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Introduction:Although Hutchinson’s sign can appear associated with benign conditions, dermoscopic findings of non-melanoma eponychium pigmentation have not yet been described in the literature. We report for the first time to our knowledge the dermoscopic findings of an acral nevus located in the proximal nail fold as well as its clinical-dermoscopic-histologic correlation. Case Report:A twenty-year-old patient presented with a homogeneous longitudinal melanonychia on the left-hand thumb, with benign dermoscopic pattern, and an irregular, 6-mm, dark-brown hyperpigmented macule on the adjacent eponychium (Hutchinson’s sign). The eponychium lesion showed on dermoscopy two irregular brown-black pigmented blotches, with superimposed parallel brown lines on a brushy distribution, with a thicker terminal end. The histopathologic examination of the proximal nail fold was performed, revealing scattered nevus cells in the epidermal basal layer and dermal-epidermal junction thecae, without any atypia or mitosis. These features were consistent with nevus of the proximal nail fold. Discussion:Previous descriptions of benign hyponychium’s pigmentations, despite the malignant appearance of the overlying melanonychia, were reported to have a similar dermoscopic pattern, known as longitudinal brushy pigmentation. This newly described dermoscopic sign on the eponychium may help distinguish Hutchinson’s sign related to subungual melanoma to non-melanoma Hutchinson’s sign.

El síndrome periódico asociado a la criopirina es una enfermedad rara y probablemente infradiagnosticada. Se presenta con manifestaciones sistémicas, entre ellas oftalmológicas, muy diversas, por lo que su diagnóstico supone un reto para el clínico. Presentamos el caso de una niña de 4 años en la que la identificación de papiledema en el examen oftalmológico constituyó el signo guía para el diagnóstico de síndrome periódico asociado a la criopirina. Pretendemos así concienciar sobre esta enfermedad de graves implicaciones y cuyo diagnóstico precoz resulta esencial para los afectados, para que sea tenido en cuenta con mayor frecuencia como diagnóstico diferencial.

Introducción Los tumores estromales gastrointestinales (GIST) son los tumores mesenquimales más frecuentes del tracto gastrointestinal. Han surgido numerosas publicaciones de GIST asociados con otras neoplasias.

In the field of molecular electronics, thin films of molecules adsorbed on insulating surfaces are used as the functional building blocks of electronic devices. Control of the structural and electronic properties of the thin films is required for reliably operating devices. Here, noncontact atomic force and Kelvin probe force microscopies have been used to investigate the growth and electrostatic landscape of pentacene on KBr(001) and KCl(001) surfaces. We have found that, together with molecular islands of upright standing pentacene, a new phase of tilted molecules appears near step edges on KBr. Local contact potential differences (LCPD) have been studied with both Kelvin experiments and density functional theory calculations. Our images reveal that differently oriented molecules display different LCPD and that their value is independent of the number of molecular layers. These results point to the formation of an interface dipole, which may be explained by a partial charge transfer from the pentacene to the surface. Moreover, the monitoring of the evolution of the pentacene islands shows that they are strongly affected by dewetting: Multilayers build up at the expense of monolayers, and in the Kelvin images, previously unknown line defects appear, which reveal the epitaxial growth of pentacene crystals.

Se evaluaron los resultados ecocardiográficos al mes en 22 pacientes con estenosis aórtica valvular tratados con prótesis CoreValve, con especial interés en la valoración de fugas valvulares y el grosor de paredes ventriculares izquierdas. Realizamos ecocardiograma previo al implante, al alta y al mes. La media de edad fue de 77 ± 4 años. Al alta 16 pacientes (76%) tenían regurgitación aórtica: 8 de grado I y 8 de grado II. Al mes sólo 13 (62%) la presentaban: 10 en grado I y 3 en grado II, y se redujo al menos un grado en 8 pacientes (38%) (p < 0,005). Se redujo el grosor septal (14,2 ± 2 mm basal frente a 11 ± 2,4 mm al mes; p < 0,001) y de pared posterior (10,9 ± 2,4 mm basal frente a 8,3 ± 1,2 mm al mes; p < 0,001).

