Search

Your search keyword '"Hu, Lide"' showing total 2 results
Start Over Author "Hu, Lide" Database Supplemental Index
2 results on '"Hu, Lide"'

1. Recent advances of phenotypic screening strategies in the application of anti-influenza virus drug discovery

Author

Jia, Huinan, Hu, Lide, Zhang, Jiwei, Huang, Xing, Jiang, Yuanmin, Dong, Guanyu, Liu, Chuanfeng, Liu, Xinyong, Kim, Meehyein, and Zhan, Peng

Abstract

Seasonal and pandemic influenza virus infections not only pose a serious threat to human health but also cause tremendous economic losses and social burdens. However, due to the inherent high variability of influenza virus RNA genomes, the existing anti-influenza virus drugs have been frequently faced with the clinical issue of emerging drug-resistant mutants. Therefore, there is an urgent need to develop efficient and broad-spectrum antiviral agents against wild-type and drug-resistant mutant strains. Phenotypic screening has been widely employed as a reliable strategy to evaluate antiviral efficacy of novel agents independent of their modes of action, either directly targeting viral proteins or regulating cellular factors involved in the virus life cycle. Here, from the point of view of medicinal chemistry, we review the research progress of phenotypic screening strategies by focusing direct acting antivirals against influenza virus. It could provide scientific insights into discovery of a distinctive class of therapeutic candidates that ensure high efficiency but low cytotoxicity, and address issues from circulation of drug-resistant influenza viruses in the future.

Published
2024
Full Text
View/download PDF

2. Emerging drug design strategies in anti-influenza drug discovery.

Author

Liu, Chuanfeng, Hu, Lide, Dong, Guanyu, Zhang, Ying, Ferreira da Silva-Júnior, Edeildo, Liu, Xinyong, Menéndez-Arias, Luis, and Zhan, Peng

Subjects
DRUG design, DRUG discovery, DRUG repositioning, DRUG development, VACCINE development, H7N9 Influenza
Abstract

Influenza is an acute respiratory infection caused by influenza viruses (IFV), According to the World Health Organization (WHO), seasonal IFV epidemics result in approximately 3–5 million cases of severe illness, leading to about half a million deaths worldwide, along with severe economic losses and social burdens. Unfortunately, frequent mutations in IFV lead to a certain lag in vaccine development as well as resistance to existing antiviral drugs. Therefore, it is of great importance to develop anti-IFV drugs with high efficiency against wild-type and resistant strains, needed in the fight against current and future outbreaks caused by different IFV strains. In this review, we summarize general strategies used for the discovery and development of antiviral agents targeting multiple IFV strains (including those resistant to available drugs). Structure-based drug design, mechanism-based drug design, multivalent interaction-based drug design and drug repurposing are amongst the most relevant strategies that provide a framework for the development of antiviral drugs targeting IFV. This article reviews the application of emerging drug design strategies in the discovery of anti-influenza virus drugs, and lists the representative inhibitors based on different drug design strategies. [Display omitted] [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results