Search

Glioblastomas multiforme (GBM) are the most frequently occurring malignant brain cancers. Treatment for GBM consists of surgical resection and subsequent adjuvant radiation therapy and chemotherapy. Despite this, GBM patient survival is limited to 12–15 months, and researchers are continually trying to develop improved therapy options. Insulin-like growth factor 2 mRNA-binding protein 2 (Imp2) is known to be upregulated in many cancers and is known to regulate the signaling activity of insulin-like growth factor 2 (IGF2). However, relatively little is known about its role in malignant development of GBM. In this study, we first found Imp2 is upregulated in GBM tissues by using clinical samples and public database search. Studies with loss and gain of Imp2 expression in in vitroGBM cell culture system demonstrated the role of Imp2 in promoting GBM cell proliferation, migration, invasion and epithelial-to-mesenchymal transition (EMT). Additionally, our results show that Imp2 regulates the activity of IGF2, which further activates PI3K/Akt signaling, thereby to promote GBM malignancy. Inhibition of Imp2 was also found to sensitize GBM to temozolomide treatment. These observations add to the current knowledge of GBM biology, and may prove useful in development of more effective GBM therapy.

Currently, mullite contained ceramics printed by DIW 3D printing cannot be used in a high temperature environment for multicycle. In the fields of environmental protection and filtration of high-temperature flue gas, 3D printed mullite contained ceramics is in widely demanded owing to the variety of structures. Thus, application of these products have been limited due to their low thermal shock resistance. In order to improve the thermal shock resistance of 3D printed mullite contained ceramics for high-temperature flue gas filter, in this work, the effect of SiC micron particles addition on the thermal shock resistance was investigated. The thermal shock behavior of 3D printed mullite ceramics was explored using a conventional water quenching technique. Furthermore, XRD and SEM were used for determining phase composition and microstructure evaluation, respectively.