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Objective: To systematically review the studies exploring the association between bevacizumab and neurodevelopmental outcomes. Methods: Embase, Medline, CINAHL, and Cochrane Library databases were searched for studies examining neurodevelopmental outcomes of preterm infants treated with bevacizumab compared to laser ablation or cryotherapy for severe retinopathy of prematurity (ROP). Results: Thirteen studies (clinical trial = 1; cohort studies = 12) were included. Random-effects model meta-analysis showed significant increased odds of cognitive impairment associated with bevacizumab treatment on both unadjusted (unadjusted odds ratio (OR) 1.61; 95% confidence interval (CI) 1.12, 2.30) and adjusted analyses (adjusted OR 1.90; 95% CI 1.22, 2.97). Infants treated with bevacizumab for severe ROP had significantly lower Bayley-III cognitive (mean difference (MD) −1.66; 95% CI −3.21, −0.12), and language composite scores (MD −5.50; 95% CI −8.24, −2.76) compared to infants treated with laser ablation or cryotherapy. Conclusion: Bevacizumab treatment for severe ROP is associated with increased risk of cognitive impairment and lower cognitive and language scores in preterm infants.

Objectives: To assess risks of mother to child horizontal transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus during rooming in and breastfeeding in infants born to mothers with the coronavirus (COVID-19) disease.Design: Retrospective observational study.Participants: Five tertiary care centers located in the United Arab Emirates. Infants born to mothers positive for SARS-CoV-2 polymerase chain reaction (PCR) at the time of delivery, born between April 1 and October 30, 2020.Methods: In this retrospective observational study, we analyzed the newborn care practices in various tertiary care hospitals and the rate of horizontal transmission of SARS-CoV-2 from mother to infant (horizontal) while rooming in, breastfeeding, and post-discharge.Results: There were total of 2,405 deliveries in the 5 stated hospitals of which 40 infants were born to mothers with positive SARS-CoV-2 PCR at the time of delivery. One infant tested positive for SARS-CoV-2 after birth at 24 h of life and had respiratory symptoms and fever. Twenty-three of the well infants were roomed in during their hospital stay and were breastfed. In 8 cases, the mother and baby were separated and isolated from the time of birth till discharge. 95% of the discharged infants were rooming in with mothers, 45% of the infants were exclusively breastfed, and 55% were on mixed feeding (breast milk and formula milk) at the follow-up. None of the infants developed significant health issues or symptoms attributable to SARS-CoV-2.Conclusion: The risk of mother to infant horizontal transmission of COVID-19 in the perinatal period is very low. Our study reaffirms the American Academy of Pediatrics guidelines that rooming in and breastfeeding of newborns born to SARS-CoV-2 positive mothers is safe without an increased risk of horizontal transmission by following mandated safety precautions.

Aim: This case highlights the importance of high index of suspicion for early diagnosis and thorough clinical examination of a newborn with tracheoesophageal atresia and fistula.Case Report: We report a case of most common type of tracheoesophageal atresia with fistula where diagnosis was missed due to unusual gastric position of nasogastric tube. Nasogastric tube reached stomach in esophageal atresia with fistula, delaying the diagnosis and management of condition. After accidental removal of tube and failure to pass again raised suspicion and was confirmed with coiled tube in esophageal pouch in X-Ray chest. Baby shifted to surgical unit for treatment, fortunately baby recovered and discharged home after surgical correction.Conclusion: Tracheoesophageal atresia with fistula can present with atypical symptoms and unusual events, challenging the early diagnosis and treatment of common types of conditions. Other association like VACTERL should be looked for, in patients.