69 results on '"Hui, Rutai"'
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2. Chinese Society of Cardiology guidelines on the diagnosis and treatment of adult fulminant myocarditis
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Jiang, Jiangang, Shu, Hongyang, Wang, Dao Wen, Hui, Rutai, Li, Chenze, Ran, Xiao, Wang, Hong, Zhang, Jing, Nie, Shaoping, Cui, Guanglin, Xiang, Dingcheng, Shao, Qun, Xu, Shengyong, Zhou, Ning, Li, Yuming, Gao, Wei, Chen, Yuguo, Bian, Yuan, Wang, Guoping, Xia, Liming, Wang, Yan, Zhao, Chunxia, Zhang, Zhiren, Zhao, Yuhua, Wang, Jianan, Chen, Shaoliang, Jiang, Hong, Chen, Jing, Du, Xianjin, Chen, Mao, Sun, Yinxian, Li, Sheng, Ding, Hu, Ma, Xueping, Zeng, Hesong, Lin, Li, Zhou, Shenghua, Ma, Likun, Tao, Ling, Chen, Juan, Zhou, Yiwu, and Guo, Xiaomei
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Fulminant myocarditis is an acute diffuse inflammatory disease of myocardium. It is characterized by acute onset, rapid progress and high risk of death. Its pathogenesis involves excessive immune activation of the innate immune system and formation of inflammatory storm. According to China’s practical experience, the adoption of the “life support-based comprehensive treatment regimen” (with mechanical circulation support and immunomodulation therapy as the core) can significantly improve the survival rate and long-term prognosis. Special emphasis is placed on very early identification,very early diagnosis,very early prediction and very early treatment.
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- 2024
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3. Associations of vitamin B6 turnover rate with the risk of cardiovascular and all-cause mortality in hypertensive adults.
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Cui, Qianwei, Zhu, Xu, Guan, Gongchang, Hui, Rutai, Zhu, Ling, Wang, Junkui, and Zhao, Jingsha
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This study was to assess the association between vitamin B6 turnover rate and mortality in hypertensive adults. Vitamin B6 status including serum pyridoxal-5′-phosphate (PLP) levels, serum 4-pyridoxal acid (4-PA) levels, and vitamin B6 turnover rate (4-PA/PLP) were obtained from the 2005–2010 National Health and Nutrition Examination Survey (NHANES) dataset of hypertensive adults with follow-up through December 30, 2019. Using Cox proportional risk regression models, Hazard ratios (HRs) and 95% confidence intervals (CIs) were analyzed for PLP, 4-PA and 4-PA/PLP quartiles in relation to cardiovascular and all-cause mortality. A total of 5434 participants were included in this study (mean age, 58.48 years; 50.4% men), and the median 4-PA/PLP was 0.75. The median follow-up time was 11.0 years, with 375 and 1387 cardiovascular and all-cause deaths, respectively. In multivariate COX regression models, PLP was negatively associated with cardiovascular mortality (HR [95% CI] quartile 4 vs. 1: 0.66 [0.47–0.94], P trend = 0.03) and 4-PA/PLP was positively associated with cardiovascular mortality (HR [95% CI] quartile 4 vs.1: 1.80 [1.21–2.67], P trend = 0.01). Similarly, the higher the quartile of PLP, the lower the risk of all-cause mortality (HR [95% CI] quartile 4 vs. 1: 0.67 [0.56–0.80], P trend < 0.01). The higher the quartile of 4-PA and 4-PA/PLP, the higher the risk of all-cause mortality (HR [95% CI] quartile 4 vs. 1: 1.22 [1.01–1.48], P trend < 0.01; and 2.09 [1.71–2.55], P trend < 0.01). The findings suggested that higher vitamin B6 turnover rate was associated with an increased risk of cardiovascular and all-cause mortality in hypertensive adults. • Vitamin B6 status was associated with cardiovascular and all-cause mortality in a hypertensive population. • Higher vitamin B6 turnover rate was associated with an increased risk of mortality in hypertensive adults. • Vitamin B6 turnover may be a biomarker of disease and mortality risk. [ABSTRACT FROM AUTHOR]
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- 2023
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4. Association of MPPED2gene variant rs10767873 with kidney function and risk of cardiovascular disease in patients with hypertension
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Zhong, Yixuan, Wu, Yiyi, Yang, Yunyun, Chen, Yu, Hui, Rutai, Zhang, Mei, and Zhang, Weili
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Changes in kidney function and the progression of chronic kidney disease (CKD) are associated with the risk of cardiovascular disease (CVD) and influenced by genetic factors. However, the association between genetic variants and kidney function in patients treated with antihypertensive drugs remains uncertain. This study aimed to examine the association between 30 variants locating at the 22 genes and the risk of kidney function evaluated by the estimated glomerular filtration rate (eGFR) in 1911 patients with hypertension from a Chinese community-based longitudinal cohort (including 1220 participants with CKD and 691 without CKD at baseline). By using multivariate linear regression analysis after adjustment for age, sex, traditional cardiovascular risk factors, and the use of antihypertensive drugs, as well as after correction for multiple comparison, patients with rs10767873T allele of the metallophosphoesterase domain containing 2 (MPPED2) gene were associated with higher level of eGFR (β= 0.041, p= 0.01) and lower levels of serum creatinine (β= −0.068, p= 0.001) and serum uric acid (β= −0.047, p= 0.02). But variant rs10767873 was not found to be associated with the risk of CKD, regardless of the types of antihypertensive drugs used. During a median 2.25-year follow-up, 152 CVD events were documented. Interestingly, patients with the rs10767873TT genotype had an increased risk of CVD events (hazard ratio, 1.74, 95% confidence interval, 1.11 to 2.73; p= 0.02) compared with patients carrying the wild-type genotype of rs10767873CC. In conclusion, our findings suggest variant rs10767873 of the MPPED2gene is associated with kidney function and risk of CVD in Chinese hypertensive patients.
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- 2023
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5. Oviductal Glycoprotein 1 Promotes Hypertension by Inducing Vascular Remodeling Through an Interaction With MYH9
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Bai, Congxia, Su, Ming, Zhang, Yaohua, Lin, Yahui, Sun, Yingying, Song, Li, Xiao, Ning, Xu, Haochen, Wen, Hongyan, Zhang, Meng, Ping, Jiedan, Liu, Jing, Hui, Rutai, Li, Hao, and Chen, Jingzhou
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- 2022
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6. Prevalence and Risk Factors for Hypertension in Adolescents Aged 12 to 17 Years: A School-Based Study in China.
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Liu, Kai, Li, Chen, Gong, Haibin, Guo, Ye, Hou, Bingjie, Chen, Liangyu, Liu, Fusong, Liu, Yajuan, Wang, Jizheng, Hou, Qing, Wang, Zengwu, Hui, Rutai, Jiang, Xiongjing, Zou, Yubao, Zhang, Yuqing, and Song, Lei
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[Figure: see text]. [ABSTRACT FROM AUTHOR]
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- 2021
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7. The burden and management competency of cardiomyopathies in China: a nationwide survey study
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Zhang, Yu, Liu, Minghao, Li, Peijin, Ma, Likun, Yin, Lixue, Cui, Yinghua, Huang, Kai, Li, Wei, Xin, Hui, Xiang, Meixiang, Dai, Cuilian, Chen, Mulei, Feng, Jinping, Zheng, Zeqi, Xu, Yawei, Chen, Yihan, Jiang, Xuejun, Ma, Genshan, Yang, Ping, Wang, Fang, Li, Xinli, Jin, Wei, Chen, Hong, Hui, Rutai, Wang, Lian, Xiao, Hongyan, Liu, Liwen, Zou, Yubao, and Song, Lei
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The public health burden of cardiomyopathies and competency in their management by health agencies in China are not well understood.
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- 2024
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8. Predictive value of free triiodothyronine (FT3) to free thyroxine (FT4) ratio in long-term outcomes of euthyroid patients with three-vessel coronary artery disease.
