57 results on '"Liu, Shuwei"'
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2. Self-Assembly Reinforced Alginate Fibers for Enhanced Strength, Toughness, and Bone Regeneration
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Cui, Min, Liu, Shuwei, Xie, Xuelai, Yang, Jinhong, Wang, Tianyuan, Jiao, Yuyang, Lin, Min, and Sui, Kunyan
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Material reinforcement commonly exists in a contradiction between strength and toughness enhancement. Herein, a reinforced strategy through self-assembly is proposed for alginate fibers. Sodium alginate (SA) microstructures with regulated secondary structures are assembled in acidic and ethanol as reinforcing units for alginate fibers. Acidity increases the flexibility of the helix and contributes to enhanced extendibility. Ethanol is responsible for formation of a stiff β-sheet, which enhances the modulus and strength. The structurally engineered SA assembly exhibits robust mechanical compatibility, and thus reinforced alginate fibers possess an improved tensile strength of 2.1 times, a prolonged elongation of 1.5 times, and an enhanced toughness of 3.0 times compared with SA fibers without reinforcement. The reinforcement through self-assembly provides an understanding of strengthening and toughening mechanism based on secondary structures. Due to a similar modulus with bones, reinforced alginate fibers exhibit good efficacy in accelerating bone regeneration in vivo.
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- 2024
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3. L-Arginine self-delivery supramolecular nanodrug for NO gas therapy.
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Zhang, Mengsi, Jin, Hao, Liu, Yi, Wan, Lanlan, Liu, Shuwei, and Zhang, Hao
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EPIGALLOCATECHIN gallate ,MANNICH reaction ,BLOOD circulation ,ARGININE ,HYDROXYL group ,TUMOR treatment ,TUMOR microenvironment - Abstract
NO gas therapy is a supplementary approach for tumor treatment due to the advantages of minimal invasion, little drug resistance, low side effect and amplified efficacy. l -Arginine (L-Arg), a natural NO source with good biocompatibility, can release NO under the stimulation of H 2 O 2 in tumor microenvironment. However, the conventional l -Arg delivery systems via noncovalent loading usually lead to inevitable premature leakage of nano-cargos during blood circulation. In this work, an efficient l -Arg self-delivery supramolecular nanodrug (SDSND) for tumor treatment is demonstrated by combining Mannich reaction and π-π stacking. l -Arg links to (-)-epigallocatechin gallate (EGCG) with the assistance of formaldehyde through Mannich reaction, and then assembles into nanometer-sized particles via π-π stacking. The guanidine group of l -Arg and the phenolic hydroxyl groups of EGCG are preserved in the SDSNDs, which allows for accomplishing gas therapy by provoking tumor cell apoptosis and combining with EGCG to amplify apoptosis, respectively. In addition, the SDSNDs exhibit high biocompatibility and avoid the premature leakage of l -Arg in blood circulation, providing an alternative l -Arg delivery system for NO gas therapy. NO gas therapy has attracted emerging interest in tumor treatment. However, the controlled NO release and the avoidance of premature leakage of NO donors remain challenging. In this work, L-Arginine (L-Arg) self-delivery supramolecular nanodrug for efficient tumor therapy is demonstrated through the Mannich reaction of L-Arg, (-)-epigallocatechin gallate (EGCG) and formaldehyde. Stimulated by tumor microenvironment, the guanidine groups of L-Arg allow for accomplishing NO release and thus provoking tumor cell apoptosis. The nanodrug also avoids the premature leakage of L-Arg in blood circulation. Moreover, the preserved phenolic hydroxyl groups of EGCG combine with L-Arg to amplify apoptosis. The nanodrug exhibits high biocompatibility and good therapeutic effect, providing an alternative L-Arg delivery system for NO gas therapy. [Display omitted] [ABSTRACT FROM AUTHOR]
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- 2023
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4. Ferroptosis and Necroptosis Produced Autologous Tumor Cell Lysates Co-Delivering with Combined Immnoadjuvants as Personalized In Situ Nanovaccines for Antitumor Immunity.
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Shi, Wanrui, Feng, Wenjie, Li, Siyuan, Cui, Yanqi, Liu, Shuwei, Jiang, Huan, Liu, Yi, and Zhang, Hao
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- 2023
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5. Ferroptosis and Necroptosis Produced Autologous Tumor Cell Lysates Co-Delivering with Combined Immnoadjuvants as Personalized In SituNanovaccines for Antitumor Immunity
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Shi, Wanrui, Feng, Wenjie, Li, Siyuan, Cui, Yanqi, Liu, Shuwei, Jiang, Huan, Liu, Yi, and Zhang, Hao
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Nanovaccine-based immunotherapy has been considered as a major pillar to stimulate the host immune system to recognize and eradicate tumor cells as well as establish a long-term immune memory to prevent tumor relapse and metastasis. However, the weak specificity and low cross-presentation of antigens, as well as the immunosuppressive microenvironments of tumor tissues, are still the major obstacles on exerting the therapeutic performance of tumor nanovaccines sufficiently. Herein, we design and construct cytosine guanine dinucleotide (CpG) oligodeoxynucleotide (ODN)-loaded aluminum hydroxyphosphate nanoparticles covered by Fe-Shikonin metal-phenolic networks (MPNs) (Alum-CpG@Fe-Shikonin NPs) as personalized in situnanovaccines for antitumor immunity. Upon internalization by tumor cells, the shell of Fe-Shikonin MPNs will disassemble into Fe2+and Shikonin to elicit the immunogenic cell death of tumor cells through ferroptosis and necroptosis. Then, dying tumor cell-released autologous tumor cell lysates will be absorbed by Alum NPs and codelivered with CpG ODN to professional antigen-presenting cells temporally and spatially to activate multistep cascade antitumor immune responses, including dendritic cell maturation, antigen cross-presentation, natural killer cell and cytotoxic T lymphocyte infiltrations, and tumor-associated macrophage repolarization. Benefiting from the synergistic effects of Alum NPs, CpG ODN, and Fe-Shikonin MPNs, our Alum-CpG@Fe-Shikonin NPs exhibit drastic cytotoxicity and accurate selectivity on eradicating primary tumor, strong abscopal effect on inhibiting distant tumor, and a long-term immune memory effect on preventing tumor metastasis and recurrence. Because our report provides a feasible strategy to in situmake full use of autologous tumor cell lysates, which present an entire spectrum of the patient’s personal epitopes without complicated ex vivoprocesses, such as extraction, purification, and sequencing, it may promote the development of personalized nanovaccines for antitumor immunity.
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- 2023
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6. Fe3O4 Composite Superparticles with RGD/Magnetic Dual-Targeting Capabilities for the Imaging and Treatment of Non-Small Cell Lung Cancer.
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Zhao, Nan, Sun, Qirui, Zhang, Lening, Jin, Hao, Zhang, Mengsi, Liu, Shuwei, and Xin, Hua
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- 2023
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7. Iron-Containing Protein-Mimic Supramolecular Iron Delivery Systems for Ferroptosis Tumor Therapy.
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Liu, Shuwei, Zhang, Mengsi, Jin, Hao, Wang, Ze, Liu, Yi, Zhang, Songling, and Zhang, Hao
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- 2023
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8. Association of rs9939609 in FTOwith BMI among Polynesian peoples living in Aotearoa New Zealand and other Pacific nations
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Krishnan, Mohanraj, Phipps-Green, Amanda, Russell, Emily M., Major, Tanya J., Cadzow, Murray, Stamp, Lisa K., Dalbeth, Nicola, Hindmarsh, Jennie Harré, Qasim, Muhammad, Watson, Huti, Liu, Shuwei, Carlson, Jenna C., Minster, Ryan L., Hawley, Nicola L., Naseri, Take, Reupena, Muagututi’a Sefuiva, Deka, Ranjan, McGarvey, Stephen T., Merriman, Tony R., Murphy, Rinki, and Weeks, Daniel E.
