36 results on '"Kollmar, Rainer"'
Search Results
2. Erster epileptischer Anfall und Epilepsien im Erwachsenenalter
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Holtkamp, Martin, May, Theodor W., Berkenfeld, Ralf, Bien, Christian G., Coban, Ingrid, Knake, Susanne, Michaelis, Rosa, Rémi, Jan, Seeck, Margitta, Surges, Rainer, Weber, Yvonne, Baum, Petra, Baumgartner, Christoph, Beyenburg, Stefan, Brandt, Christian, Brodisch, Peter, Brückner, Sabine, Chatzikonstantinou, Anastasios, Conrad, Stefan, Fauser, Susanne, Focke, Niels, Freiman, Thomas, Freitag, Hedwig, Fudali, Monika, Geiger-Riess, Mirijam, Greshake, Benedikt, Grimmer, Anja, Hebel, Jonas, Held, Lynna, Kaufmann, Elisabeth, Kerling, Frank, Knieß, Tobias, Kollmar, Rainer, Krämer, Günter, Kürsten, Kathrin, Laufs, Helmut, Lüsebrink, Arne, Lutz, Martin, Möddel, Gabriel, Müffelmann, Birgitt, Noachtar, Soheyl, Rösche, Johannes, Rozinat, Klaus, Rüegg, Stephan, Schäfer, Ulrike, Schmidt, Pia Magdalena, Schmitt, Friedhelm C., Schmitt, Jörg, Schneider, Ulf C., Schulze-Bonhage, Andreas, Speicher, Pascal, Strzelczyk, Adam, Stutterheim, Katrin, Thorbecke, Rupprecht, Trollmann, Regina, Urbach, Horst, von Oertzen, Tim J., von Podewils, Felix, von Wrede, Randi, Wagner, Kathrin, Weber, Raimund, Wehner, Tim, Wendtland, Frank, Winter, Yaroslav, Woermann, Friedrich, and Zieglgänsberger, Dominik
- Abstract
In der neuen S2k-Leitlinie „Erster epileptischer Anfall und Epilepsien im Erwachsenenalter“ werden Empfehlungen zu klinisch relevanten Fragestellungen in fünf großen Themenblöcken gegeben: Management erster epileptischer Anfall, Pharmakotherapie, Epilepsiechirurgie, komplementäre und supportive Therapieverfahren und psychosoziale Aspekte.
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- 2024
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3. First epileptic seizure and epilepsies in adulthood
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Holtkamp, Martin, May, Theodor W., Berkenfeld, Ralf, Bien, Christian G., Coban, Ingrid, Knake, Susanne, Michaelis, Rosa, Rémi, Jan, Seeck, Margitta, Surges, Rainer, Weber, Yvonne, Baum, Petra, Baumgartner, Christoph, Beyenburg, Stefan, Brandt, Christian, Brodisch, Peter, Brückner, Sabine, Chatzikonstantinou, Anastasios, Conrad, Stefan, Fauser, Susanne, Focke, Niels, Freiman, Thomas, Freitag, Hedwig, Fudali, Monika, Geiger-Riess, Mirijam, Greshake, Benedikt, Grimmer, Anja, Hebel, Jonas, Held, Lynna, Kaufmann, Elisabeth, Kerling, Frank, Knieß, Tobias, Kollmar, Rainer, Krämer, Günter, Kürsten, Kathrin, Laufs, Helmut, Lüsebrink, Arne, Lutz, Martin, Möddel, Gabriel, Müffelmann, Birgitt, Noachtar, Soheyl, Rösche, Johannes, Rozinat, Klaus, Rüegg, Stephan, Schäfer, Ulrike, Schmidt, Pia Magdalena, Schmitt, Friedhelm C., Schmitt, Jörg, Schneider, Ulf C., Schulze-Bonhage, Andreas, Speicher, Pascal, Strzelczyk, Adam, Stutterheim, Katrin, Thorbecke, Rupprecht, Trollmann, Regina, Urbach, Horst, von Oertzen, Tim J., von Podewils, Felix, von Wrede, Randi, Wagner, Kathrin, Weber, Raimund, Wehner, Tim, Wendtland, Frank, Winter, Yaroslav, Woermann, Friedrich, and Zieglgänsberger, Dominik
- Abstract
The new S2k guideline “First epileptic seizure and epilepsies in adulthood” provides recommendations on clinically relevant issues in five major topics: management of first epileptic seizures, pharmacotherapy, epilepsy surgery, complementary and supportive treatment, and psychosocial aspects.
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- 2024
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4. 57/w nach kardiopulmonaler Reanimation
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Poli, Sven and Kollmar, Rainer
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- 2022
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5. Contrast-Induced Encephalopathy.
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Kollmar, Rainer and Biesel, Julia
- Abstract
The article describes the case of an 86-year old patient with acute posterolateral ST elevation myocardial infarction in the setting of triple-vessel coronary heart disease and was diagnosed with contrast-induced encepalopathy. The patient demonstrated reduced alertness, left-sided hemiparesis, bilateral signs of pyramidal tract dysfunction, cortical hyperdensity and cortical edema. The patient was treated with the antiepileptic drug levetiracetam and showed improved neurological symptoms.