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Yuan, Deshan, Zhang, Ce, Jia, Sida, Liu, Yue, Jiang, Lin, Xu, Lianjun, Zhang, Yin, Xu, Jingjing, Xu, Bo, Hui, Rutai, Gao, Runlin, Gao, Zhan, Song, Lei, and Yuan, Jinqing
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Background and Aims: Whether routine assessment of FT3/FT4 ratio in euthyroid patients with three-vessel disease (3VD) could help identify high-risk individuals remains unclear. This study evaluated the relationship between FT3/FT4 ratio and long-term clinical outcomes in this specific population.Methods and Results: This study included 2106 euthyroid patients with 3VD (stenoses of ≥50% in right coronary artery, left circumflex and left anterior descending). Patients were categorized into three groups according to tertiles of FT3/FT4 ratio (Q1>2.58,n = 704; 2.2 ≤ Q2<2.58, n = 706; Q3<2.22, n = 696). The median follow-up time was 5.3 years, during which 206 deaths and 332 MACCEs (consisting of all-cause death, myocardial infarction, and stroke) occurred. Compared with the other two groups, patients with low level of FT3/FT4 ratio tended to be female, older, diabetic, and had significantly higher incidences of all-cause death, cardiac death and MACCE (all P < 0.05). Cox regression analysis showed that patients with low level of FT3/FT4 ratio had higher risks of long-term cardiac death (adjusted HR = 1.87, 95% CI 1.06-3.28, P = 0.030) and MACCE (adjusted HR = 1.43, 95% CI 1.07-1.93, P = 0.017) than those with high level of FT3/FT4 ratio. Subgroup analysis showed there was a significant interaction between FT3/FT4 ratio and age (≥65 years vs.<65 years) for MACCE (P = 0.029).Conclusion: Low level of FT3/FT4 ratio is independently associated with an increased risk of long-term cardiac death and MACCE in euthyroid patients with 3VD. Routine assessment of FT3/FT4 ratio might be helpful to identify high-risk individuals in this specific population. [ABSTRACT FROM AUTHOR]- Published
- 2021
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9. Body mass index and mortality in patients with severe coronary artery diseases: A cohort study from China.
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Feng, Xinxing, Zhang, Ce, Jiang, Lin, Xu, Lianjun, Tian, Jian, Zhao, Xueyan, Wang, Dong, Zhang, Yin, Sun, Kai, Xu, Bo, Hui, Rutai, Gao, Runlin, Lou, Huiling, Yuan, Jinqing, and Song, Lei
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Background and Aims: It is still controversial whether obesity and overweight increase the risk of mortality for patients with coronary artery disease. The current study aimed to investigate the relationship between body mass index (BMI) and mortality in patients with triple-vessel disease (TVD).Methods and Results: From April 2004 to February 2011, 8943 patients with angiographically confirmed TVD were consecutively enrolled. Patients were divided into five groups according to BMI: underweight (<18.5 kg/m2), normal weight (18.5-23.9 kg/m2), overweight: (24-27.9 kg/m2), mild obesity (28-31.9 kg/m2), and severe obesity (≥32 kg/m2). The primary end point was all-cause death. Subgroup analysis was performed for treatment strategies: revascularization and medical treatment alone. During a median follow-up of 7.5 years, lower risks of mortality were observed in patients with overweight (adjusted HR 0.85, 95% CI 0.75-0.97) and mild obesity (adjusted HR 0.83, 95% CI 0.69-1.00) compared to those with normal weight. Polynomial Cox regression suggested a U-shape association between BMI and adjusted mortality risk. In the revascularization subgroup, there was a significantly higher mortality risk in patients with severe obesity (adjusted HR 1.57, 95% CI 1.03-2.40) than in those with normal weight. While in the medical treatment subgroup, mortality risk decreased as BMI increased, with the lowest risk being observed in patients with severe obesity.Conclusion: There is a U-shape relationship between BMI and all-cause death in patients with TVD, with increased risks among both underweight and severely obese patients. This relationship may be influenced by treatment strategies. [ABSTRACT FROM AUTHOR]- Published
- 2021
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10. Optimal blood pressure levels in different phases of peripheral thrombolysis period in acute ischemic stroke
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He, Mingli, Wang, Hongrui, Tang, Yi, Cui, Bing, Xu, Bingchao, Sun, Yongan, Zhang, Guanghui, He, Xiaobing, Niu, Xiaoqin, Wang, Bei, Xu, Bei, Li, Zaipo, Hui, Rutai, and Wang, Yibo
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Supplemental Digital Content is available in the text
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- 2021
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11. Improvement in sudden cardiac death risk prediction by the enhanced American College of Cardiology/American Heart Association strategy in Chinese patients with hypertrophic cardiomyopathy.
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Liu, Jie, Wu, Guixin, Zhang, Ce, Ruan, Jieyun, Wang, Dong, Zhang, Mo, Wang, Limei, Yang, Yaoyao, Li, Xinrong, Wang, Yilu, Hui, Rutai, Zou, Yubao, Kang, Lianming, Wang, Jizheng, and Song, Lei
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Background: The lack of validated and effective sudden cardiac death (SCD) risk prediction methods is the biggest barrier to perform the lifesaving treatment with a prophylactic implantable cardioverter-defibrillator in Chinese patients with hypertrophic cardiomyopathy (HCM).Objective: This study aimed to evaluate the efficacy of 3 existing SCD risk prediction methods recommended by the 2011 American College of Cardiology Foundation and American Heart Association (ACCF/AHA) guideline, the 2014 European Society of Cardiology (ESC) guideline, and the 2019 enhanced American College of Cardiology (ACC)/AHA strategy in Chinese patients with HCM.Methods: The present study consisted of 1369 consecutive adult patients with HCM without a history of SCD events. The primary end point was a composite of SCD and equivalent events, namely, resuscitation from cardiac arrest and appropriate implantable cardioverter-defibrillator shock therapy for ventricular tachycardia or fibrillation.Results: During follow-up of 3.2 ± 2.4 years, 39 patients reached SCD end points, of whom 26 (66.7%) were correctly predicted as those at a high risk of SCD by using methods recommended by the 2019 enhanced ACC/AHA strategy, 20 (51.3%) by the 2011 ACCF/AHA guideline, but only 5 (12.8%) by the 2014 ESC guideline. The 2019 enhanced ACC/AHA strategy showed a higher C-statistic (0.647) for SCD prediction than did the 2011 ACCF/AHA guideline (0.598) and 2014 ESC guideline (0.605) and resulted in the correct reclassification of SCD risk when compared with the 2011 ACCF/AHA guideline (net reclassification index 0.113; P = .074) and 2014 ESC guideline (net reclassification index 0.245; P = .038).Conclusion: The 2019 enhanced ACC/AHA strategy showed better predictive performance for SCD risk stratification in Chinese patients with HCM, with a notably high sensitivity. [ABSTRACT FROM AUTHOR]- Published
- 2020
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12. N-terminal pro-brain natriuretic peptide and sudden cardiac death in hypertrophic cardiomyopathy
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Wu, Guixin, Liu, Jie, Wang, Shuiyun, Yu, Shiqin, Zhang, Ce, Wang, Dong, Zhang, Mo, Yang, Yaoyao, Kang, Lianming, Zhao, Shihua, Hui, Rutai, Zou, Yubao, Wang, Jizheng, and Song, Lei
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ObjectiveElevated levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) are associated with heart failure-related death in hypertrophic cardiomyopathy (HCM), but the relationship between NT-proBNP level and sudden cardiac death (SCD) in HCM remains undefined.MethodsThe study prospectively enrolled 977 unrelated patients with HCM with available NT-proBNP results who were prospectively enrolled and followed for 3.0±2.1 years. The Harrell’s C-statistic under the receiver operating characteristic curve was calculated to evaluate discrimination performance. A combination model was constructed by adding NT-proBNP tertiles to the HCM Risk-SCD model. The correlation between log NT-proBNP level and cardiac fibrosis as measured by late gadolinium enhancement (LGE) or Masson’s staining was analysed.ResultsDuring follow-up, 29 patients had SCD. Increased log NT-proBNP levels were associated with an increased risk of SCD events (adjusted HR 22.27, 95% CI 10.93 to 65.63, p<0.001). The C-statistic of NT-proBNP in predicting SCD events was 0.80 (p<0.001). The combined model significantly improved the predictive efficiency of the HCM Risk-SCD model from 0.72 to 0.81 (p<0.05), with a relative integrated discrimination improvement of 0.002 (p<0.001) and net reclassification improvement of 0.67 (p<0.001). Furthermore, log NT-proBNP levels were significantly correlated with cardiac fibrosis as detected either by LGE (r=0.257, p<0.001) or by Masson’s trichrome staining in the myocardium (r=0.198, p<0.05).ConclusionNT-proBNP is an independent predictor of SCD in patients with HCM and may help with risk stratification of this disease.