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The fat mass and obesity associated (FTO) locus consistently associates with higher body mass index (BMI) across diverse ancestral groups. However, previous small studies of people of Polynesian ancestries have failed to replicate the association. In this study, we used Bayesian meta-analysis to test rs9939609, the most replicated FTOvariant, for association with BMI with a large sample (n= 6095) of Aotearoa New Zealanders of Polynesian (Māori and Pacific) ancestry and of Samoan people living in the Independent State of Samoa and in American Samoa. We did not observe statistically significant association within each separate Polynesian subgroup. Bayesian meta-analysis of the Aotearoa New Zealand Polynesian and Samoan samples resulted in a posterior mean effect size estimate of +0.21 kg/m2, with a 95% credible interval [+0.03 kg/m2, +0.39 kg/m2]. While the Bayes Factor (BF) of 0.77 weakly favors the null, the BF = 1.4 Bayesian support interval is [+0.04, +0.20]. These results suggest that rs9939609 in FTOmay have a similar effect on mean BMI in people of Polynesian ancestries as previously observed in other ancestral groups.
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- 2023
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9. Enhancing Tumor Therapy of Fe(III)-Shikonin Supramolecular Nanomedicine via Triple Ferroptosis Amplification.
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Feng, Wenjie, Shi, Wanrui, Wang, Ze, Cui, Yanqi, Shao, Xinxin, Liu, Shuwei, Rong, Li, Liu, Yi, and Zhang, Hao
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- 2022
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10. Stabilizing lithium plating in polymer electrolytes by concentration-polarization-induced phase transformation
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Cheng, Qian, Jin, Tianwei, Miao, Yupeng, Liu, Zhe, Borovilas, James, Zhang, Hanrui, Liu, Shuwei, Kim, So-Yeon, Zhang, Ruiwen, Wang, Haozhen, Chen, Xi, Chen, Long-Qing, Li, Ju, Min, Wei, and Yang, Yuan
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It is widely accepted that concentration polarization in liquid electrolytes promotes whisker growth during metal deposition, and therefore, high salt concentration is favored. Here, we report unexpected opposite behaviors in solid polymer electrolytes: concentration polarization can induce phase transformation in a polyethylene oxide (PEO) electrolyte, forming a new PEO-rich but salt-/plasticizer-poor phase at the lithium/electrolyte interface, as unveiled by stimulated Raman scattering microscopy. The new phase has a significantly higher Young’s modulus (∼1–3 GPa) than a bulk polymer electrolyte (<1 MPa). We hereby propose a design rule for PEO electrolytes: their compositions should be near the boundary between single-phase and two-phase regions in the phase diagram so that the applied current can induce the formation of a mechanically rigid PEO-rich phase to suppress lithium whiskers. LiFePO4/PEO/Li cells with concentration-polarization-induced phase transformation can be reversibly cycled 100 times, while cells without such transformation fail within 10 cycles, demonstrating the effectiveness of this strategy.
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- 2022
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11. Copper Ion and Ruthenium Complex Codoped Polydopamine Nanoparticles for Magnetic Resonance/Photoacoustic Tomography Imaging-Guided Photodynamic/Photothermal Dual-Mode Therapy.
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Zhang, Mengsi, Wang, Lu, Liu, Heng, Wang, Ze, Feng, Wenjie, Jin, Hao, Liu, Shuwei, Lan, Shijie, Liu, Yi, and Zhang, Hao
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- 2022
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12. Annual NO and N2O emissions under different fertilisation regimes from a greenhouse vegetable cropping system in subtropical China
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Lin, Feng, Zhang, Yaojun, McDaniel, Marshall D., Liu, Shuwei, and Zou, Jianwen
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Context Overuse of N fertiliser in vegetable cropping systems is known to release of nitric and nitrous oxide to the atmosphere in China. Optimisation of N fertilisation regimes has the potential to mitigate NO and N2 O emissions from these N-rich systems. Aims We investigated the effects of different N fertilisation regimes on NO and N2 O emissions, and vegetable yields, with particular efforts to estimate annual direct emission factors of NO and N2 O under different N fertilisation regimes in greenhouse vegetable fields. Methods Annual NO and N2 O fluxes were taken simultaneously using the static chamber-based method from a greenhouse vegetable system in south-east China with four N fertiliser treatments: (1) no N fertiliser (control); (2) chemical N fertiliser application (CF); (3) organic N fertiliser application (OF); and (4) organic-chemical mixed N fertiliser application (MF). Key results N fertilisers significantly increased NO and N2 O emissions. Direct emission factors of N fertiliser for NO and N2 O were the largest for MF, with an average of 0.99% and 0.67%, respectively. Vegetable yields were only significantly enhanced under OF treatment. Conclusions Relative to the use of chemical N fertiliser, the application of organic-chemical mixed N fertiliser showed not to be effective for mitigating NO and N2 O emissions. Instead, sole application of organic N fertiliser was a viable option to enhance vegetable yields but without increasing NO and N2 O emissions in greenhouse vegetable systems. Implications Substituting the use of chemical N fertiliser with organic N fertiliser input could benefitvegetable production but without stimulating NO and N2 O emissions from vegetable cropping systems in sub-tropical China.
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- 2022
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13. Elevated CO2negates O3impacts on terrestrial carbon and nitrogen cycles
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Xia, Longlong, Lam, Shu Kee, Kiese, Ralf, Chen, Deli, Luo, Yiqi, van Groenigen, Kees Jan, Ainsworth, Elizabeth A., Chen, Ji, Liu, Shuwei, Ma, Lei, Zhu, Yuhao, and Butterbach-Bahl, Klaus
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Increasing tropospheric concentrations of ozone (e[O3]) and carbon dioxide (e[CO2]) profoundly perturb terrestrial ecosystem functions through carbon and nitrogen cycles, affecting beneficial services such as their capacity to combat climate change and provide food. However, the interactive effects of e[O3] and e[CO2] on these functions and services remain unclear. Here, we synthesize the results of 810 studies (9,109 observations), spanning boreal to tropical regions around the world, and show that e[O3] significantly decreases global net primary productivity and food production as well as the capacity of ecosystems to store carbon and nitrogen, which are stimulated by e[CO2]. More importantly, simultaneous increases in [CO2] and [O3] negate or even overcompensate the negative effects of e[O3] on ecosystem functions and carbon and nitrogen cycles. Therefore, the negative effects of e[O3] on terrestrial ecosystems would be overestimated if e[CO2] impacts are not considered, stressing the need for evaluating terrestrial carbon and nitrogen feedbacks to concurrent changes in global atmospheric composition.
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- 2021
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14. Type-I Collagen Polypeptide-Based Composite Nanofiber Membranes for Fast and Efficient Bone Regeneration
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Jin, Hao, Zhu, Xuanqi, Liu, Heng, Wang, Lu, Liu, Shuwei, and Zhang, Hao
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The clinical treatment of bone defects includes allogeneic bone transplantation and autologous bone transplantation. However, they all have their own limitations, and the scope of application is limited. In recent years, bone tissue engineering scaffolds based on a variety of materials have been well developed and achieved good bone regeneration ability. However, most scaffold materials always face problems such as high biotoxicity, leading to inflammation and poor bioactivity, which limits the bone regeneration effect and prolongs the bone regeneration time. In our work, we prepared hydroxyapatite, erythropoietin (EPO), and osteogenic growth peptide (OGP) codoped type-I collagen (Col I) polypeptide nanofiber membranes (NFMs) by electrostatic spinning. In cell experiments, the composite NFMs had low cytotoxicity and promoted osteogenic differentiation of rat bone marrow mesenchymal stem cells. Quantitative real-time polymerase chain reaction and alkaline phosphatase staining confirmed the high expression of osteogenic genes, and alizarin red S staining directly confirmed the appearance of calcium nodules. In animal experiments, the loaded hydroxyapatite formed multiple independent mineralization centers in the defect center. Under the promotion of Col I, EPO, and OGP, the bone continued to grow along the mineralization centers as well as inward the defect edge, and the bone defect completely regenerated in about two months. The hematological and histological analyses proved the safety of the experiments. This kind of design to promote bone regeneration by simulating bone composition, introducing mineralization center and signal molecules, can shorten repair time, improve repair effect, and has good practical prospects in the future.