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- 2024
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6. Intravenous alteplase for stroke with unknown time of onset guided by advanced imaging: systematic review and meta-analysis of individual patient data
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Thomalla, Götz, Boutitie, Florent, Ma, Henry, Koga, Masatoshi, Ringleb, Peter, Schwamm, Lee H, Wu, Ona, Bendszus, Martin, Bladin, Christopher F, Campbell, Bruce C V, Cheng, Bastian, Churilov, Leonid, Ebinger, Martin, Endres, Matthias, Fiebach, Jochen B, Fukuda-Doi, Mayumi, Inoue, Manabu, Kleinig, Timothy J, Latour, Lawrence L, Lemmens, Robin, Levi, Christopher R, Leys, Didier, Miwa, Kaori, Molina, Carlos A, Muir, Keith W, Nighoghossian, Norbert, Parsons, Mark W, Pedraza, Salvador, Schellinger, Peter D, Schwab, Stefan, Simonsen, Claus Z, Song, Shlee S, Thijs, Vincent, Toni, Danilo, Hsu, Chung Y, Wahlgren, Nils, Yamamoto, Haruko, Yassi, Nawaf, Yoshimura, Sohei, Warach, Steven, Hacke, Werner, Toyoda, Kazunori, Donnan, Geoffrey A, Davis, Stephen M, Gerloff, Christian, Acosta, Boris Raul, Aegidius, Karen, Albiker, Christian, Alegiani, Anna, Almendrote, Miriam, Alonso, Angelika, Althaus, Katharina, Amarenco, Pierre, Amiri, Hemasse, Anders, Bettina, Aniculaesei, Adriana, Appleton, Jason, Arenillas, Juan, Back, Christina, Bähr, Christian, Bardutzky, Jürgen, Baronnet-Chauvet, Flore, Bathe-Peters, Rouven, Bayer-Karpinska, Anna, Becerra, Juan L., Beck, Christoph, Belchí Guillamon, Olga, Benoit, Amandine, Berhoune, Nadia, Bindila, Daniela, Birchenall, Julia, Blanc-Lasserre, Karine, Blanco Gonzales, Miguel, Bobinger, Tobias, Bodechtel, Ulf, Bodiguel, Eric, Bojaryn, Urszula, Bonnet, Louise, Bouamra, Benjamin, Bourgeois, Paul, Boutitie, Florent, Breuer, Lorenz, Breynaert, Ludovic, Broughton, David, Brouns, Raf, Brugirard, Sébastian, Bruneel, Bart, Buggle, Florian, Cakmak, Serkan, Calleja, Ana, Calvet, David, Carrera, David, Chen, Hsin-Chieh, Cheng, Bastian, Cheripelli, Bharath, Cho, Tae-Hee, Choe, Chi-un, Choy, Lillian, Christensen, Hanne, Ciatipis, Mareva, Cloud, Geoffrey, Cogez, Julien, Cortijo, Elisa, Crozier, Sophie, Damgaard, Dorte, Dani, Krishna, De Coene, Beatrijs, De Hollander, Isabel, De Keyser, Jacques, De Klippel, Nina, De Maeseneire, Charlotte, De Smedt, Ann, del Mar Castellanos Rodrigo, Maria, Deltour, Sandrine, Demeestere, Jelle, Derex, Laurent, Desfontaines, Philippe, Dittrich, Ralf, Dixit, Anand, Dobbels, Laurens, Domigo, Valérie, Dorado, Laura, Druart, Charlotte, Dupont, Kristina Hougaard, Dusart, Anne, Dziewas, Rainer, Ebinger, Martin, Ebner, Matthias, Edjali-Goujon, Myriam, Eisele, Philipp, El Tawil, Salwa, Elhfnawy, Ahmed, Endres, Matthias, Etexberria, Ana, Evans, Nicholas, Fandler, Simon, Fazekas, Franz, Felix, Sandra, Fiebach, Jochen B., Fiehler, Jens, Filipov, Alexandra, Filipski, Katharina, Fleischmann, Robert, Foerch, Christian, Ford, Ian, Gaenslen, Alexandra, Galinovic, Ivana, Gancedo, Elena Meseguer, Ganeshan, Ramanan, García Esperón, Carlos, Garrido, Alicia, Gattringer, Thomas, Geraghty, Olivia, Geran, Rohat, Gerloff, Christian, Gerner, Stefan, Godon-Hardy, Sylvie, Göhler, Jos, Golsari, Amir, Gomis, Meritxell, Gorriz, David, Gramse, Verena, Grau, Laia, Griebe, Martin, Guerrero, Cristina, Guerzoglu, Damla, Guettier, Sophie, Guiraud, Vincent, Gumbinger, Christoph, Gunreben, Ignaz, Haertig, Florian, Hametner, Christian, Hanseeuw, Bernard, Hansen, Andreas, Hansen, Jakob, Harbo, Thomas, Harloff, Andreas, Harmel, Peter, Häusler, Karl Georg, Heinen, Florian, Held, Valentin, Hellwig, Simon, Hemelsoet, Dimitri, Hennerici, Michael, Herm, Juliane, Hermans, Sylvia, Hernández, María, Hervas Vicente, Jose, Hjort, Niels, Hobeanu, Cristina, Hobohm, Carsten, Höfner, Elmar, Hohenbichler, Katharina, Hommel, Marc, Hoppe, Julia, Hornberger, Eva, Hoyer, Carolin, Huang, Xuya, Ipsen, Nils, Isern, Irina, Ispierto, Lourdes, Iversen, Helle, Jeppesen, Lise, Jimenez, Marta, Jungehülsing, Jan, Jüttler, Eric, Kalladka, Dheeraj, Kallmünzer, Bernd, Kar, Arindam, Kellert, Lars, Kemmling, André, Kessler, Tobias, Khan, Usman, Klein, Matthias, Kleinschnitz, Christoph, Klockziem, Matti, Knops, Michael, Koehler, Luzie, Koehrmann, Martin, Kohlfürst, Heinz, Kollmar, Rainer, Kraft, Peter, Krause, Thomas, Kristensen, Bo, Kröber, Jan M., Kurka, Natalia, Ladoux, Alexandre, Laloux, Patrice, Lamy, Catherine, Landrault, Emmanuelle, Lauer, Arne, Lebely, Claire, Leempoel, Jonathan, Lees, Kennedy, Leger, Anne, Legrand, Laurence, Lemmens, Robin, Li, Lin, Löbbe, Anna-Mareike, London, Frederic, Lopez-cancio, Elena, Lorenz, Matthias, Louw, Stephen, Lovelock, Caroline, Lozano Sánchez, Manuel, Lucente, Giuseppe, Lückl, Janos, Luna, Alain, Macha, Kosmas, Machet, Alexandre, Mackenrodt, Daniel, Madzar, Dominik, Majoie, Charles, Männer, Anika, Maqueda, Vicky, Marstrand, Jacob, Martinez, Alicia, Marzina, Annika, Mechthouff, Laura, Meden, Per, Meersman, Guy, Meier, Julia, Mellerio, Charles, Menn, Oliver, Meyer, Nadja, Michalski, Dominik, Michels, Peter, Michelsen, Lene, Millán Torne, Monica, Minnerup, Jens, Modrau, Boris, Moeller, Sebastian, Møller, Anette, Morel, Nathalie, Moreton, Fiona, Morin, Ludovic, Moulin, Thierry, Moynihan, Barry, Mueller, Anne K., Muir, Keith W., Mulero, Patricia, Mundiyanapurath, Sibu, Mutzenbach, Johannes, Nagel, Simon, Naggara, Oliver, Nallasivan, Arumugam, Navalpotro, Irene, Nave, Alexander