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With the capability to switch at high speed, there are important concerns about Parasitic Turn-On (PTO) when using SiC MOSFETs in switching applications with fundamental half-bridge configuration [1]. In this work, we present 1200V SiC planar MOSFETs with low specific ON-resistance (Rsp), fast switching characteristics and high immunity to PTO. The PTO immunity is verified by experimental comparison to several commercially available SiC MOSFETs.

Static three-dimensional (3D) cell culture has been demonstrated in ultralow attachment well plates, hanging droplet plates, and microtiter well plates with hydrogels or magnetic nanoparticles. Although it is simple, reproducible, and relatively inexpensive, thus potentially used for high-throughput screening, statically cultured 3D cells often suffer from a necrotic core due to limited nutrient and oxygen diffusion and waste removal and have a limited in vivo-like tissue structure. Here, we overcome these challenges by developing a pillar/perfusion plate platform and demonstrating high-throughput, dynamic 3D cell culture. Cell spheroids were loaded on the pillar plate with hydrogel by simple sandwiching and encapsulation and cultured dynamically in the perfusion plate on a digital rocker. Unlike traditional microfluidic devices, fast flow velocity was maintained within perfusion wells and the pillar plate was separated from the perfusion plate for cell-based assays. It was compatible with common lab equipment and allowed cell culture, testing, staining, and imaging in situ. The pillar/perfusion plate enhanced cell growth by rapid diffusion, reproducibility, assay throughput, and user friendliness in a dynamic 3D cell culture.

IMPORTANCE: Although intravascular ultrasonography (IVUS) guidance promotes favorable outcomes after percutaneous coronary intervention (PCI), many catheterization laboratories worldwide lack access. OBJECTIVE: To investigate whether systematic implementation of quantitative coronary angiography (QCA) to assist angiography-guided PCI could be an alternative strategy to IVUS guidance during stent implantation. DESIGN, SETTING, AND PARTICIPANTS: This randomized, open-label, noninferiority clinical trial enrolled adults (aged ≥18 years) with chronic or acute coronary syndrome and angiographically confirmed native coronary artery stenosis requiring PCI. Patients were enrolled in 6 cardiac centers in Korea from February 23, 2017, to August 23, 2021, and follow-up occurred through August 25, 2022. All principal analyses were performed according to the intention-to-treat principle. INTERVENTIONS: After successful guidewire crossing of the first target lesion, patients were randomized in a 1:1 ratio to receive either QCA- or IVUS-guided PCI. MAIN OUTCOMES AND MEASURES: The primary outcome was target lesion failure at 12 months, defined as a composite of cardiac death, target vessel myocardial infarction, or ischemia-driven target lesion revascularization. The trial was designed assuming an event rate of 8%, with the upper limit of the 1-sided 97.5% CI of the absolute difference in 12-month target lesion failure (QCA-guided PCI minus IVUS-guided PCI) to be less than 3.5 percentage points for noninferiority. RESULTS: The trial included 1528 patients who underwent PCI with QCA guidance (763; mean [SD] age, 64.1 [9.9] years; 574 males [75.2%]) or IVUS guidance (765; mean [SD] age, 64.6 [9.5] years; 622 males [81.3%]). The post-PCI mean (SD) minimum lumen diameter was similar between the QCA- and IVUS-guided PCI groups (2.57 [0.55] vs 2.60 [0.58] mm, P = .26). Target lesion failure at 12 months occurred in 29 of 763 patients (3.81%) in the QCA-guided PCI group and 29 of 765 patients (3.80%) in the IVUS-guided PCI group (absolute risk difference, 0.01 percentage points [95% CI, –1.91 to 1.93 percentage points]; hazard ratio, 1.00 [95% CI, 0.60-1.68]; P = .99). There was no difference in the rates of stent edge dissection (1.2% vs 0.7%, P = .25), coronary perforation (0.2% vs 0.4%, P = .41), or stent thrombosis (0.53% vs 0.66%, P = .74) between the QCA- and IVUS-guided PCI groups. The risk of the primary end point was consistent regardless of subgroup, with no significant interaction. CONCLUSIONS AND RELEVANCE: Findings of this randomized clinical trial indicate that QCA and IVUS guidance during PCI showed similar rates of target lesion failure at 12 months. However, due to the lower-than-expected rates of target lesion failure in this trial, the findings should be interpreted with caution. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT02978456