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- 2024
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15. Transforming Passive Employee Engagement Into Active Engagement: Supervisor Development Feedback Valences on Feedback-Seeking Behavior
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Liu, Shuwei, Wang, Jiyong, and Wang, Rui
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Employees’ feedback-seeking behavior is an important way to develop and maintain self-awareness and interpersonal acuity, reduce uncertainty, boost creativity and improve innovative behavior and performance. Especially during the COVID-19 pandemic, working from home has become the new normal, supervisor feedback and employees feedback-seeking has an increasingly important impact on team creativity and team innovation performance.In the practice of organizational management, there is frequently a “feedback vacuum” between managers and employees. There is increasing research on feedback-seeking behavior in the field of OBHRM. This paper is the first to evaluate the impact of work meaning and positive attributions on workers’ feedback-seeking behavior, and the cross-level effects of supervisor development feedback including variable valence. The paper analyzes supervisor-employee paired data from 158 supervisors and 659 employees using multi-source, multi-temporal data to draw the following conclusions: (1) Positive supervisor development feedback has a significant cross-level positive effect on employee feedback-seeking behavior, whereas negative supervisor development feedback does not affect employee feedback-seeking behavior; (2) Work meaningfulness mediates the cross-level relationship between positive supervisor development feedback and employees’ feedback-seeking behaviors, whereas negative supervisor development feedback and employees’ feedback-seeking behaviors do not; (3) Positive attributions positively moderate the relationship between positive supervisor development feedback and work meaningfulness; while positively moderating the relationship between negative supervisor development feedback and work meaningfulness; (4) Positive attributions have a moderating effect on supervisor development feedback that influences the indirect relationship to feedback-seeking behavior by work meaningfulness.
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- 2024
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16. Cu(II)-Doped Polydopamine-Coated Gold Nanorods for Tumor Theranostics
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Liu, Shuwei, Wang, Lu, Lin, Min, Wang, Dandan, Song, Ziqi, Li, Shuyao, Ge, Rui, Zhang, Xue, Liu, Yi, Li, Zhimin, Sun, Hongchen, Yang, Bai, and Zhang, Hao
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Gold nanorods (AuNRs) are potentially useful in tumor theranostics, but the poor stability, high toxicity, and rapid removal by the immune system seriously limit their theranostic applications. In our study, we demonstrate the fabrication of Cu(II)-doped polydopamine-coated AuNR (AuNR@CuPDA), which significantly improves the potentials in tumor theranostics. Besides the improvement of physiological stability and biocompatibility, the PDA shell increases the photothermal performance and prolongs the blood circulation time of AuNRs. The half-life of AuNRs during blood circulation increases from 0.7 to 4.5 h after PDA coating, and the injected dose per gram of tumor tissue is 4.6% ID g–1for AuNR@CuPDA. In addition to computer tomography imaging, the loading of Cu(II) in PDA shell endows AuNR@CuPDA with magnetic resonance imaging function. Cu(II) doped in PDA shell also exhibits chemotherapeutic behavior, and the tumor inhibitor rate is 31.2%. Further combining 808 nm laser-driven photothermal therapy, tumors were completely ablated, and no recurrence was observed. Liver and renal functions tests and histological analysis of major organs confirm that AuNR@CuPDA is in good safety.
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- 2024
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17. Mitigation of N2O emissions in water-saving paddy fields: Evaluating organic fertilizer substitution and microbial mechanisms
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Kong, Delei, Zhang, Xianduo, Yu, Qidong, Jin, Yaguo, Jiang, Peikun, Wu, Shuang, Liu, Shuwei, and Zou, Jianwen
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Water-saving irrigation strategies can successfully alleviate methane emissions from rice fields, but significantly stimulate nitrous oxide (N2O) emissions because of variations in soil oxygen level and redox potential. However, the relationship linking soil N2O emissions to nitrogen (N) functional genes during various fertilization treatments in water-saving paddy fields has rarely been investigated. Furthermore, the mitigation potential of organic fertilizer substitution on N2O emissions and the microbial mechanism in rice fields must be further elucidated. Our study examined how soil N2O emissions were affected by related functional microorganisms [ammonia-oxidizing archaea (AOA), ammonia-oxidizing bacteria (AOB), nirS, nirKand nosZ] to various fertilization treatments in a rice field in southeast China over two years. In this study, three fertilization regimes were applied to rice cultivation: a no nitrogen (N) (Control), an inorganic N (Ni), and an inorganic N with partial N substitution with organic manure (Ni+No). Over two rice-growing seasons, cumulative N2O emissions averaged 0.47, 4.62 and 4.08 kg ha−1for the Control, Niand Ni+Notreatments, respectively. In comparison to the Nitreatment, the Ni+Nofertilization regime considerably reduced soil N2O emissions by 11.6% while maintaining rice yield, with a lower N2O emission factor from fertilizer N (EF) of 0.95%. Nitrogen fertilization considerably raised the AOB, nirS, nirKand nosZgene abundances, in comparison to the Control treatment. Moreover, the substitution of organic manure for inorganic N fertilizer significantly decreased AOB and nirSgene abundances and increased nosZgene abundance. The AOB responded to N fertilization more sensitively than the AOA. Total N2O emissions significantly correlated positively with AOB and nirSgene abundances while having a negative correlation with nosZgene abundance and the nosZ/nirSratio across N-fertilized plots. In summary, we conclude that organic manure substitution for inorganic N fertilizer decreased soil N2O emissions primarily by changing the soil NO3−-N, pH and DOC levels, thus inhibiting the activities of ammonia oxidation in nitrification and nitrite reduction in denitrification, and strengthening N2O reduction in denitrification from water-saving rice paddies.
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- 2024
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18. Microstructure and mechanical properties of Al/steel dissimilar welds fabricated by friction surfacing assisted friction stir lap welding
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Zhou, Li, Yu, Mingrun, Liu, Baiyang, Zhang, Zili, Liu, Shuwei, Song, Xiaoguo, and Zhao, Hongyun
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Al/steel dissimilar welds were obtained by friction stir lap welding (FSLW) with an Al interlayer, which was fabricated by friction surfacing (FS). In present study, the tool pin was totally plunged into the Al plate and interlayer without stirring steel, which avoided the tool wear. The Al plate and interlayer were remarkably intermixed as pin length increased. A diffusion layer, instead of the intermetallic layer, was found at the Al/steel interface, indicating the enhanced atomic migration and related interfacial bonding. The maximum failure load of the joints of 2.8kN was reached when the 2.5mm pin tool was used. The heterogeneous microstructure, which was caused by the intermixing, was responsible for the fracture, according to the fracture profiles. Necking and dimples were depicted from the fractographies, indicating that the joints were failed by plastic fracture.
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- 2020
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19. Tumor Microenvironment-Responsive Nanoshuttles with Sodium Citrate Modification for Hierarchical Targeting and Improved Tumor Theranostics.
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Liu, Shuwei, Wang, Lu, Zhang, Mengsi, Tao, Kepeng, Wang, Bo, Lin, Min, Zhang, Xue, Liu, Yi, Hou, Yuchuan, Zhang, Hao, and Yang, Bai
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- 2019
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20. High Methane Emissions Largely Attributed to Ebullitive Fluxes from a Subtropical River Draining a Rice Paddy Watershed in China.
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Wu, Shuang, Li, Shuqing, Zou, Ziheng, Hu, Tao, Hu, Zhiqiang, Liu, Shuwei, and Zou, Jianwen
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- 2019
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21. Gas-Flow-Driven Aligned Growth of Graphene on Liquid Copper.
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Xue, Xudong, Xu, Qiang, Wang, Huaping, Liu, Shuwei, Jiang, Qianqing, Yu, Zhiwei, Zhou, Xiahong, Ma, Tianbao, Wang, Liping, and Yu, Gui
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- 2019
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22. Divergent effects of biochar amendment and replacing mineral fertilizer with manure on soil respiration in a subtropical tea plantation
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Han, Zhaoqiang, Xu, Pinshang, Li, Zhutao, Guo, Shumin, Li, Shuqing, Liu, Shuwei, Wu, Shuang, Wang, Jinyang, and Zou, Jianwen
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Manure application rather than biochar amendment increased acidic soil respiration.Biochar application promoted soil C sequestration in the tea plantation.Manure application stimulated CO2emissions by altering ecological clusters’ abundance.Gemmatimonadetesmight be the dominant hosts for C-cycling genes.
