15 results on '"Khoshnia, Masoud"'
Search Results
2. Volatile Organic Compounds and Mortality from Ischemic Heart Disease: a Case-Cohort Study
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Nalini, Mahdi, Poustchi, Hossein, Bhandari, Deepak, Chang, Cindy M., Blount, Benjamin C., Wang, Lanqing, Feng, Jun, Gross, Amy, Khoshnia, Masoud, Pourshams, Akram, Sotoudeh, Masoud, Gail, Mitchell H., Graubard, Barry I., Dawsey, Sanford M, Kamangar, Farin, Boffetta, Paolo, Brennan, Paul, Abnet, Christian C., Malekzadeh, Reza, Freedman, Neal D., and Etemadi, Arash
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Volatile organic compounds (VOCs) are major components of air pollution and tobacco smoke, two known risk factors for cardiovascular diseases. VOCs are ubiquitous in the environment and originate from a wide range of sources, including the burning of biomass, fossil fuels, and consumer products. Direct evidence for associations between specific VOCs and ischemic heart disease (IHD) mortality in the general population is scarce.
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- 2024
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3. Long-term opiate use and risk of cardiovascular mortality: results from the Golestan Cohort Study
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Nalini, Mahdi, Shakeri, Ramin, Poustchi, Hossein, Pourshams, Akram, Etemadi, Arash, Islami, Farhad, Khoshnia, Masoud, Gharavi, Abdolsamad, Roshandel, Gholamreza, Khademi, Hooman, Zahedi, Mahdi, Abedi-Ardekani, Behnoush, Vedanthan, Rajesh, Boffetta, Paolo, Dawsey, Sanford M, Pharaoh, Paul D, Sotoudeh, Masoud, Abnet, Christian C, Day, Nicholas E, Brennan, Paul, Kamangar, Farin, and Malekzadeh, Reza
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- 2021
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4. Individual and Combined Effects of Environmental Risk Factors for Esophageal Cancer Based on Results From the Golestan Cohort Study.
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Sheikh, Mahdi, Poustchi, Hossein, Pourshams, Akram, Etemadi, Arash, Islami, Farhad, Khoshnia, Masoud, Gharavi, Abdolsamad, Hashemian, Maryam, Roshandel, Gholamreza, Khademi, Hooman, Zahedi, Mahdi, Abedi-Ardekani, Behnoush, Boffetta, Paolo, Kamangar, Farin, Dawsey, Sanford M., Pharaoh, Paul D., Abnet, Christian C., Day, Nicholas E., Brennan, Paul, and Malekzadeh, Reza
- Abstract
Background & Aims Northeast Iran has one of the highest reported rates of esophageal squamous cell carcinoma (ESCC) worldwide. Decades of investigations in this region have identified some local habits and environmental exposures that increase risk. We analyzed data from the Golestan Cohort Study to determine the individual and combined effects of the major environmental risk factors of ESCC. Methods We performed a population-based cohort of 50,045 individuals, 40 to 75 years old, from urban and rural areas across Northeast Iran. Detailed data on demographics, diet, lifestyle, socioeconomic status, temperature of drinking beverages, and different exposures were collected using validated methods, questionnaires, and physical examinations, from 2004 through 2008. Participants were followed from the date of enrollment to the date of first diagnosis of esophageal cancer, date of death from other causes, or date of last follow-up, through December 31, 2017. Proportional hazards regression models were used to estimate hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) for the association between different exposures and ESCC. Results During an average 10 years of follow-up, 317 participants developed ESCC. Opium smoking (HR 1.85; 95% CI 1.18–2.90), drinking hot tea (≥60°C) (HR 1.60; 95% CI 1.15–2.22), low intake of fruits (HR 1.48; 95% CI 1.07–2.05) and vegetables (HR 1.62; 95% CI 1.03–2.56), excessive tooth loss (HR 1.66; 95% CI 1.04–2.64), drinking unpiped water (HR 2.04; 95% CI 1.09–3.81), and exposure to indoor air pollution (HR 1.57; 95% CI 1.08–2.29) were significantly associated with increased risk of ESCC, in a dose-dependent manner. Combined exposure to these risk factors was associated with a stepwise increase in the risk of developing ESCC, reaching a more than 7-fold increase in risk in the highest category. Approximately 75% of the ESCC cases in this region can be attributed to a combination of the identified exposures. Conclusions Analysis of data from the Golestan Cohort Study in Iran identified multiple risk factors for ESCC in this population. Our findings support the hypothesis that the high rates of ESCC are due to a combination of factors, including thermal injury (from hot tea), exposure to polycyclic aromatic hydrocarbons (from opium and indoor air pollution), and nutrient-deficient diets. We also associated ESCC risk with exposure to unpiped water and tooth loss. Graphical abstract [ABSTRACT FROM AUTHOR]
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- 2019
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5. Opium Use and Risk of Pancreatic Cancer: A Prospective Cohort Study.