AbstractGiven the increasing attention being paid to companies’ microlevel green efforts, this study aims to provide insights into green corporate social responsibility (CSR) communication targeting internal audiences (i.e., employees). Building on the social identity theory and group engagement model, this research examines the persuasive power of two types of social norms—descriptive and injunctive—in green CSR messages. Also, it investigates the underlying mechanism of individuals’ green behavioral decision making at work. Across two studies, results demonstrate that a descriptive norm message is more effective than a standard or injunctive norm message to enhance employees’ intentions to adopt green actions, engage in the company’s green programs, and help their colleagues to perform green behaviors. Additionally, a descriptive norm message advances three antecedents of motivation—expectancy, instrumentality, and valence—which in turn positively influence green behavioral decisions. This research contributes to developing the literature stream of green message framing by targeting a specific internal audience group and provides empirical implications for practitioners.

La escala UKPDS (acrónimo inglés de «Estudio Prospectivo de Diabetes del Reino Unido») tiene un valor limitado para la predicción de eventos de enfermedad arterial coronaria (EAC). El estudio pretende investigar el valor añadido de la angiografía coronaria por tomografía computarizada (ACTC) sobre la escala de riesgo UKPDS para la predicción a 10 años de eventos cardiacos adversos en pacientes asintomáticos con diabetes tipo 2.

AbstractOnion (Allium cepaL.) is an economically important vegetable crop worldwide. However, various fungal diseases, including Fusarium basal rot (FBR), neck rot, and white rot, reduce onion production or bulb storage life. FBR caused by Fusariumspecies is among the most destructive onion diseases. In this study, we identified Fusariumspecies associated with FBR in Jeolla and Gyeongsang Provinces in South Korea and evaluated fungicides against the pathogens. Our morphological and molecular analyses showed that FBR in onions is associated with Fusarium commune, Fusarium oxysporum, and Fusarium proliferatum. We selected seven fungicides (fludioxonil, hexaconazole, mandestrobin, penthiopyrad, prochloraz-manganese, pydiflumetofen, and tebuconazole) and evaluated their inhibitory effects on mycelial growth of the pathogens at three different concentrations (0.01, 0.1, and 1 mg/mL). We found that prochloraz-manganese was highly effective, inhibiting 100% of the mycelial growth of the pathogens at all concentrations, followed by tebuconazole. Fludioxonil showed < 50% inhibition at 1 mg/mL for the tested isolates.

Son escasos los datos sobre la duración y el impacto pronóstico del tratamiento antiagregante plaquetario doble (TAPD) tras una intervención coronaria percutánea (ICP) del tronco coronario izquierdo (TCI) con stentsfarmacoactivos de segunda generación. El objetivo de este estudio es investigar los patrones de prescripción y el efecto pronóstico a largo plazo de la duración del TAPD en pacientes sometidos a ICP del TCI con stentsfarmacoactivos segunda generación.

Purpose: Hepatitis B is a major prognostic factor after hematopoietic stem cell transplantation (HSCT). Currently, no consensus exists regarding the management of various scenarios that can lead to reverse seroconversion of the hepatitis B surface antigen (HBsAg-RS). This study focused on HBsAg-RS, which serves as an indicator of active hepatitis, and aimed to obtain exploratory information on the associated patient and treatment factors. Methods: This single-center retrospective study utilized clinical data extracted from the electronic medical records of Seoul St. Mary’s Hospital, Korea. Patients who underwent HSCT between January 2013 and December 2018 and tested negative for hepatitis B surface antigen (HBsAg) before undergoing HSCT were included. The associations between HBsAg-RS and demographic information, baseline hepatitis B serological markers, and vaccination status were statistically analyzed. Results: This study included 1,344 patients, of whom 83.3% tested positive for the hepatitis B surface antibody (HBsAb) during HSCT. HBsAg-RS occurred in 2.2% of HBsAb-negative patients and 3.0% of HBsAb-positive patients, indicating no significant difference in reactivation rates according to HBsAb status. However, positivity for hepatitis B core antibody (HBcAb) was significantly associated with hepatitis B reactivation (HBsAg-RS rate: 8.0%). The vaccination rates were highest in patients who were negative for both HBsAb and HBcAb and had a transient protective effect. Conclusion: The sufficient patient population enabled the identification of an association between baseline HBcAb positivity and the development of HBsAg-RS. Further prospective studies are warranted to determine optimal vaccination strategies for preventing HBsAg-RS.

