing, Chen, Yuhong, and Lu, Jieli
- Abstract
Background and Aims: The joint effect of famine exposure and adulthood obesity on risk of dyslipidemia remains unclear. Thus, we aim to explore the joint effect of famine exposure and adulthood obesity on the risk of dyslipidemia, and the potential effect of adult general or abdominal obesity on the association between famine exposure and dyslipidemia.Methods and Results: We conducted a community-based cohort study in 8880 subjects aged 40 years or older. Participants were divided into nonexposed, fetal-exposed, childhood-exposed, adolescent-exposed according to birth date. General obesity and abdominal obesity were defined according to body mass index (BMI: overweight≥24.0 kg/m2, obesity≥28.0 kg/m2) and waist-to-hip ratio (WHR, men/women: moderate≥0.90/0.85, high≥0.95/0.90). Dyslipidemia was defined using the National Cholesterol Education Program Adult Treatment Panel III criteria. Compared with nonexposed participants, fetal-exposed individuals had significantly increased risk of dyslipidemia (OR:1.24, 95%CI: 1.03-1.50) in the whole study. Significant increased risk of dyslipidemia related to famine exposure was observed in women [ORs (95%CIs) were 1.36 (1.05-1.76) and 1.70 (1.22-2.37) for the fetal and childhood-exposed group, respectively] but not in men. Moreover, both general and central obesity had significant multiplicative interactions with famine exposure for the risk of dyslipidemia (P for interaction = 0.0001 and < 0.0001, respectively). Significant additive interaction was found between famine exposure and WHR on risk of dyslipidemia in women, with the relative excess risk due to interaction (RERI) and 95% CI of 0.43 (0.10-0.76).Conclusion: Coexistence of early-life undernutrition and adulthood obesity was associated with a higher risk of dyslipidemia in later life. [ABSTRACT FROM AUTHOR]- Published
- 2022
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15. The effect of SGLT2 inhibition on prostate cancer: Mendelian randomization and observational analysis using electronic healthcare and cohort data
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Zheng, Jie, Lu, Jieli, Qi, Jiying, Yang, Qian, Zhao, Huiling, Liu, Haoyu, Chen, Zhihe, Huang, Lanhui, Ye, Youqiong, Xu, Min, Xu, Yu, Wang, Tiange, Li, Mian, Zhao, Zhiyun, Zheng, Ruizhi, Wang, Shuangyuan, Lin, Hong, Hu, Chunyan, Ling Chui, Celine Sze, Au Yeung, Shiu Lun, Luo, Shan, Dimopoulou, Olympia, Dixon, Padraig, Harrison, Sean, Liu, Yi, Robinson, Jamie, Yarmolinsky, James, Haycock, Philip, Yuan, Jinqiu, Lewis, Sarah, Yuan, Zhongshang, Gaunt, Tom R., Smith, George Davey, Ning, Guang, Martin, Richard M., Cui, Bin, Wang, Weiqing, and Bi, Yufang
- Abstract
We evaluated the effect of sodium-glucose cotransporter 2 (SGLT2) inhibition on prostate cancer by evidence triangulation. Using Mendelian randomization, we found that genetically proxied SGLT2 inhibition reduced the risk of overall (odds ratio = 0.56, 95% confidence interval [CI] = 0.38 to 0.82; 79,148 prostate cancer cases and 61,106 controls), advanced, and early-onset prostate cancer. Using electronic healthcare data (nSGLT2i = 24,155; nDPP4i = 24,155), we found that the use of SGLT2 inhibitors was associated with a 23% reduced risk of prostate cancer (hazard ratio = 0.77, 95% CI = 0.61 to 0.99) in men with diabetes. Using data from two prospective cohorts (n4C = 57,779; nUK_Biobank = 165,430), we found little evidence to support the association of HbA1cwith prostate cancer, implying a non-glycemic effect of SGLT2 inhibition on prostate cancer. In summary, this study provides multiple layers of evidence to support the beneficial effect of SGLT2 inhibition on reducing prostate cancer risk. Future trials are warranted to investigate whether SGLT2 inhibitors can be recommended for prostate cancer prevention.
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- 2024
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16. Association of social determinants, lifestyle, and metabolic factors with mortality in Chinese adults: A nationwide 10-year prospective cohort study
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Lu, Jieli, Li, Mian, He, Jiang, Xu, Yu, Zheng, Ruizhi, Zheng, Jie, Qin, Guijun, Qin, Yingfen, Chen, Yuhong, Tang, Xulei, Ye, Zhen, Xu, Min, Wang, Tiange, Shi, Lixin, Su, Qing, Yu, Xuefeng, Yan, Li, Zhao, Zhiyun, Wan, Qin, Chen, Gang, Gao, Zhengnan, Wang, Guixia, Shen, Feixia, Gu, Xuejiang, Luo, Zuojie, Chen, Li, Hou, Xinguo, Huo, Yanan, Li, Qiang, Qiao, Hong, Zhang, Yinfei, Zeng, Tianshu, Hu, Chunyan, Cao, Qiuyu, Jia, Xiaojing, Liu, Chao, Wang, Youmin, Wu, Shengli, Yang, Tao, Deng, Huacong, Qi, Hongyan, Wu, Xueyan, Zhang, Di, Dai, Meng, Li, Donghui, Lai, Shenghan, Chen, Lulu, Zhao, Jiajun, Mu, Yiming, Hu, Weiguo, Ning, Guang, Hu, Ruying, Bi, Yufang, and Wang, Weiqing
- Abstract
Nationwide estimates of the impact of common modifiable risk factors on mortality remain crucial. We aim to assess the influence of social determinants, lifestyle, and metabolic factors on mortality in 174,004 adults aged ≥40 years from the China Cardiometabolic Disease and Cancer Cohort (4C) Study. We reveal that 17 modifiable factors are independently associated with mortality, accounting for 64.8% of all-cause mortality, 77.4% of cardiovascular mortality, and 44.8% of cancer mortality. Low education emerges as the leading factor for both all-cause and cancer mortality, while hypertension is predominant for cardiovascular mortality. Moreover, low gross domestic product per capita and high ambient particulate matter with a diameter of <2.5 μm (PM2.5) air pollution account for 7.8% and 4.3% for all-cause mortality, respectively, using a different method. Gender-specific analyses reveal distinct patterns, with women’s mortality primarily associated with social determinants and men exhibiting stronger associations with lifestyle factors. Targeted health interventions are essential to mitigate mortality risks effectively in China.
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- 2024
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17. The Differences of Graphene Oxide Products Made from Three Kinds of Flake Graphites.