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Moossavi, Shirin, Mohamadnejad, Mehdi, Pourshams, Akram, Poustchi, Hossein, Islami, Farhad, Sharafkhah, Maryam, Mirminachi, Babak, Nasseri-Moghaddam, Siavosh, Semnani, Shahryar, Shakeri, Ramin, Etemadi, Arash, Merat, Shahin, Khoshnia, Masoud, Dawsey, Sanford M., Pharoah, Paul D., Brennan, Paul, Abnet, Christian C., Boffetta, Paolo, Kamangar, Farin, and Malekzadeh, Reza
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Background: We examined the association between opium consumption and pancreatic cancer incidence in a large-scale prospective cohort of the general population in northeastern Iran. Methods: A total of 50,045 adults were systematically followed up (median of 7.4 years), and incident cases of pancreatic cancer were identified. Self-reported data on opium consumption was collected at baseline. Cumulative use (-year) was defined as number of nokhods (a local unit, approximately 0.2 g) of opium consumed per day multiplied by number of years consuming. Adjusted HRs and 95% confidence intervals (CIs) for the association between opium consumption and pancreatic cancer were calculated using Cox proportional hazards regression models. Results: Overall, 54 confirmed cases of pancreatic cancer were identified. Opium use of more than 81 nokhod-years (high cumulative use), compared with never use, was strongly associated with pancreatic cancer even after adjustments for multiple potential confounding factors [HR = 3.01; 95% CI, 1.25-7.26]. High cumulative consumption of opium was significantly associated with risk of pancreatic cancer after adjusting for cumulative dose of cigarette smoking [HR = 3.56; 95% CI, 1.49-8.50]. In a sensitivity analysis, we excluded participants (including 2 pancreatic cancer cases) who were recruited within the first 5 years of starting opium consumption; high cumulative use of opium was still associated with pancreatic cancer risk [HR = 2.75; 95% CI, 1.14-6.64]. Conclusions: Our results showed a positive association between opium consumption and pancreatic cancer. Impact: This is the first prospective large-scale study to show the association of opium consumption with pancreatic cancer as a risk factor. [ABSTRACT FROM AUTHOR]
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- 2018
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6. Incidence, early case fatality and determinants of stroke in Iran: Golestan Cohort Study.