Along with the trend of a steady utilization decline in the U.S. nursing home beds, post-acute care (PAC) utilization at the skilled nursing facilities has declined. This study was a cross-sectional, retrospective review of hospital discharge-based claim data. We evaluate the factors associated with utilizing post-acute care at rehabilitation facilities among those with extremity fractures in the state of Nevada. All Nevada hospital discharges of aged ≥65 years with extremity fractures between 2018 and 2021 were divided to post-acute care locations by (1) rehabilitation facilities (skilled nursing facility and inpatient rehabilitation facility) and (2) homes (with and without services). PAC utilization at facilities declined from 55.1% in 2018 to 49.7% in 2021 (P< .001). In response, PAC utilization at homes continuously upwards, particularly, homes with services from 18.8% in 2018 to 24.5% in 2021 (P< .001). Older age, female, lower extremity fractures, comorbidities, and Medicare beneficiaries were associated with higher probabilities of utilizing post-acute rehabilitation facilities. Racial minorities, COVID-19 pandemic, upper extremities, Medicaid beneficiaries, rural hospitals, and prolonged hospital length of stay were associated with lower probabilities of PAC utilization at facilities. Caregiver burdens and workforce training is urgently warranted to respond to this utilization shift. Effective geriatrics workforce training might advance care efficiency of older adults with extremity fractures and guide to the insights of establishing the age-friendly state of Nevada in response to this utilization shift trends.

KAERI (Korea Atomic Energy Research Institute) developed the conceptual design of PGSFR (Prototype Gen-IV Sodium Cooled Fast Reactor) and Burner Reactor. Since the reactor characteristics of the PGSFR and Burner Reactor are different, the shape, size and the arrangement of the main components in the reactors must be different. Therefore, the conceptual design for the fuel handling and transfer systems needs to be performed coinciding with the structure of the reactor. Especially, because a redan structure dividing hot and cold pool is installed in the reactor vessel, the conceptual design of the fuel handling and transfer system largely changes depending on the location of the redan structure. Various elements of the conceptual design and an integral arrangement for the fuel handling and transfer system were arranged according to the characteristics, sizes and shapes of the reactors. In this paper, the conceptual designs of the fuel handling and transfer system for PGSFR and Burner Reactor are described. Especially, an A-frame method is selected as the fuel handling and transfer system for the Burner Reactor, considering the layout of the internal structure. The tilt angle, diameter and length of A-frame is determined and the strength evaluation of the A-frame is performed.

Intraosseous lipoma is a very rare benign lipoma, accounting for less than 0.1% of primary bone tumors. Incidentally found in most cases, it frequently involves the metaphysis of the long bones of the lower extremity or calcaneus but rarely occurs in the upper extremity. Intraosseous lipoma of the carpal bones, especially, has yet to be reported, except for 3 cases of scaphoid and capitate involvement. Herein, we report 2 cases of intraosseous lipoma in the capitate and hamate bones with a literature review. Two patients complained of wrist discomfort despite conservative treatment and were diagnosed by computed tomography, magnetic resonance imaging, and surgical biopsy. They were treated with intralesional curettage and autologous bone graft, and their symptoms improved and showed no evidence of recurrence, both clinically and radiologically.