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- 2023
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23. Tumor Microenvironment-Responsive Nanoshuttles with Sodium Citrate Modification for Hierarchical Targeting and Improved Tumor Theranostics
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Liu, Shuwei, Wang, Lu, Zhang, Mengsi, Tao, Kepeng, Wang, Bo, Lin, Min, Zhang, Xue, Liu, Yi, Hou, Yuchuan, Zhang, Hao, and Yang, Bai
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Enhancement of permeability and the retention effect is one of the main pathways for the accumulation of nanomaterials in tumor sites, but poor cellular internalization and rapid clearance of nanomaterials always hamper the efficacy of imaging diagnosis and treatment. With the consideration of both high tumor accumulation and cellular internalization, positively charged nanomaterials can adhere to the tumor cell membrane by an electrostatic force, which is conducive to cellular internalization, but they are easily recognized and cleared during blood circulation. However, negatively charged nanomaterials show an enhanced stealth-like effect and possess a long blood circulation time, which is conducive to tumor accumulation. Therefore, in this work, on the basis of the shielding effect of citrate ions to positive charge and the protonation under an acidic tumor microenvironment, pH-sensitive sodium citrate-modified polyaniline nanoshuttles (NSs) with negative charge during blood circulation but positive charge in tumor sites are designed. With this hierarchical targeting strategy, the blood circulation half-life increases from 4.35 to 7.33 h, and the retention rate of NSs in tumors increases from 5.29 to 8.57% ID/g. Because the retention rate of NSs is increased, the magnetic resonance imaging resolution and signal intensity are significantly improved. A synergistic treatment of tumors is further achieved by means of photothermal therapy with laser irradiation and chemotherapy via heat-stimulated drug release.
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- 2019
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24. High Methane Emissions Largely Attributed to Ebullitive Fluxes from a Subtropical River Draining a Rice Paddy Watershed in China
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Wu, Shuang, Li, Shuqing, Zou, Ziheng, Hu, Tao, Hu, Zhiqiang, Liu, Shuwei, and Zou, Jianwen
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Rivers are of increasing concern as sources of atmospheric methane (CH4), while estimates of global CH4emissions from rivers are poorly constrained due to a lack of representative measurements in tropical and subtropical latitudes. Measurements of complete CH4flux components from subtropical rivers draining agricultural watersheds are particularly important since these rivers are subject to large organic and nutrient loads. Two-year measurements of CH4fluxes were taken to assess the magnitude of CH4emissions from the Lixiahe River (a tributary of the Grand Canal) draining a subtropical rice paddy watershed in China. Over the two-year period, annual CH4emissions averaged 29.52 mmol m–2d–1, amounting to 10.78 mol m–2yr–1, making the river a strong source of atmospheric CH4. The CH4emissions from rivers during the rice-growing season (June–October) accounted for approximately 70% of the annual total, with flux rates at 1–2 orders of magnitude greater than those for rice paddies in this area. Ebullition contributed to 44–56% of the overall CH4emissions from the rivers and dominated the emission pathways during the summer months. Our data highlight that rivers draining agricultural watersheds may constitute a larger component of anthropogenic CH4emissions than is currently documented in China.
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- 2019
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25. Gas-Flow-Driven Aligned Growth of Graphene on Liquid Copper
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Xue, Xudong, Xu, Qiang, Wang, Huaping, Liu, Shuwei, Jiang, Qianqing, Yu, Zhiwei, Zhou, Xiahong, Ma, Tianbao, Wang, Liping, and Yu, Gui
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- 2019
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26. Multidrug resistant tumors-aimed theranostics on the basis of strong electrostatic attraction between resistant cells and nanomaterialsElectronic supplementary information (ESI) available: Additional element distribution, UV-vis-NIR absorption spectra of VCR, TGA spectrum, zeta potential, IR thermal images, ESR spectrum, MRI, colloidal and photothermal stabilities, flow cytometry, cell viabilities, nonspecific cellular adhesion of CuPani and VCR-PEG-CuPani NSs, drug release curves and SEM images. See DOI: 10.1039/c9bm01017c
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Liu, Shuwei, Wang, Lu, Li, Shuyao, Meng, Xuya, Sun, Bin, Zhang, Xue, Zhang, Lening, Liu, Yi, Lin, Min, Zhang, Hao, and Yang, Bai
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Chemotherapy is one of the most common and effective ways for the clinical treatment of tumors, but tumor cells develop resistance toward drugs after a long period of chemotherapy. Interestingly, the gene expression of resistant cells usually generates increased sialic acid and raises the negative potential of the cell membranes, which is potentially useful to design novel theranostic models. In this work, we demonstrate multidrug resistant tumors-aimed theranostics by the virtue of the strong electrostatic attraction between resistant cells and nanomaterials. Human oral epithelial carcinoma vincristine-resistant tumor (KBV) and human oral epithelial carcinoma tumor (KB) were employed and compared as the tumor models. Polyethylene glycol-coated and Cu(ii) and vincristine codoped polyaniline nanoshuttles (VCR-PEG-CuPani NSs), which possessed multifunctions, positive charges, and blood circulation half-life of 6.26 ± 0.16 h, were employed as the nanomaterials for performing the tumor theranostics. Because of the stronger electrostatic attraction with KBV than that with KB, VCR-PEG-CuPani NSs showed higher enrichment of 8.05 ± 0.39% ID g−1for KBV and a lower value of 6.02 ± 0.22% ID g−1for KB. The higher accumulation of VCR-PEG-CuPani NSs in KBV tumors further improved the efficacy of tumor theranostics, such as those using magnetic resonance imaging, chemotherapy, and photothermal therapy.
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- 2019
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27. Targeted multifunctional nanomaterials with MRI, chemotherapy and photothermal therapy for the diagnosis and treatment of bladder cancerElectronic supplementary information (ESI) available: Additional UV absorption spectra of VCR, IR thermal images, colloidal stability, MRI performance of Fe3O4@PDA-VCR-FA SPs and the content of VCR released from Fe3O4@PDA-VCR SPs. See DOI: 10.1039/c9bm01377f
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TaoThese authors contributed equally., Kepeng, Liu, Shuwei, Wang, Lu, Qiu, Heping, Li, Binxi, Zhang, Mengsi, Guo, Mengyuan, Liu, Heng, Zhang, Xue, Liu, Yi, Hou, Yuchuan, and Zhang, Hao
- Abstract
Bladder cancer is a common urinary tract tumor in clinic, and its morbidity and mortality are always high. Surgical treatment is operator dependent, residual tumor cells often lead to tumor recurrence, and chemotherapy after surgery causes high side effects. So, it is urgent to develop new methods for the theranostics of bladder cancer. Among them, functional nanomaterials have shown good application in tumor theranostics, but they are rarely used in bladder cancer. In our work, we demonstrate the fabrication of folate-modified vincristine-loaded polydopamine-coated Fe3O4superparticles (Fe3O4@PDA-VCR-FA SPs), and applied them in the theranostics of bladder cancer. The PDA shell not only improves the colloidal stability and biocompatibility, but also enhances the photothermal effect and prolongs the blood circulation half-life. The half-life of Fe3O4@PDA-VCR-FA SPs in blood is calculated as 2.83 h, and the tumor retention rate is 5.96 %ID g−1, these data are significantly higher than those before folic acid modification. The superparamagnetism of Fe3O4and loading of vincristine endow Fe3O4@PDA-VCR-FA SPs with magnetic resonance imaging and chemotherapy capabilities. Further by employing NIR laser-triggered photothermal therapy, bladder tumors were ablated completely, and no recurrence was observed. Blood and histological tests of the major organs confirm that Fe3O4@PDA-VCR-FA SPs show good biosafety.
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- 2019
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28. Synthesis of reduced cubic phase WO3−xnanosheet by direct reduction of H2WO4·H2O
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Fang, Zhenxing, Jiao, Shihui, Wang, Boran, Yin, Wen, Liu, Shuwei, Gao, Ruiqin, Liu, Zihe, Pang, Guangsheng, and Feng, Shouhua
- Abstract
The cubic phase WO3−xwith two-dimensional nanosheet structure is prepared at a relative low temperature through thermal decomposition method. The starting material and decomposition environment are the key factors to obtain the cubic phase WO3−x. The cubic crystal structure is stabilized by the large amounts of oxygen vacancies. The dark blue cubic WO3−xexhibits electrocatalysis performance for hydrogen evolution reaction (HER) in acidic solution (an overpotential −294 mV at the current density of 10 mA/cm2). The cubic phase WO3−xshows good photothermal stability with eminent photothermal conversion effect (photothermal conversion efficiency is 48.7% at 808 nm).
