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Purpose: This study was aimed to research the relationship of inflammation and algesic substance in repeated bout effect after high intensity eccentric exercise of upper extreme muscles. Methods: Seven males who did not exercise regularly performed high intensity eccentric exercise in their non-dominant arm for two times. The exercise was designed to leave an interval of two weeks between the first and second exercise. Measurements used were perceived muscle soreness using VAS, indirect muscle damage markers using ROM, C1R and CK, inflammation using IL-6 and CRP and algesic substance using PGE2. Measurement periods were before and after exercise; as well as the first four days, and the seventh day. Results: The changes of perceived muscle soreness and indirect muscle damage markers were significantly restrained during the second exercise. On the other hand, the inflammation and algesic substance were not changed. However, CRP might be restrained during the second exercise. Conclusion: We could not find the repeated bout effect for inflammation and algesic substance after high intensity eccentric exercise in arm flexors. But, it might be possible to decrease CRP at the second exercise. [ABSTRACT FROM AUTHOR]