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6 results on '"Liu, Zhiqian Lucy"'

1. Identification of Active Coagulation Factor IX Variants with Insertion or Fusion of Unstructured Polypeptide Xten

Author

Liu, Zhiqian Lucy, van der Flier, Arjan, Bardan, Sara, Ding, Sheng, Schellenberger, Volker, Kulman, John, and Peters, Robert

Abstract

Liu: Biogen: Employment. van der Flier:Biogen: Employment. Bardan:Biogen: Employment. Ding:Amunix: Employment. Schellenberger:Amunix Operating Inc: Employment. Kulman:Biogen: Employment. Peters:Biogen: Employment.

Published
2015
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2. Prolonged Half-Life and Improved Recovery of Recombinant Factor IX-XTEN Fusion Proteins in Hemophilia B Mouse Model

Author

van der Flier, Arjan, Liu, Zhiqian Lucy, Liu, Zhan, Mercury, Oblaise, Ismail, Ayman, Seth-Chhabra, Ekta, Kulman, John, Schellenberger, Volker, Light, David R., and Peters, Robert

Abstract

van der Flier: Biogen: Employment. Liu:Biogen: Employment. Liu:Biogen: Employment, Equity Ownership, Honoraria, Research Funding. Mercury:Biogen: Employment. Ismail:Biogen: Employment. Seth-Chhabra:Biogen: Employment, Equity Ownership, Honoraria, Patents & Royalties, Research Funding. Kulman:Biogen: Employment. Schellenberger:Amunix Operating Inc: Employment. Light:Biogen: Employment, Equity Ownership. Peters:Biogen: Employment.

Published
2015
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3. Identification of Active Coagulation Factor IX Variants with Insertion or Fusion of Unstructured Polypeptide Xten

Author

Liu, Zhiqian Lucy, van der Flier, Arjan, Bardan, Sara, Ding, Sheng, Schellenberger, Volker, Kulman, John, and Peters, Robert

Abstract

Background:A variety of approaches have been used to extend the half-life of human factor IX (FIX) in the circulation, including PEGylation and recombinant fusion of either the Fc domain of IgG or albumin to the C-terminus of FIX. Introduction of XTENs, unstructured hydrophilic polypeptides of defined amino acid composition and low immunogenic potential, represents a promising alternative approach for generating FIX variants with improved pharmacokinetic properties. Moreover, the hydrophilic properties of XTEN have the potential to increase the solubility of FIX and thereby render it suitable for subcutaneous administration, which is currently an unmet need. Because XTEN is introduced into FIX by DNA recombination, the location, length, composition and number of XTEN modifications can be readily varied, and impact of these modifications on the activity and clearance of FIX can be evaluated.

Published
2015
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5. Assessing Structure-Activity Relationships in FVIII By Integration of Structural, Biophysical, and Biochemical Data Obtained with Anti-FVIII Antibodies

Author

Liu, Zhiqian Lucy, Bou-Assaf, George, Zhang, Ming, Goodman, Allison, Chiu, Po-lin, Chambers, Melissa, Walz, Thomas, Peters, Robert, and Kulman, John

Abstract

Liu: Biogen Idec: Employment. Bou-Assaf:Biogen Idec: Employment. Zhang:Biogen Idec: Employment. Goodman:Biogen Idec: Employment. Walz:Biogen Idec: Honoraria, Research Funding. Peters:Biogen Idec: Employment. Kulman:Biogen Idec: Employment.

Published
2014
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