Human organoids have the potential to revolutionize in vitro disease modeling by providing multicellular architecture and function that are similar to those in vivo. This innovative and evolving technology, however, still suffers from assay throughput and reproducibility to enable high‐throughput screening (HTS) of compounds due to cumbersome organoid differentiation processes and difficulty in scale‐up and quality control. Using organoids for HTS is further challenged by the lack of easy‐to‐use fluidic systems that are compatible with relatively large organoids. Here, these challenges are overcome by engineering “microarray three‐dimensional (3D) bioprinting” technology and associated pillar and perfusion plates for human organoid culture and analysis. High‐precision, high‐throughput stem cell printing, and encapsulation techniques are demonstrated on a pillar plate, which is coupled with a complementary deep well plate and a perfusion well plate for static and dynamic organoid culture. Bioprinted cells and spheroids in hydrogels are differentiated into liver and intestine organoids for in situ functional assays. The pillar/perfusion plates are compatible with standard 384‐well plates and HTS equipment, and thus may be easily adopted in current drug discovery efforts. A pillar/perfusion plate is developed to generate human organoids robustly by printing progenitor cells in hydrogels on pillars using a 3D bioprinter or transferring single spheroids to pillars via a sandwiching and inverting method. Organoid differentiation is performed in static and dynamic conditions by sandwiching the pillar plate onto a deep well plate or a perfusion well plate.

Respiratory complications are an important cause of postoperative morbidity. We aimed to investigate whether continuous positive airway pressure (CPAP) administered immediately after major abdominal surgery could prevent postoperative morbidity.

The sinking of organic particles in the ocean and their degradation by marine microorganisms is one of the main drivers of the biological pump. Yet, the mechanisms determining the magnitude of the pump remain poorly understood, limiting our ability to predict this carbon flux in future ocean scenarios. Current ocean models assume that the biological pump is governed by the competition between sinking speed and degradation rate, with the two processes independent from one another. Contrary to this paradigm, we show that sinking itself is a primary determinant of the rate at which bacteria degrade particles. Heterotrophic bacterial degradation rates were obtained from a laboratory study on model surface-colonized particles at atmospheric pressure under a range of flow speeds to mimic different sinking velocities. We find that even modest sinking speeds of 8 m day−1enhance degradation rates more than 10-fold compared with degradation rates of non-sinking particles. We discovered that the molecular mechanism underlying this sinking-enhanced degradation is the flow-induced removal from the particles of the oligomeric breakdown products, which otherwise compete for enzymatic activity. This mechanism applies across several substrates and bacterial strains, suggesting its potentially broad occurrence under natural marine conditions. Integrating our findings into a mathematical model of particulate carbon flux, we propose that the coupling of sinking and degradation may contribute, in conjunction with other processes, to determining the magnitude of the vertical carbon flux in the ocean.

[Display omitted] The synthesis and characterization of two series of biobased novel poly(1,4-cyclohexylenedimethylene terephthalate-co-1,4-cyclohexylene dimethylene 2,6-naphthalenedicarboxylate) copolyesters containing isosorbide (ISB) content (PCITN) ranging from 0 to 11 mol% relative to the total diol amount was carried out in this study. The Novel PCITN was containing 2,6-naphthalenedicarboxylic acid (NDA) content ranging from 0 to 100 mol% relative to the total diacid amount. The synthesized PCITN were thoroughly characterized for their actual chemical composition, molecular weight, thermal properties, thermal stability, dimensional stability, transmittance (%), and birefringence. All the copolyesters showed the characteristics of random copolyesters and their composition and thermal properties could be controlled by the molar feed ratio of diol and diacid moieties. Results indicate that ISB significantly improves the glass transition temperature (T g) of resultant copolyesters. It was also found that synthesized copolyesters have a high T g and wide processing window compared to conventional homopolyesters. Exceptional performance properties: such as high T g , T m , high thermal stability, dimensional stability, good moisture barrier, good transmittance, and low birefringence of fabricated PCI 6 TN 70 film, make it suitable for versatile industrial applications especially for biomedical, packaging, and optical applications. [ABSTRACT FROM AUTHOR]