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Lin, Yu, Ding, Defang, Hu, Chunyan, Li, Zhen, Shen, Yi, and Xia, Fan
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- 2021
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18. Multiomic identification of factors associated with progression to cystic kidney disease in mice with nephron Ift88 disruption
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Hu, Chunyan, Beebe, Katherine, Hernandez, Edgar J., Lazaro-Guevara, Jose M., Revelo, Monica P., Huang, Yufeng, Maschek, J. Alan, Cox, James E., and Kohan, Donald E.
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- 2022
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19. Experimental Investigation of Flame Dynamics Based on High-Speed Images in Swirl Combustion Systems
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Li, Yao, Hu, Chunyan, Zhao, Qianpeng, Yang, Jinhu, Tan, Xiangmin, and Xu, Gang
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The interaction mechanism of internally-staged-swirling stratified flame is complex, and the pilot flame has a manifest influence on flame stability. To study this, a series of experimental investigations for the pilot flame has been carried out in a model swirl combustor by only supplying the pilot fuel. The CH*chemiluminescence images of the pilot flame are acquired by a high-speed camera with a CH*bandpass filter, whose dynamic characteristics are identified by image statistical analysis and proper orthogonal decomposition (POD) analysis. And the fast algorithm based on matrix theory proposed in this paper increases the operation efficiency and operability of POD. With the pilot equivalence ratio Φincrease, the pilot flame gradually shows an unstable state, whose POD energy distribution is significantly different. In the unstable state, the flame dynamics include three modes—spiral motion mode, flame shedding mode, and axial oscillation mode, whose formation reasons have also been further analyzed in combination with the experimental characteristics. And the fast Fourier transform (FFT) analysis of the time coefficients for the first four POD modes indicates all the dominant frequency is 280 Hz, which means the model combustor is in resonance. In addition, a sensitivity analysis based on the different image resolutions further reveals the robustness of the POD method and its optimization direction. These results emphasize the important influence of the pilot fuel flow rate on the stability of the pilot flame.
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- 2022
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20. Sex-Dependent Effects of Nephron Ift88 Disruption on BP, Renal Function, and Cystogenesis
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Hu, Chunyan, Lakshmipathi, Jayalakshmi, Binning, Elizabeth, Hyndman, Kelly A., Stuart, Deborah, and Kohan, Donald E.
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- 2021
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21. Krüppel-like factor 5-induced overexpression of long non-coding RNA DANCR promotes the progression of cervical cancer via repressing microRNA-145-3p to target ZEB1
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Hu, Chunyan, Han, Yu, Zhu, Genhai, Li, Guifei, and Wu, Xiurong
- Abstract
ABSTRACTLong non-coding RNA (lncRNA) differentiation antagonizing non-protein coding RNA (DANCR) participates in the development of diverse cancers. Nevertheless, the impact of DANCR on cervical cancer (CC) remains largely unknown. This study aims to explore the effects of DANCR sponging microRNA-145-3p (miR-145-3p) on CC. Expression of KLF5, DANCR, miR-145-3p, and zinc finger E-box binding homeobox 1 (ZEB1) in CC and adjacent normal tissues was determined. Human CC cell lines were, respectively, treated with silenced DANCR or miR145-3p mimic/inhibitor. Then, the viability, migration, invasion, and apoptosis of CC cells were measured. The cell growth in vivowas observed as well. Chromatin immunoprecipitation assay was performed to analyze the binding of KLF5 and DANCR promoter. Interaction among DANCR, miR-145-3p, and ZEB1 was assessed. KLF5, DANCR, and ZEB1 were upregulated but miR-145-3p was downregulated in CC tissues. KLF5 activated DANCR expression and the high DANCR expression was related to tumor staging, infiltrating muscle depth and lymphatic metastasis of CC patients. Reduced DANCR or elevated miR-145-3p repressed malignant behaviors of CC cells. The tumor diameter and weight were also repressed by DANCR silencing or miR-145-3p elevation. The effect of DANCR knockdown on CC cells could be reversed by miR-145-3p inhibitor. MiR-145-3p was targeted by DANCR and ZEB1 was targeted by miR-145-3p. KLF5-induced overexpression of DANCR promotes CC progression via suppressing miR-145-3p to target ZEB1. This study may provide potential targets for CC treatment.
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- 2021
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22. Expression of Podoplanin in Sinonasal Squamous Cell Carcinoma and Its Clinical Significance.
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Wang, Huan, Hu, Chunyan, Song, Xiaole, Hu, Li, Li, Wanpeng, Yu, Hongmeng, Sun, Xicai, and Wang, Dehui
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SQUAMOUS cell carcinoma ,CANCER cells ,PROGRESSION-free survival ,METASTASIS ,IMMUNOSTAINING ,ESOPHAGEAL cancer - Abstract
Background: It was recently suggested that the upregulation of podoplanin (PDPN) in cancer cells plays a significant role in tumor invasion and metastasis and that it is significantly associated with poor prognosis in oral, cutaneous, and esophageal squamous cell carcinoma. The aim of this study was to investigate the expression pattern of PDPN in sinonasal squamous cell carcinoma (SNSCC) and to evaluate its role as a prognostic factor for survival outcome. Patients and methods: This study included 59 subjects with SNSCC. We retrospectively collected the clinical features of these patients from medical records and retrieved the associated formalin-fixed, paraffin-embedded tissues for PDPN immunohistochemical staining. Furthermore, PDPN expression was analyzed in relation to the patients' clinicopathological features and prognosis. Results: We observed positive staining for PDPN in both cancer cells and stromal cancer-associated fibroblasts (CAFs). Positive expression of PDPN in cancer cells of patients with SNSCC was significantly correlated with the primary tumor site (p = 0.009) and local recurrence (p = 0.024). In addition, patients with PDPN-positive cancer cells had significantly lower overall survival (OS) and disease-free survival (DFS) rates than did patients with PDPN-negative cancer cells (both p < 0.05). Multivariate analysis revealed that PDPN expression in cancer cells was an independent prognostic factor for both OS (p = 0.038) and DFS (p = 0.039). Conclusions: Our findings demonstrated that PDPN overexpression may be both an independent prognostic biomarker and a therapeutic target in SNSCC. [ABSTRACT FROM AUTHOR]
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- 2020
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23. A utility and easily fabricated dual-mode fiber film for efficient and comfortable thermal management
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Yu, Jiyuan, Zheng, Jian, Wang, Wei, Zhu, Zhijia, Hu, Chunyan, and Liu, Baojiang
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A simple dual-mode film with excellent utility is fabricated for personal thermal management.
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- 2024
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24. The clinical characteristics of situational syncope in children and adults undergoing head-up tilt testing.
