179 results on '"Longtin A"'
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2. La Base de données sur les innovations sociales du CRISES : portée et limites d’une innovation méthodologique
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Longtin, David, Bouchard, Marie J., Michaud, Valérie, and Rousselière, Damien
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Depuis les années 1990, l’étude des innovations sociales fait l’objet de débats entourant les problèmes de recherche, les approches théoriques et les méthodes. La majorité des recherches ont privilégié les études de cas. Toutefois, plus récemment, des chercheurs ont commencé à réaliser des méta-études à partir de banques de données qualitatives. Cet article examine une démarche novatrice mise en œuvre par le Centre de recherche sur les innovations sociales (CRISES). Partant de centaines d’étude de cas, le CRISES a mis sur pied une base de données sur l’innovation sociale en vue de réaliser des analyses statistiques. Après avoir présenté les tendances en sciences sociales à la constitution de banques de données et à la réalisation de méta-études, nous exposons la méthodologie et les assises épistémologiques du projet afin d’en dégager l’originalité au regard des cartographies d’innovations sociales. L’article se conclut par une évaluation des limites méthodologiques et de la portée analytique du projet.
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- 2024
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3. Surgical Resident Perspectives on the Preferred Qualities of Effective Intraoperative Teachers: A Qualitative Analysis.
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Collings, Amelia T., Doster, Dominique L., Longtin, Krista, Choi, Jennifer, Torbeck, Laura, and Stefanidis, Dimitrios
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- 2023
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4. Risk and protective factors for severe acute respiratory coronavirus virus 2 (SARS-CoV-2) infection among healthcare workers: A test-negative case–control study in Québec, Canada
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Carazo, Sara, Villeneuve, Jasmin, Laliberté, Denis, Longtin, Yves, Talbot, Denis, Martin, Richard, Denis, Geoffroy, Ducharme, Francine, Paquet-Bolduc, Bianka, Anctil, Geneviève, Hegg-Deloye, Sandrine, and De Serres, Gaston
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AbstractObjectives:In Québec, Canada, we evaluated the risk of severe acute respiratory coronavirus virus 2 (SARS-CoV-2) infection associated with (1) the demographic and employment characteristics among healthcare workers (HCWs) and (2) the workplace and household exposures and the infection prevention and control (IPC) measures among patient-facing HCWs.Design:Test-negative case-control study.Setting:Provincial health system.Participants:HCWs with PCR-confirmed coronavirus disease 2019 (COVID-19) diagnosed between November 15, 2020, and May 29, 2021 (ie, cases), were compared to HCWs with compatible symptoms who tested negative during the same period (ie, controls).Methods:Adjusted odds ratios (aORs) of infection were estimated using regression logistic models evaluating demographic and employment characteristics (all 4,919 cases and 4,803 controls) or household and workplace exposures and IPC measures (2,046 patient-facing cases and 1,362 controls).Results:COVID-19 risk was associated with working as housekeeping staff (aOR, 3.6), as a patient-support assistant (aOR, 1.9), and as nursing staff (aOR, 1.4), compared to administrative staff. Other risk factors included being unexperienced (aOR, 1.5) and working in private seniors’ homes (aOR, 2.1) or long-term care facilities (aOR, 1.5), compared to acute-care hospitals. Among patient-facing HCWs, exposure to a household contact was reported by 9% of cases and was associated with the highest risk of infection (aOR, 7.8). Most infections were likely attributable to more frequent exposure to infected patients (aOR, 2.7) and coworkers (aOR, 2.2). Wearing an N95 respirator during contacts with COVID-19 patients (aOR, 0.7) and vaccination (aOR, 0.2) were the measures associated with risk reduction.Conclusion:In the context of the everchanging SARS-CoV-2 virus with increasing transmissibility, measures to ensure HCW protection, including vaccination and respiratory protection, and patient safety will require ongoing evaluation.