H., Nederkoorn, Paul, Neeb, Lars, Neugebauer, Hermann, Neumann-Haefelin, Tobias, Nighoghossian, Norbert, Oberndorfer, Stefan, Opherk, Christian, Oppel, Lorenz, Oppenheim, Catherine, Orthgieß, Johannes, Ostergaard, Leif, Paindeville, Perrine, Palomeras, Ernest, Panitz, Verena, Patel, Bhavni, Peeters, Andre, Peeters, Dirk, Pellisé, Anna, Pelz, Johann, Pereira, Anthony, Pérez de la Ossa, Natalia, Perry, Richard, Petraza, Salvador, Peysson, Stéphane, Pfeilschifter, Waltraud, Pichler, Alexander, Pierskalla, Alexandra, Pledl, Hans-Werner, Poli, Sven, Pomrehn, Katrin, Poulsen, Marika, Prats, Luis, Presas, Silvia, Prohaska, Elisabeth, Puetz, Volker, Puig, Josep, Puig Alcántara, Josep, Purrucker, Jan, Quenardelle, Veronique, Ramachandran, Sankaranarayanan, Raphaelle, Soulliard, Raposo, Nicolas, Reiff, Tilman, Remmers, Michel, Renou, Pauline, Ribitsch, Martin, Richter, Hardy, Ringleb, Peter, Ritter, Martin, Ritzenthaler, Thomas, Rodier, Gilles, Rodriguez-Regent, Christine, Rodríguez-Yáñez, Manuel, Roennefarth, Maria, Roffe, Christine, Rosenbaum, Sverre, Rosso, Charlotte, Röther, Joachim, Rozanski, Michal, Ruiz de Morales, Noelia, Russo, Francesca, Rutgers, Matthieu, Sagnier, Sharmilla, Samson, Yves, Sánchez, Josep, Sauer, Tamara, Schäfer, Jan H., Schieber, Simon, Schill, Josef, Schlak, Dennis, Schlemm, Ludwig, Schmidt, Sein, Schonewille, Wouter, Schröder, Julian, Schulz, Andreas, Schurig, Johannes, Schwarting, Sönke, Schwarz, Alexander, Schwarzbach, Christopher, Seidel, Matthias, Seiler, Alexander, Sembill, Jochen, Serena Leal, Joaquin, Shetty, Ashit, Sibon, Igor, Simonsen, Claus Z., Singer, Oliver, Sivagnanaratham, Aravinth, Smets, Ide, Smith, Craig, Soors, Peter, Sprigg, Nikola, Spruegel, Maximilian, Stark, David, Steinert, Susanne, Stösser, Sebastian, Stuermlinger, Markus, Swinnen, Bart, Tamazyan, Ruben, Tembl, Jose, Terceno Izaga, Mikel, Thijs, Vincent, Thomalla, Götz, Touze, Emmanuel, Truelsen, Thomas, Turc, Guillaume, Turine, Gaetane, Tütüncü, Serdar, Tyrell, Pippa, Ustrell, Xavier, Vadot, Wilfried, Vallet, Anne-Evelyne, Vallet, Pauline, van den Berg, Lucie, van den Berg, Sophie, van Eendenburg, Cecile, Van Hooff, Robbert-Jan, van Sloten, Isabelle, Vanacker, Peter, Vancaester, Evelien, Vanderdonckt, Patrick, Vandermeeren, Yves, Vanhee, Frederik, Veltkamp, Roland, Vestergaard, Karsten, Viguier, Alain, Vilas, Dolores, Villringer, Kersten, Voget, Dieke, von Schrader, Jörg, von Weitzel, Paul, Warburton, Elisabeth, Weber, Claudia, Weber, Jörg, Wegscheider, Karl, Wegscheider, Mirko, Weimar, Christian, Weinstich, Karin, Weise, Christopher, Weise, Gesa, Willems, Chris, Winder, Klemens, Wittayer, Matthias, Wolf, Marc, Wolf, Martin, Wolff, Valerie, Wollboldt, Christian, Wollenweber, Frank, Wouters, Anke, Yalo, Bertrand, Yger, Marion, Younan, Nadia, Yperzeele, Laetita, Zegarac, Vesna, Zeiner, Pia, Ziemann, Ulf, Zonneveld, Thomas, Zuber, Mathieu, Akutsu, Tsugio, Aoki, Junya, Aoki, Junya, Arakawa, Shuji, Doijiri, Ryosuke, Egashira, Yusuke, Enomoto, Yukiko, Fukuda-Doi, Mayumi, Furui, Eisuke, Furuta, Konosuke, Gotoh, Seiji, Hamasaki, Toshimitsu, Hasegawa, Yasuhiro, Hirano, Teryuki, Homma, Kazunari, Ichijyo, Masahiko, Ide, Toshihiro, Igarashi, Shuichi, Iguchi, Yasuyuki, Ihara, Masafumi, Ikenouchi, Hajime, Inoue, Manabu, Inoue, Tsuyoshi, Itabashi, Ryo, Ito, Yasuhiro, Iwama, Toru, Kamiyama, Kenji, Kamiyoshi, Shoko, Kanai, Haruka, Kanematsu, Yasuhisa, Kanzawa, Takao, Kimura, Kazumi, Kitayama, Jiro, Kitazono, Takanari, Koga, Masatoshi, Kondo, Rei, Kudo, Kohsuke, Kusumi, Masayoshi, Kuwahara, Ken, Matsumoto, Shoji, Matsuoka, Hideki, Mihara, Ban, Minematsu, Kazuo, Miura, Ken, Miwa, Kaori, Morita, Naomi, Mouri, Wataru, Murata, Kayo, Nagakane, Yoshinari, Nakase, Taizen, Ohara, Hiromi, Ohara, Nobuyuki, Ohnishi, Hideyuki, Ohta, Hajime, Ohtaki, Masafumi, Ohtani, Ryo, Ohtsuki, Toshiho, Ohyama, Hideo, Okada, Takashi, Okada, Yasushi, Osaki, Masato, Sakai, Nobuyuki, Sanbongi, Yoshiki, Sasaki, Naoshi, Sasaki, Makoto, Sato, Shoichiro, Seki, Kenta, Shimizu, Wataru, Shiokawa, Yoshiaki, Sozu, Takashi, Suzuki, Junichiro, Suzuki, Rieko, Takagi, Yasushi, Takizawa, Shunya, Tanahashi, Norio, Tanaka, Eijiro, Tanaka, Ryota, Tateishi, Yohei, Terada, Tomoaki, Terasaki, Tadashi, Todo, Kenichi, Tokunaga, Azusa, Toyoda, Kazunori, Tsujino, Akira, Ueda, Toshihiro, Uesaka, Yoshikazu, Uotani, Mihoko, Urabe, Takao, Watanabe, Masao, Yagita, Yoshiki, Yakushiji, Yusuke, Yamamoto, Haruko, Yasui, Keizo, Yonehara, Toshiro, Yoshimura, Sohei, Yoshimura, Shinichi, Aarnio, K., Alemseged, F., Anderson, C., Ang, T., Archer, M.L., Attia, J., Bailey, P., Balabanski, A., Barber, A., Barber, P.A., Bernhardt, J., Bivard, A., Blacker, D., Bladin, C.F., Brodtmann, A., Cadilhac, D., Campbell, B.C.V., Carey, L., Celestino, S., Chan, L., Chang, W.H., ChangI, A., Chen, C.H., Chen, C.-I., Chen, H.F., Chen, T.C., Chen, W.H., Chen, Y.Y., Cheng, C.A., Cheong, E., Chiou, Y.W., Choi, P.M., Chu, H.J., Chuang, C.S., Chung, T.C., Churilov, L., Clissold, B., Connelly, A., Coote, S., Coulton, B., Cowley, E., Cranefield, J., Curtze, S., D'Este, C., Davis, S.M., Day, S., Desmond, P.M., Dewey, H.M., Ding, C., Donnan, G.A., Drew, R., Eirola, S., Field, D., Frost, T., Garcia-Esperon, C., George, K., Gerraty, R., Grimley, R., Guo, Y.C., Hankey, G., Harvey, J., Ho, S.C., Hogan, K., Howells, D., Hsiao, P.M., Hsu, C.H., Hsu, C.T., Hsu, C.