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Zou, Runmei, Wang, Shuo, Lin, Ping, Hu, Chunyan, Wang, Yuwen, Li, Fang, Xu, Yi, and Wang, Cheng
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Objective: Situational syncope is a subtype of neurally mediated syncope and associated with specific circumstances. This paper is to assess the clinical characteristics and underlying causes of situational syncope.Methods: This is a retrospective study of patients who underwent head-up tilt testing (HUTT). Medical records including age at HUTT, gender, number of syncopal episodes, family history of syncope, triggers before the syncopal episode, position during the syncopal episode and the responses to HUTT were reviewed.Results: Among 3140 patients, 354 patients (mean age 28.3 ± 16.6 years old, with 184 males and 170 females) were diagnosed with situational syncope. The causes of situational syncope included micturition (50.85%), defecation (15.82%), bathing (10.45%), swallowing (6.50%), cough (4.80%), post-dinner (3.95%), singing (3.11%), teeth brushing (2.26%), and hair grooming (2.26%). Patients with syncope triggered by micturition, cough, post-dinner were more likely to be men, while those caused by bathing, swallowing, singing, teeth brushing and hair grooming were more likely to be women. 34.75% of patients with situational syncope were between the ages of 10-19 years old, and 20.34% were between the ages of 40-49 years old. 74.01% of situational syncopal events occurred in an upright position. 47.74% of patients had positive responses to HUTT.Conclusions: These findings show that micturition was the most common cause of situational syncope in both children and adults. There were significant gender and age differences among situational syncope triggered by different causes. Most of situational syncope occurred in the upright position and nearly half of the patients had positive responses to HUTT. [ABSTRACT FROM AUTHOR]- Published
- 2020
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25. Controlled Synthesis of Co@N-Doped Carbon by Pyrolysis of ZIF with 2‑Aminobenzimidazole Ligand for Enhancing Oxygen Reduction Reaction and the Application in Zn–Air Battery.
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Zhang, Minghui, Zhang, Erhuan, Hu, Chunyan, Zhao, Yong, Zhang, Han-ming, Zhang, Yijie, Ji, Muwei, Yu, Jiali, Cong, Guangtao, Liu, Huichao, Zhang, Jiatao, Zhu, Caizhen, and Xu, Jian
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- 2020
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26. Expression of Podoplanin in Sinonasal Squamous Cell Carcinoma and Its Clinical Significance
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Wang, Huan, Hu, Chunyan, Song, Xiaole, Hu, Li, Li, Wanpeng, Yu, Hongmeng, Sun, Xicai, and Wang, Dehui
- Abstract
Background It was recently suggested that the upregulation of podoplanin (PDPN) in cancer cells plays a significant role in tumor invasion and metastasis and that it is significantly associated with poor prognosis in oral, cutaneous, and esophageal squamous cell carcinoma. The aim of this study was to investigate the expression pattern of PDPN in sinonasal squamous cell carcinoma (SNSCC) and to evaluate its role as a prognostic factor for survival outcome.Patients and methods This study included 59 subjects with SNSCC. We retrospectively collected the clinical features of these patients from medical records and retrieved the associated formalin-fixed, paraffin-embedded tissues for PDPN immunohistochemical staining. Furthermore, PDPN expression was analyzed in relation to the patients’ clinicopathological features and prognosis.Results We observed positive staining for PDPN in both cancer cells and stromal cancer-associated fibroblasts (CAFs). Positive expression of PDPN in cancer cells of patients with SNSCC was significantly correlated with the primary tumor site (p = 0.009) and local recurrence (p = 0.024). In addition, patients with PDPN-positive cancer cells had significantly lower overall survival (OS) and disease-free survival (DFS) rates than did patients with PDPN-negative cancer cells (both p < 0.05). Multivariate analysis revealed that PDPN expression in cancer cells was an independent prognostic factor for both OS (p = 0.038) and DFS (p = 0.039).Conclusions Our findings demonstrated that PDPN overexpression may be both an independent prognostic biomarker and a therapeutic target in SNSCC.
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- 2020
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27. Optimization of Flow Matching Schemes for a Heavy Gas Turbine Burning Syngas
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Guo, Lei, Li, Guoqing, Hu, Chunyan, Lei, Zhijun, Huang, Enliang, Gong, Jianbo, and Xu, Gang
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A heavy-duty gas turbine, designed for natural gas, was used to burn the syngas with two different calorific values. This study was mainly to optimize the flow matching scheme for the gas turbine. Two models of gas turbine burning syngas with different calorific values were established and the calculation models of different flow matching schemes were provided. The optimum scheme was obtained by evaluating thermal efficiency and work output under different operating conditions. The results showed that the highest unit efficiency was achieved by, without significant drop in work output, increasing the throat area of the turbine nozzle and reducing the initial temperature of the gas. On the premise of ensuring the safety of the gas turbine unit, increasing the pressure ratio of the compressor could further improve the unit efficiency and the work output. Simply adjusting the angle of the inlet guide vane fails to match the flow of compressor and turbine. The measures such as reducing inlet temperature of turbine or air bleed still need to be adopted, but the thermal efficiency dropped significantly in this process.
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- 2020
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28. Controlled Synthesis of Co@N-Doped Carbon by Pyrolysis of ZIF with 2-Aminobenzimidazole Ligand for Enhancing Oxygen Reduction Reaction and the Application in Zn–Air Battery
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Zhang, Minghui, Zhang, Erhuan, Hu, Chunyan, Zhao, Yong, Zhang, Han-ming, Zhang, Yijie, Ji, Muwei, Yu, Jiali, Cong, Guangtao, Liu, Huichao, Zhang, Jiatao, Zhu, Caizhen, and Xu, Jian
- Abstract
The Co/N-doped carbon material, as an important electrocatalytic material, has been attracted intense interest in ORR and Zn–air battery. Here, we report an efficient Co@N-doped carbon catalyst (Co@N-C-1) obtained by pyrolysis of ZIF precursor with 2-aminobenzimidazole. The introduction of 2-aminobenzimidazole results in the formation of hierarchical meso/microporous structure of the as-prepared Co@N-C-1, effectively avoiding the aggregation of Co nanoparticles during pyrolysis and the higher N content, which contributes to enhance the ORR electrocatalytic activities. The obtained Co@N-C-1 exhibits remarkable ORR performance with a half-wave potential of 0.938 V vs RHE in alkaline media. As the air catalyst of zinc–air batteries, Co@N-C-1 displays 1.439 V of open-circuit voltage and 1413.3 Wh·kg–1of energy density.
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- 2020
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29. Tuning thermal decomposition of ammonium perchlorate by nanoporous Gd2O3for improved safety and enhanced propellant efficiency
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Zhou, Xuezhen, Hu, Chunyan, Liu, Xiaojun, Chen, Weifan, Tang, Qun, and Li, Yongxiu
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Nanoporous Gd2O3powders (NGPs) with different specific surface areas were prepared by a non-aqueous sol-gel method and utilized to tune the exothermal decomposition of ammonium perchlorate (AP) for enhanced propellant efficiency and improved safety. It is found that with the increasing dosage of NGPs into AP, the two exothermal peaks of AP merge into one intense exothermal peak, indicating that an “energy stacking” has been achieved. Meanwhile, the unique delay of the first exothermal peak of AP is conducive to the safety of AP in application process. Furthermore, the dependence of decomposition heat of AP on dosage and calcination temperature is more evident than on the surface areas of NGPs, suggesting that the promotion effect of NGPs on the thermal decomposition of AP does not only rely on the surface interaction. Therefore, an electron transfer mechanism is proposed to illustrate the decomposition process of AP tuned by NGPs.