Background and purpose Compressed sensing is used for accelerated acquisitions with incoherently under-sampled k-space data, and intracranial time-of-flight magnetic resonance angiography is suitable for compressed sensing. Compressed sensing time-of-flight is beneficial in decreasing acquisition time and increasing spatial resolution while maintaining acquisition time. In this retrospective study, we aimed to evaluate the image quality and diagnostic performance of compressed sensing time-of-flight with high spatial resolution and compare with parallel imaging time-of-flight using digital subtraction angiography as a reference.Material and methods In total, 39 patients with 46 intracranial aneurysms underwent parallel imaging and compressed sensing time-of-flight in the same imaging session and digital subtraction angiography before or after magnetic resonance angiography. The overall image quality, artefacts and diagnostic confidence were assessed by two observers. The contrast ratio, maximal aneurysm diameters and diagnostic performance were evaluated.Results Compressed sensing time-of-flight showed significantly better overall image quality, degree of artefacts and diagnostic confidence in both observers, with better inter-observer agreement. The contrast ratio was significantly higher for compressed sensing time-of-flight than for parallel imaging time-of-flight in both observers (source images, P <0.001; maximum intensity projection images, P< 0.05 for both observers); however, the measured maximal diameters of aneurysms were not significantly different. Compressed sensing time-of-flight showed higher sensitivity, specificity, accuracy and positive and negative predictive values for detecting aneurysms than parallel imaging time-of-flight in both observers, with better inter-observer agreement. Compressed sensing time-of-flight was preferred over parallel imaging time-of-flight by both observers; however, parallel imaging time-of-flight was preferred in cases of giant and large aneurysms.Conclusions Compressed sensing-time-of-flight provides better image quality and diagnostic performance than parallel imaging time-of-flight. However, neuroradiologists should be aware of under-sampling artefacts caused by compressed sensing.

Purpose: The present study aimed at classifying cannabis festival attendees based on their motivation and travel activities, profiling the resultant latent groups with demographic and travel characteristics and examining the association between the groups. Design/methodology/approach: With a quantitative-exploratory approach, this study collected 392 out-of-state visitors' responses to a cannabis festival in Denver, Colorado and classified them according to their motivation and activity participation. Using the classification results, the study profiled the festival visitors based on their demographic and travel characteristics. Latent class analysis, analysis of variance (ANOVA) and cross-tabulation were employed. Findings: The results revealed that festival visitors were categorized into four latent groups by motivation and three latent groups by travel activity participation. Regarding motivation, the cannabis seekers (relatively young, White/Caucasian and residents in liberal states) and multi-purpose seekers (relatively young, Black/African American and residents in conservative states) were strongly motivated by cannabis-related factors. For travel activity participation, moderate participants were more likely to be first-time visitors, whereas active and passive participants were classified as repeat visitors. Originality/value: The current study filled the research gap in the quantitative exploration of cannabis tourism industry in general and cannabis festival segment specifically. The findings contribute to (1) better understanding of out-of-state visitors' motivation and travel behaviors while attending a cannabis themed festival and (2) serving as a seminal work in the context of cannabis tourism literature since the recreational cannabis legalization in the United States.

Stable isotope labeling of microbial taxa of interest and their sorting provide an efficient and direct way to answer the question “who does what?” in complex microbial communities when coupled with fluorescence in situ hybridization or downstream ‘omics’ analyses. We have developed a platform for automated Raman-based sorting in which optical tweezers and microfluidics are used to sort individual cells of interest from microbial communities on the basis of their Raman spectra. This sorting of cells and their downstream DNA analysis, such as by mini-metagenomics or single-cell genomics, or cultivation permits a direct link to be made between the metabolic roles and the genomes of microbial cells within complex microbial communities, as well as targeted isolation of novel microbes with a specific physiology of interest. We describe a protocol from sample preparation through Raman-activated live cell sorting. Subsequent cultivation of sorted cells is described, whereas downstream DNA analysis involves well-established approaches with abundant methods available in the literature. Compared with manual sorting, this technique provides a substantially higher throughput (up to 500 cells per h). Furthermore, the platform has very high sorting accuracy (98.3 ± 1.7%) and is fully automated, thus avoiding user biases that might accompany manual sorting. We anticipate that this protocol will empower in particular environmental and host-associated microbiome research with a versatile tool to elucidate the metabolic contributions of microbial taxa within their complex communities. After a 1-d preparation of cells, sorting takes on the order of 4 h, depending on the number of cells required.

