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In this study, the antioxidant capacities, phenolic properties, and minerals of strawberries produced in four different districts of Konya/Türkiye were compared. The methanolic extracts were examined for total phenolic contents (TPC), total flavonoid contents (TFC), and antioxidant capacities, assessed using ferric reducing antioxidant power (FRAP) and 2,2-diphenyl-1-picrylhydrazyl (DPPH). The phenolic compositions of the samples were analyzed using HPLC-PDA, with 25 phenolic standards. The mineral content of samples was analyzed using ICP-OES. The measured quantities of TPC and TFC ranged between 79.800 and 15.100 mg GAE/100 g and 5.600 and 10.000 mg QE/100 g, respectively. FRAP and DPPH values varied between 1.192 and 1.610 mM FeSO4.7 H2O/100 g FW and 2.691 and 4.239 mg/ml, respectively. The samples from the Yalıhüyük and Derbent regions were found to possess similar phenolic contents and antioxidant capacities, followed by the Bozkır and Seydişehir samples. Of the tested phenolic compounds, only six were detected as common components in all the samples, yet their quantities varied. p-OH benzoic acid was the major component, followed by pinocembrin, chrysin, t‑cinnamic acid, caffeic acid phenethyl ester (CAPE), and gallic acid. K was found to be the most prevalent element in all samples, followed by Ca and Na. Although Derbent and Yalıhüyük strawberries were closely clustered, factor analysis indicated distinct groupings for each district. In conclusion, the distinct variations in phenolic composition across all samples suggest significant diversity influenced by regional factors, emphasizing the need for further exploration and understanding of these variations in strawberry cultivation.

Purpose: The enrichment of health-promoting compounds in plants and foods has received significant research attention over the past years, leading researchers to use cutting-edge technologies like elicitation in agriculture and food production systems. Engineered nanoparticles (NPs) have been shown to function as effective elicitors, enhancing the synthesis of secondary metabolites. Although carbon dots (CDs) are at the forefront due to their favorable characteristics, such as being green, biocompatible, and low toxicity, their functions as elicitors have not been thoroughly investigated. The aim of this study was, therefore, to investigate the potential effect of sugar beet molasses carbon dots (SBM-CDs), characterized by their endogenous food-borne nature as elicitors, on the agronomic and bioactive compounds of wheatgrass juice obtained from hydroponically cultivated wheatgrasses. Methods: Wheatgrasses were grown with and without SBM-CDs extracted from molasses at 50–200 mg L− 1concentrations through a nutrient solution in a hydroponic system. After 7 days, wheatgrass juice was obtained by squeezing wheatgrass. The effects of SBM-CDs were investigated by assessing the agronomic parameters and bioactive compounds of wheatgrass juice. Results: The amount of β-carotene, vitamin E, vitamin C, and chlorophyll a increased by 150%, 84%, 25%, and 89%, respectively, with the application of 200 mg L− 1SBM-CDs (p< 0.01) in comparison with the control group (the application without SBM-CDs). Besides, this application resulted in a 34% increase in the total quantity of tested phenolic compounds. Conclusions: These data suggest that our biomass-derived renewable CDs may be a novel category of elicitors for enhancing the production of bioactive compounds in wheatgrass.

We presented intracardiac electrograms during the parahisian pacing, which represent three types of retrograde conduction and focus on the mechanism of types of retrograde conduction on wide QRS complexes and conclude that the two types of QRS of the retrograde conduction resulted from the presence or absence of retrograde block at the right bundle branch.

Coronary artery disease is the leading cause of mortality worldwide. Regular physical activity is part of a comprehensive management strategy for these patients. We investigated the parameters that influence physical activity in patients with a history of coronary revascularization.

The native extracellular matrix (ECM) serves as a unique platform for tissue engineering because it provides an organ-specific scaffold in terms of both matrix composition and tissue architecture. However, efficacious cell-seeding techniques for recellularizing the ECM constructs with appropriate cell types to restore biological function remain under development. In this study, the impact of spraying as a seeding technique for repopulation of decellularized small intestine was investigated. In a series of experiments, CaCo-2 cells were first used to investigate the effect of spray device type and pressure on cell viability and to optimize parameters for seeding intestinal epithelial cells. High cell viability and a homogeneous cell distribution were obtained when cell suspensions were sprayed through an airbrush at low pressure. Next, the effect of seeding method and spray pressure on the size and dispersal of intestinal organoids, a more complex and clinically relevant intestinal stem cell population, was evaluated. The feasibility of seeding intestinal epithelial cells onto decellularized scaffolds was next studied using sprayed CaCo-2 cells, which survived the spray-seeding process and formed a monolayer on the scaffold. Finally, airbrush seeding was used to spray intestinal organoids onto the scaffolds, with cell survival and tissue architecture evaluated after 1 week of culture. Organoids seeded through pipetting onto the decellularized scaffold survived, but demonstrated aggregation, with cells organized around multiple small lumens. In contrast, organoids airbrush spray seeded at 0.35 bar onto the decellularized scaffold not only engrafted but also demonstrated formation of an epithelial monolayer that resembled the absorptive surface found on intestinal villi. The results suggest that seeding cells through airbrush spraying holds great potential for use in tissue engineering, especially for large-scale tubular organ recellularization.