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- 2017
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29. Spatiotemporal variations of dissolved CH4 concentrations and fluxes from typical freshwater types in an agricultural irrigation watershed in Eastern China.
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Zhang, Tianrui, Wu, Shuang, Fang, Xiantao, Han, Zhaoqiang, Li, Shuqing, Wang, Jinyang, Liu, Shuwei, and Zou, Jianwen
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DISSOLVED oxygen in water ,FRESH water ,IRRIGATION ,METHANE ,WATERSHEDS ,WIND speed - Abstract
Inland freshwater ecosystems are of increasing concerns in global methane (CH 4) budget in the atmosphere. Agricultural irrigation watersheds are a potential CH 4 emission hotspot owing to the anthropogenic carbon and nutrients loading. However, large-scale spatial variations of CH 4 concentrations and fluxes in agricultural catchments remain poorly understood, constraining an accurate regional estimate of CH 4 budgets. Here, we examined the spatiotemporal variations of dissolved CH 4 concentrations and fluxes from typical freshwater types (ditch, reservoir and river) within an agricultural irrigation watershed from Hongze catchment, which is subjected to intensive agricultural and rural activities in Eastern China. The dissolved CH 4 concentrations and fluxes showed similar temporal variations among the three freshwater types, with the highest rates in summer and the lowest rates in winter. The total CH 4 emission from this agricultural irrigation watershed was estimated to be 0.002 Gg CH 4 yr
−1 , with annual mean CH 4 concentration and flux of 0.12 μmol L−1 and 0.58 mg m−2 d−1 , respectively. Diffusive CH 4 fluxes varied in samples taken from different freshwater types, the annual mean CH 4 fluxes for ditch, reservoir and river were 0.31 ± 0.06, 0.71 ± 0.13 and 0.72 ± 0.25 mg m−2 d−1 , respectively. Among three freshwater types, the CH 4 fluxes were the lowest in ditch, which was associated with the lowest responses of CH 4 fluxes to water dissolved oxygen (DO), nitrate nitrogen (NO 3− -N) and sediment dissolved organic carbon (DOC) concentrations in ditch. In addition, water velocity and wind speed were significantly lower in ditch than in reservoir and river, suggesting that they also played important roles in explaining the spatial variability of dissolved CH 4 concentrations and fluxes. These results highlighted a need for more field measurements with wider spatial coverage and finer frequency, which would further improve the reliability of flux estimates for assessing the contribution of agricultural watersheds to the regional and global CH 4 budgets. [Display omitted] • CH 4 concentrations and fluxes showed similar temporal variations among water types. • The CH 4 fluxes were significantly lower in ditches than in reservoirs and rivers. • The most sensitive responses of CH 4 fluxes to water parameters were found in rivers. • Water velocity and wind speed are responsible for spatial variability of CH 4 fluxes. [ABSTRACT FROM AUTHOR]- Published
- 2022
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30. Cu2+-Loaded Polydopamine Nanoparticles for Magnetic Resonance Imaging-Guided pH- and Near-Infrared-Light-Stimulated Thermochemotherapy
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Ge, Rui, Lin, Min, Li, Xing, Liu, Shuwei, Wang, Wenjing, Li, Shuyao, Zhang, Xue, Liu, Yi, Liu, Lidi, Shi, Feng, Sun, Hongchen, Zhang, Hao, and Yang, Bai
- Abstract
Cancer multimodal treatment by combining the effects of different theranostics agents can efficiently improve treatment efficacy and reduce side effects. In this work, we demonstrate the theranostics nanodevices on the basis of Cu2+-loaded polydopamine nanoparticles (CuPDA NPs), which are able to offer magnetic resonance imaging (MRI)-guided thermochemotherapy (TCT). Systematical studies reveal that after Cu2+ions loading, the molar extinction coefficient of PDA NPs is greatly enhanced by 4 times, thus improving the performance in photothermal therapy. Despite Cu2+ions being toxic, the release of Cu2+is mainly stimulated in acidic environment. Once the NPs deposit in the slightly acidic tumor microenvironment (pH ≈ 6.5–6.8), the release rate boosts ∼30%, which effectively avoids the systematic toxicity during chemotherapy. Meanwhile, due to the increment of the electron–proton dipole–dipole interaction correlation time τC, the spin–lattice relaxation time (T1) for PDA NPs is found to be shortened by Cu2+loading, which boosts the longitudinal relaxivity (r1). Hence, CuPDA NPs can be used as T1-weighted contrast agent in MRI. In addition, due to the naturally existing DA in the human body with stealth effect, CuPDA NPs have an outstanding tumor retention rate as high as 8.2% ID/g. Further in vitro and in vivo tests indicate that CuPDA NPs possess long blood circulation time, good photothermal and physiological stability, and biocompatibility, which are potential nanodevices for MRI-guided TCT with minimal side effects.
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- 2017
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31. Direct Chemical-Vapor-Deposition-Fabricated, Large-Scale Graphene Glass with High Carrier Mobility and Uniformity for Touch Panel Applications
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Sun, Jingyu, Chen, Zhaolong, Yuan, Long, Chen, Yubin, Ning, Jing, Liu, Shuwei, Ma, Donglin, Song, Xiuju, Priydarshi, Manish K., Bachmatiuk, Alicja, Rümmeli, Mark H., Ma, Tianbao, Zhi, Linjie, Huang, Libai, Zhang, Yanfeng, and Liu, Zhongfan
- Abstract
In this work, we report the transfer-free measurement of carrier dynamics and transport of direct chemical vapor deposition (CVD) grown graphene on glass with the aid of ultrafast transient absorption microscopy (TAM) and demonstrate the use of such graphene glass for high-performance touch panel applications. The 4.5 in.-sized graphene glass was produced by an optimized CVD procedure, which can readily serve as transparent conducting electrode (TCE) without further treatment. The graphene glass exhibited an intriguing optical transmittance and electrical conductance concurrently, presenting a sheet resistance of 370–510 Ω·sq–1at a transmittance of 82%, much improved from our previous achievements. Moreover, direct measurement of graphene carrier dynamics and transport by TAM revealed the similar biexponential decay behavior to that of CVD graphene grown on Cu, along with a carrier mobility as high as 4820 cm2·V–1·s–1. Such large-area, highly uniform, transparent conducting graphene glass was assembled to integrate resistive touch panels that demonstrated a high device performance. Briefly, this work aims to present the great feasibility of good quality graphene glass toward scalable and practical TCE applications.
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- 2016
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32. Influence of tribofilm on superlubricity of highly-hydrogenated amorphous carbon films in inert gaseous environments
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Liu, ShuWei, Zhang, ChenHui, Osman, Eryilmaz, Chen, XinChun, Ma, TianBao, Hu, YanZhong, Luo, JianBin, and Ali, Erdemir
- Abstract
In this study, we mainly focus on the structural morphology and inter-atomic bonding state of tribofilms resulting from a highly-hydrogenated amorphous carbon (a-C:H) film in order to ascertain the underlying mechanisms for its superlubric behavior (i.e., less than 0.01 friction coefficient). Specifically, we achieved superlubricity (i.e., friction coefficients of down to 0.003) with this film in dry nitrogen and argon atmospheres especially when the tribo-pair is made of an a-C:H coated Si disk sliding against an a-C:H coated steel ball, while the a-C:H coated disk against uncoated ball does not provide superlubricity. We also found that the state of superlubricity is more stable in argon than in nitrogen and the formation of a smooth and uniformly-thick carbonaceous tribofilm appears to be one of the key factors for the realization of such superlubricity. Besides, the interfacial morphology of sliding test pairs and the atomic-scale bond structure of the carbon-based tribofilms also play an important role in the observed superlubric behavior of a-C:H films. Using Raman spectroscopy and high resolution transmission electron microscopy, we have compared the structural differences of the tribofilms produced on bare and a-C:H coated steel balls. For the a-C:H coated ball as mating material which provided superlow friction in argon, structural morphology of the tribofilm was similar or comparable to that of the original a-C:H coating; while for the bare steel ball, the sp2-bonded C fraction in the tribofilm increased and a fingerprint-like nanocrystalline structure was detected by high resolution transmission electron microscopy (HRTEM). We also calculated the shear stresses for different tribofilms, and established a relationship between the magnitude of the shear stresses and the extent of sp3-sp2phase transformation.