The cannabis tourism market has seen tremendous growth in recent years. However, research activities by academic scholars and industry professionals have barely scratched the surface to explore this emerging tourism segment. This study addresses the gap by comparing resident perceptions on cannabis tourism in two states, Colorado and Oregon. A quantitative survey was distributed to Colorado (n = 254) and Oregon (n = 165) residents. Results of the study revealed that the respondents in each state appear to have different views on perceived impact from, benefit of, and support level for cannabis tourism. Overall, Colorado residents' attachment was higher than Oregon respondents. Additionally, Colorado residents showed that if they had a higher place identity, they were less likely to perceive negative impacts. In a similar context, the study results also confirmed that there was a stronger causal relationship between respondents' perceived impact and support for cannabis tourism among Colorado respondents than Oregon respondents, indicating that Colorado residents' support for cannabis tourism was more significantly influenced by their perceived positive and negative impact levels than Oregon respondent. Considering the continued evolvement in the legal and economic landscapes of cannabis tourism, policy makers and industry professionals should engage in continual conversations on how to plan and manage this new tourism segment for community and state development.

Zinc plating using the principle of sacrificial anode is used to prevent steel corrosion. Pure zinc plating has some problems and Zn-Mn alloy plating has been studied as one of the measures to increase the corrosion resistance. Zn-Mn alloy plating can be applied to automotive parts requiring high corrosion resistance despite high plating cost. In this study, Zn-Mn alloy plating was electrodeposited in acidic chloride solution. The effects of electrolytic conditions on the composition of the alloy plating in the chloride bath were investigated. As the current density increased, the Zn content decreased and the Mn content increased. As the temperature of the electrolyte increased, the Zn content decreased and the Mn content increased.

Cryopreservation in cryovials extends cell storage at low temperatures, and advances in organoid cryopreservation improve reproducibility and reduce generation time. However, cryopreserving human organoids presents challenges due to the limited diffusion of cryoprotective agents (CPAs) into the organoid core and the potential toxicity of these agents. To overcome these obstacles, we developed a cryopreservation technique using a pillar plate platform. To demonstrate cryopreservation application to human brain organoids (HBOs), early stage HBOs were produced by differentiating induced pluripotent stem cells (iPSCs) into neuroectoderm (NE) in an ultralow attachment (ULA) 384-well plate. The NE was transferred and encapsulated in Matrigel on the pillar plate. The NE on the pillar plate was exposed to four commercially available CPAs, including the PSC cryopreservation kit, CryoStor CS10, 3dGRO, and 10% DMSO, before being frozen overnight at −80 °C and subsequently stored in a liquid nitrogen dewar. We examined the impact of the CPA type, organoid size, and CPA exposure duration on cell viability post-thaw. Additionally, the differentiation of NE into HBOs on the pillar plate was assessed using RT-qPCR and immunofluorescence staining. The PSC cryopreservation kit proved to be the least toxic for preserving the early stage HBOs on the pillar plate. Notably, smaller HBOs showed higher cell viability postcryopreservation than larger ones. An incubation period of 80 min with the PSC kit was essential to ensure optimal CPA diffusion into HBOs with a diameter of 400–600 μm. These cryopreserved early stage HBOs successfully matured over 30 days, exhibiting gene expression patterns akin to noncryopreserved HBOs. The cryopreserved early stage HBOs on the pillar plate maintained high viability after thawing and successfully differentiated into mature HBOs. This on-chip cryopreservation method could extend to other small organoids, by integrating cryopreservation, thawing, culturing, staining, rinsing, and imaging processes within a single system, thereby preserving the 3D structure of the organoids.

We investigated the expression and stability of enhanced green fluorescent protein (eGFP) under extreme conditions using two types of high-copy-number vectors and two types of anchoring motifs (CotB and C-terminally truncated ∆CotB spore coat proteins) for the development of a spore surface display system in Bacillus subtilis. The fused cotB-gfpand ΔcotB-gfpDNA fragments were cloned into the pUB19 (pUB110-derived) and pHY300PLK vectors. Four types of expression vectors were transformed into B.subtilis 168. The expression level of eGFP on the surface of spores prepared from B. subtilistransformants was measured by flow cytometry. When pUB19 vector was used, the activities of ∆CotB-eGFP and CotB-eGFP were 17.9 and 5.6 times higher than those of the pHY300PLK vector, respectively. In addition, the activity of pUB19-∆CotB-eGFP was 1.76 times higher than that of pUB19-CotB-eGFP. Overall, the activity of eGFP was more stable under extreme conditions (heat, pH, and protease challenges) when ∆CotB was used as an anchoring motif instead of CotB. Compared to the control groups, the activities of ΔCotB-eGFP and CotB-eGFP were maintained at 56% and 41% at 80 °C and 88% and 55% at pH 10, respectively. The activities of ΔCotB-eGFP and CotB-eGFP were maintained at 62% and 41%, respectively, when treated with 0.03 U of proteinase K. In addition, the activities were maintained at 77% and 36%, respectively, when treated with 5.5 U of trypsin.