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- 2020
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30. A novel flower-like Z-type heterojunction CuS/Bi7O9I3composite catalyst prepared under mild conditions for degradation of antibiotics and sterilization under visible lightElectronic supplementary information (ESI) available. See DOI: 10.1039/d0en00627k
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Yang, Ruixiang, Li, Hongjuan, Wang, Yatao, Zhu, Zhijia, Hu, Chunyan, Zhao, Tao, Wang, Wei, and Liu, Baojiang
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In order to solve problems of the photo-generated charge recombination and low utilization efficiency of visible light in achieving green and sustainable development, a novel flower-like Z-type heterojunction CuS/Bi7O9I3composite catalyst was successfully prepared through a facile and mild process. The preparatory conditions of Bi7O9I3and CuS are low temperature and normal pressure with environment friendly reagents. The degradation performance of the catalyst was evaluated using ciprofloxacin (CIP) antibiotic. The results showed that degradation rate of the CuS/Bi7O9I3composite catalyst was 5 and 4 times that of the single CuS and Bi7O9I3catalysts, respectively. The actual performance of the catalyst was evaluated using simulated wastewater containing different ions and real water sources. Results showed that the new CuS/Bi7O9I3composite catalyst has excellent degradation and practical performances. At the same time, there is a synergistic effect between the photothermal and catalytic effects of the catalyst. The rapid temperature increase obviously inhibited the biological activity of bacteria, thereby affecting its metabolism and enhancing the destruction of the composite catalyst. Finally, using the free radical capture, VB-XPS and ESR measurements, photocatalytic mechanisms are proposed.
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- 2020
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31. The Dynamic Time-frequency Relationship between International Oil Prices and Investor Sentiment in China: A Wavelet Coherence Analysis
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Ye, Zhengke, Hu, Chunyan, He, Linjie, Ouyang, Guangda, and Wen, Fenghua
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We take a fresh look at the interaction between crude oil prices and investor sentiment from the novel perspective of both the time and the frequency domains. By using principal component analysis, we first construct an investor sentiment indicator. Then, crude oil prices are decomposed into three oil price shocks through an SVAR model. Lastly, the dynamic relationship between investor sentiment and oil price shocks is comprehensively studied from both the time and the frequency domains via wavelet coherence analysis. Our results show the leading position of crude oil prices in the co-movement relationship with investor sentiment. Further, we distinguish the different effects of oil price shocks on investor sentiment at different times and frequencies. We also find that the patterns of the co-movement between oil prices (oil price shocks) and investor sentiment change not only with time but also with frequency.
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- 2020
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32. The adsorptive removal of Cr(VI) ions and antibacterial activity studies on hydrothermally synthesized iron oxide and zinc oxide nanocomposite.
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Olivera, Sharon, Hu, Chunyan, Nagananda, Govinahalli Shivashankara, Reddy, Narendra, Venkatesh, Krishna, Muralidhara, Handanahally Basavarajaiah, Inamuddin, and Asiri, Abdullah M.
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CHROMIUM ions ,ANTIBACTERIAL agents ,DRUG activation ,HYDROTHERMAL synthesis ,IRON oxide synthesis ,ZINC oxide synthesis ,NANOCOMPOSITE materials - Abstract
Highlights • Hydrothermally synthesized iron oxide and zinc oxide nanocomposite. • Adsorptive removal of Cr(VI) ions using iron oxide and zinc oxide nanocomposite. • Imparting antibacterial and antioxidant properties to the treated water using iron oxide and zinc oxide nanocompsite. • Achieving removal efficiency of 97.8% for Cr(VI) ions using iron oxide and zinc oxide nanocomposite. • Achieving adsorption capacity of 36.5 mg/g using iron oxide and zinc oxide nanocomposite. Abstract The synthesis of a multifunctional composite using Fe 2 O 3 and ZnO endowed with antioxidant and antibacterial properties for the adsorption of chromium(VI) ions was reported. Typical approaches of eliminating metal ions from wastewater focus on removing only the contaminants. In this research, a composite was developed that is not only highly efficient in removing Cr(VI) ions but also imparts antibacterial and antioxidant properties to the treated water. The characterizations of the composite were conducted using powder X-ray diffraction (pXRD), Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy-Energy-dispersive X-ray spectroscopy (SEM-EDS), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS) and Brunauer–Emmett–Teller (BET). BET surface area revealed that the sheet-like Fe 2 O 3 were present alongside hexagonal ZnO rods. The adsorption data corroborated well with Freundlich isotherm (R
2 = 0.99844) better than the Langmuir model (R 2 = 0.97993) indicating the prevalence of multi-layer sorption. Pseudo-second-order kinetics model described the adsorption process well implying chemisorption was the major contributor to the adsorption capacity. The composite exhibited additional useful character by inhibiting up to 12% of 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radicals when used in the concentration range of 10–50 µL. It also showed antibacterial property by removing more than 99% of Staphylococcus aureus after an exposure time of six hours. It is proposed that Fe 2 O 3 –ZnO composite may be highly effective for multi-purpose water treatment. Graphical abstract Image, graphical abstract [ABSTRACT FROM AUTHOR] - Published
- 2018
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33. Interference With Endothelial PPAR (Peroxisome Proliferator-Activated Receptor)-γ Causes Accelerated Cerebral Vascular Dysfunction in Response to Endogenous Renin-Angiotensin System Activation.
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Nair, Anand R., Agbor, Larry N., Mukohda, Masashi, Liu, Xuebo, Hu, Chunyan, Wu, Jing, and Sigmund, Curt D.