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Motamed-Gorji, Nazgol, Hariri, Sanam, Masoudi, Sahar, Sharafkhah, Maryam, Nalini, Mahdi, Oveisgharan, Shahram, Khoshnia, Masoud, Motamed-Gorji, Nogol, Gharavi, Abdolsamad, Etemadi, Arash, Poustchi, Hossein, Zand, Ramin, and Malekzadeh, Reza
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Objectives: While few studies investigated the incidence of stroke in Iran, no Iranian cohort has estimated the standardized-incidence rate and early fatality of first-ever-stroke subtypes along with associated factors.Methods: Golestan Cohort Study is a prospective study launched in northeastern Iran in 2004, including 50,045 individuals aged 40-75 at baseline. Age-standardized incidence rate of first-ever-stroke was calculated per 100,000 person-years, according to World Standard Population. The 28-day case fatality was calculated by dividing the number of fatal first-ever-stroke during the first 28 days by total events. Cox proportional hazard models were conducted to assess incidence and fatality risk factors. We used Population Attributable Fractions to estimate the incidence and early fatality proportions reduced by ideal risk factor control.Results: 1,135 first-ever-strokes were observed during 8.6 (median) years follow-up. First-ever-stroke standardized incidence rate was estimated 185.2 (95% CI: 173.2-197.2) per 100,000 person-years. The 28-day case fatality was 44.1% (95% CI: 40.4-48.2). Hypertension and pre-stroke physical activity were the strongest risk factors associated with first-ever-stroke incidence (Hazard ratio: 2.83; 2.47-3.23) and 28-day case fatality (Hazard ratio: 0.59; 0.44-0.78), respectively. Remarkably, opium consumption was strongly associated with hemorrhagic stroke incidence (Hazard ratio: 1.52; 1.04-2.23) and ischemic stroke fatality (Hazard ratio: 1.44; 1.01-2.09). Overall, modifiable risk factors contributed to 83% and 61% of first-ever-stroke incidence and early fatality, respectively.Conclusion: Efficient risk factor control can considerably reduce stroke occurrence and fatality in our study. Establishing awareness campaigns and 24-hour stroke units seem necessary for improving the stroke management in this area. [ABSTRACT FROM AUTHOR]- Published
- 2022
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7. Mortality from respiratory diseases associated with opium use: a population-based cohort study
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Rahmati, Atieh, Shakeri, Ramin, Khademi, Hooman, Poutschi, Hossein, Pourshams, Akram, Etemadi, Arash, Khoshnia, Masoud, Sohrabpour, Amir Ali, Aliasgari, Ali, Jafari, Elham, Islami, Farhad, Semnani, Shahryar, Gharravi, Abdolsamad, Abnet, Christian C, Pharoah, Paul D P, Brennan, Paul, Boffetta, Paolo, Dawsey, Sanford M, Malekzadeh, Reza, and Kamangar, Farin
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BackgroundRecent studies have suggested that opium use may increase mortality from cancer and cardiovascular diseases. However, no comprehensive study of opium use and mortality from respiratory diseases has been published. We aimed to study the association between opium use and mortality from respiratory disease using prospectively collected data.MethodsWe used data from the Golestan Cohort Study, a prospective cohort study in northeastern Iran, with detailed, validated data on opium use and several other exposures. A total of 50 045 adults were enrolled from 2004 to 2008, and followed annually until June 2015, with a follow-up success rate of 99%. We used Cox proportional hazard regression models to evaluate the association between opium use and outcomes of interest.ResultsDuring the follow-up period, 331 deaths from respiratory disease were reported (85 due to respiratory malignancies and 246 due to non-malignant aetiologies). Opium use was associated with an increased risk of death from any respiratory disease (adjusted HR 95% CI 3.13 (2.42 to 4.04)). The association was dose-dependent with a HR of 3.84 (2.61 to 5.67) for the highest quintile of cumulative opium use versus never use (Ptrend<0.001). The HRs (95% CI) for the associations between opium use and malignant and non-malignant causes of respiratory mortality were 1.96 (1.18 to 3.25) and 3.71 (2.76 to 4.96), respectively.ConclusionsLong-term opium use is associated with increased mortality from both malignant and non-malignant respiratory diseases.
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- 2017
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8. Serum Progranulin Levels in Type 2 Diabetic Patients with Metabolic Syndrome
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Shafaei, Azam, Marjani, Abdoljalal, and Khoshnia, Masoud
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Introduction. The role of progranulin in individuals with metabolic syndrome is not exactly clear.We aimed to assess the serum level of progranulin in type 2 diabetic patients with and without metabolic syndrome and compare them with healthy controls.