Purpose: The purpose of this paper is to understand how festival quality, satisfaction and intention to return among cannabis festival attendees were interrelated by using the 2018 Mile High 420 Cannabis Festival in Denver, Colorado, USA. Design/methodology/approach: This study employed an online survey with festival attendees to the 2018 Mile High 420 Festival. A total of 664 attendees participated in the survey. Findings: Findings of the study revealed the demographic profile of cannabis festival attendees (i.e. relatively young, single and evenly distributed in terms of gender and residency) and its relationships with respondents’ perceived festival qualities. In addition, two dimensions of festival quality unique to the context of marijuana festival influenced attendees’ satisfaction and intent to return significantly. Festival attendees’ travel characteristics were used to describe attendees’ satisfaction and intent to return to a different degree. This research has also highlighted a lack of research in the area of cannabis events/festivals. Originality/value: This study is the first investigation that studied a cannabis-themed festival in the tourism literature. As legalization of recreational cannabis has been embraced in the USA and abroad (i.e. Canada), the findings of this empirical study will help the industry professionals and policy makers to understand this unprecedented SIT market and can be used as the benchmarks for their legal and operational practicality. Further, this study highlights research gaps in the tourism literature, and identifies those areas where future study is unlikely to provide new knowledge.

We present that the tailored nanopatterning with tunable shape, depth, and dimension for diverse application-specific designs can be realized by utilizing controlled dynamic nanoinscribing (DNI), which can generate bur-free plastic deformation on various flexible substrates viacontinuous mechanical inscription of a small sliced edge of a nanopatterned mold in a compact and vacuum-free system. Systematic controlling of prime DNI processing parameters including inscribing force, temperature, and substrate feed rate can determine the nanopattern depths and their specific profiles from rounded to angular shapes as a summation of the force-driven plastic deformation and heat-driven thermal deformation. More complex nanopatterns with gradient depths and/or multidimensional profiles can also be readily created by modulating the horizontal mold edge alignment and/or combining sequential DNI strokes, which otherwise demand laborious and costly procedures. Many practical user-specific applications may benefit from this study by tailor-making the desired nanopattern structures within desired areas, including precision machine and optics components, transparent electronics and photonics, flexible sensors, and reattachable and wearable devices. We demonstrate one vivid example in which the light diffusion direction of a light-emitting diode can be tuned by application of specifically designed DNI nanopatterns.

Supplemental Digital Content is available in the text.

We experimentally investigate the cross-plane figure of merit (ZT) for an Al2O3/ZnO (AO/ZnO) superlattice film by measuring cross-plane electrical and thermal conductivity and Seebeck coefficient using the 3-ω method and an in-house Seebeck coefficient measurement system recently developed for 300–500 K and examine how ZTfactors depend on the AO layer inside the AO/ZnO superlattice film using measured thermoelectric properties. The AO/ZnO superlattice film exhibited maximum power factor of ∼276.2 μW/m K2with low thermal conductivity (∼0.31 W/m K), producing ZT≥ 0.45 at 500 K, which is approximately 2,650% improvement compared with an undoped ZnO film (∼0.017). The enhanced ZTperformance of the AO/ZnO superlattice film can be explained by enhanced phonon scattering at the interface and minority carrier blocking at the interfacial barrier due to the AO layer, suggesting that the interfacial AO layer is important to enhance ZTin oxide-based films. These results open new applications for micro- or nanoscale thin film-based thermoelectric devices.

Supplemental Digital Content is available in the text.