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Low-salt diet is beneficial in salt-sensitive hypertension but may provoke cardiovascular risk in patients with heart failure, diabetes mellitus, or other cardiovascular abnormalities because of endogenous renin-angiotensin system activation. PPAR (peroxisome proliferator-activated receptor)-γ is a transcription factor which promotes an antioxidant pathway in the endothelium. We studied transgenic mice expressing a dominant-negative mutation in PPAR-γ selectively in the endothelium (E-V290M) to test the hypothesis that endothelial PPAR-γ plays a protective role in response to low salt-mediated renin-angiotensin system activation. Plasma renin and Ang II (angiotensin II) were significantly and equally increased in all mice fed low salt for 6 weeks. Vasorelaxation to acetylcholine was not affected in basilar artery from E-V290M at baseline but was significantly and selectively impaired in E-V290M after low salt. Unlike basilar artery, low salt was not sufficient to induce vascular dysfunction in carotid artery or aorta. Endothelial dysfunction in the basilar artery from E-V290M mice fed low salt was attenuated by scavengers of superoxide, inhibitors of NADPH oxidase, or blockade of the Ang II AT1 (angiotensin type-1) receptor. Simultaneous AT1 and AT2 receptor blockade revealed that the restoration of endothelial function after AT1 receptor blockade was not a consequence of AT2 receptor activation. We conclude that interference with PPAR-γ in the endothelium produces endothelial dysfunction in the cerebral circulation in response to low salt-mediated activation of the endogenous renin-angiotensin system, mediated at least in part, through AT1 receptor activation and perturbed redox homeostasis. Moreover, our data suggest that the cerebral circulation may be particularly sensitive to inhibition of PPAR-γ activity and renin-angiotensin system activation. [ABSTRACT FROM AUTHOR]
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- 2018
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34. Effect of Source-Classified Collection of Municipal Solid Waste on Heavy Metals and Pozzolanic Properties of Incineration Residues.
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Shi, Dezhi, Wang, Pan, Xu, Xiaoyi, Gu, Li, Li, Lei, Ma, Hua, and Hu, Chunyan
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The adoption of source-classified collection of municipal solid waste (MSW) systems has improved waste management and resource conservation in developing countries, including China. Here, we evaluated the effects of a new MSW source-classified collection system on the distribution and leaching of heavy metals in incineration residues as well as on the pozzolanic properties of residues used as additives in cement production. Cu, Cr, and Mn were found primarily in bottom ash, while the volatile metals Zn, Pb, and Cd became enriched primarily in fly ash during combustion. However, effective presorting of MSW prior to incineration reduced the heavy metal content of the MSW source material and increased the combustion efficiency and heat values of MSW. The system of source-classified collection of MSW resulted in decreased concentrations of heavy metals in bottom ash, as well as decreased leachate toxicity, which improved the viability of bottom ash for use as a non-hazardous raw material in cement production. The consistently high temperatures sustained during incineration of source-classified MSW increased the concentrations and leachate toxicity of Cd, Pb, Cu, Zn, and Cr in fly ash. Pozzolanic activity testing revealed that bottom ash may be used as a pozzolanic material in cement production, but that fly ash is not suitable. In contrast to bottom ash from the incineration of mixed MSW, bottom ash from the incineration of source-classified MSW fully satisfies China’s “Pozzolanic materials used for cement production” standards due to its low loss on ignition, high grindability, and the desired rupture strength, compressive strength, and stability that it adds to mortar mixtures. [ABSTRACT FROM AUTHOR]
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- 2018
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35. Detection and differential diagnosis of cancer relapse using circulating tumor DNA profiling in a patient with synchronous breast and rectal cancer
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Zhang, Shu, Hu, Chunyan, Fan, Jun, Zheng, Baiyang, Wu, Wei, Mi, Xiao, Chen, Rongrong, Xia, Xuefeng, and Xu, Yan
- Abstract
ABSTRACTBackground: In Chinese women, breast and colorectal cancers are highly prevalent. In the early stage, the primary treatment for these cancers is surgical resection. However, many patients develop a metastatic recurrence. Thus, tools that help estimate the risk of recurrence are critical. Although synchronous breast and rectal cancer is uncommon, estimating recurrence risk is even more challenging in patients with two histologically distinct malignancies. Methods: Next generation sequencing (NGS) allows the comprehensive detection of simultaneous genome abnormalities. NGS-based circulating tumor DNA (ctDNA) profiling is a new molecular technique that has demonstrated great potential in the detection and differential diagnosis of cancer relapse. Results: We present a 43-year-old female patient with synchronous breast and rectal cancer that was surgically removed 2 years prior. During regular follow-up, elevated carcinoembryonic antigen (CEA) levels were detected. ctDNA profiling revealed multiple somatic mutations that were identical to those found in rectal cancer samples. Thus, we suspected relapse of rectal cancer. Positron emission tomography-computed tomography (PET-CT) and pathogenic analysis confirmed lung metastasis of rectal cancer. Conclusions: This case demonstrated the utility of ctDNA profiling in the detection and differential diagnosis of cancer relapse in a patient with synchronous breast and rectal cancer.
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- 2019
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36. Late-stage tumors induce anemia and immunosuppressive extramedullary erythroid progenitor cells
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Zhao, Lintao, He, Ran, Long, Haixia, Guo, Bo, Jia, Qingzhu, Qin, Diyuan, Liu, Si-Qi, Wang, Zhongyu, Xiang, Tong, Zhang, Jue, Tan, Yulong, Huang, Jiani, Chen, Junying, Wang, Fang, Xiao, Minglu, Gao, Jianbao, Yang, Xinxin, Zeng, Hao, Wang, Xinxin, Hu, Chunyan, Alexander, Peter B., Symonds, Alistair L. J., Yu, Jia, Wan, Yisong, Li, Qi-Jing, Ye, Lilin, and Zhu, Bo
- Abstract
Impaired immunity in patients with late-stage cancer is not limited to antitumor responses, as demonstrated by poor vaccination protection and high susceptibility to infection1–3. This has been largely attributed to chemotherapy-induced impairment of innate immunity, such as neutropenia2, whereas systemic effects of tumors on hematopoiesis and adoptive immunity remain incompletely understood. Here we observed anemia associated with severe deficiency of CD8+T cell responses against pathogens in treatment-naive mice bearing large tumors. Specifically, we identify CD45+erythroid progenitor cells (CD71+TER119+; EPCs) as robust immunosuppressors. CD45+EPCs, induced by tumor growth–associated extramedullary hematopoiesis, accumulate in the spleen to become a major population, outnumbering regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs). The CD45+EPC transcriptome closely resembles that of MDSCs, and, like MDSCs, reactive oxygen species production is a major mechanism underlying CD45+EPC–mediated immunosuppression. Similarly, an immunosuppressive CD45+EPC population was detected in patients with cancer who have anemia. These findings identify a major population of immunosuppressive cells that likely contributes to the impaired T cell responses commonly observed in patients with advanced cancer.