Transradial access is widely used for both diagnostic and interventional cardiac procedures. The use of transradial access offers several advantages, including decreased bleeding, fewer vascular complications, and reduced length of hospital stay and cost. However, the small size of the radial artery limits the size of the equipment that can be used via this approach. In this study we sought to investigate whether preprocedural manual heating of the radial artery facilitates radial artery puncture.

AbstractWe have carried out a several-year-long study of the Amanos Mountains, on the basis of which we present new sedimentary and structural evidence, which we combine with existing data, to produce the first comprehensive synthesis in the regional geological setting. The ca. N-S-trending Amanos Mountains are located at the northwesternmost edge of the Arabian plate, near the intersection of the African and Eurasian plates. Mixed siliciclastic-carbonate sediments accumulated on the north-Gondwana margin during the Palaeozoic. Triassic rift-related sedimentation was followed by platform carbonate deposition during Jurassic-Cretaceous. Late Cretaceous was characterised by platform collapse and southward emplacement of melanges and a supra-subduction zone ophiolite. Latest Cretaceous transgressive shallow-water carbonates gave way to deeper-water deposits during Palaeocene-Eocene. Eocene southward compression, reflecting initial collision, resulted in open folding, reverse faulting and duplexing. Fluvial, lagoonal and shallow-marine carbonates accumulated during Late Oligocene(?)-Early Miocene, associated with basaltic magmatism. Intensifying collision during Mid-Miocene initiated a foreland basin that then infilled with deep-water siliciclastic gravity flows. Late Miocene-Early Pliocene compression created mountain-sized folds and thrusts, verging E in the north but SE in the south. The resulting surface uplift triggered deposition of huge alluvial outwash fans in the west. Smaller alluvial fans formed along both mountain flanks during the Pleistocene after major surface uplift ended. Pliocene-Pleistocene alluvium was tilted towards the mountain front in the west. Strike-slip/transtension along the East Anatolian Transform Fault and localised sub-horizontal Quaternary basaltic volcanism in the region reflect regional transtension during Late Pliocene-Pleistocene (<4 Ma).

Dopamine (DA) is an important electroactive neurotransmitter. The concentration of DA in the body of a healthy person is approximately 1.0 × 10−7−1.0 × 10−3M. A decrease in dopamine concentration is associated with Parkinson’s disease. Thus, it is important to determine the amount of dopamine in early diagnosis of Parkinson’s disease. Different methods such as immunoassay, flow injection analysis (FIA), high performance liquid chromatography (HPLC) etc could be used for determination of dopamine but they are expensive and have long determination times, and pre analytic processes. In this study, a tyrosinase based amperometric biosensor was developed with carbon paste electrode modified with carbon nano dot 3-Chloropropyl-trimethoxysilane (CDs-CPTMS) for determination of the amount of dopamine. CDs-CPTMS was synthesized for the first time. Determination of dopamine was carried out by the reduction of dopamine-o-quinone at −0.15 V versus Ag/AgCl. The effect of temperature, pH, and substrate concentration on the dopamine response of the prepared biosensor and interference effect were investigated. There was no interference effect of uric acid and ascorbic acid. The designed biosensor has wide working range (0.001–0.01 μM and 0.01−0.1 μM), low limit of detection, very good reproducibility and shelf life. In addition, the preparation of the biosensor is practical and cost-effective.

Entrainment is an important tool for the diagnosis and location of reentry. The usefulness of this maneuver requires that, prior to cessation of ventricular pacing, the atrial rate accelerates to the ventricular pacing rate. Moreover, it is important to verify the continuation of the tachycardia following cessation of entrainment. The recognizing the last entrained atrial beat is utmost important to avoid erroneous A–A–V labeling.

The ‘smoker's paradox’ refers to the observation of favorable prognosis in current smokers following an acute ST elevation myocardial infarction (STEMI) in the era of fibrinolysis, however, several STEMI studies have demonstrated conflicting results in patients undergoing primary percutaneous coronary intervention (p-PCI).