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- 2016
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33. Associating occupants' interaction with windows with air change rate --One case study.
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Liu, Shuwei, Jian, Yiwen, Liu, Jingjing, Guo, Ruimin, and Zhu, Wenbo
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NATURAL ventilation ,KALMAN filtering ,INDOOR air quality ,SPRING ,RESIDENTIAL mobility - Abstract
Air change rate (ACR) significantly influences the indoor thermal environment and indoor air quality. Moreover, as a matter of fact, ACR varies with time during natural ventilation. However, to date only a few studies have accounted for the dynamic ACR for the actual in-use buildings. To address this issue, a field measurement of outdoor/indoor environments and the window state was conducted in a dormitory in Beijing in spring, summer, and autumn. Transient Mass Balance Equation (TMBE) method associated with the extended Kalman filter (Hereinafter referred to as Kalman filter method) was adopted to obtain the dynamic results of the ACR. Then the correlations of outdoor/indoor environments with the ACR and the probability of window opening were investigated. The results confirm the validity of Kalman filter method for tracking the dynamic nature of natural ventilation in residential units, and further demonstrate that occupants' interaction with windows does not simply refer to opening/closing windows, but also refer to adjusting the extent of the window being open in response to occupants' ventilation needs. Therefore, in addition to the probability of window opening, ventilation needs, i.e., the dynamic ACR, as the underlying trigger for window opening behavior, should be used as an indispensable part of describing occupants' interaction with windows. This study provides a complete framework to describe occupants' interactions with windows by combining the dynamic ACR and the probability of window opening. • Occupants' interaction with window includes opening window and adjusting its opening width. • Kalman filter method is validated for tracking the dynamic ACR in residential units. • The probability of window opening and the ACR are not always positively correlated. • In addition to window state, understanding the dynamic ACR is a necessary part. • This study expands the idea of natural ventilation research in residential units. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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34. Correction to "Cu2+-Loaded Polydopamine Nanoparticles for Magnetic Resonance Imaging-Guided pH- and Near-Infrared-Light-Stimulated Thermochemotherapy".
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Ge, Rui, Lin, Min, Li, Xing, Liu, Shuwei, Wang, Wenjing, Li, Shuyao, Zhang, Xue, Liu, Yi, Liu, Lidi, Shi, Feng, Sun, Hongchen, Zhang, Hao, and Yang, Bai
- Published
- 2021
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35. Correction to Fe3O4@polydopamine Composite Theranostic Superparticles Employing Preassembled Fe3O4 Nanoparticles as the Core.
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Ge, Rui, Li, Xing, Lin, Min, Wang, Dandan, Li, Shuyao, Liu, Shuwei, Tang, Qi, Liu, Yi, Jiang, Jinlan, Liu, Lidi, Sun, Hongchen, Zhang, Hao, and Yang, Bai
- Published
- 2021
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36. Fe3O4@polydopamine Composite Theranostic Superparticles Employing Preassembled Fe3O4Nanoparticles as the Core
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Ge, Rui, Li, Xing, Lin, Min, Wang, Dandan, Li, Shuyao, Liu, Shuwei, Tang, Qi, Liu, Yi, Jiang, Jinlan, Liu, Lidi, Sun, Hongchen, Zhang, Hao, and Yang, Bai
- Abstract
Iron oxide (Fe3O4), polydopamine (PDA), and in particular their composites are examples of the safest nanomaterials for developing multifunctional nanodevices to perform noninvasive tumor diagnosis and therapy. However, the structures and performances of Fe3O4–PDA nanocomposites should be further perfected to enhance the theranostic efficiency. In this work, we demonstrate the fabrication of PDA-capped Fe3O4(Fe3O4@PDA) superparticles (SPs) employing preassembled Fe3O4nanoparticles (NPs) as the cores. Owing to the collective effect of preassembled Fe3O4NPs, the superparamagnetism and photothermal performance of Fe3O4@PDA SPs are greatly enhanced, thus producing nanodevices with improved magnetic resonance imaging (MRI)-guided photothermal efficiency. Systematical studies reveal that the molar extinction coefficient of the as-assembled Fe3O4SPs is 3 orders of magnitude higher than that of individual Fe3O4NPs. Also due to the high aggregation degree of Fe3O4NPs, the T2-weighted MRI contrast is greatly enhanced for the SPs with r2relaxivity of 230.5 mM–1s–1, which is ∼2.5 times larger than that of individual Fe3O4NPs. The photothermal stability, physiological stability, and biocompatibility, as well as the photothermal performance of Fe3O4SPs, are further improved by enveloping with PDA shell.
- Published
- 2016
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37. Soil Respiration and Litter Decomposition Increased Following Perennial Forb Invasion into an Annual Grassland
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ZHANG, Ling, MA, Xiaochi, WANG, Hong, LIU, Shuwei, SIEMANN, Evan, and ZOU, Jianwen
- Abstract
Exotic plant invasions may alter ecosystem carbon processes, especially when native plants are displaced by plants of a different functional group. Forb invasions into grasslands are common, yet little is known about how they impact carbon cycling. We conducted a field study over 2 years from April 2010 to March 2012 in China to examine changes in soil respiration (Rsoil) following invasion of exotic perennial forb species (Alternanthera philoxeroidesor Solidago canadensis) into an annual grassland dominated by a native annual graminoid (Eragrostis pilosa). Measurements of Rsoilwere taken once a week in stands of the native annual graminoid or one of the forb species using static chamber-gas chromatograph method. Aboveground litterfall of each of the three focal species was collected biweekly and litter decomposition rates were measured in a 6-month litterbag experiment. The monthly average and annual cumulative Rsoilincreased following invasion by either forb species. The increases in cumulative Rsoilwere smaller with invasion of Solidago(36%) than Alternanthera(65%). Both invasive forbs were associated with higher litter quantity and quality (e.g.,C:N ratio) than the native annual graminoid. Compared to the native annual graminoid, the invasive forbs Alternanthera(155%) and Solidago(361%) produced larger amounts of more rapidly decomposing litter, with the litter decay constant kbeing 3.8, 2.0 and 1.0 for Alternanthera, Solidagoand Eragrostis, respectively. Functional groups of the invasive plants and the native plants they replaced appear to be useful predictors of directions of changes in Rsoil, but the magnitude of changes in Rsoilseems to be sensitive to variations in invader functional traits.
- Published
- 2016
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38. Correction to “Cu2+-Loaded Polydopamine Nanoparticles for Magnetic Resonance Imaging-Guided pH- and Near-Infrared-Light-Stimulated Thermochemotherapy”
- Author
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Ge, Rui, Lin, Min, Li, Xing, Liu, Shuwei, Wang, Wenjing, Li, Shuyao, Zhang, Xue, Liu, Yi, Liu, Lidi, Shi, Feng, Sun, Hongchen, Zhang, Hao, and Yang, Bai
- Published
- 2021
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39. Cupreous Complex-Loaded Chitosan Nanoparticles for Photothermal Therapy and Chemotherapy of Oral Epithelial Carcinoma
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Lin, Min, Wang, Dandan, Liu, Shuwei, Huang, Tingting, Sun, Bin, Cui, Yan, Zhang, Daqi, Sun, Hongchen, Zhang, Hao, Sun, Hui, and Yang, Bai
- Abstract
Electron transition materials on the basis of transition metal ions usually possess higher photothermal transduction efficiency but lower extinction ability, which have not been considered as efficient photothermal agents for therapeutic applications. In this work, we demonstrate a facile and feasible approach for enhancing 808 nm photothermal conversion effect of d orbits transition Cu(II) ions by forming Cu-carboxylate complexes. The coordination with carboxylate groups greatly enlarges the splitting energy gap of Cu(II) and the capability of electron transition, thus enhancing the extinction ability in near-infrared region. The cupreous complexes are further loaded in biocompatible and biodegradable polymer nanoparticles (NPs) of chitosan to temporarily lower the toxicity, which allows the photothermal therapy of human oral epithelial carcinoma (KB) cells in vitro and KB tumors in vivo. Animal experiments indicate the photothermal tumor inhibition rate of 100%. In addition, the gradual degradation of chitosan NPs leads to the release of cupreous complexes, thus exhibiting additional chemotherapeutic behavior in KB tumor treatment. Onefold chemotherapy experiments indicate the tumor inhibition rate of 93.1%. The combination of photothermal therapy and chemotherapy of cupreous complex-loaded chitosan NPs indicates the possibility of inhibiting tumor recurrence.