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- 2021
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13. East Asian–Specific Common Variant in TNNI3Predisposes to Hypertrophic Cardiomyopathy
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Wu, Guixin, Liu, Liwen, Zhou, Zhengyang, Liu, Jie, Wang, Bo, Ruan, Jieyun, Yang, Qianli, Kanchwala, Mohammed, Dai, Penggao, Zhang, Channa, Wang, Dong, Kang, Lianming, Wang, Shuiyun, Hui, Rutai, Zou, Yubao, Xing, Chao, Song, Lei, and Wang, Jizheng
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- 2020
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14. Elevated Methylation of FOXP3 (Forkhead Box P3)-TSDR (Regulatory T-Cell-Specific Demethylated Region) Is Associated With Increased Risk for Adverse Outcomes in Patients With Acute Coronary Syndrome.
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Zhu, Ling, Jia, Lei, Liu, Zhongwei, Zhang, Yong, Wang, Junkui, Yuan, Zuyi, and Hui, Rutai
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Demethylation of the forkhead box P3 (FOXP3) corresponds with stability of FOXP3 expression and immunosuppressive function of regulatory T cells (Tregs). Previous studies have demonstrated that reduction in Tregs is associated with acute coronary syndrome (ACS). The aim of this study was to establish the relationship between methylation level of FOXP3-TSDR (Treg-specific demethylated region) and clinical outcomes of ACS. We first evaluated the prognostic significance of methylation levels of FOXP3-TSDR in patients with ACS (n=171). Then, we explored the possible mechanism of methylation levels of FOXP3-TSDR on clinical outcomes of ACS in vivo. We analyzed methylation of FOXP3-TSDR, percentage of Tregs in total peripheral blood, and atherosclerotic lesions in aortic root in ApoE-/- mice (n=48; 6 groups). During the follow-up of 4.5±0.8 years, survival free of major adverse cardiovascular events was the lowest in the highest tertile of FOXP3-TSDR methylation (log-rank P=0.004). Multivariate analysis showed that FOXP3-TSDR methylation was independently and positively related to major adverse cardiovascular events (adjusted hazard ratio, 2.13; 95% CI, 1.21-3.75; P=0.009). We observed a duration-dependent increase in the methylation levels of FOXP3-TSDR in mice fed with Western diet at a period of 0, 3, 6, 9, 12, and 15 weeks. Elevated methylation levels of FOXP3-TSDR were significantly correlated of severity of atherosclerosis. We further found that FOXP3-TSDR methylation was inversely related to the percentages of Treg TGF-β (transforming growth factor-β) and IL (interleukin)-10 levels. Our results indicate that elevated methylation levels of FOXP3-TSDR are associated with increased risk for adverse outcomes in patients with ACS. [ABSTRACT FROM AUTHOR]
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- 2019
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15. Effects of Blood Pressure in the Early Phase of Ischemic Stroke and Stroke Subtype on Poststroke Cognitive Impairment.
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He, Mingli, Wang, Jin’e, Liu, Na, Xiao, Xiao, Geng, Shan, Meng, Pin, Ji, Niu, Sun, Yong’an, Xu, Bingchao, Xu, Yingda, Zhou, Xinyu, Zhang, Guanghui, He, Xiaobing, Cai, Zenglin, Li, Zaipo, Wang, Bei, Xu, Bei, Hui, Rutai, Wang, Yibo, and Wang, Jin'e
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- 2018
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16. Predictive value of in-hospital white blood cell count in Chinese patients with triple-vessel coronary disease
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Zhao, Xueyan, Jiang, Lin, Xu, Lianjun, Tian, Jian, Xu, Yujun, Zhao, Yanyan, Feng, Xinxing, Wu, Yajie, Zhang, Yin, Wang, Dong, Sun, Kai, Xu, Jingjing, Liu, Ru, Xu, Bo, Zhao, Wei, Hui, Rutai, Gao, Runlin, Song, Lei, and Yuan, Jinqing
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Aims The predictive value of white blood cells in triple-vessel coronary artery disease (TVD) remains unclear. This study aimed to examine the relationship between WBC counts and long-term prognosis of TVD.Methods A total of 8943 consecutive patients with triple-vessel coronary artery disease were enrolled from April 2004 to February 2011. The primary endpoint was all-cause death and the secondary endpoints were major adverse cardiovascular and cerebrovascular events (MACCEs; a composite of all-cause death, myocardial infarction or stroke).Results After a median of 7.5 years of follow-up, 7678 patients were included in the final analysis. Multivariable analysis showed that the white blood cell count was an independent predictor of death (hazard ratio: 1.04, p< 0.01) and MACCE (hazard ratio: 1.03, p= 0.02). In white blood cell differential analysis, increased monocytes (hazard ratio: 1.93, p= 0.001) and eosinophils (hazard ratio: 1.82, p< 0.01), and decreased lymphocytes (hazard ratio: 0.89, p= 0.02) were independent predictors of death. Increased monocytes (hazard ratio: 1.62, P= 0.002) and eosinophils (hazard ratio: 1.55, p< 0.01) were independent predictors of MACCE. A combination of monocyte, lymphocyte and eosinophil counts with the Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery (SYNTAX) score improved the predictive value for mortality (area under the curve from 0.569 to 0.611; integrated discrimination improvement = 0.012; net reclassification improvement = 0.299) and improved slightly with SYNTAX score II (all p< 0.05).Conclusion Total and differential white blood cell counts are independent prognostic factors of long-term mortality and MACCE in triple-vessel coronary artery disease. A combination of monocyte, lymphocyte and eosinophil counts improved the predictive value for mortality with the SYNTAX score, and improved it slightly with SYNTAX score II.
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- 2019
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17. A life support-based comprehensive treatment regimen dramatically lowers the in-hospital mortality of patients with fulminant myocarditis: a multiple center study
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Li, Sheng, Xu, Shengyong, Li, Chenze, Ran, Xiao, Cui, Guanglin, He, Mengying, Miao, Kun, Zhao, Chunxia, Yan, Jiangtao, Hui, Rutai, Zhou, Ning, Wang, Yan, Jiang, Jiangang, Zhang, Jing, and Wang, Daowen
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Fulminant myocarditis (FM) has unacceptable high mortality. This study aimed to evaluate the therapeutic efficacy of a life support-based comprehensive treatment regimen (LSBCTR), a completely novel treatment regimen, for FM. A total of 169 FM patients recruited from January 2008 to December 2018 were divided into two groups: patients receiving LSBCTR (81 cases), which includes (i) mechanical life support (positive pressure respiration, intra-aortic balloon pump with or without extracorporeal membrane oxygenation), (ii) immunomodulation therapy using sufficient doses of glucocorticoids and immunoglobulins, and (iii) application of neuraminidase inhibitors, and those receiving conventional treatment (88 cases). The endpoints were in-hospital death and heart-transplantation. Of all the population, 44 patients (26.0%) died in hospitals. In-hospital mortality was 3.7% (3/81) for LSBCTR group and 46.6% (41/88) for traditional treatment (P<0.001). Early application of LSBCTR, mechanical life support, neuraminidase inhibitors, and immunomodulation therapy significantly contributed to reduction in in-hospital mortality. This study describes a novel treatment regimen for FM patients that dramatically reduces in-hospital mortality. Its generalization and clinical application will efficiently save lives although further optimization is needed. This study offers an insight that virus infection induced inflammatory waterfall results in cardiac injury and cardiogenic shock and is the therapeutic target.