-S., Hsu, J.P., Hsu, Y.D., Hsu, Y.T., Hu, C.J., Huang, C.C., Huang, H.Y., Huang, M.Y., Huang, S.C., Huang, W.S., Jackson, D., Jeng, J.S., Jiang, S.K., Kaauwai, L., Kasari, O., King, J., Kleinig, T.J., Koivu, M., Kolbe, J., Krause, M., Kuan, C.W., Kung, W.L., Kyndt, C., Lau, C.L., Lee, A., Lee, C.Y., Lee, J.T., Lee, Y., Lee, Y.C., Levi, C., Levi, C.R., Lien, L.M., Lim, J.C., Lin, C.C., Lin, C.H., Lin, C.M., Lin, D., Liu, C.H., Liu, J., Lo, Y.C., Loh, P.S., Low, E., Lu, C.H., Lu, C.J., Lu, M.K., Ly, J., Ma, H., Macaulay, L., Macdonnell, R., Mackey, E., Macleod, M., Mahadevan, J., Maxwell, V., McCoy, R., McDonald, A., McModie, S., Meretoja, A., Mishra, S., Mitchell, P.J., Miteff, F., Moore, A., Muller, C., Ng, F., Ng, F.C., Ng, J-L., O'Brian, W., O'Collins, V., Oxley, T.J., Parsons, M.W., Patel, S., Peng, G.S., Pesavento, L., Phan, T., Rodrigues, E., Ross, Z., Sabet, A., Sallaberger, M., Salvaris, P., Shah, D., Sharma, G., Sibolt, G., Simpson, M., Singhal, S., Snow, B., Spratt, N., Stark, R., Sturm, J., Sun, M.C., Sun, Y., Sung, P.S., Sung, Y.F., Suzuki, M., Tan, M., Tang, S.C., Tatlisumak, T., Thijs, V., Tiainen, M., Tsai, C.H., Tsai, C.K., Tsai, C.L., Tsai, H.T., Tsai, L.K., Tseng, C.H., Tseng, L.T., Tsoleridis, J., Tu, H., Tu, H.T-H., Vallat, W., Virta, J., Wang, W.C., Wang, Y.T., Waters, M., Weir, L., Wijeratne, T., Williams, C., Wilson, W., Wong, A.A., Wong, K., Wu, T.Y., Wu, Y.H., Yan, B., Yang, F.C., Yang, Y.W., Yassi, N., Yeh, H.L., Yeh, J.H., Yeh, S.J., Yen, C.H., Young, D., Ysai, C.L., Zhang, W.W., Zhao, H., Zhao, L., Althaus-Knaurer, Katharina, Bendszus, Martin, Berrouschot, Jörg, Bluhmki, Erich, Bovi, Paolo, Chatellier, Gilles, Cove, Lynda, Davis, Stephen, Dixit, A., Donnan, Geoffrey, Dziewas, Rainer, Ehrenkrona, Christina, Eschenfelder, Christoph, Fatar, Marc, Francisco Arenillas, Juan, Gruber, Franz, Hacke, Werner, Kala, Lalit, Kapeller, Peter, Kaste, Markku, Kessler, Christof, Köhrmann, Martin, Laage, Rico, Lees, Kennedy R., Leys, Didier, Luna Rodriguez, Alain, Mas, Jean-Louis, Mikulik, Robert, Molina, Carlos, Muddegowda, Girish, Muir, Keith, Niederkorn, Kurt, Nuñez, Xavier, Oppenheim, Catherine, Poli, Sven, Ringleb, Peter, Schellinger, Peter, Schwab, Stefan, Serena, Joaquin, Sobesky, Jan, Steiner, Thorsten, Svenson, Ann-Sofie, Toni, Danilo, Veltkamp, Roland, von Kummer, Rüdiger, Wahlgren, Nils, Wardlaw, Joanna, Betensky, Rebecca A., Boulouis, Gregoire, Carandang, Raphael A., Copen, William A., Cougo, Pedro, Cutting, Shawna, Drake, Kendra, Ford, Andria L., Hallenbeck, John, Harris, Gordon J., Hoesch, Robert, Hsia, Amie, Kase, Carlos, Latour, Lawrence, Lauer, Arne, Lev, Michael H., Muzikansky, Alona, Nagaraja, Nandakumar, Schwamm, Lee H., Searls, Eric, Song, Shlee S., Starkman, Sidney, Warach, Steven, Wu, Ona, Yoo, Albert J., and Zand, Ramin
- Abstract
Patients who have had a stroke with unknown time of onset have been previously excluded from thrombolysis. We aimed to establish whether intravenous alteplase is safe and effective in such patients when salvageable tissue has been identified with imaging biomarkers.
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- 2020
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7. A Single Injection of N-Oleoyldopamine, an Endogenous Agonist for Transient Receptor Potential Vanilloid-1, Induced Brain Hypothermia, but No Neuroprotective Effects in Experimentally Induced Cerebral Ischemia in Rats
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Tejada de Rink, Maria Mercedes, Naumann, Ulrike, Kollmar, Rainer, Schwab, Stefan, Dietel, Barbara, Harada, Hideki, and Tauchi, Miyuki
- Abstract
Targeted temperature management, or therapeutic hypothermia, is a potent neuroprotective approach after ischemic brain injury. Hypothermia should be induced as soon as possible after the onset of acute stroke to assure better outcomes. Accordingly, drugs with a fast-acting hypothermic effect sustainable through the period of emergency transportation to hospital would have clinical advantages.Activation of the transient receptor potential vanilloid-1 (TRPV1) can induce hypothermia. Our immunohistochemical investigations confirmed that TRPV1 was distributed to perivascular and periventricular regions of the rat brain, where TRPV1 can be easily detected by TRPV1 agonists. An endogenous TRPV1 selective agonist, N-oleoyldopamine (OLDA), and a synthetic antagonist, AMG 9810, were injected intraperitoneally into healthy adult male Wister rats, and brain and core temperatures and gross motor activities were monitored. Comparison with baseline temperatures showed that TRPV1 injection immediately induced mild hypothermia (p< 0.05 in brain and p< 0.01 in body), and AMG 9810 induced immediate mild hyperthermia (not significant). However, the OLDA-induced hypothermia did not decrease lesion volume after middle carotid artery occlusion in rats. Relative to vehicle, OLDA yielded poorer outcomes and AMG 9810 yielded better outcomes in neurological scores and lesion size. Our study showed that, as an agonist of TRPV1, OLDA has suitable hypothermia-inducing properties, but did not decrease lesion volume. Therefore, the search for novel TRPV1 agonists and/or antagonists providing hypothermia and neuroprotection should continue. Further investigations should also target OLDA-induced transient hypothermia combined with long-term hypothermia maintenance with surface cooling, which mimics the anticipated clinical use of this class of drug.