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- 2023
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5. Trends in Clostridioides difficileinfection rates in Canadian hospitals during the coronavirus disease 2019 (COVID-19) pandemic
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Choi, Kelly B., Du, Tim, Silva, Anada, Golding, George R., Pelude, Linda, Mitchell, Robyn, Rudnick, Wallis, Hizon, Romeo, Al-Rawahi, Ghada N, Chow, Blanda, Davis, Ian, Evans, Gerald A., Frenette, Charles, Johnstone, Jennie, Kibsey, Pamela, Katz, Kevin C., Langley, Joanne M., Lee, Bonita E., Longtin, Yves, Mertz, Dominik, Minion, Jessica, Science, Michelle, Srigley, Jocelyn A., Stagg, Paula, Suh, Kathryn N., Thampi, Nisha, Wong, Alice, Comeau, Jeannette L., and Hota, Susy S.
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AbstractThe coronavirus disease 2019 (COVID-19) pandemic has placed significant burden on healthcare systems. We compared Clostridioides difficileinfection (CDI) epidemiology before and during the pandemic across 71 hospitals participating in the Canadian Nosocomial Infection Surveillance Program. Using an interrupted time series analysis, we showed that CDI rates significantly increased during the COVID-19 pandemic.
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- 2023
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6. Investigation of individual nurses' relative hand hygiene performance using an anonymous automated electronic hand hygiene monitoring system and a nursing assignment schedule.
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Tremblay, Maxime-Antoine, Yin, Hui, Ould-Brahim, Fares, Abou Sader, Mona, and Longtin, Yves
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• Monitoring hand hygiene behavior of individual nurses is not routinely performed. • We tested whether an anonymous monitoring system could estimate individual behavior. • We found a link between a patient room's hand hygiene rate and its assigned nurse. • An anonymous monitoring system can estimate individual staff hand hygiene behavior. We investigated whether an anonymous automated electronic monitoring system (EMS) could be used to compare hand hygiene (HH) performance of individual nurses. Prospective observational cohort study. HH performance in 10 acute-care patient rooms was estimated through an EMS that anonymously measured HH events, and room entries and exits. The association between patient room's HH compliance and the nurse in charge of each room was investigated by comparing percentile rank distributions, and through a negative binomial model. Over 99 days, there were 38,596 HH events and 135,546 room entries and exits (global HH performance, 28%). For 10 of 54 (19%) nurses, the median HH percentile rank of the rooms to which they were assigned was higher than the group average (P <.001; range of percentiles, 64th to 85th). A lower median percentile was seen in 9/54 (17%) participants (P <.001; range of percentiles, 22nd to 39th). The negative binomial model confirmed this association and identified 15 of 54 high performers (range of adjusted incidence rate ratios [aIRR], 1.17-1.83) and 16 of 54 low performers (range of aIRR, 0.37-0.77). An association exists between a room's HH rate and its assigned nurse. This association could hold potential value for an individualized feedback strategy. [ABSTRACT FROM AUTHOR]
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- 2023
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7. Association of the Timing and Extent of Cardiac Implantable Electronic Device Infections With Mortality
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Han, Hui-Chen, Wang, Jia, Birnie, David H., Alings, Marco, Philippon, François, Parkash, Ratika, Manlucu, Jaimie, Angaran, Paul, Rinne, Claus, Coutu, Benoit, Low, R. Aaron, Essebag, Vidal, Morillo, Carlos, Healey, Jeffrey S., Redfearn, Damian, Toal, Satish, Becker, Giuliano, DeGrâce, Michel, Thibault, Bernard, Crystal, Eugene, Tung, Stanley, LeMaitre, John, Sultan, Omar, Bennett, Matthew, Bashir, Jamil, Ayala-Paredes, Felix, Gervais, Philippe, Rioux, Leon, Hemels, Martin E. W., Bouwels, Leon H. R., Exner, Derek V., Dorian, Paul, Connolly, Stuart J., Longtin, Yves, and Krahn, Andrew D.