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- 2019
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18. Effects of Blood Pressure in the Early Phase of Ischemic Stroke and Stroke Subtype on Poststroke Cognitive Impairment
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He, Mingli, Wang, Jin’e, Liu, Na, Xiao, Xiao, Geng, Shan, Meng, Pin, Ji, Niu, Sun, Yong’an, Xu, Bingchao, Xu, Yingda, Zhou, Xinyu, Zhang, Guanghui, He, Xiaobing, Cai, Zenglin, Li, Zaipo, Wang, Bei, Xu, Bei, Hui, Rutai, and Wang, Yibo
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Supplemental Digital Content is available in the text.
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- 2018
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19. Analysis of the genes involved in Mendelian forms of low-renin hypertension in Chinese early-onset hypertensive patients
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Liu, Kai, Qin, Fang, Sun, Xiaolu, Zhang, Yang, Wang, Jizheng, Wu, Yajie, Ma, Wenjun, Wang, Wei, Wu, Xueyi, Qin, Ying, Zhang, Huimin, Zhou, Xianliang, Wu, Haiying, Hui, Rutai, Zou, Yubao, Jiang, Xiongjing, and Song, Lei
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Supplemental Digital Content is available in the text
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- 2018
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20. Community-based stroke system of care improves patient outcomes in Chinese rural areas
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He, Mingli, Wang, Jin’e, Dong, Qing, Ji, Niu, Meng, Pin, Liu, Na, Geng, Shan, Qin, Sizhou, Xu, Wenyan, Zhang, Chuantong, Li, Dabo, Zhang, Huamin, Zhu, Jinping, Qin, Hua, Hui, Rutai, and Wang, Yibo
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BackgroundBuilding effective and efficient stroke care systems is a key step in improving prevention, treatment and rehabilitation of stroke. The aim of this study was to evaluate the effectiveness of this stroke system of care on stroke management during a 2-year follow-up.MethodsA stroke system of care was developed from November 2009 to November 2010 in three townships in Ganyu County. Additional three matched townships were invited as controls. We first investigated the stroke incidence of these populations. Subsequently, this stroke system of care and an educational campaign in the three intervention townships were implemented and the effectiveness of the system was evaluated in the next 2 years.ResultsAt postintervention, more patients in the intervention communities obtained stroke knowledge and then the proportion of patients with stroke who were admitted within 3 hours of onset markedly increased in 2012 (12.0% vs 8.1%, p=0.044) and in 2013 (15.2% vs 9.7%, p=0.008) compared with those in the control communities. In the intervention communities, this proportion of patients with acute ischaemic stroke who received thrombolytic treatment was markedly raised from 2.1% in 2012 to 3.0% in 2013. More importantly, the fatality rate substantially decreased in 2013 in the intervention communities compared with that in the control communities (6.1% vs 9.7%, p=0.032). Similarly, the disability rate significantly decreased in 2013 (45.3% vs 51.5%, p=0.045).ConclusionsThe community-based stroke system of care was effective and practical for optimising stroke treatments and improving patient outcomes.Trial registration numberChiCTR-RCH-13003408, Post-results.
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- 2018
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21. Titin-Truncating Variants Increase the Risk of Cardiovascular Death in Patients With Hypertrophic Cardiomyopathy
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Zhang, Ce, Zhang, Hongju, Wu, Guixin, Luo, Xiaoliang, Zhang, Channa, Zou, Yubao, Wang, Hu, Hui, Rutai, Wang, Jizheng, and Song, Lei
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Titin-truncating variants (TTNtv) have been detected in a variety of cardiomyopathies and represent the most common cause of dilated cardiomyopathy. However, their significance in hypertrophic cardiomyopathy (HCM) is still unclear.
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- 2017
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22. Clinical Features and Outcomes of Takayasu Arteritis with Neurological Symptoms in China: A Retrospective Study.
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Yang, Lirui, Zhang, Huimin, Jiang, Xiongjing, Song, Lei, Qin, Fang, Zou, Yubao, Wu, Haiying, Bian, Jin, Zhou, Xianliang, Hui, Rutai, and Zheng, Deyu
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- 2015
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23. Readthrough of SCN5A Nonsense Mutations p.R1623X and p.S1812X Questions Gene-therapy in Brugada Syndrome
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Teng, Siyong, Huang, Jian, Gao, Zhan, Hao, Jie, Yang, Yuejin, Zhang, Shu, Pu, Jielin, Hui, Rutai, Wu, Yongjian, and Fan, Zheng
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Purpose: Nonsense mutation readthrough is used as a gene-specific treatment in some genetic diseases. The response to readthrough treatment is determined by the readthrough efficiency of various nonsense mutations. In this manuscript, we aimed to explore the harmful effects of nonsense mutation suppression. Methods: HEK293 cells were transfected with two SCN5A (encode cardiac Na+ channel) nonsense mutations, p.R1623X and p.S1812X. We applied two readthrough-enhancing methods (either aminoglycosides or a siRNA-targeting eukaryotic release factor eRF3a (a GTPase that binds eRF1)) to suppress these SCN5A nonsense mutations. When either of readthrough methods was used, the sodium channel proteins were examined by western blot and immunoblotting and recorded by whole cell patch-clamp to observe the functional characterization of the restored channels. Results: Upon readthrough treatment, the sodium currents were restored to the mutant cDNAs. These mutations reduced full-length sodium channel protein levels, and the sodium currents were reduced to 3% of wild-type. The mutant cDNA sodium currents were increased to 30% of wild-type, and the fulllength proteins also increased. However, the functional characterization of these channels from cDNAs carrying p.R1623X and p.S1812X exhibited abnormal biophysical properties, including a negative shift in steady-state sodium channel inactivation, a positive shift in sodium channel activation and robust late sodium currents. The ramp test showed prolonged QT intervals. Conclusion: These results demonstrated that readthrough-enhancing methods effectively suppressed nonsense mutations in SCN5A and restored the expression of full-length channels. However, the restored channels may increase the risk of arrhythmia.
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- 2017
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24. China’s treatment regimen for fulminant myocarditis is bringing wonderful achievement to the world
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Zhang, Jing, Hang, Weijian, Hui, Rutai, Zhao, Qiong, and Desai, Shashank
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- 2019
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25. Plasma Uric Acid as a Prognostic Marker in Patients With Hypertrophic Cardiomyopathy
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Zhu, Ling, Wang, Jizheng, Wang, Yilu, Jia, Lei, Sun, Kai, Wang, Hu, Zou, Yubao, Tian, Tao, Liu, Yan, Zou, Juan, Hui, Rutai, Yuan, Zuyi, and Song, Lei
- Abstract
Uric acid (UA) has been shown to be an independent risk factor for various cardiovascular diseases. However, its significance in hypertrophic cardiomyopathy (HCM) has not yet been evaluated. The objective of the present study was to evaluate clinical implications of plasma UA levels on the prognosis of patients with HCM.
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- 2015
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26. Correlation of Ventricular Arrhythmias With Genotype in Arrhythmogenic Right Ventricular Cardiomyopathy.
