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The pharmacological activity of crude methanol extracts of Gliricidia maculataleaves were studied in the excision and granuloma wound models in rats. The rate of contraction was 86.65% ± 9.1% in treated compared with 92.43% ± 2.9% in control groups and the epithelialization time was prolonged to 20.2 ± 3.9 days in treated compared with 17.2 ± 0.9 days in control groups. Similarly, granuloma formation was not inhibited but disruption of endothelial cells and neovascularization was observed in the haemorrhaged granulomas. The low tensile strength in the excision wound was due to a low level of hydroxyproline 22.43 ± 9.9 µg/g tissue with a turnover of 19.05% ± 6.6% collagen compared with original levels of 32.44 ± 6.4 µg/g tissue of hydroxyproline and 24.20% ± 4.8% collagen. In the granuloma model, significant differences were observed in the treated group with 43.88 ± 6.8 µg/g tissue hydroxyproline and 61.88 ± 2.5 µg/g tissue in the control. Copyright © 1998 John Wiley & Sons, Ltd.

The pharmacological activity of crude methanol extracts of Gliricidia maculata leaves were studied in the excision and granuloma wound models in rats. The rate of contraction was 86.65% ± 9.1% in treated compared with 92.43% ± 2.9% in control groups and the epithelialization time was prolonged to 20.2 ± 3.9 days in treated compared with 17.2 ± 0.9 days in control groups. Similarly, granuloma formation was not inhibited but disruption of endothelial cells and neovascularization was observed in the haemorrhaged granulomas. The low tensile strength in the excision wound was due to a low level of hydroxyproline 22.43 ± 9.9 µg/g tissue with a turnover of 19.05% ± 6.6% collagen compared with original levels of 32.44 ± 6.4 µg/g tissue of hydroxyproline and 24.20% ± 4.8% collagen. In the granuloma model, significant differences were observed in the treated group with 43.88 ± 6.8 µg/g tissue hydroxyproline and 61.88 ± 2.5 µg/g tissue in the control. Copyright © 1998 John Wiley & Sons, Ltd.

The aqueous extract of Tridax procumbensleaves was lyophilized and studied on the excision wound model, rat skin fibroblast and rat paw oedema. Tridax procumbensdid not significantly increase the fibroblast count compared with ibuprofen. Wound contraction was comparable in the Tridaxand ibuprofen treated groups. Epithelialization was significant in the Tridaxgroup. The aspirin treated group showed significant retardation in both parameters (p< 0.001). The fibroblast cell count, hydroxyproline/DNA ratio and collagen synthesis were insignificant in the control and Tridaxtreatment, while ibuprofen and aspirin treatment had a significant effect (p< 0.01) on the above mentioned parameters. In the carageenin induced oedema model, inhibition of oedema was comparable in 200 mg/kg Tridaxand 50 mg/kg ibuprofen treatment, and the specific activity of the enzyme gamma glutamyl transpeptidase was comparable in the Tridax, ibuprofen and aspirin at 200 mg/kg, groups. © 1998 John Wiley & Sons, Ltd.

The aqueous extract of Tridax procumbens leaves was lyophilized and studied on the excision wound model, rat skin fibroblast and rat paw oedema. Tridax procumbens did not significantly increase the fibroblast count compared with ibuprofen. Wound contraction was comparable in the Tridax and ibuprofen treated groups. Epithelialization was significant in the Tridax group. The aspirin treated group showed significant retardation in both parameters (p &lt; 0.001). The fibroblast cell count, hydroxyproline/DNA ratio and collagen synthesis were insignificant in the control and Tridax treatment, while ibuprofen and aspirin treatment had a significant effect (p &lt; 0.01) on the above mentioned parameters. In the carageenin induced oedema model, inhibition of oedema was comparable in 200 mg/kg Tridax and 50 mg/kg ibuprofen treatment, and the specific activity of the enzyme gamma glutamyl transpeptidase was comparable in the Tridax, ibuprofen and aspirin at 200 mg/kg, groups. © 1998 John Wiley & Sons, Ltd.