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- 2018
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37. Effect of Source-Classified Collection of Municipal Solid Waste on Heavy Metals and Pozzolanic Properties of Incineration Residues
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Shi, Dezhi, Wang, Pan, Xu, Xiaoyi, Gu, Li, Li, Lei, Ma, Hua, and Hu, Chunyan
- Abstract
The adoption of source-classified collection of municipal solid waste (MSW) systems has improved waste management and resource conservation in developing countries, including China. Here, we evaluated the effects of a new MSW source-classified collection system on the distribution and leaching of heavy metals in incineration residues as well as on the pozzolanic properties of residues used as additives in cement production. Cu, Cr, and Mn were found primarily in bottom ash, while the volatile metals Zn, Pb, and Cd became enriched primarily in fly ash during combustion. However, effective presorting of MSW prior to incineration reduced the heavy metal content of the MSW source material and increased the combustion efficiency and heat values of MSW. The system of source-classified collection of MSW resulted in decreased concentrations of heavy metals in bottom ash, as well as decreased leachate toxicity, which improved the viability of bottom ash for use as a non-hazardous raw material in cement production. The consistently high temperatures sustained during incineration of source-classified MSW increased the concentrations and leachate toxicity of Cd, Pb, Cu, Zn, and Cr in fly ash. Pozzolanic activity testing revealed that bottom ash may be used as a pozzolanic material in cement production, but that fly ash is not suitable. In contrast to bottom ash from the incineration of mixed MSW, bottom ash from the incineration of source-classified MSW fully satisfies China’s “Pozzolanic materials used for cement production” standards due to its low loss on ignition, high grindability, and the desired rupture strength, compressive strength, and stability that it adds to mortar mixtures.
- Published
- 2018
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38. Genetic Interference With Endothelial PPAR-γ (Peroxisome Proliferator-Activated Receptor-γ) Augments Effects of Angiotensin II While Impairing Responses to Angiotensin 1-7.
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De Silva, T. Michael, Chunyan Hu, Kinzenbaw, Dale A., Modrick, Mary L., Sigmund, Curt D., Faraci, Frank M., and Hu, Chunyan
- Abstract
Pharmacological activation of PPAR-γ (peroxisome proliferator-activated receptor-γ) protects the vasculature. Much less is known on the cell-specific impact of PPAR-γ when driven by endogenous ligands. Recently, we found that endothelial PPAR-γ protects against angiotensin II-induced endothelial dysfunction. Here, we explored that concept further examining whether effects were sex dependent along with underlying mechanisms. We studied mice expressing a human dominant-negative mutation in PPAR-γ driven by the endothelial-specific vascular cadherin promoter (E-V290M), using nontransgenic littermates as controls. Acetylcholine (an endothelium-dependent agonist) produced similar relaxation of carotid arteries from nontransgenic and E-V290M mice. Incubation of isolated arteries with angiotensin II (1 nmol/L) overnight had no effect in nontransgenic, but reduced responses to acetylcholine by about 50% in male and female E-V290M mice (P<0.05). Endothelial function in E-V290M mice was restored to normal by inhibitors of superoxide (tempol), NADPH oxidase (VAS-2870), Rho kinase (Y-27632), ROCK2 (SLX-2119), NF-κB (nuclear factor-kappa B essential modulator-binding domain peptide), or interleukin-6 (neutralizing antibody). In addition, we hypothesized that PPAR-γ may influence the angiotensin 1-7 arm of the renin-angiotensin system. In the basilar artery, dilation to angiotensin 1-7 was selectively reduced in E-V290M mice by >50% (P<0.05), an effect reversed by Y-27632. Thus, effects of angiotensin II are augmented by interference with endothelial PPAR-γ through sex-independent mechanisms, involving oxidant-inflammatory signaling and ROCK2 (Rho kinase). The study also provides the first evidence that endothelial PPAR-γ interacts with angiotensin 1-7 responses. These critical roles for endothelial PPAR-γ have implications for pathophysiology and therapeutic approaches for vascular disease. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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39. Folate-targeted polymersomes loaded with both paclitaxel and doxorubicin for the combination chemotherapy of hepatocellular carcinoma.
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Zhu, Dunwan, Wu, Shengjie, Hu, Chunyan, Chen, Zhuo, Wang, Hai, Fan, Fan, Qin, Yu, Wang, Chun, Sun, Hongfan, Leng, Xigang, Kong, Deling, and Zhang, Linhua
- Subjects
COMBINATION drug therapy ,POLYMERSOMES ,LIVER cancer ,PACLITAXEL ,JUNO protein ,DOXORUBICIN - Abstract
Combination chemotherapy is a promising method of improving cancer treatment, but the distinct pharmacokinetics of combined drugs and non-specific drug distribution slow down the development in the clinic. In this study, folate (FA) receptor-targeted polymersomes with apparent bilayered lamellar structure were successfully developed to co-encapsulate a hydrophobic-hydrophilic chemotherapeutic drug pair (PTX and DOX) in a single vesicle for enhancing the combination chemotherapeutic effect. Hydrophobic PTX was loaded into the thick hydrophobic lamellar membrane by the self-assembly of triblock copolymer PCL 8000 -PEG 8000 -PCL 8000 , while hydrophilic DOX was encapsulated into the hydrophilic reservoir using a trans-membrane ammonium sulfate gradient method. In vitro release study indicated that the drugs were released from the polymersomes in a controlled and sustained manner. Cellular uptake study indicated that FA-targeted Co-PS had higher internalization efficiency in FA receptor-overexpressing BEL-7404 cells than non-targeted Co-PS. In vitro cytotoxicity assay demonstrated that FA-targeted Co-PS exhibited less cytotoxic effect than free drug cocktail, but suppressed the growth of tumor cells more efficiently than non-targeted Co-PS. Ex vivo imaging biodistribution studies revealed that FA-targeted Co-PS led to highly efficient targeting and accumulation in the BEL-7404 xenograft tumor. Furthermore, the in vivo antitumor study showed that the combination chemotherapy of polymersomes to BEL-7404 tumor via intravenous injection was superior to free drug cocktail treatment, and the FA-targeted Co-PS exhibited significantly higher tumor growth inhibition than non-targeted Co-PS group. Therefore, the newly developed FA-targeted co-delivery polymersomes hold great promise for simultaneous delivery of multiple chemotherapeutics and would have great potential in tumor-targeting and combination chemotherapy. Statement of Significance Combination chemotherapy is a promising method of improving cancer treatment, but the distinct pharmacokinetics of combined drugs and non-specific drug distribution slow down the development in the clinic. In our study, novel folate-targeted co-delivery polymersomes (Co-PS) were successfully developed to encapsulate a hydrophobic-hydrophilic chemotherapeutic drug pair (paclitaxel and doxorubicin) into the different compartments of the vesicle. In vivo studies revealed that the combination chemotherapy of polymersomes to BEL-7404 xenograft tumor via intravenous injection was superior to free drug cocktail treatment, and the FA-targeted Co-PS exhibited significantly higher tumor growth inhibition than non-targeted Co-PS group. Therefore, the newly developed FA-targeted co-delivery polymersomes hold great promise for simultaneous delivery of multiple chemotherapeutics and would have great potential in tumor-targeting and combination chemotherapy. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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40. Adaptive algorithms: users must be more vigilant
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Zhang, Jian and Hu, Chunyan
- Abstract
Letter to the Editor
- Published
- 2023
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41. Micelle or polymersome formation by PCL-PEG-PCL copolymers as drug delivery systems
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Hu, Chunyan, Chen, Zhuo, Wu, Shengjie, Han, Yanfeng, Wang, Hai, Sun, Hongfan, Kong, Deling, Leng, Xigang, Wang, Chun, Zhang, Linhua, and Zhu, Dunwan
- Abstract
Polymeric micelles and polymersomes may have great potential as the drug delivery vehicles for solubilization of hydrophobic drugs.