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Bao, Jingru, Wang, Jizheng, Yao, Yan, Wang, Yilu, Fan, Xiaohan, Sun, Kai, He, Ding Sheng, Marcus, Frank I., Zhang, Shu, Hui, Rutai, and Song, Lei
- Abstract
Although mutations of several genes are associated with arrhythmogenic right ventricular cardiomyopathy (ARVC), the exact correlation between genotype and ventricular arrhythmia features remains unclear. This study was aimed to examine the possible association of the 9 known genes of ARVC with clinical and electrophysiological characteristics.Ninety subjects diagnosed with ARVC who underwent electrophysiological study were recruited for screening the 9 known ARVC-causing genes. A total of 53 mutations were identified in 57 (63%) subjects. Mutation carriers had more frequent clinical ventricular tachycardia (VT; 89% versus 55%; P<0.001) and negative T waves in V
1 to V3 (61% versus 33%; P=0.016). Subjects with plakophilin-2 (PKP2) mutations also had more frequent VT than those without mutations in PKP2. Comparison between subjects with multiple and single mutations showed that syncope occurred more often in the former group (58% versus 24%; P=0.018). VT was significantly more often induced in mutation carriers compared with noncarriers (75% versus 39%; P=0.001), as well as in PKP2 mutation carriers compared with subjects without PKP2 mutations (80% versus 48%; P=0.002). Induced VT with a rate ≥200 bpm was more often documented in mutation carriers (88% versus 54%; P=0.013), as well as in PKP2 mutation carriers (91% versus 67%; P=0.041).Pathogenic gene mutations were found in nearly two thirds of subjects diagnosed with ARVC. Mutation carriers, especially PKP2, had a higher proportion of a history of VT and more inducible fast VT. [ABSTRACT FROM AUTHOR]- Published
- 2013
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27. Clinical Features and Outcomes of Takayasu Arteritis with Neurological Symptoms in China: A Retrospective Study
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Yang, Lirui, Zhang, Huimin, Jiang, Xiongjing, Song, Lei, Qin, Fang, Zou, Yubao, Wu, Haiying, Bian, Jin, Zhou, Xianliang, Hui, Rutai, and Zheng, Deyu
- Abstract
Objective.To describe the clinical features and longterm outcomes of patients with Takayasu arteritis (TA) in China who experienced neurological symptoms.Methods.A retrospective study was undertaken of patients with TA who attended a single study center from 2002 to 2013, who also exhibited neurological symptoms (n = 274). Clinical and imaging features were analyzed, as well as longterm outcomes.Results.The mean age at disease onset was 28.2 ± 11.2 years, with a female-to-male ratio of 4.3:1. The most common neurological manifestation was dizziness (214, 78.1%), the most frequent type of TA was type III (112, 40.9%), and the most common affected artery was the left subclavian (147, 53.6%). Involvement of 3 or 4 branches of the aortic arch was observed in 28% of patients. Among 30 patients experiencing a stroke (10.9%), steno-occlusive lesions of the subclavian artery and common carotid artery were frequently observed in patients with ischemic stroke, while steno-occlusive lesions of the descending aorta, abdominal aorta, and/or renal arteries were more frequently observed with hemorrhagic stroke. Heart failure was the most common cardiovascular event in those who died (n = 6) and in surviving cohorts.Conclusion.Neurological features in patients with TA were variable, and correlated with the number of arteries and the site of artery involvement. Resistant hypertension was one of the most important risk factors for hemorrhagic stroke in patients with TA.
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- 2015
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28. A Variant in the Endoglin Gene is Associated with the Development of Sporadic Intracranial Aneurysms
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Lin, Yahui, Yu, Hui, Song, Weihua, Zhang, Yinhui, Zhang, Channa, Zhu, Yufang, Pang, Qi, Hui, Rutai, and Chen, Jingzhou
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Intracranial aneurysms (IAs) are acquired lesions in the brain and can pose potential risk of rupture leading to subarachnoid hemorrhage. Endoglin plays a pivotal role in the vascular development and disease. Variations of endoglin gene have been shown to be risk factors for IAs in different racial population. In the present study, we investigated the correlation between polymorphism in the endoglin gene with IAs in Chinese Han population. The association of endoglin D366H variant (rs1800956) with sporadic IAs was tested in 313 patients with intracranial aneurysms, and 450 controls. The difference in allelic frequency between patients and control group was evaluated with the chi-square test. The frequency of the GG+CG genotype of rs1800956 was significantly higher in patients with IAs than in controls [22.0% vs 15.3%, P = .018; crude OR(odds ratio), 1.56; 95% CI(confidence interval), 1.08-2.26]. Multivariate analysis showed that rs1800956G conferred a risk to IAs [adjusted OR, 1.56 [95% CI, 1.08-2.26]; P=.019], independent of conventional factors, including age, sex, blood pressure, smoking, and alcohol consumption. The variant rs1800956 of endoglin might raise the risk of sporadic IAs among individuals of Chinese Han ethnicity.
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- 2014
29. Common Genetic Variants of MGP Are Associated With Calcification on the Arterial Wall but Not With Calcification Present in the Atherosclerotic Plaques.
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Wang, Yibo, Chen, Jinxing, Zhang, Yu, Yu, Weifeng, Zhang, Channa, Gong, Ling, Shao, Liying, Lu, Jinguo, Gao, Yang, Chen, Xuannan, Chen, Xi, and Hui, Rutai
- Abstract
Two endophenotypes of arterial calcification, calcification on arterial wall and calcification in atherosclerotic plaques, are associated with different types of cardiovascular events. Mgp-deficient mice showed matrix Gla protein (MGP) is strongly associated with calcification on arterial wall without atherosclerotic plaques, and MGP variants were not significantly associated with myocardial infarction. MGP may play different roles in the 2 endophenotypes.We analyzed the associations of MGP variants rs4236, rs1800801, and rs1800802 with the 2 endophenotypes determined by multidetector computed tomography angiography. A total of 585 with calcification on coronary artery wall, 675 with calcification in coronary atherosclerotic plaques, 454 with calcification on aortic wall, and 725 controls were enrolled. After Bonferroni correction, rs4236 and rs1800801 were still associated with calcification on arterial wall, the odds ratios were 0.708 (95% confidence interval, 0.540-0.928) for rs4236 and 0.652 (95% confidence interval, 0.479-0.888) for rs1800801 in coronary artery wall calcification, and 0.699 (95% confidence interval, 0.525-0.931) for rs4236 and 0.650 (95% confidence interval, 0.467-0.905) for rs1800801 in aortic wall calcification, respectively. The variants were correlated with calcification severity by ln(CAC Agatston score+1) in coronary artery wall calcification but not in atherosclerotic plaque calcification. In accordance with their associations with calcification on arterial wall, rs4236C and rs1800801A were associated with higher MGP plasma levels, whereas rs1800802C was associated with lower MGP levels in normal controls. Because of the role of calcification in plaque vulnerability, their associations with acute myocardial infarction were also determined in 771 controls and 752 patients, no association was found.MGP genetic variants showed association with calcification on arterial wall but not with calcification in atherosclerotic plaques. [ABSTRACT FROM AUTHOR]
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- 2013
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30. A Family with Liddle Syndrome Caused by a Novel Missense Mutation in the PY Motif of the Beta-Subunit of the Epithelial Sodium Channel.
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Gao, Linggen, Wang, Linping, Liu, Yaxin, Zhou, Xianliang, Hui, Rutai, and Hu, Aihua
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Objective: To identify the gene mutation in β and γ subunits of the epithelial sodium channel (ENaC) in an adolescent and family members with Liddle syndrome, an autosomal dominant form of secondary hypertension. Study design: We screened an adolescent with severe hypertension who was clinically diagnosed with Liddle syndrome for mutations in the C-terminus of the SCNN1B and SCNN1G genes. We also screened for these mutations in his family members, in 100 hypertensive patients, and in 100 controls. Results: The index case, a 14-year-old boy, was diagnosed with Liddle syndrome by the identification of a novel missense mutation, P614L, in the PY motif of the β subunit of the ENaC. Testing of relatives considered at risk revealed 6 subjects heterozygous for the mutation. All genetically affected subjects had a history of severe hypertension as well as hypokalemia. No other variants in the β or γ subunits of the ENaC were detected. Conclusion: Based on direct DNA sequencing, we have detected a novel mutation that causes Liddle syndrome. This confirms the diagnosis and helps guide effective therapy for this adolescent and his affected relatives. These findings provide further evidence that the conserved PY motif is critical to regulation of ENaC activity. [ABSTRACT FROM AUTHOR]
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- 2013
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31. The Role of Tumor Necrosis Factor-[alpha] Promoter Genetic Variation in Takayasu Arteritis Susceptibility and Medical Treatment.
