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Background: Venous leg ulcers (VLUs) constitute a worldwide public health problem and have a significant impact on patient quality of life. The treatment is complex, with high failure rates. Objectives: The objective was to identify the influence of compression strength and patient and wound variables on VLUs healing. Methods: A total of 102 patients were supervised for 48 weeks since the commencement of the treatment. The patients were divided into two groups according to two different compression systems, one group with moderate compression pressure of 35–40 mmHg and the second with high pressure >45 mmHg. Results: Deep venous reflux, dermatitis, ulcer infection, duration of the ulcer, and the ulcer size (US) are statistically significantly lower (P < 0.001) in patients with healed wounds. These factors have also shown statistical significance related to prolonged healing time. Patients with VLU in which high pressure was applied, healed considerably faster in relation to VLU in which moderate pressure was applied (P = 0.008). Conclusion: Deep venous reflux, dermatitis, ulcer infection, duration of the ulcer, and the US were independently correlated with worse healing rates. Higher compression pressure leads to faster and higher proportions of VLUs healed. The authors recommended a holistic approach to wound healing with careful and individualized assessment of risk factors among patients with VLUs. [ABSTRACT FROM AUTHOR]

Background The basic goal of this research was to determine and evaluate the prognostic factors related to the delay of venous ulcer healing in patients treated with multilayer compression bandage. Methods The research involved a group of 100 patients of both sexes with venous ulcerations of the lower extremities. Patients were monitored for 24 weeks from the very beginning of the treatment. Ulcerations were treated with the use of multiple layer compression bandages. Results Of the total number of tested patients, 58 (58%) were females and 42 (42%) were males. The average age of patients was 62.7 ± 6.53 years, where the male population was older. During the 24-week monitoring period, 25 patients (25%) did not heal completely. Lipodermosclerosis has a significant positive prognostic significance in healing chronic venous ulcers ( p < 0.05). The infection proved to be the most important prognostic factor in the delay of ulcer healing ( p < 0.01). The number and surface of ulcerative changes show a significant positive correlation with delay of venous ulcer healing ( p < 0.001). Conclusion The results of this study show a significant positive correlation between the number and surface of ulcerative changes and the delay of venous ulcer healing. Further trials are necessary to identify the best treatment options, especially for nonhealing ulcers. [ABSTRACT FROM AUTHOR]