The effects of the morphology of anatase TiO2substrates on the adsorption nature of Ru‐bipyridyl complexes with carboxylate groups as anchoring moieties have been investigated with infrared absorption spectroscopy and electron microscopy. The investigated dyes were the recently synthesized [Ru(dcbpyH2)2(bpy‐TPA2)](PF6)2, Ru‐TPA2, and the well‐known (Bu4N)2[Ru(dcbpyH)2(NCS)2], N719, complexes. As substrates, TiO2paste films and pristine anatase nanopowder were used. Scanning electron microscopy images show big differences in the grain size, shape, and dispersity of the titania nanoparticles. The attenuated total reflection Fourier transform infrared spectra suggest that the coordination of both complexes on the TiO2paste films occurs via bidentate or bridging linkage. The adsorption of the dyes on pristine anatase nanopowder appears to be via bridging or bidentate chelate linkage for the dye N719 as well, however, the Ru‐TPA2complex appears to bind via unidentate or ester‐like linkage or by direct physisorpion via H‐bonding.

El propósito de este estudio es analizar la relación entre foramen oval permeable e ictus criptogénico en pacientes de edad ≥ 55 años.

ABSTRACTManagement accounting Literature supports that the differential use of accounting based measures reflects different needs. However, literature on nonfinancial measures has practically focused on the importance/weight given to these measures in the firm performance measurement systems. We extend current knowledge by carrying this differential use of financial information over to nonfinancial information. Thus, in this paper, we argue that nonfinancial measures may also not be a monolithic category and, therefore, the phenomenon of an increase in their use could also be approached by posing the question of how nonfinancial information is used. From the analysis of thirty one cases of manufacturing firms we find that i)the perception of managers about the usefulness of nonfinancial information characteristics of relevance and reliability changes depending on the contextual scenarios the companies face, and ii)these perceptions result in the existence of two differential uses of nonfinancial measures.

Healthy human adults are able to hydrolyze dietary nucleic acids and nucleotides in the gastrointestinal tract, thus facilitating absorption of the resulting nucleosides. However, little is directly known of the ability of infants to hydrolyze nucleic acids early in life. Purified RNA (50, 100, 250, and 500 mg/L) in a suitable medium was exposed to jejunal explants of weaning piglets to determine if enzymes expressed by the explants were sufficient to hydrolyze the nucleic acid. Aliquots from the media were taken at time intervals, from 0 to 6 hours, and assayed for ribonucleoside content by high-performance liquid chromatography. The investigators found a significant increase of free ribonucleosides during the study period and for all RNA concentrations tested, thus suggesting that intestinal explants are able to hydrolyze RNA. The kinetics of nucleoside concentrations varied for each nucleoside. For example, inosine increased over the entire 6-hour period and adenosine increased for the first 2 hours, decreasing afterward. It is concluded that cells from the intestinal epithelium are capable of hydrolyzing RNA. These results suggest that RNA present in human milk is hydrolyzed in the intestinal tract of the breast-fed infant, thus providing an additional source of nucleosides. The results indicate that current supplementation of infant formulas with nucleotides should be reconsidered to take into account the contribution of RNA present in human milk to the pool of bioavailable nucleotides.

Healthy human adults are able to hydrolyze dietary nucleic acids and nucleotides in the gastrointestinal tract, thus facilitating absorption of the resulting nucleosides. However, little is directly known of the ability of infants to hydrolyze nucleic acids early in life.

This study was designed to characterize sperm migration in the female genital tract of Cebus apella. Forty-eight cycles of eighteen females mated during the periovulatory period were studied. Eggs were searched for and spermatozoa were counted in segmental fiushings of the genital tract performed in situ 1–7 h, 19–31 h, or 45–56 h after coitus. Of 14 eggs recovered, 8 were fertilized, thus assuring a reasonable normality of prefertilization phenomena in both males and females.A downward gradient of several orders of magnitude in sperm numbers was recognized from cervix to ampulla, particularly over the first interval. The population in the cervix and uterus decreased progressively between the first and last interval. Spermatozoa were recovered from the ampulla as early as 1 h after mating. Different trends were observed in the isthmus and ampulla. From the first to the last interval, sperm numbers decreased in the ampulla, but not in the isthmus. The number of spermatozoa recovered from the ampulla of the ovulatory side 1–31 h postcoitum was higher in postovulatory than in preovulatory monkeys, while in the nonovulatory side, recovery was similar in the two conditions. This finding suggests that the passage of spermatozoa up to the site of fertilization is under local control and is synchronized with ovulation.The pattern of sperm migration that emerges from these data bears similarities to the pattern in nonprimate species as well as distinctive features. A unique feature in common with the pattern in humans is the early establishment of a fairly abundant and persistent sperm population in the ampulla.