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Lv, Naqiang, Dang, Aimin, Zhu, Xilin, Liu, Ying, Liu, Yiwen, Zheng, Deyu, Hui, Rutai, and Liu, Guozhang
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- 2011
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32. Factors Influencing Prognosis in Patients With Marfan Syndrome After Aortic Surgery.
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Gao, Linggen, Zhou, Xianliang, Zhang, Lin, Wen, Dan, Chang, Qian, Wu, Yongbo, Sun, Lizhong, and Hui, Rutai
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MARFAN syndrome ,AORTIC aneurysms ,BLOOD pressure ,SMOKING ,AORTIC valve surgery ,HEALTH outcome assessment ,HEART reoperation ,RETROSPECTIVE studies ,PROGNOSIS - Abstract
Objective: Aortic aneurysm formation leading eventually to aortic rupture or dissection in early adult life is a fatal outcome of Marfan syndrome (MFS). Advances in the treatment of the syndrome have improved prognosis, but the long-term reoperation rate is still high. It remains unknown which factors influence the long-term prognosis, including the reoperation and mortality rates, in surgically treated Chinese patients with MFS. The authors studied 125 such patients to investigate factors influencing prognosis after aortic surgery. Design: A retrospective clinical investigation. Setting: An academic medical center. Subjects: One hundred twenty-five Marfan patients who had undergone aortic surgery. Interventions: None. Measurements and Main Results: The indications for aortic surgery were aortic aneurysm and/or dissection in the 125 Marfan patients. The most commonly performed procedure was the Bentall in 92 patients. Sixteen patients underwent total arch replacement combined with stented elephant trunk implantation. Ten patients underwent the David procedure. Overall in-hospital and 30-day mortality rate was 1.6%. The survival rate was 97.5%, 91.4%, and 74.2% at 1, 5, and 10 years after surgery, respectively. The reoperation rate was 2.5%, 12.9%, and 32.9% at 1, 5, and 10 years after surgery, respectively. Multivariate analysis revealed that increased systolic blood pressure (Sys BP) was the predictor of death (p < 0.05), and body mass index and smoking were significant predictors of reoperation (p < 0.05). Conclusions: The present findings report the factors influencing the prognosis of Chinese patients with MFS after aortic surgical procedures. Managing these risk factors may enable health care professionals to improve the prognosis of MFS patients after aortic surgical procedures. [Copyright &y& Elsevier]
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- 2011
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33. Confirmation of genomewide association signals in Chinese Han population reveals risk loci for ischemic stroke.
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Ding H, Xu Y, Bao X, Wang X, Cui G, Wang W, Hui R, Wang DW, Ding, Hu, Xu, Yujun, Bao, Xunna, Wang, Xiaojing, Cui, Guanglin, Wang, Wei, Hui, Rutai, and Wang, Dao Wen
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- 2010
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34. Potential diagnostic biomarkers in serum of idiopathic pulmonary arterial hypertension.
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Zhang, Jianqiang, Zhang, Ying, Li, Ning, Liu, Zhihong, Xiong, Changming, Ni, Xinhai, Pu, Yaoli, Hui, Rutai, He, Jianguo, and Pu, Jielin
- Abstract
Summary: Background: The pathogenesis of idiopathic pulmonary arterial hypertension (IPAH) is unknown, and the syndrome of IPAH remains a diagnostic and therapeutic challenge. The present study investigated the disease-specific proteins that aid in the diagnosis of IPAH and thus to study their role in the disease process. Methods: A comparative proteomic analysis was used for clinical screening of serum proteins in 10 patients with IPAH and compared with 10 normal subjects. Furthermore, enzyme linked immunosorbent assay (ELISA) was performed for comparison with serum proteins between individual IPAH patients and controls. Results: Nine proteins and their isoforms, including leucine-rich α-2-glycoprotein (LRG), haptoglobin precursor, albumin isoform 2, transferrin variant, C3 complement, hydroxypyruvate reductase isoform 1, RAF1, fibrinogen isoformγ-A and fibrinogen isoformγ-B showed significant changes in serum of IPAH patients compared with controls by proteomic analysis. And significant higher serum levels of LRG in IPAH patients compared with controls were found by ELISA. Correlation analysis disclosed a significant association between serum LRG concentrations and New York Heart Association (NYHA) functional class (r =0.71, P <0.01) and cardiac output (CO) (r =−0.65, P <0.01). Conclusions: These results indicate that there are significant differences in the expression of proteins in the serum of patients with IPAH and normal subjects. And the measurement of LRG, RAF1 and C3 complement levels in the serum may be helpful for the diagnosis of IPAH. In particular, LRG may be a specific prognostical biomarker of IPAH. [Copyright &y& Elsevier]
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- 2009
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35. A functional variant of NEDD4L is associated with hypertension, antihypertensive response, and orthostatic hypotension.
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Fang Luo, Yibo Wang, Xiaojian Wang, Kai Sun, Xianliang Zhou, Rutai Hui, Luo, Fang, Wang, Yibo, Wang, Xiaojian, Sun, Kai, Zhou, Xianliang, and Hui, Rutai
- Abstract
NEDD4L is involved in the regulation of plasma volume and blood pressure by controlling cell surface expression of the kidney epithelial Na(+) channel. Previously, the cryptic splice variant rs4149601(G/A) A allele of NEDD4L, generating isoform I, was estimated to decrease blood pressure by downregulating Na(+) reabsorption. However, a recent functional study showed that isoform I should lead to abnormal Na(+) reabsorption increases by antagonistically downregulating epithelial Na(+) channel activities. To determine whether the variant rs4149601 A allele is a risk factor for hypertension, has an impact on the antihypertensive response to hydrochlorothiazide, and is associated with orthostatic hypotension, we performed a case-control study of hypertension (n=1686), a 4-week clinical trial (n=542), and a case-control study of orthostatic hypotension (n=793) in Chinese subjects. We found that the A allele was significantly associated with hypertension after appropriate adjustment (odds ratio: 1.39; 95% CI: 1.13 to 1.72; P=0.002). The blood pressure reduction in A carriers after hydrochlorothiazide treatment was greater than that in GG carriers, with differences of 6.1 mm Hg (P=0.009) in systolic blood pressure and 2.7 mm Hg (P=0.027) in diastolic blood pressure. The A allele was significantly associated with orthostatic hypotension after adjustment for cardiovascular risk factors (odds ratio: 0.68; 95% CI: 0.48 to 0.98; P=0.039). In conclusion, rs4149601 is a genetic risk factor for hypertension and a protective factor against orthostatic hypotension in hypertensive subjects, and the antihypertensive response to hydrochlorothiazide is more sensitive in A allele carriers than in GG carriers. Consequently, the A allele may be a useful marker for predicting hypertension, orthostatic hypotension, and antihypertensive response to hydrochlorothiazide. [ABSTRACT FROM AUTHOR]
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- 2009
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36. VEGF receptor-2 variants are associated with susceptibility to stroke and recurrence.
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Zhang W, Sun K, Zhen Y, Wang D, Wang Y, Chen J, Xu J, Hu FB, Hui R, Zhang, Weili, Sun, Kai, Zhen, Yisong, Wang, Daowen, Wang, Yibo, Chen, Jinxing, Xu, Jianfeng, Hu, Frank B, and Hui, Rutai
- Published
- 2009
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37. Dimethylarginine dimethylaminohydrolase (DDAH) – A critical regulator of hypertensive left ventricular hypertrophy?