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- 2016
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9. Polypill for the prevention of cardiovascular disease (PolyIran): study design and rationale for a pragmatic cluster randomized controlled trial
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Ostovaneh, Mohammad Reza, Poustchi, Hossein, Hemming, Karla, Marjani, Hajiamin, Pourshams, Akram, Nateghi, Alireza, Majed, Masoud, Navabakhsh, Behrouz, Khoshnia, Masoud, Jaafari, Elham, Mohammadifard, Noushin, Malekzadeh, Fatemeh, Merat, Shahin, Sadeghi, Masoumeh, Naemi, Mohammad, Etemadi, Arash, Thomas, G Neil, Sarrafzadegan, Nizal, Cheng, KK, Marshall, Tom, and Malekzadeh, Reza
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Background The complexity of treatment regimens, costs and pill burden decrease the medication adherence and contribute to shortfall in cardiovascular preventive drug coverage. The polypill, a fixed dose combination pill of established drugs, is expected to increase adherence and reduce the costs whilst preventing major cardiovascular events (MCVE).Design and methods The PolyIran trial is a pragmatic cluster randomized trial nested within the Golestan Cohort Study (GCS). Subjects were randomized to either non-pharmacological preventive interventions alone (minimal care arm) or together with a polypill (polypill arm) comprising hydrochlorothiazide, aspirin, atorvastatin and either enalapril or valsartan. This study benefits from the infrastructure of the primary health care system in Iran and the interventions are delivered by the local auxiliary health workers (Behvarz) to the participants. The primary outcome of the study is the occurrence of first MCVE within five years defined as non-fatal and fatal myocardial infarction, unstable angina, sudden death, heart failure, coronary artery revascularization procedures, and non-fatal and fatal stroke.Trial status From February 2011 to April 2013, 8410 individuals (236 clusters) attended the eligibility assessment. Of those, 3421 in the polypill arm and 3417 in the minimal care arm were eligible. The study is ongoing.Conclusion The infrastructure of GCS and the primary health care system in Iran enabled the conduct of this pragmatic large-scale trial. If the polypill strategy proves effective, it may be implemented to prevent cardiovascular disease in developing countries.
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- 2015
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10. Polypill for the prevention of cardiovascular disease (PolyIran): study design and rationale for a pragmatic cluster randomized controlled trial
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Ostovaneh, Mohammad Reza, Poustchi, Hossein, Hemming, Karla, Marjani, Hajiamin, Pourshams, Akram, Nateghi, Alireza, Majed, Masoud, Navabakhsh, Behrouz, Khoshnia, Masoud, Jaafari, Elham, Mohammadifard, Noushin, Malekzadeh, Fatemeh, Merat, Shahin, Sadeghi, Masoumeh, Naemi, Mohammad, Etemadi, Arash, Thomas, G Neil, Sarrafzadegan, Nizal, Cheng, KK, Marshall, Tom, and Malekzadeh, Reza
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- 2015
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11. Abstract 13476: Spatial Risk Factors Impact Cardiovascular Mortality: Analysis From the Golestan Cohort Study
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Hadley, Michael, Nalini, Mahdi, Adhikari, Samrachana, Szymonifka, Jackie, Etemadi, Arash, Kamangar, Farin, Khoshnia, Masoud, McChane, Jesse, Pourshams, Akram, Poustchi, Hossein, Sepanlou, Sadaf G, Boffetta, Paolo, Malekzadeh, Reza, and Vedanthan, Rajesh
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Introduction:Spatial risk factors are increasingly recognized to predict cardiovascular events independently of traditional risk factors. However, these spatial risk factors have been studied only individually and primarily in high-income countries.Hypothesis:We hypothesize that spatial risk factors independently predict all-cause and cardiovascular mortality.Methods:We developed exposure models for the following spatial risk factors in Golestan Provence, Iran: outdoor air pollution, proximity to traffic, proximity to health facilities, population density, land cover, socioeconomic environment, and light-at-night. Spatial exposures were assigned to 50,045 individuals in the Golestan Cohort Study, who have been followed-up for up to 12 years. Using a multivariable Cox proportional hazards spatial frailty model, we determined the impact of these exposures, as well as household fuel use and traditional risk factors, on cardiovascular mortality.Results:Spatial surfaces demonstrated spatial variability of the spatial risk factors (Figure), and outdoor air pollution also displayed temporal variability. Exposure to outdoor air pollution 5 years prior to enrollment, household kerosene and biomass fuel use, and proximity to advanced health facilities independently increased total and cardiovascular mortality (Table).Conclusions:Both outdoor air pollution and household fuel use independently predicted cardiovascular mortality in a middle-income country. Following this approach, future studies can better estimate the total impact of the environment on cardiovascular events.