The Mustafakemalpaşa Fault (MF), located among Manyas, Ulubat and Orhaneli faults, is a right lateral strike-slip and 47 km in length. The MF begins with a pressure ridge at the west and exhibits complex jog terminations at east ends in restraining left stepovers. The western section of the fault bounds Miocene and Quaternary units and continues towards İlyasçılar. The central segment of the fault, starts with approximately 750-m leftward stepover, exhibits a sinusoidal geometry between Kapaklıoluk and Kabulbaba. In this section, MF traverses mountainous terrain and cuts Ophiolite, Jurassic limestones and Miocene detritals, forming dextral faulting features and gaining reverse component. The eastern section exhibits left stepping en-echelon pattern and consists 2.5-km offset on the Orhaneli River. In this study, palaeoseismological findings related to the Holocene activity and active tectonic properties of the MF are presented. The trenches exposed mismatched stratigraphy, demonstrating evidence of events across the fault. We identified three events (before BC 2190, later AD 1425 and 1850) that have occurred during the past 4000 years. We suggest a long non-characteristic recurrence interval and ~0.7 mm/y slip-rate for MF, based on trench data and offset of the Late Pliocene drainage of Orhaneli River.

High global temperatures will be a great challenge for agricultural production in the near future. Therefore, adaptation of agricultural crops to the high temperatures or development of new heat-tolerant crops with known bioactive compounds is an important strategy for nutritional health and crop improvement programs. In this context, the bioactive compounds of newly developed high temperature-tolerant tomato lines were investigated in terms of lycopene, β-carotene, ascorbic acid and phenolic compounds to assist breeders for the selection of high temperature tolerant tomato varieties with high nutritional quality. Nineteen tomato lines, including control varieties from the “Turkey F1 Hybrid vegetable variety and quality line development” project and the GAP Agricultural Research Institute, were selected for the investigation. Line 11 was superior in lycopene and β-carotene content, while line 18 was superior in ascorbic acid content as compared to control varieties Cansun F1 and Alsancak RN F1. Urfa 2012 and line 28 were found to have the highest numbers of phenolic compounds. Chlorogenic acid, naringenin, trans-ferulic acid and rutin were key phenolic compounds detected in each of the tomato lines. These newly released tomato lines can be used as value-added germplasm or parent sources to develop new heat-tolerant cultivars in breeding programs or as commercial cultivars for their superior functional qualities.

The transition of the tachycardia from narrow to wide by a spontaneous atrial premature contraction causing a long‐short sequence and right bundlebranch block

Differential diagnoses of regularly irregular narrow QRS tachycardias are AV re‐entrant tachycardia (AVRT) with alternating antegrade AVN pathways, atypical AV nodal re‐entrant tachycardia (AVNRT) with alternating antegrade AVN pathways, and atrial tachycardia (AT) with alternating antegrade AVN pathways or with Wenckebach periodicity.

Transseptal catheterization has become part of the interventional electrophysiologist's technical armamentarium since the development of left atrial catheter ablation and percutaneous technologies for treating mitral and aortic valve disease. Although frequently performed, the procedure's most feared complication is aortic root penetration. Focal atrial tachycardia has been described as the most common late sequela of surgical valve replacements. We present a complicated case involving the inadvertent delivery of an 8 French sheath across the noncoronary cusp during radiofrequency catheter ablation for left atrial tachycardia originating from the mitral annulus in a patient with prior mitral valve replacement.

Transseptal catheterization has become part of the interventional electrophysiologist׳s technical armamentarium since the development of left atrial catheter ablation and percutaneous technologies for treating mitral and aortic valve disease. Although frequently performed, the procedure׳s most feared complication is aortic root penetration. Focal atrial tachycardia has been described as the most common late sequela of surgical valve replacements. We present a complicated case involving the inadvertent delivery of an 8 French sheath across the noncoronary cusp during radiofrequency catheter ablation for left atrial tachycardia originating from the mitral annulus in a patient with prior mitral valve replacement.

Since restricted resident work hours have reduced resident participation in traditional educational activities, we wanted to evaluate e-mail–based education in an internal medicine residency. One internal medicine faculty member sent four clinical case-based questions per week to all internal medicine residents over a 10-month period (132 questions total). The mean percentage of participation on a set of questions was 69% (range, 43% to 97%). The mean percentage of correct answers on all questions for all residents was 70% (range, 15% to 100%). Seventy-three percent of the question sets resulted in an electronic interaction between the residents and the faculty sponsor. Based on an anonymous survey, 96% of the residents found the program useful. The faculty sponsor spent 60 to 150 minutes per week on this activity. We think that this program increased overall reading since it did not replace any traditional activity; further, it provided practice with board-type questions. This approach can supplement the educational curriculum for internal medicine training.