- Published
- 2017
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42. Numerical study of effect of compressor swirling flow on combustor design in a MTE
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Mu, Yong, Wang, Chengdong, Liu, Cunxi, Liu, Fuqiang, Hu, Chunyan, Xu, Gang, and Zhu, Junqiang
- Abstract
An effect of the swirling flow on the combustion performance is studied by the computational fluid dynamics (CFD) in a micro-gas turbine with a centrifugal compressor, dump diffuser and forward-flow combustor. The distributions of air mass and the Temperature Pattern Factor (as: Overall Temperature Distribution Factor -OTDF) in outlet are investigated with two different swirling angles of compressed air as 0° and 15° in three combustors. The results show that the influences of swirling flow on the air distribution and OTDF cannot be neglected. Compared with no-swirling flow, the air through outer liner is more, and the air through the inner liner is less, and the pressure loss is bigger under the swirling condition in the same combustor. The Temperature Pattern Factor changes under the different swirling conditions.
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- 2017
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43. Investigation of the expression of apoptosis-inducing factor-mediated apoptosis in Hirschsprung’s disease
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Ge, Xin, Hu, Chunyan, Guo, Qingqing, Li, Wei, Zhao, Yuying, Yang, Weili, Wang, Yudu, Li, Peng, Gao, Ya, and Huang, Qiang
- Abstract
Supplemental Digital Content is available in the text.One of the widely accepted hypotheses of Hirschsprung’s disease (HD) is that the absence of ganglion cells in the distal part of the intestine is caused by the death of enteric neural crest-derived cells following migration. Although a caspase-dependent pathway has not yet been detected in the HD bowel, it is unclear whether a caspase-independent pathway contributes toward aganglionosis. In the current study, we observed highly condensed marginal heterochromatin in nuclei only in the transitional segment using electron microscopy and a high proportion of TUNEL-positive cells were observed in the transitional segment. Activation of caspase was not observed in any segments of the HD bowel upon characterization of the apoptotic pathway. Rather, real-time PCR results showed that apoptosis-inducing factor (AIF) and calpain-1mRNAs were highly expressed in the transitional segment, whereas autophagy protein 5 (Atg5) was highly expressed in the narrow segment. Western blot results were consistent with mRNA levels, with increased AIF, calpain-1, and Atg5expressions in the transitional segment compared with the dilated segment. Furthermore, correlation analysis indicated an inverse correlation between calpain-1and Atg5mRNA levels in both the narrow segment and the transitional segment. These results indicated that apoptosis occurs in the HD bowel. The detection of related genes indicates that the AIF-mediated apoptotic pathway may be responsible for the absence of ganglion cells in HD and calpain-1 may act as the regulatory switch between autophagy and apoptosis.
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- 2017
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44. KOH activated carbon derived from biomass-banana fibers as an efficient negative electrode in high performance asymmetric supercapacitor
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K, Chaitra, T, Vinny R, P, Sivaraman, Reddy, Narendra, Hu, Chunyan, Venkatesh, Krishna, S, Vivek C, N, Nagaraju, and N, Kathyayini
- Abstract
Here we demonstrate the fabrication, electrochemical performance and application of an asymmetric supercapacitor (AS) device constructed with β–Ni(OH)2/MWCNTs as positive electrode and KOH activated honeycomb-like porous carbon (K-PC) derived from banana fibers as negative electrode. Initially, the electrochemical performance of hydrothermally synthesized β–Ni(OH)2/MWCNTs nanocomposite and K-PC was studied in a three-electrode system using 1M KOH. These materials exhibited a specific capacitance (Cs) of 1327F/g and 324F/g respectively at a scan rate of 10mV/s. Further, the AS device i.e., β–Ni(OH)2/MWCNTs// K-PC in 1M KOH solution, demonstrated a Cs of 156F/g at scan rate of 10mV/s in a broad cell voltage of 0–2.2V. The device demonstrated a good rate capability by maintaining a Cs of 59F/g even at high current density (25A/g). The device also offered high energy density of 63Wh/kg with maximum power density of 5.2kW/kg. The AS device exhibited excellent cycle life with 100% capacitance retention at 5000th cycle at a high current density of 25A/g. Two AS devices connected in series were employed for powering a pair of LEDs of different colors and also a mini fan.
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- 2017
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45. Data-driven subgroups of prediabetes and the associations with outcomes in Chinese adults
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Zheng, Ruizhi, Xu, Yu, Li, Mian, Gao, Zhengnan, Wang, Guixia, Hou, Xinguo, Chen, Li, Huo, Yanan, Qin, Guijun, Yan, Li, Wan, Qin, Zeng, Tianshu, Chen, Lulu, Shi, Lixin, Hu, Ruying, Tang, Xulei, Su, Qing, Yu, Xuefeng, Qin, Yingfen, Chen, Gang, Gu, Xuejiang, Shen, Feixia, Luo, Zuojie, Chen, Yuhong, Zhang, Yinfei, Liu, Chao, Wang, Youmin, Wu, Shengli, Yang, Tao, Li, Qiang, Mu, Yiming, Zhao, Jiajun, Hu, Chunyan, Jia, Xiaojing, Xu, Min, Wang, Tiange, Zhao, Zhiyun, Wang, Shuangyuan, Lin, Hong, Ning, Guang, Wang, Weiqing, Lu, Jieli, and Bi, Yufang
- Abstract
Prediabetes and its pathophysiology remain important issues. We aimed to examine the cluster characteristics of prediabetes and explore their associations with developing diabetes and its complications based on 12 variables representing body fat, glycemic measures, pancreatic β cell function, insulin resistance, blood lipids, and liver enzymes. A total of 55,777 individuals with prediabetes from the China Cardiometabolic Disease and Cancer Cohort (4C) were classified at baseline into six clusters. During a median of 3.1 years of follow-up, significant differences in the risks of diabetes and its complications between clusters were observed. The odds ratios of diabetes stepwisely increase from cluster 1 to cluster 6. Clusters 1, 4, and 6 have increased chronic kidney diseases risks, while the prediabetes in cluster 4, characterized by obesity and insulin resistance, confers higher risks of cardiovascular diseases compared with others. This subcategorization has potential value in developing more precise strategies for targeted prediabetes prevention and treatment.