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- 2020
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8. Neuroprotektion in der Neurointensivmedizin
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Kollmar, Rainer
- Abstract
Unter Neuroprotektion versteht man in der Intensivmedizin meist unterschiedliche Maßnahmen zur Verhinderung einer sekundären Gehirnschädigung nach initialem Trauma, etwa bei Schlaganfall, intrakranieller Blutung oder nach Reanimation. Jedes Hirntrauma unterscheidet sich aufgrund der primären Schädigungsform in Schädigungsmuster und Dynamik. Je nach Pathophysiologie der Erkrankung gibt es daher zielgerichtete Therapieansätze. Daneben sind neuroprotektive Methoden wünschenswert, die bei einem Großteil der Patienten mit akuter Hirnschädigung wirksam sind. Tatsächlich werden bei allen Formen der akuten Hirnschädigung bestimmte pathophysiologische Abläufe angestoßen (beispielsweise Reperfusionsschäden, eine Schädigung der Blut-Hirn-Schranke und Exzitotoxizität), die je nach Intensität zu einer sekundären Hirnschädigung führen können. Vieles deutet darauf hin, dass die Herstellung physiologischer Normalbedingungen zu einer günstigen Situation für das geschädigte Gehirn führt. Der vorliegende Beitrag schildert zunächst die Relevanz neuroprotektiver Maßnahmen in der neurologischen Intensivmedizin. Daraufhin werden allgemeine pathophysiologische Mechanismen bei Hirntraumata beschrieben. Im Anschluss wird näher auf die Pathophysiologie und Therapieoptionen bei Hirndruckkrisen (Senkung des intrakraniellen Drucks), Anämie (Transfusionsmanagement) sowie Hyper- und Hypoglykämien (Einstellung des Blutzuckerspiegels) eingegangen. Zuletzt werden Einsatz und Nutzen der therapeutischen Hypothermie diskutiert. Dieses Verfahren nimmt als klinisch einzig wirksame Einzelmaßnahme zur Neuroprotektion eine Sonderstellung ein; ein Fokus liegt hier auf der Anwendung nach Herz-Kreislauf-Stillstand und Reanimation.
- Published
- 2019
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9. Therapeutic hypothermia for acute ischaemic stroke. Results of a European multicentre, randomised, phase III clinical trial
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van der Worp, H Bart, Macleod, Malcolm R, Bath, Philip MW, Bathula, Raj, Christensen, Hanne, Colam, Bridget, Cordonnier, Charlotte, Demotes-Mainard, Jacques, Durand-Zaleski, Isabelle, Gluud, Christian, Jakobsen, Janus Christian, Kallmünzer, Bernd, Kollmar, Rainer, Krieger, Derk W, Lees, Kennedy R, Michalski, Dominik, Molina, Carlos, Montaner, Joan, Roine, Risto O, Petersson, Jesper, Perry, Richard, Sprigg, Nikola, Staykov, Dimitre, Szabo, Istvan, Vanhooren, Geert, Wardlaw, Joanna M, Winkel, Per, and Schwab, Stefan
- Abstract
Introduction We assessed whether modest systemic cooling started within 6 hours of symptom onset improves functional outcome at three months in awake patients with acute ischaemic stroke.Patients and methods In this European randomised open-label clinical trial with blinded outcome assessment, adult patients with acute ischaemic stroke were randomised to cooling to a target body temperature of 34.0–35.0°C, started within 6 h after stroke onset and maintained for 12 or 24 h , versus standard treatment. The primary outcome was the score on the modified Rankin Scale at 91 days, as analysed with ordinal logistic regression.Results The trial was stopped after inclusion of 98 of the originally intended 1500 patients because of slow recruitment and cessation of funding. Forty-nine patients were randomised to hypothermia versus 49 to standard treatment. Four patients were lost to follow-up. Of patients randomised to hypothermia, 15 (31%) achieved the predefined cooling targets. The primary outcome did not differ between the groups (odds ratio for good outcome, 1.01; 95% confidence interval, 0.48–2.13; p= 0.97). The number of patients with one or more serious adverse events did not differ between groups (relative risk, 1.22; 95% confidence interval, 0.65–1.94; p= 0.52).Discussion In this trial, cooling to a target of 34.0–35.0°C and maintaining this for 12 or 24 h was not feasible in the majority of patients. The final sample was underpowered to detect clinically relevant differences in outcomes.Conclusion Before new trials are launched, the feasibility of cooling needs to be improved.
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- 2019
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10. Targeted Temperature Management for Subarachnoid Hemorrhage: Excellent Outcome After Severe Vasospasm—A Case Series
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Mäder, Lisa, Ganai, Ajaz, Aroyo, Ilia, Schill, Josef, Tröscher-Weber, Regina, Huppert, Peter, Kotterer, Otto, Geletneky, Karsten, and Kollmar, Rainer
- Abstract
Targeted temperature management (TTM) might improve outcome of patients with severe subarachnoid hemorrhage (SAH) in which vasospasm, delayed cerebral ischemia (DCI), and increased intracranial pressure (ICP) are frequent and severe complications. A series of patients (n= 3) with severe aneurysmatic SAH were treated by TTM if they developed ICP crisis and/or severe vasospasm diagnosed by angiography. Once these complications were detected, body core temperature (BCT) was rapidly decreased to 35°C or 33°C, if necessary. BCT induced and maintained by surface cooling remained at the desired level for at least 72 hours. Rewarming was performed by 1°C, only if the target parameters ICP and velocities in the serial Doppler sonography indicating macrovascular vasospasm improved to regular levels. In case of increase of ICP or middle cerebral arteries velocities BCT was decreased again to the last effective level. The patients developed vasospasm between days 6 and 12 after SAH. All aneurysms were treated by coiling. BCT was reduced between days 6 and 12 after SAH. Total duration of BCT <36.5°C was between 5.5 and 8 days. It remained <35°C for 4–6 days, and at 33°C for 3 days on average. ICP could be sufficiently controlled in all patients, because no ICP crisis was observed during TTM and after rewarming. Two patients developed minor DCI. Side effects of prolonged ventilation of 7–18 days included pneumonia for two patients that could be treated sufficiently. Other complications were one case of ventriculitis and two temporary deliriums. Outcome of the patients was good because no focal neurological symptoms could be detected after rehabilitation. TTM represents a promising treatment approach for severe SAH in which standard treatment is often limited and experimental. It deserves further clinical investigation in a larger cohort.