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Bai, Yongyi and Hui, Rutai
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HYPERTROPHY ,PATHOLOGY ,CARDIOVASCULAR diseases ,ARTERIAL diseases ,HYPERTENSION - Abstract
Summary: Left ventricular hypertrophy (LVH) is an early manifestation of cardiovascular target organ damage in patients with arterial hypertension. It is not only a target organ response to increased after-load, but is also the most potent cardiovascular risk factor. LVH is multifactorial sign which has several causative factors in addition to blood pressure. Asymmetrical dimethylarginine (ADMA) is an endogenous inhibitor of NO synthase. ADMA plasma levels have been shown to be elevated in diseases related to endothelial dysfunction such as hypertension, hyperlipidemia, diabetes mellitus. Because cardiac remodeling is associated with endothelial NO pathway, some recent studies investigated whether the plasma ADMA was related to LVH and found that there is a link between ADMA and left ventricular mass and geometry. ADMA was two times higher in patients with concentric LVH than in those normal controls. In many experimental systems, accumulation of ADMA is accompanied by reduced dimethylarginine dimethylaminohydrolase (DDAH) activity. Plasma ADMA is cleared in small part by urinary excretion, but the bulk of ADMA is degraded by DDAH. Therefore, we proposed that change in DDAH activity could disturb the metabolism of ADMA and result in hypertensive LVH through the ADMA/NO pathway. [Copyright &y& Elsevier]
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- 2008
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38. Telomeres, cardiovascular aging, and potential intervention for cellular senescence
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Zhang, WeiLi, Hui, RuTai, and Yang, ShuJun
- Abstract
A consistent association has been observed between leukocyte telomere length (LTL) and atherosclerosis, but the mechanisms underlying these associations are still not well understood. Premature biology aging was evident in atherosclerotic plaques, characterized by reduced cell proliferation, irreversible growth arrest and apoptosis, and telomere attrition. As atherosclerosis is a state of chronic low-grade inflammation and increased oxidative stress, shortened LTL in patients with atherosclerosis might stem from the two sources, one is an accelerated rate in hematopoietic stem cells (HSCs) replication to replace leukocytes consumed in the inflammatory process, and another is the increase in the loss of telomere repeats per replication. Thus, diminished HSC reserves at birth and age-dependent telomere attrition afterward are mirrored in shortened LTL during the adulthood. In addition, the inter-individual variation of LTL in the general population can be partly explained by genetic factors regulating telomere maintenance and the rate of HSCs replication. Atherosclerosis is an aging-related disease, and practically all humans develop atherosclerosis if they live long enough. Here we overview the potential roles of LTL dynamics in the imbalance between injurious oxidative stress/inflammation and endothelial repair during the pathogenesis of age-related atherosclerosis, and discuss the possibility that preventing accelerated cellular senescence is a potential target in prevention of atherosclerosis.
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- 2014
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39. Community-Based Stroke System of Care for Chinese Rural Areas
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He, Mingli, Wang, Jin’e, Gong, Ling, Dong, Qing, Ji, Niu, Xing, Houxun, Zhou, Yuan, Qin, Sizhou, Wang, Huizheng, Zhang, Huamin, Hui, Rutai, and Wang, Yibo
- Abstract
Stroke system of care plays key roles both in providing effective therapies and in improving the overall outcome of patients with stroke. Our purpose was to develop and evaluate the system in Chinese rural areas.
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- 2014
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40. Clinical Manifestations and Longterm Outcome for Patients with Takayasu Arteritis in China
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Yang, Lirui, Zhang, Huimin, Jiang, Xiongjing, Zou, Yubao, Qin, Fang, Song, Lei, Guan, Ting, Wu, Haiying, Xu, Lianjun, Liu, Yaxin, Zhou, Xianliang, Bian, Jin, Hui, Rutai, and Zheng, Deyu
- Abstract
Objective.To describe a large cohort of patients with Takayasu arteritis in China.Methods.We retrospectively analyzed 566 patients hospitalized in Fuwai Hospital between 2002 and 2013. Data collected were clinical characteristics, laboratory findings, angiographic features, treatment, and longterm outcome.Results.The female to male ratio was 3.8 to 1, and the mean age of onset was 28.9 ± 12.0 years. The most common inflammatory symptom, initial symptom, and coexisting disease were fever (52, 9.2%), dizziness (214, 37.8%), and hypertension (HTN; 392, 69.3%), respectively. Pulmonary artery, coronary artery involvement, and aortic regurgitation were found in 83 (14.7%), 66 (11.7%), and 181 (36.7%) patients, respectively. Elevation of the erythrocyte sedimentation rate was observed in 131 patients (23.1%). Treatment included drugs, interventional therapy, autologous blood vessel transplant, artificial blood vessel transplant, and aortic valve replacement. During a mean followup of 5.0 ± 0.2 years, 32 patients died, including 1 patient who died suddenly during coronary angiography. HTN, major complications, and a progressive disease course were significant prognostic markers.Conclusion.HTN, rather than fever, is the leading reason for patients with Takayasu arteritis to see a doctor in China. HTN, major complications, and a progressive disease course are statistically significant predictors of survival. Because of cardiovascular events associated with the disease, early diagnosis and treatment are urgent to improve prognosis.
- Published
- 2014
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41. Correlation of Ventricular Arrhythmias With Genotype in Arrhythmogenic Right Ventricular Cardiomyopathy
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Bao, Jingru, Wang, Jizheng, Yao, Yan, Wang, Yilu, Fan, Xiaohan, Sun, Kai, He, Ding Sheng, Marcus, Frank I., Zhang, Shu, Hui, Rutai, and Song, Lei
- Abstract
Although mutations of several genes are associated with arrhythmogenic right ventricular cardiomyopathy (ARVC), the exact correlation between genotype and ventricular arrhythmia features remains unclear. This study was aimed to examine the possible association of the 9 known genes of ARVC with clinical and electrophysiological characteristics.
- Published
- 2013
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42. Common Genetic Variants of MGPAre Associated With Calcification on the Arterial Wall but Not With Calcification Present in the Atherosclerotic Plaques
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Wang, Yibo, Chen, Jinxing, Zhang, Yu, Yu, Weifeng, Zhang, Channa, Gong, Ling, Shao, Liying, Lu, Jinguo, Gao, Yang, Chen, Xuannan, Chen, Xi, and Hui, Rutai
- Abstract
Two endophenotypes of arterial calcification, calcification on arterial wall and calcification in atherosclerotic plaques, are associated with different types of cardiovascular events. Mgp-deficient mice showed matrix Gla protein (MGP) is strongly associated with calcification on arterial wall without atherosclerotic plaques, and MGPvariants were not significantly associated with myocardial infarction. MGP may play different roles in the 2 endophenotypes.
- Published
- 2013
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43. Coronary Artery Involvement in Takayasu Arteritis in 45 Chinese Patients
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Sun, Teng, Zhang, Huimin, Ma, Wenjun, Yang, Lirui, Jiang, Xiongjing, Wu, Haiying, Hui, Rutai, and Zheng, Deyu
- Abstract
Objective.We investigated the clinical characteristics, potential difficulties in diagnosis, and therapy for coronary artery involvement in patients with Takayasu arteritis (TA).Methods.Of 587 consecutive patients hospitalized with TA from 1998 to 2011, those found to have > 50% reduction of diameter of coronary artery by angiography were recruited. We defined the first finding of coronary involvement as baseline. The clinical features, laboratory data, coronary angiographic findings, treatment, and followup outcomes were summarized retrospectively.Results.A total of 45 (7.7%, 45/587) patients with coronary involvement were identified, including 40 with typical angina, and 15 with myocardial infarction. Some had complications such as peripheral vascular murmur, pulseless disease, and hypertension. The average age at onset of cardiac symptoms was 40.3 ± 12.8 years (range 15–64) and 36 were female. At admission, erythrocyte sedimentation rates were elevated in 27 patients (60%) and C-reactive protein levels in 23 (51.1%). The ostia (37.4%) and proximal segments (33.3%) of coronary artery were most frequently involved. The treatment was stent implantation in 10 patients and coronary artery bypass grafting in 13. One female patient suffered sudden death during the angiography. During a mean followup of 5.8 ± 4.5 years, 8 patients died.Conclusion.Coronary artery involvement in TA that leads to cardiovascular events, especially to cardiovascular death, is not rare. Early diagnosis and therapy should be emphasized.
