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1. The skeletal changes in endemic fluorosis are described from an area of the Punjab where the fluorine content of water and soil is very high.2. A detailed description of a fluorotic skeleton is given, with its various anthropometric measurements.3. The vertebral changes demonstrated the pathogenesis of the neurological complications observed in this condition.

Neuralgic amyotrophy of the upper limbs, or the "shoulder-girdle syndrome," has been described for a number of years (Spillane,1 1943), but no similar condition is known to involve the lower limbs (Parsonage and Turner,2 1948). We have come across a number of cases of a peculiar type of occupational neuritis characterized chiefly by weakness and wasting of muscles in the anterior and posterior compartments of the leg, resembling in many ways the shoulder-girdle syndrome. We are not aware that this condition has previously been described. The standard neurological textbooks3-7 do not describe the condition beyond the statement that toxic neuritis of these nerves may occur after infections and septicemic states, like typhoid, dysentery, and pneumonia. Cases similar to the above but associated with signs of peripheral neuropathy elsewhere have been observed by Chhuttani and Taylor8 (1953) from the Middle East.The essential clinical picture is very

Two decades have elapsed since Iverson and Roholm 1 popularized liver biopsy as a diagnostic procedure. Ever since, numerous series of papers have been published from different countries emphasizing the importance and efficacy of this procedure as a diagnostic and research method.2-4 Its importance in conditions which affect the liver parenchyma diffusely, namely, hepatitis, fatty liver, amyloidosis, etc., is already established. More recently, however, the postmortem sampling technique adopted by Braunstein 5 has further established the accuracy of liver biopsy in the diagnosis and estimation of degree of cirrhosis of the liver.The incidence of various liver diseases depends upon the nutritional standards of a country, being highest in Asia and Africa. It is therefore likely that certain differences may be expected from the pattern of various liver diseases described from outside Asia. With this object in view the following observations have been collected. METHODS AND MATERIAL This report