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- 2019
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11. An injectable implant to stimulate the sphenopalatine ganglion for treatment of acute ischaemic stroke up to 24 h from onset (ImpACT-24B): an international, randomised, double-blind, sham-controlled, pivotal trial
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Bornstein, Natan M, Saver, Jeffrey L, Diener, Hans Christoph, Gorelick, Philip B, Shuaib, Ashfaq, Solberg, Yoram, Thackeray, Lisa, Savic, Milan, Janelidze, Tamar, Zarqua, Natia, Yarnitsky, David, Molina, Carlos A, Shuaib, Ashfaq, Hill, Michael, Vaclavik, Daniel, Skoloudik, David, Fiksa, Jan, Andersen, Grethe, Jakala, Pekka, Tatlisumak, Turgut, Kuzmanovski, Igor, Guillon, Benoit, Chabriat, Hugues, Mahagne, Marie Helene, Timsit, Serge, Ronziere, Thomas, Ingorokva, Gocha, Beridze, Maya, Beridze, Mzia, Zarqua, Natia, Kharaishvili, Nino, Kakabadze, Nodar, Janelidze, Tamar, Griewing, Bernd, Hobohm, Carsten, Schneider, Dietmar, Weimar, Christian, Poppert, Holger, Kimmig, Hubert, Berrouschot, Joerg, Ringleb, Peter, Schwab, Stefan, Kohrmann, Martin, Kallmunzer, Bernd, Kollmar, Rainer, Endres, Matthias, Hausler, Karl-Georg, Cheung, Raymond, Wai Hong Leung, Thomas, Dorodnicov, Elena, Halevi, Hen, Auriel, Eitan, Streifler, Jonathan, Leker, Ronen, Schwammenthal, Yvonne, Toni, Danilo, Agnelli, Giancarlo, Caso, Valeria, Słowik, Agnieszka, Czlonkowska, Anna, Lubinski, Ignacy, Kochanowicz, Jan, Sobolewski, Piotr, Brola, Waldemar, Salgado, Antonio Vasco, Correia, Carlos, Azevedo, Elsa, Roriz, Jose, Zarkov, Marija, Savic, Milan, Petrovic, Zarko, Krastev, Georgi, Dvorak, Miloslav, Rodriguez Campello, Ana, Nunez, Antonio Gil, Molina, Carlos, Purroy, Francisco, Marti-Fabregas, Joan, Arenillas, Juan, Alonso, Maria, Cardona, Pedro, Blanco Gonzalez, Miguel, Tur, Silvia, Segura Martin, Tomas, Anzhelika, Payenok, Shownkeen, Harish, Concha, Mauricio, Sethi, Pramod, Sen, Souvik, Zaidi, Syed, Zaidi, Syed, and Devlin, Thomas
- Abstract
Sphenopalatine ganglion stimulation increased cerebral collateral blood flow, stabilised the blood–brain barrier, and reduced infarct size, in preclinical models of acute ischaemic stroke, and showed potential benefit in a pilot randomised trial in humans. The pivotal ImpACT-24B trial aimed to determine whether sphenopalatine ganglion stimulation 8–24 h after acute ischaemic stroke improved functional outcome.
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- 2019
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12. Outcomes of Hypothermia in Addition to Decompressive Hemicraniectomy in Treatment of Malignant Middle Cerebral Artery Stroke: A Randomized Clinical Trial
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Neugebauer, Hermann, Schneider, Hauke, Bösel, Julian, Hobohm, Carsten, Poli, Sven, Kollmar, Rainer, Sobesky, Jan, Wolf, Stefan, Bauer, Miriam, Tittel, Sascha, Beyersmann, Jan, Woitzik, Johannes, Heuschmann, Peter U., and Jüttler, Eric
- Abstract
IMPORTANCE: Moderate hypothermia in addition to early decompressive hemicraniectomy has been suggested to further reduce mortality and improve functional outcome in patients with malignant middle cerebral artery (MCA) stroke. OBJECTIVE: To investigate whether moderate hypothermia vs standard treatment after early hemicraniectomy reduces mortality at day 14 in patients with malignant MCA stroke. DESIGN, SETTING, AND PARTICIPANTS: This randomized clinical trial recruited patients from August 2011 through September 2015 at 6 German university hospitals with dedicated neurointensive care units. Of the patients treated with hemicraniectomy and assessed for eligibility, patients were randomly assigned to either standard care or moderate hypothermia. Data analysis was completed from December 2016 to June 2018. INTERVENTIONS: Moderate hypothermia (temperature, 33.0 ± 1.0°C) was maintained for at least 72 hours immediately after hemicraniectomy. MAIN OUTCOMES AND MEASURES: The primary outcome was mortality rate at day 14 compared with the Fisher exact test and expressed as odds ratio (ORs) with 95% CIs. Rates of patients with serious adverse events were estimated for the period of the first 14 days after hemicraniectomy and 12 months of follow-up. Secondary outcome measures included functional outcome at 12 months. RESULTS: Of the 50 study participants, 24 were assigned to standard care and 26 to moderate hypothermia. Twenty-eight were male (56%); the mean (SD) patient age was 51.3 (6.6) years. Recruitment was suspended for safety concerns: 12 of 26 patients (46%) in the hypothermia group and 7 of 24 patients (29%) receiving standard care had at least 1 serious adverse event within 14 days (OR, 2.05 [95% CI, 0.56-8.00]; P = .26); after 12 months, rates of serious adverse events were 80% (n = 20 of 25) in the hypothermia group and 43% (n = 10 of 23) in the standard care group (hazard ratio, 2.54 [95% CI, 1.29-5.00]; P = .005). The mortality rate at day 14 was 19% (5 of 26 patients) in the hypothermia group and 13% (3 of 24 patients) in the group receiving standard care (OR, 1.65 [95% CI, 0.28-12.01]; P = .70). There was no significant difference regarding functional outcome after 12 months of follow-up. INTERPRETATION: In patients with malignant MCA stroke, moderate hypothermia early after hemicraniectomy did not improve mortality and functional outcome compared with standard care, but may cause serious harm in this specific setting. TRIAL REGISTRATION: http://www.drks.de, identifier DRKS00000623
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- 2019
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13. Targeted Temperature Management: Peltier's Element-Based Focal Brain Cooling Protects Penumbra Neurons from Progressive Damage in Experimental Cerebral Ischemia
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Tauchi, Miyuki, Tejada de Rink, Maria Mercedes, Fujioka, Hiroshi, Okayama, Satoko, Nakamura, Kei-ichiro, Dietel, Barbara, Achenbach, Stephan, Kollmar, Rainer, Schwab, Stefan, Ushijima, Kazuo, and Harada, Hideki
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Targeted temperature management (TTM), or therapeutic hypothermia, is one of the most potent neuroprotective approaches after ischemic and traumatic brain injuries. TTM has been applied clinically with various methods, but effective achievement and maintenance of the target temperature remain challenging. Furthermore, timing of cooling and target body and brain temperature to optimize effectiveness for neuroprotection and to minimize side effects are yet to be standardized. Focal brain cooling is a potential strategy to minimize adverse effects of systemic TTM. In this study, we report on a focal brain cooling device for animals and its effectiveness of focal cooling in several animal models of ischemic cerebral stroke. A focal brain cooling device was constructed using a Peltier's element, a thermoelectric heat pump. The device was validated for its cooling ability, and optimal settings to induce an effective intracranial temperature were determined using male Sprague-Dawley rats. Transient and permanent middle cerebral artery occlusions were experimentally induced, and focal brain cooling was applied using the device varying the timing and duration of cooling. The stroke-induced infarct and edema volumes were evaluated from Nissl-stained cryosections. The focal brain cooling device was able to decrease and subsequently maintained cerebral hypothermia in free-moving rats without altering the core temperature. The device with validated intracranial temperatures produced neuroprotective effects in the acute phase of ischemic neural death, reperfusion injury, progressing damage to the penumbra, and edema formation. In conclusion, our validated focal cooling device enabled rapid and accurate cerebral TTM in rats. Using this device, we were able to test the neuroprotective effect of focal TTM in several pathological stages of cerebral ischemia, which warrants further studies to develop clinically feasible TTM procedures for patients with cerebral stroke.
