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The employment of drugs acting on the central nervous system has been predicated largely on an empirical basis, the anticholinesterase compounds serving as an exception. As our understanding of the chemical constituents and their function in brain broadens, one can begin to see that basic theoretical information will be the foundation for new therapeutic approaches in this field. The observation that the effect of reserpine may be mediated through its action on liberating serotonin,2 the changes observed with diethylaminoethanol, an analogue of acetylcholine,3 and the utilization of antimetabolites of serotonin,4 all of which modify behavior, are a few examples of this theoretical approach.It has been found that iproniazid is a potent monoamine oxidase inhibitor in vivo,5 and since serotonin can be degraded by this enzyme, it is apparent that the mechanism of action of such a drug may result in an increase in cerebral serotonin,

Summary: A study was undertaken to determine the accuracy of the barium-enema examination in detecting carcinoma of the colon. It was divided into two parts, one to determine the accuracy of barium-enema examinations in proved cases of carcinoma of the colon and the second to determine the likelihood of false-positive reports of carcinoma based on such examinations. Of 707 cases in which lesions histologically proved to be carcinoma of the colon were located above the region of proctoscopic visualization, the lesion was either missed or misdiagnosed in 49 cases — an over-all diagnostic error of 6.9 per cent. If one excludes those carcinomas that were found but misinterpreted, those associated with chronic ulcerative colitis, and those recurring at anastomoses, the diagnostic accuracy in this series was 95.9 per cent. Of 577 cases in which a roentgenologic diagnosis of carcinoma of the colon was made, false-positive diagnoses were made in five cases—an error of 0.87 per cent. The difficulties in detecting carcinoma of the colon by means of the barium-enema examination are discussed. The overwhelming majority of the lesions missed were located either in the cecum or the sigmoid colon.

1. A new, specific and sensitive urinary assay for separate normetanephrine (NM) and separate metanephrine (M) is described. 2. This test employs high-voltage paper electrophoresis after passage of the urine through a resin column. 3. There is no difference in the urinary excretions of either separate NM or separate M in normotensive or hypertensive subjects. 4. Phaeochromocytoma patients excrete significantly larger amounts of separate NM and separate M than normotensive or hypertensive subjects. 5. Incorrect results are occasionally obtained with other urinary assay tests which measure either the combined metanephrines or different urinary catecholamine metabolites for the diagnosis of phaeochromocytoma.

Reports the implication of the deployment of broadband statewide for the economic output in Michigan. Increase of internet connections; Protection of citizens form natural disaster; Level of fluidity to financial structure.