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- 2015
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40. Structural development of human brain white matter from mid-fetal to perinatal stage
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Gimi, Barjor, Molthen, Robert C., Ouyang, Austin, Yu, Qiaowen, Mishra, Virendra, Chalak, Lina, Jeon, Tina, Sivarajan, Muraleedharan, Jackson, Greg, Rollins, Nancy, Liu, Shuwei, and Huang, Hao
- Published
- 2015
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41. Characterisation of low molecular weight glutenin subunit genes from Pseudoroegneria spicataand Pd. strigosa
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Qin, Lumin, Liang, Yu, Yang, Daozheng, Xia, Guangmin, and Liu, Shuwei
- Abstract
We report the characterisation of nine novel low molecular weight glutenin subunit (LMW-GS) genes from two Pseudoroegneriaspecies, Pd. spicataand Pd. strigosa. We found that all nine LMW-GS genes possess the same primary structure shared by other published LMW-GS. Five genes encode LMW-i type subunits, three encode LMW-m type subunits and one encodes a peptide similar to B-3 hordeins of Hordeum chilense. No LMW-s type subunit genes were found in Pseudoroegneria. One subunit, PSt24-LMW-2, contains six conserved cysteine residues, and the other eight subunits all contain eight cysteine residues. We show that one cysteine residue is located in the signal peptide of PSt24-LMW-1, suggesting a mature peptide containing only seven cysteine residues. Phylogenetic analysis indicates that the LMW-GS genes from the St genome cluster together and suggests a distant relationship with LMW-GS of the A and B genomes of wheat. Slippage/unequal crossing over and illegitimate recombination are effective mechanisms for enriching variations of seed storage proteins.
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- 2015
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42. Fe(III) fertilization mitigating net global warming potential and greenhouse gas intensity in paddy rice-wheat rotation systems in China.
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Liu, Shuwei, Zhang, Ling, Liu, Qiaohui, and Zou, Jianwen
- Subjects
GLOBAL warming research ,IRON fertilizers ,FERTILIZER application ,CROPPING systems ,CROP rotation ,GREENHOUSE gas analysis ,SOIL composition ,CARBON dioxide ,METHANE content of soils ,NITROUS oxide ,RICE farming ,WHEAT farming ,AGRICULTURE & the environment - Abstract
A complete accounting of net greenhouse gas balance (NGHGB) and greenhouse gas intensity (GHGI) affected by Fe(III) fertilizer application was examined in typical annual paddy rice-winter wheat rotation cropping systems in southeast China. Annual fluxes of soil carbon dioxide (CO
2 ), methane (CH4 ) and nitrous oxide (N2 O) were measured using static chamber method, and the net ecosystem exchange of CO2 (NEE) was determined by the difference between soil CO2 emissions (RH ) and net primary production (NPP). Fe(III) fertilizer application significantly decreased RH without adverse effects on NPP of rice and winter wheat. Fe(III) fertilizer application decreased seasonal CH4 by 27–44%, but increased annual N2 O by 65–100%. Overall, Fe(III) fertilizer application decreased the annual NGHGB and GHGI by 35–47% and 30–36%, respectively. High grain yield and low greenhouse gas intensity can be reconciled by Fe(III) fertilizer applied at the local recommendation rate in rice-based cropping systems. [Copyright &y& Elsevier]- Published
- 2012
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43. Functional changes in the frontal cortex in Parkinson’s disease using a rat model.
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Hou, Zhongyu, Lei, Hao, Hong, Shuhui, Sun, Bo, Fang, Ke, Lin, Xiangtao, Liu, Maili, Yew, David T.W., and Liu, Shuwei
- Subjects
NEURAL physiology ,CEREBRAL cortex ,LABORATORY rats ,ANIMAL models in research ,BASAL ganglia ,VITAMIN C ,DOPAMINE ,PHYSIOLOGY - Abstract
Abstract: In recent years, investigations of the pathologic mechanism of Parkinson’s disease (PD) have mainly concentrated on the basal ganglia. However, recent studies have confirmed that pathological changes in PD are accompanied by functional motor changes of the cerebral cortex. Rats were injected with 6-hydroxydopamine and ascorbic acid in the right substantia nigra. In this rat model of PD, magnetic resonance spectroscopy showed the ratio of N-acetyl-aspartic acid to creatine in a lesion in the right frontal cortex was significantly lower than the same ratio in a control group of rats. The ratio of choline to creatine in a lesion in the right frontal cortex was not significantly different between the PD-model rats and control rats. In addition, the optical densities of neurofilament protein and synaptophysin positive sites decreased significantly on the side of the brain with the injury compared with the side without the injury, and with both sides in the control rats. The density of synapses in the frontal cortex on the lesioned side was decreased compared with the unlesioned side. There were abnormal changes in the presynaptic membrane, postsynaptic membrane and synaptic vesicles, and the typical synaptic structure was no longer apparent on the lesioned side. We hypothesized loss of neurons and synapses, abnormal synaptic structure and neuron and synaptic dysfunction of the frontal cortex with a lesion in the injury side of the frontal cortex in PD-model rats. These changes might have an important role in the pathologic mechanism of PD. [Copyright &y& Elsevier]
- Published
- 2010
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44. Iron-Containing Protein-Mimic Supramolecular Iron Delivery Systems for Ferroptosis Tumor Therapy
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Liu, Shuwei, Zhang, Mengsi, Jin, Hao, Wang, Ze, Liu, Yi, Zhang, Songling, and Zhang, Hao
- Abstract
Ferroptosis provides an innovative theoretical basis and method for tumor therapy but is limited by the low efficiency of conventional iron delivery systems. Herein, an efficient supramolecular iron delivery system (SIDS) is demonstrated upon the hydrolysis of FeCl3, condensation of amino acids, and self-assembly of iron-containing components. The as-assembled SIDS possesses a shuttle-like core/shell structure with β-FeOOH as the core and Fe3+/polyamino acid coordinated networks as shells. The iron content of SIDS is up to 42 wt %, which is greatly higher than that of ferritin. The iron-containing protein-mimic structure and shuttle-like morphology of SIDS facilitate tumor accumulation and cell internalization. Once exposed to the tumor microenvironment with overexpressed glutathione (GSH), the SIDS will disassemble, accompanied by the depletion of GSH and the release of Fe2+, leading to dual amplified ferroptosis. Primary studies indicate that SIDS exhibits outstanding antitumor efficacy on bladder cancer.