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- 2019
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12. Su1971 Chronic Hepatitis B Infection Is Not Associated With Increased Risk of Vascular Mortality While Having an Association With Metabolic Syndrome.
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Katoonizadeh, Aezam, Sharafkhah, Maryam, Khoshnia, Masoud, Poustchi, Hossein, and Malekzadeh, Reza
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- 2016
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13. The association between Metabolic Syndrome and serum levels of lipid peroxidation and interleukin-6 in Gorgan.
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Sarbijani, Hamide Mojaz, Khoshnia, Masoud, and Marjani, Abdoljalal
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Background There are limited studies on the relationship between inflammatory marker such as IL-6 and lipid peroxidation and metabolic syndrome. Objective The aim of present study was to assess IL-6 and lipid peroxidation in subjects with and without the metabolic syndrome and their association with metabolic syndrome components. Methods Age and gender matched 40 subjects with metabolic syndrome and 40 control groups took part in this study. Results The mean malondialdehyde level was significantly higher in overweight and obese subjects with metabolic syndrome than control groups ( P < 0.05). The mean level of IL-6 in men and the mean level of malondialdehyde in women with metabolic syndrome was significantly higher than control groups ( p < 0.05). There were significant positive correlation between malondialdehyde and fasting blood glucose, triglyceride and systolic blood pressure ( p < 0.05). Conclusions Our results suggest that higher levels of IL-6 and malondialdehyde may cause insulin resistance and metabolic disorders in all subjects with metabolic syndrome. Malondialdehyde level shows strong association with some metabolic syndrome components. This means the greater risk of metabolic syndrome. [ABSTRACT FROM AUTHOR]
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- 2016
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14. Tu1941 Opium Use and Risk of Pancreatic Cancer: A Prospective Cohort Study.
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Mohamadnejad, Mehdi, Pourshams, Akram, Poustchi, Hossein, Islami, Farhad, sharafkhah, maryam, Moossavi, Shirin, Nasseri-Moghaddam, Siavosh, Semnani, Shahryar, Shakeri, Ramin, Etemadi, Arash, Merat, Shahin, Khoshnia, Masoud, Dawsey, Sanford M., Pharoah, Paul D., Brennan, Paul, Abnet, Christian C., Boffetta, Paolo, Kamangar, Farin, and Malekzadeh, Reza
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- 2015
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15. Tu1864 Gastroesophageal Reflux Disease and Overall and Cause-Specific Mortality -A Prospective Study of 50,000 Individuals.
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Islami, Farhad, Pourshams, Akram, Nasseri-Moghaddam, Siavosh, Khademi, Hooman, Poustchi, Hossein, Khoshnia, Masoud, Norouzi, Alireza, Amiriani, Taghi, Sohrabpour, Amir A., Asgari, Ali Ali, Jafari, Elham, Semnani, Shahryar, Abnet, Christian C., Pharoah, Paul, Kamangar, Farin, Dawsey, Sanford M., Boffetta, Paolo, and Malekzadeh, Reza
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- 2014
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