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- 2013
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44. Depression increases the risk of hypertension incidence
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Meng, Lin, Chen, Dongmei, Yang, Yang, Zheng, Yang, and Hui, Rutai
- Abstract
It has long been known that depression is associated with hypertension but whether depression is a risk factor for hypertension incidence is still inconclusive.
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- 2012
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45. Telomere Length and Risk of Stroke in Chinese
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Ding, Hu, Chen, Chen, Shaffer, John R., Liu, Lei, Xu, Yujun, Wang, Xiaojing, Hui, Rutai, and Wang, Dao Wen
- Abstract
Accumulating evidence suggests that telomere length is a maker for biological aging of the cardiovascular system. Whether stroke is associated with accelerated biological aging as measured by telomere length has not been conclusively demonstrated. Our aim was to determine whether mean leukocyte telomere length is a predictor for the development of stroke.
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- 2012
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46. Variants on Chromosome 9p21.3 Correlated With ANRILExpression Contribute to Stroke Risk and Recurrence in a Large Prospective Stroke Population
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Zhang, Weili, Chen, Yu, Liu, Peng, Chen, Jingzhou, Song, Lei, Tang, Yue, Wang, Yuyao, Liu, Jibin, Hu, Frank B., and Hui, Rutai
- Abstract
ANRILencodes a long antisense noncoding RNA in the INK4locus. Although ANRILhas been proven to be associated with coronary heart disease, its roles in stroke are inconsistent, and sparse data are available regarding hemorrhagic stroke.
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- 2012
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47. The Role of Tumor Necrosis Factor-α Promoter Genetic Variation in Takayasu Arteritis Susceptibility and Medical Treatment
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LV, NAQIANG, DANG, AIMIN, ZHU, XILIN, LIU, YING, LIU, YIWEN, ZHENG, DEYU, HUI, RUTAI, and LIU, GUOZHANG
- Abstract
OBJECTIVE: Tumor necrosis factor-α (TNF-α) is a multifunctional proinflammatory cytokine that influences the pathogenesis of Takayasu arteritis (TA). There is still no evidence of the relationship between TNF-α gene promoter polymorphisms and TA. We examined whether variations in the TNF-α promoter region may lead to TA susceptibility and disease progression. METHODS: Five TNF-α gene promoter polymorphisms (–238G/A, –308G/A, –857C/T, –863C/A, and –1031C/T) were analyzed in 110 Chinese Han patients with TA, with a control group of 362 unrelated healthy individuals. Genotypes of TNF-α gene promoter polymorphisms were identified by direct sequencing. TNF-α plasma concentrations were determined by ELISA. RESULTS: Our results indicated that the frequency of the –863A allele was significantly lower in the patients with TA than in the controls (18.2% vs 25.7%; p = 0.011), but the significance was lost after Bonferroni correction (pc= 0.055). The frequency of –863CA/AA genotypes was significantly lower in the patients with refractory TA than in those with the 863CC genotype (22.4% vs 44.2%; pc< 0.01). The frequency of the GGCCT haplotype was significantly higher in patients than in the controls, while the frequencies of GGCAT and GGCCC haplotypes were significantly lower in patients than in controls. The plasma TNF-α concentrations were significantly lower in the subjects carrying the –863A allele than in those without. Patients with active TA had a significant increase in plasma levels of TNF-α compared with remission patients and the control group. CONCLUSION: Polymorphisms of the TNF-α promoter are not associated with TA in the Chinese Han population. The A allele of the –863C/A polymorphism is associated with decreased TNF-α expression, which might affect medical treatment.
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- 2011
48. Inverse association of plasma level of high-density lipoprotein cholesterol with intracerebral hemorrhage
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Wang, Xinguo, Li, Shaohua, Bai, Yongyi, Fan, Xiaohan, Sun, Kai, Wang, Jizheng, and Hui, Rutai
- Abstract
This study aimed to investigate whether plasma levels of HDL cholesterol (HDL-C) were associated with the risk of intracerebral hemorrhage (ICH). Plasma HDL-C was determined via enzymatic methods, and ICH was ascertained via medical history, physical examination, and brain imaging (computed tomography or magnetic resonance imaging). The multivariable logistic regression model was used to calculate the odds ratios (OR) and 95% confidence intervals (CI) of ICH according to levels of plasma cholesterol. A total of 170 patients with ICH were identified from 6,046 participants. After adjustment for conventional cardiovascular risk factors, the OR was 2.06 (95% CI, 1.25-3.12; P< 0.01) for participants in the first tertile of HDL-C levels (<1.38 mmol/l) and 1.13 (95% CI, 0.72-1.78; P= 0.59) for participants in the second tertile (1.38-1.64 mmol/l), compared with participants in the third tertile (∩≥1.65 mmol/l). Subgroup analysis indicated that the detrimental effects of HDL-C were more significant in men and lean participants than in their corresponding controls, independent of hypertension. The results presented herein indicate that low plasma HDL-C (<1.38 mmol/l) may be associated with risk of ICH.
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- 2011
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49. Inverse association of plasma level of high-density lipoprotein cholesterol with intracerebral hemorrhage
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Wang, Xinguo, Li, Shaohua, Bai, Yongyi, Fan, Xiaohan, Sun, Kai, Wang, Jizheng, and Hui, Rutai
- Abstract
This study aimed to investigate whether plasma levels of HDL cholesterol (HDL-C) were associated with the risk of intracerebral hemorrhage (ICH). Plasma HDL-C was determined via enzymatic methods, and ICH was ascertained via medical history, physical examination, and brain imaging (computed tomography or magnetic resonance imaging). The multivariable logistic regression model was used to calculate the odds ratios (OR) and 95% confidence intervals (CI) of ICH according to levels of plasma cholesterol. A total of 170 patients with ICH were identified from 6,046 participants. After adjustment for conventional cardiovascular risk factors, the OR was 2.06 (95% CI, 1.25-3.12; P < 0.01) for participants in the first tertile of HDL-C levels (<1.38 mmol/l) and 1.13 (95% CI, 0.72-1.78; P = 0.59) for participants in the second tertile (1.38-1.64 mmol/l), compared with participants in the third tertile (∩≥1.65 mmol/l). Subgroup analysis indicated that the detrimental effects of HDL-C were more significant in men and lean participants than in their corresponding controls, independent of hypertension. The results presented herein indicate that low plasma HDL-C (<1.38 mmol/l) may be associated with risk of ICH.
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- 2011
50. Association of common variants of CYP4A11and CYP4F2with stroke in the Han Chinese population
- Author
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Ding, Hu, Cui, Guanglin, Zhang, Lan, Xu, Yujun, Bao, Xunna, Tu, Yuanchao, Wu, Bin, Wang, Qi, Hui, Rutai, Wang, Wei, Dackor, Ryan T., Kissling, Grace E., Zeldin, Darryl C., and Wang, Dao Wen
- Abstract
20-Hydroxyeicosatetraenoic acid has been shown to play an important role in cerebral vascular function. We hypothesized that polymorphisms in genes encoding 20-Hydroxyeicosatetraenoic acid synthesizing enzymes might confer susceptibility to stroke.
- Published
- 2010
- Full Text
- View/download PDF
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