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- 2018
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14. Leflunomide as Cause of Aseptic Meningitis
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Mäder, Lisa, Kollmar, Rainer, and Lorenz, Hanns-Martin
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- 2021
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15. Diagnosis of Spontaneous Cervical Artery Dissection May Be Associated with Increased Prevalence of Posttraumatic Stress Disorder.
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Speck, Verena, Noble, Adam, Kollmar, Rainer, and Schenk, Thomas
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Background: Receiving information that one has a dissected cervical artery, which can cause a stroke at any time, is obviously traumatic, but details about the psychiatric and psychosocial sequelae are not known. We investigated the prevalence of and risk factors for posttraumatic stress disorder (PTSD) in patients with spontaneous cervical artery dissection (CD) and the impact of PTSD on their psychosocial functioning. Methods: Patients admitted because of CD between 2006 and 2010 were retrospectively examined using a diagnostic PTSD measure (Posttraumatic Diagnostic Scale). Patients between 2011 and 2012 were examined prospectively. To identify potential predictors for PTSD, we examined all patients’ stress coping strategies (brief COPE inventory), anxiety and depression (Hospital Anxiety and Depression Scale), impairment by preventive medication, time since diagnosis and their neurologic (modified Rankin Scale) and cognitive status. To identify the psychosocial impact of PTSD, we examined quality of life (Short-Form 36). Results: Data of 47 retrospectively contacted patients and 15 prospectively examined patients were included. Twenty-eight patients (45.2%) met the diagnostic criteria for PTSD. A significantly reduced health-related quality of life (HRQoL) was found in 27 patients (43.5%) for mental health and in 8 patients (12.9%) for physical health. Results of logistic regression analysis revealed that the use of maladaptive coping strategies was predictive of the disorder (P < .0001). Age, sex, mRS score, impairment caused by medication, and time since diagnosis were not predictive for PTSD. The presence of PTSD itself was the only significant predictor for reduced mental HRQol (P = .0004). Age, sex, mRS score, impairment caused by medication, and total Hospital Anxiety and Depression Scale score were not predictive for reduced mental HRQoL. Conclusions: PTSD seems to occur frequently in patients with CD and is associated with reduced mental HRQoL. Because the presence of a maladaptive coping style is correlated with PTSD, teaching patients better coping skills might be helpful. [Copyright &y& Elsevier]
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- 2014
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16. Granulocyte colony-stimulating factor in patients with acute ischemic stroke: results of the AX200 for Ischemic Stroke trial.
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Ringelstein, E Bernd, Thijs, Vincent, Norrving, Bo, Chamorro, Angel, Aichner, Franz, Grond, Martin, Saver, Jeff, Laage, Rico, Schneider, Armin, Rathgeb, Frank, Vogt, Gerhard, Charissé, Gabriele, Fiebach, Jochen B, Schwab, Stefan, Schäbitz, Wolf R, Kollmar, Rainer, Fisher, Marc, Brozman, Miroslav, Skoloudik, David, and Gruber, Franz
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- 2013
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17. Granulocyte Colony—Stimulating Factor in Patients With Acute Ischemic Stroke.
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Bernd Ringelstein, E., Thijs, Vincent, Norrving, Bo, Chamorro, Angel, Aichner, Franz, Grond, Martin, Saver, Jeff, Laage, Rico, Schneider, Armin, Rathgeb, Frank, Vogt, Gerhard, Charissé, Gabriele, Fiebach, Jochen B., Schwab, Stefan, Schäbitz, Wolf R., Kollmar, Rainer, Fisher, Marc, Brozman, Miroslav, Skoloudik, David, and Gruber, Franz
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- 2013
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18. Intrazerebrale Blutung: Update zur Intensivtherapie
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Kollmar, Rainer, Unterberg, Andreas, and Steiner, Thorsten
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- 2015
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19. Head and Neck Cooling Decreases Tympanic and Skin Temperature, But Significantly Increases Blood Pressure.
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Koehn, Julia, Kollmar, Rainer, Cimpianu, Camelia-Lucia, Kallmünzer, Bernd, Moeller, Sebastian, Schwab, Stefan, and Hilz, Max J.
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- 2012
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20. A Structured Reading Algorithm Improves Telemetric Detection of Atrial Fibrillation After Acute Ischemic Stroke.
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Kallmiinzer, Bernd, Breuer, Lorenz, Hering, Christiane, Raaz-Schrauder, Dorette, Kollmar, Rainer, Huttner, Hagen B., Schwab, Stefan, and Kohrmann, Martin
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- 2012
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21. Weight approximation in stroke before thrombolysis: the WAIST-Study: a prospective observational "dose-finding" study.
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Breuer L, Nowe T, Huttner HB, Blinzler C, Kollmar R, Schellinger PD, Schwab S, Köhrmann M, Breuer, Lorenz, Nowe, Tim, Huttner, Hagen B, Blinzler, Christian, Kollmar, Rainer, Schellinger, Peter D, Schwab, Stefan, and Köhrmann, Martin
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- 2010
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22. AXIS: a trial of intravenous granulocyte colony-stimulating factor in acute ischemic stroke.
