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This study is based on the coupling of geological field data with geophysical studies in the geological mapping of the Central Domain of the Mbere Division (Adamawa-Cameroon). The first step was to calculate the residual grid associated with the geophysical data that will be used for the mapping of the basement. The second step before mapping consisted in calculating the analytical signal associated with the residual grid, used to interpret the geological formations under cover or in intrusion. Subsequently, a geological mapping approach based on the categorisation of geophysical signatures into ranges using the Encom Discover program was adopted. This approach is based on the analysis of the relief of geophysical anomalies. The process of categorisation which is done iteratively, takes into consideration in the same georeferenced space, the resolution of the input data, the variation of the field considered and the structural model previously interpreted. The result of the categorisation is then compared to the spatial distribution of outcrop data to build the geological model. The application of this approach to the Central Domain of the Mbere Division led to the production of a synthetic geological map at a scale of 1/75,000. The superposition of this map to the topographic model allows to observe a concordance between the Cretaceous basins represented by their edge faults and the topographic depression zones. The various mineral indicators (primary and secondary) collected during the fieldwork, combined with the geological model (1:75,000 scale) as well as the Cretaceous deposits and vein intrusion models were used to create the mineral indicators and targets map for this sector. All these models can thus be used to underpin mineral exploration projects in the study area.