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- 2023
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46. Protocol for analysis of liquid chromatography-mass spectrometry metabolomics data using R to understand how metabolites affect disease
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Lin, Hong, Hu, Chunyan, Wang, Shuangyuan, Xu, Yu, Xu, Min, Bi, Yufang, and Lu, Jieli
- Abstract
Liquid-chromatography-mass-spectrometry-based metabolomics is widely used in prospective case-control studies for disease prediction. Given the large amount of clinical and metabolomics data involved, data integration and analyses are crucial to provide an accurate understanding of the disease. We provide a comprehensive analysis approach to explore associations among clinical risk factors, metabolites, and disease. We describe steps for performing Spearman correlation, conditional logistic regression, casual mediation, and variance partitioning to investigate the potential effects of metabolites on disease.
- Published
- 2023
- Full Text
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47. CD200+cytotoxic T lymphocytes in the tumor microenvironment are crucial for efficacious anti–PD-1/PD-L1 therapy
- Author
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Wang, Xinxin, Zha, Haoran, Wu, Wei, Yuan, Ting, Xie, Shuanglong, Jin, Zheng, Long, Haixia, Yang, Fei, Wang, Zhongyu, Zhang, Anmei, Gao, Jianbao, Jiang, Ying, Wang, Lujing, Hu, Chunyan, Wan, Yisong Y., Li, Qi-Jing, Symonds, Alistair L. J., Jia, Qingzhu, and Zhu, Bo
- Abstract
Anti–PD-1/PD-L1 therapy, either by anti–PD-1 antibody or anti–PD-L1 antibody, has efficacy by reinvigorating tumor-infiltrating CD8+T cells in a subset of patients with cancer, but it has unequal effects on heterogeneous CD8+T cell populations. Hence, the subset crucial to efficacious PD-1 blockade therapy remains elusive. Here, we found an increase in tumor-infiltrating CD200+cytotoxic T lymphocytes (CTLs) upon PD-1/PD-L1 blockade, with higher proportions of CD200+T cells positively related to a favorable clinical outcome to anti–PD-1/PD-L1 therapy in three independent cohorts of patients with cancer. Using multiple mouse tumor models, we demonstrated that CD200+CTLs are essential for efficacious anti–PD-L1 therapy. Mechanistically, we observed a unique chromatin landscape in CD200+CTLs and found that these cells are enriched for tumor antigen–specific CTLs and have antitumor effector functions. Coinoculation of CD200+CTLs with tumor cells led to robust tumor regression in two transplanted mouse models. Clinically, we found that infiltration of CD200+CTLs into tumors could predict immunotherapy efficacy in six patient cohorts. Together, our findings reveal that CD200+CTLs in the tumor microenvironment are crucial for efficacious anti–PD-1/PD-L1 therapy and could serve as a predictor of successful immunotherapy in the clinic.
- Published
- 2022
- Full Text
- View/download PDF
48. Encapsulation of Laccase in Silica Colloidosomes forCatalysis in Organic Media.
- Author
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Zhang, Chi, Hu, Chunyan, Zhao, Yongliang, Möller, Martin, Yan, Kelu, and Zhu, Xiaomin
- Published
- 2013
- Full Text
- View/download PDF
49. Amino acids, microbiota-related metabolites, and the risk of incident diabetes among normoglycemic Chinese adults: Findings from the 4C study
- Author
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Wang, Shuangyuan, Li, Mian, Lin, Hong, Wang, Guixia, Xu, Yu, Zhao, Xinjie, Hu, Chunyan, Zhang, Yi, Zheng, Ruizhi, Hu, Ruying, Shi, Lixin, Du, Rui, Su, Qing, Wang, Jiqiu, Chen, Yuhong, Yu, Xuefeng, Yan, Li, Wang, Tiange, Zhao, Zhiyun, Liu, Ruixin, Wang, Xiaolin, Li, Qi, Qin, Guijun, Wan, Qin, Chen, Gang, Xu, Min, Dai, Meng, Zhang, Di, Tang, Xulei, Gao, Zhengnan, Shen, Feixia, Luo, Zuojie, Qin, Yingfen, Chen, Li, Huo, Yanan, Li, Qiang, Ye, Zhen, Zhang, Yinfei, Liu, Chao, Wang, Youmin, Wu, Shengli, Yang, Tao, Deng, Huacong, Zhao, Jiajun, Lai, Shenghan, Mu, Yiming, Chen, Lulu, Li, Donghui, Xu, Guowang, Ning, Guang, Wang, Weiqing, Bi, Yufang, and Lu, Jieli
- Abstract
Although previous studies suggest that amino acids (AAs) and microbiota-related metabolites (MRMs) are associated with type 2 diabetes mellitus (T2DM), the results remain unclear among normoglycemic populations. We test 28 serum AAs and 22 MRMs in 3,414 subjects with incident diabetes and matched normoglycemic controls from the China Cardiometabolic Disease and Cancer Cohort (4C) Study. In fully adjusted logistic regression models, per SD increment of branched-chain AAs, aromatic AAs, asparagine, alanine, glutamic acid, homoserine, 2-aminoadipic acid, histidine, methionine, and proline are positively associated with incident T2DM. In the MRM panel, serum carnitines, N-acetyltryptophan, and uric acid are positively associated with incident T2DM. Causal mediation analyses indicate 34 significant causal mediation linkages, with 88.2% through obesity and lipids. Variances explained in the serum metabolites are modestly limited in the comprehensive catalog of risk factor–metabolite–diabetes associations. These findings reveal that systematic AAs and MRMs change profile before T2DM onset and support a potential role of metabolic alterations in the pathogenesis of diabetes.
- Published
- 2022
- Full Text
- View/download PDF
50. Study on the stability of non-cohesive river bank.
- Author
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YU, Minghui, WEI, Hongyan, LIANG, Yanjie, and HU, Chunyan
- Subjects
RIPARIAN areas ,FLUMES ,EXPERIMENTAL design ,WATER current meters ,MEANDERING rivers ,HYDRODYNAMICS - Abstract
Abstract: Frequent bank collapse in nature highlights the need to study the mechanism of bank stability. This paper presents a theoretical analysis and a flume experimental study on the interaction of hydrodynamic conditions and non-cohesive banks of meandering and straight rivers. No bank collapse occurs if the bank angle is smaller than a critical value. The critical angle is a function of a dimensionless parameter K
UD , which is directly proportional to the square of flow velocity near river bed and inversely proportional to the median diameter of bank material. Furthermore, the critical angle reduces with flow velocity and is higher in meandering rivers than in straight rivers. Formulas for estimating the threshold of bank stability are obtained by curve fitting method with experimental data. The results agree with the data measured in the middle and lower reaches of the Yangtze River. [ABSTRACT FROM AUTHOR]- Published
- 2010
- Full Text
- View/download PDF
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