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Schäbitz WR, Laage R, Vogt G, Koch W, Kollmar R, Schwab S, Schneider D, Hamann GF, Rosenkranz M, Veltkamp R, Fiebach JB, Hacke W, Grotta JC, Fisher M, Schneider A, Schäbitz, Wolf R, Laage, Rico, Vogt, Gerhard, Koch, Winfried, and Kollmar, Rainer
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- 2010
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23. Granulocyte Colony–Stimulating Factor in Patients With Acute Ischemic Stroke
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Ringelstein, E. Bernd, Thijs, Vincent, Norrving, Bo, Chamorro, Angel, Aichner, Franz, Grond, Martin, Saver, Jeff, Laage, Rico, Schneider, Armin, Rathgeb, Frank, Vogt, Gerhard, Charissé, Gabriele, Fiebach, Jochen B., Schwab, Stefan, Schäbitz, Wolf R., Kollmar, Rainer, Fisher, Marc, Brozman, Miroslav, Skoloudik, David, Gruber, Franz, Leal, Joaquin Serena, Veltkamp, Roland, Köhrmann, Martin, Berrouschot, Jörg, Egerer, Gerlinde, Mikus, Gerd, Limmroth, Volker, Kieser, Meinhard, Bracoud, Luc, Fiebach, Jochen B., Hermier, Marc, Bouffard, Juliette, and Weber, Rüdiger
- Abstract
Granulocyte colony–stimulating factor (G-CSF; AX200; Filgrastim) is a stroke drug candidate with excellent preclinical evidence for efficacy. A previous phase IIa dose–escalation study suggested potential efficacy in humans. The present large phase IIb trial was powered to detect clinical efficacy in acute ischemic stroke patients.
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- 2013
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24. Preclinical and Clinical Studies Targeting Stroke
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Lyden, Moderator:Patrick, Gupta, Participants:Rishi, Kollmar, Rainer, and Lyden, Patrick D.
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- 2013
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25. Head and Neck Cooling Decreases Tympanic and Skin Temperature, But Significantly Increases Blood Pressure
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Koehn, Julia, Kollmar, Rainer, Cimpianu, Camelia-Lucia, Kallmünzer, Bernd, Moeller, Sebastian, Schwab, Stefan, and Hilz, Max J.
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Localized head and neck cooling might be suited to induce therapeutic hypothermia in acute brain injury such as stroke. Safety issues of head and neck cooling are undetermined and may include cardiovascular autonomic side effects that were identified in this study.
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- 2012
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26. A Structured Reading Algorithm Improves Telemetric Detection of Atrial Fibrillation After Acute Ischemic Stroke
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Kallmünzer, Bernd, Breuer, Lorenz, Hering, Christiane, Raaz-Schrauder, Dorette, Kollmar, Rainer, Huttner, Hagen B., Schwab, Stefan, and Köhrmann, Martin
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Anticoagulation is a highly effective secondary prevention in patients with cardioembolic stroke and atrial fibrillationflutter (AF). However, the condition remains underdiagnosed, because paroxysmal AF may be missed by diagnostic tests in the acute phase. In this study, the sensitivity of AF detection was assessed for serial electrocardiographic recordings and continuous stroke unit telemetric monitoring with or without a structured algorithm to analyze telemetric data (SEA-AF).
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- 2012
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27. Nachrichten aus der internationalen Fachliteratur
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Lichert, Frank, Schulz-Stübner, Sebastian, Gross, Horst, Ruchalla, Elke, Bone, Hans-Georg, Hossfeld, Björn, Bernhard, Michael, Pommer, Peter, and Kollmar, Rainer
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- 2012
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28. Weight Approximation in Stroke Before Thrombolysis
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Breuer, Lorenz, Nowe, Tim, Huttner, Hagen B., Blinzler, Christian, Kollmar, Rainer, Schellinger, Peter D., Schwab, Stefan, and Köhrmann, Martin
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Because of the narrow therapeutic range for thrombolysis in stroke, accurate weight-based dosing is essential for efficacy and safety. Stroke patients are frequently incapable to communicate their correct body weight (BW). Thus, dosing is often based on BW estimation, which may lead to dosing errors. The aim of our study was to evaluate availability of BW information, accuracy of estimations, and final dosing of Alteplase (tissue plasminogen activator tPA) in a routine clinical setting.
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- 2010
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29. AXIS
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Schäbitz, Wolf R., Laage, Rico, Vogt, Gerhard, Koch, Winfried, Kollmar, Rainer, Schwab, Stefan, Schneider, Dietmar, Hamann, Gerhard F., Rosenkranz, Michael, Veltkamp, Roland, Fiebach, Jochen B., Hacke, Werner, Grotta, James C., Fisher, Marc, and Schneider, Armin
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Granulocyte colony-stimulating factor (G-CSF) is a promising stroke drug candidate. The present phase IIa study assessed safety and tolerability over a broad dose range of G-CSF doses in acute ischemic stroke patients and explored outcome data.
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- 2010
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30. Hypothermia Reduces Perihemorrhagic Edema After Intracerebral Hemorrhage
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Kollmar, Rainer, Staykov, Dimitre, Dörfler, Arnd, Schellinger, Peter D., Schwab, Stefan, and Bardutzky, Jürgen
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The prognosis of spontaneous intracerebral hemorrhage (sICH) is poor because of the mass effect arising from the hematoma and the associated peri-hemorrhagic edema, leading to increased intracranial pressure. Because the efficacy of surgical and anti-edematous treatment strategies is limited, we investigated the effects of mild induced hypothermia in patients with large sICH.
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- 2010
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31. Critical illness polyneuropathy and myopathy in the intensive care unit
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Zink, Wolfgang, Kollmar, Rainer, and Schwab, Stefan
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Improvements in the survival of critically ill patients over the past few decades have led to an increased incidence of acquired muscular weakness in intensive care units. Zink and colleagues review the clinical and diagnostic features of critical illness polyneuropathy and myopathy and discuss preventive and therapeutic approaches to these severe and costly medical complications.
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- 2009
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32. Different Degrees of Hypothermia After Experimental Stroke
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Kollmar, Rainer, Blank, Tobias, Han, Junliang L., Georgiadis, Dimitrios, and Schwab, Stefan
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The neuroprotective role of mild therapeutic hypothermia was established in animal models of cerebral ischemia. Still, several issues, including optimal target temperature, remain unclear. The optimal depth of hypothermia in a rat model of focal cerebral ischemia was investigated.
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- 2007
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33. Rise of the machines
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Schwab, Stefan and Kollmar, Rainer
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- 2004
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34. Ice-cold saline for the induction of mild hypothermia in patients with acute ischemic stroke: a pilot study.
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Kollmar R, Schellinger PD, Steigleder T, Köhrmann M, Schwab S, Kollmar, Rainer, Schellinger, Peter D, Steigleder, Tobias, Köhrmann, Martin, and Schwab, Stefan
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- 2009
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35. Ice-Cold Saline for the Induction of Mild Hypothermia in Patients With Acute Ischemic Stroke
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Kollmar, Rainer, Schellinger, Peter D., Steigleder, Tobias, Ko[Combining Diaeresis]hrmann, Martin, and Schwab, Stefan
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Background and Purpose—Neuroprotective effects of induced hypothermia depend on its time point of initiation after acute brain injury. Preliminary studies in cardiac arrest patients indicate that rapid infusion of ice cold saline (ICS) is safe and effective for induction of hypothermia. We investigated its use in patients with acute ischemic stroke (AIS).
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- 2009
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36. Abstract 2653.
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Staykov, Dimitre, Wagner, Ingrid, Doerfler, Arnd, Schwab, Stefan, and Kollmar, Rainer
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- 2012
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