1. The landscape of genomic imprinting across diverse adult human tissues
- Author
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Baran, Yael, Subramaniam, Meena, Biton, Anne, Tukiainen, Taru, Tsang, Emily K., Rivas, Manuel A., Pirinen, Matti, Gutierrez-Arcelus, Maria, Smith, Kevin S., Kukurba, Kim R., Zhang, Rui, Eng, Celeste, Torgerson, Dara G., Urbanek, Cydney, Li, Jin Billy, Rodriguez-Santana, Jose R., Burchard, Esteban G., Seibold, Max A., MacArthur, Daniel G., Montgomery, Stephen B., Zaitlen, Noah A., and Lappalainen, Tuuli
- Abstract
Genomic imprinting is an important regulatory mechanism that silences one of the parental copies of a gene. To systematically characterize this phenomenon, we analyze tissue specificity of imprinting from allelic expression data in 1582 primary tissue samples from 178 individuals from the Genotype-Tissue Expression (GTEx) project. We characterize imprinting in 42 genes, including both novel and previously identified genes. Tissue specificity of imprinting is widespread, and gender-specific effects are revealed in a small number of genes in muscle with stronger imprinting in males. IGF2shows maternal expression in the brain instead of the canonical paternal expression elsewhere. Imprinting appears to have only a subtle impact on tissue-specific expression levels, with genes lacking a systematic expression difference between tissues with imprinted and biallelic expression. In summary, our systematic characterization of imprinting in adult tissues highlights variation in imprinting between genes, individuals, and tissues.
- Published
- 2015
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