- Published
- 2022
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45. Fe(III)‐Shikonin Supramolecular Nanomedicine for Combined Therapy of Tumor via Ferroptosis and Necroptosis
- Author
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Feng, Wenjie, Shi, Wanrui, Liu, Shuwei, Liu, Huiwen, Liu, Yi, Ge, Pengfei, and Zhang, Hao
- Abstract
Most of the antitumor chemotherapeutic drugs execute the therapeutic performance upon eliciting tumor cell apoptosis, which may cause chemoresistance of tumors. Design of novel drugs to eradicate apoptosis‐resistant tumors via non‐apoptotic cell death pathways is promising for improving the long‐term chemotherapeutic efficacy. Herein, a Fe(III)‐Shikonin metal‐polyphenol‐coordinated supramolecular nanomedicine for combined therapy of tumor via ferroptosis and necroptosis is designed. The construction of the nanomedicine based on the coordinated self‐assembly between Fe3+and Shikonin not only overcomes the shortcomings of Shikonin including its low bioavailability and high toxicity toward normal tissues, but also integrates the theranostics functions of Fe ions. Under the exposure of the high concentration of glutathione (GSH) in tumor cells, the as‐prepared nanomedicine will disassemble into Fe2+and Shikonin, followed by stimulating the tumor cell death through ferroptosis and necroptosis. In addition, benefiting from the stealth effect of polyethylene glycol (PEG) and the targeting ability of cyclo(Arg‐Gly‐Asp‐d‐Phe‐Lys) (cRGD) to αvβ3‐integrin, NH2‐PEG‐cRGD‐modified nanomedicine exhibits a GSH‐responsive therapy toward 4T1 tumor in vivo and self‐enhanced longitudinal relaxation (T1)‐weighted imaging property. Since the self‐assembly of natural Shikonin and human body‐necessary Fe element is facile and feasible, the work may provide a promising supramolecular nanomedicine for next‐generation chemotherapeutic applications. A Fe(III)‐Shikonin supramolecular nanomedicine based on the coordinated self‐assembly between Fe3+and Shikonin and further modification with NH2‐PEG‐cRGD is designed. Under the exposure of the high concentration of GSH in tumor cells, the as‐prepared nanomedicine will disassemble into Fe2+and Shikonin, following by stimulating the tumor cell death through ferroptosis and necroptosis.
- Published
- 2022
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46. Fe(III)‐Shikonin Supramolecular Nanomedicine for Combined Therapy of Tumor via Ferroptosis and Necroptosis (Adv. Healthcare Mater. 2/2022)
- Author
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Feng, Wenjie, Shi, Wanrui, Liu, Shuwei, Liu, Huiwen, Liu, Yi, Ge, Pengfei, and Zhang, Hao
- Abstract
Enzyme‐Responsive Drug Release In article number 2101926, Yi Liu, Pengfei Ge, Hao Zhang, and co‐workers construct a Fe(III)‐Shikonin metal‐polyphenol‐coordinated supramolecular nanomedicine for combined therapy of tumors. The as‐prepared nanomedicine will disassemble into Fe2+and Shikonin in response to the high concentration of glutathione in tumor cells, followed by the up‐regulation of the intracellular reactive oxygen species level and the depletion of the intracellular glutathione level, resulting in the tumor cell death via ferroptosis and necroptosis.
- Published
- 2022
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47. Enhancing Tumor Therapy of Fe(III)-Shikonin Supramolecular Nanomedicine via Triple Ferroptosis Amplification
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Feng, Wenjie, Shi, Wanrui, Wang, Ze, Cui, Yanqi, Shao, Xinxin, Liu, Shuwei, Rong, Li, Liu, Yi, and Zhang, Hao
- Abstract
Ferroptosis has been considered as a promising pathway to overcome apoptosis-induced tumor chemoresistance. However, the antitumor efficacy of ferroptosis-inducing agents is still limited because of the complexity and diversity of tumor microenvironments. Herein, we demonstrate a triple ferroptosis amplification strategy for tumor therapy by associating iron-based nanocarriers, ferroptosis molecular drugs, and H2O2-producing enzymes. Fe(III)-Shikonin (FeShik) metal-polyphenol-coordinated networks are employed to load a ferroptosis inducer of sorafenib (SRF) inside and glucose oxidase (GOx) outside, thus producing SRF@FeShik-GOx supramolecular nanomedicines (SNs). After delivering into glutathione (GSH)-overexpressed tumor cells, FeShik will disassemble and release Fe2+to induce cell death via ferroptosis. At the same time, GOx executes its catalytic activity to produce an acid environment and plenty of H2O2for stimulating •OH generation via the Fenton reaction. Moreover, SRF will suppress the biosynthesis of GSH by inhibiting system Xc–, further deactivating the enzymatic activity of glutathione peroxidase 4 (GPX4). Up-regulation of the oxidative stress level and down-regulation of GPX4 expression can dramatically accelerate the accumulation of lethal lipid peroxides, leading to ferroptosis amplification of tumor cells. The current strategy that utilizes ferroptosis-inducing agents as both nanocarriers and cargoes provides a pathway to enhance the efficacy of ferroptosis-based tumor therapy.
- Published
- 2022
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48. Fe(III)-Doped Polyaminopyrrole Nanoparticle for Imaging-Guided Photothermal Therapy of Bladder Cancer
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Liu, Heng, Zhang, Mengsi, Jin, Hao, Tao, Kepeng, Tang, Chao, Fan, Yanpeng, Liu, Shuwei, Liu, Yi, Hou, Yuchuan, and Zhang, Hao
- Abstract
Clinically, the surgical treatment of bladder cancer often faces the problem of tumor recurrence, and the surgical treatment combined with postoperative chemotherapy to inhibit tumor recurrence also faces high toxicity and side effects. Therefore, the need for innovative bladder cancer treatments is urgent. For the past few years, with the development of nano science and technology, imaging-guided therapy using nanomaterials with both imaging and therapy functions has shown great advantages and can not only identify the locations of the tumors but also exhibit biodistributions of nanomaterials in the tumors, significantly improving the accuracy and efficacy of treatment. In this work, we synthesized Fe(III)-doped polyaminopyrrole nanoparticles (FePPy-NH2NPs). With low cytotoxicity and a blood circulation half-life of 7.59 h, high levels of FePPy-NH2NPs accumulated in bladder tumors, with an accumulation rate of up to 5.07%ID/g. The coordination of Fe(III) and the amino group in the structure can be used for magnetic resonance imaging (MRI), whereas absorption in the near-infrared region can be applied to photoacoustic imaging (PAI) and photothermal therapy (PTT). MRI and PAI accurately identified the location of the tumor, and based on the imaging data, laser irradiation was employed accurately. With a high photothermal conversion efficiency of 44.3%, the bladder tumor was completely resected without recurrence. Hematological analysis and histopathological analysis jointly confirmed the high level of safety of the experiment.
- Published
- 2022
- Full Text
- View/download PDF
49. Quantum Dot Light-Emitting Diode with Quantum Dots Inside the Hole Transporting Layers
- Author
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Leck, Kheng Swee, Divayana, Yoga, Zhao, Dewei, Yang, Xuyong, Abiyasa, Agus Putu, Mutlugun, Evren, Gao, Yuan, Liu, Shuwei, Tan, Swee Tiam, Sun, Xiao Wei, and Demir, Hilmi Volkan
- Abstract
We report a hybrid, quantum dot (QD)-based, organic light-emitting diode architecture using a noninverted structure with the QDs sandwiched between hole transporting layers (HTLs) outperforming the reference device structure implemented in conventional noninverted architecture by over five folds and suppressing the blue emission that is otherwise observed in the conventional structure because of the excess electrons leaking towards the HTL. It is predicted in the new device structure that 97.44% of the exciton formation takes place in the QD layer, while 2.56% of the excitons form in the HTL. It is found that the enhancement in the external quantum efficiency is mainly due to the stronger confinement of exciton formation to the QDs.
- Published
- 2013
- Full Text
- View/download PDF
50. Synthesis, Structure, and Physical Properties of 5,7,14,16‐Tetraphenyl‐8:9,12:13‐bisbenzo‐hexatwistacene
- Author
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Xiao, Jinchong, Liu, Shuwei, Liu, Yi, Ji, Li, Liu, Xuewei, Zhang, Hua, Sun, Xiaowei, and Zhang, Qichun
- Abstract
A novel compound, 5,7,14,16‐tetraphenyl‐8:9,12:13‐bisbenzo‐hexatwistacene (TBH), has been successfully synthesized through a retro‐Diels–Alder reaction. Single‐crystal structure analysis indicated that TBHhas a twisted configuration with a torsion angle of 27.34°. The HOMO–LUMO gap of TBHcalculated from the difference between the half‐wave redox potentials (E1/2ox=+0.40 eV and E1/2red=−1.78 eV) is 2.18 eV, which is in good agreement with the band gap (2.19 eV) derived from the UV/Vis absorption data. In addition, organic light‐emitting devices using TBHas emitter have been fabricated. The results revealed that TBHis a promising red light‐emitting candidate for applications in organic light‐emitting diodes.
- Published
- 2012
- Full Text
- View/download PDF
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