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IMPORTANCE: Cardiac implantable electronic device (CIED) infection is a potentially devastating complication with an estimated 12-month mortality of 15% to 30%. The association of the extent (localized or systemic) and timing of infection with all-cause mortality has not been established. OBJECTIVE: To evaluate the association of the extent and timing of CIED infection with all-cause mortality. DESIGN, SETTING, AND PARTICIPANTS: This prospective observational cohort study was conducted between December 1, 2012, and September 30, 2016, in 28 centers across Canada and the Netherlands. The study included 19 559 patients undergoing CIED procedures, 177 of whom developed an infection. Data were analyzed from April 5, 2021, to January 14, 2023. EXPOSURES: Prospectively identified CIED infections. MAIN OUTCOMES AND MEASURES: Time-dependent analysis of the timing (early [≤3 months] or delayed [3-12 months]) and extent (localized or systemic) of infection was performed to determine the risk of all-cause mortality associated with CIED infections. RESULTS: Of 19 559 patients undergoing CIED procedures, 177 developed a CIED infection. The mean (SD) age was 68.7 (12.7) years, and 132 patients were male (74.6%). The cumulative incidence of infection was 0.6%, 0.7%, and 0.9% within 3, 6, and 12 months, respectively. Infection rates were highest in the first 3 months (0.21% per month), reducing significantly thereafter. Compared with patients who did not develop CIED infection, those with early localized infections were not at higher risk for all-cause mortality (no deaths at 30 days [0 of 74 patients]: adjusted hazard ratio [aHR], 0.64 [95% CI, 0.20-1.98]; P = .43). However, patients with early systemic and delayed localized infections had an approximately 3-fold increase in mortality (8.9% 30-day mortality [4 of 45 patients]: aHR, 2.88 [95% CI, 1.48-5.61]; P = .002; 8.8% 30-day mortality [3 of 34 patients]: aHR, 3.57 [95% CI, 1.33-9.57]; P = .01), increasing to a 9.3-fold risk of death for those with delayed systemic infections (21.7% 30-day mortality [5 of 23 patients]: aHR, 9.30 [95% CI, 3.82-22.65]; P < .001). CONCLUSIONS AND RELEVANCE: Findings suggest that CIED infections are most common within 3 months after the procedure. Early systemic infections and delayed localized infections are associated with increased mortality, with the highest risk for patients with delayed systemic infections. Early detection and treatment of CIED infections may be important in reducing mortality associated with this complication.
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- 2023
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8. Surgical Resident Perspectives on the Preferred Qualities of Effective Intraoperative Teachers: A Qualitative Analysis
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Collings, Amelia T., Doster, Dominique L., Longtin, Krista, Choi, Jennifer, Torbeck, Laura, and Stefanidis, Dimitrios
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- 2023
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9. Persistence of infectivity in elderly individuals diagnosed with severe acute respiratory coronavirus virus 2 (SARS-CoV-2) infection 10 days after onset of symptoms: A cross-sectional study
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Longtin, Yves, Parkes, Leighanne O., Charest, Hugues, Rajarison, Stacy, Zaharatos, Gerasimos J., Fafard, Judith, Roger, Michel, and De Serres, Gaston
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AbstractWe performed viral culture of nasopharyngeal specimens in individuals aged 79 and older, infected with severe acute respiratory coronavirus virus 2 (SARS-CoV-2), 10 days after symptom onset. A positive viral culture was obtained in 10 (45%) of 22 participants, including 4 (33%) of 12 individuals with improving symptoms. The results of this small study suggest that infectivity may be prolonged among older individuals.
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- 2023
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10. Covid-19 vaccine acceptance, hesitancy, and refusal among Canadian healthcare workers: A multicenter survey.
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Dzieciolowska, Stefania, Hamel, Denis, Gadio, Souleymane, Dionne, Maude, Gagnon, Dominique, Robitaille, Lucie, Cook, Erin, Caron, Isabelle, Talib, Amina, Parkes, Leighanne, Dubé, Ève, and Longtin, Yves
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• Healthcare worker acceptance of novel COVID-19 vaccines is poorly understood. • In our study, 80% of healthcare workers accepted receiving a novel COVID-19 vaccine. • Predictors of vaccine acceptance included age > 50 and exposure to COVID-19. • Most who refused vaccination were open to receiving the vaccine within a year. Determinants of COVID-19 vaccine acceptance among healthcare workers (HCW) remains poorly understood. We assessed HCWs' willingness to be vaccinated and reasons underlying hesitancy. Cross-sectional survey across 17 healthcare institutions. HCWs eligible for vaccination (Pfizer-BioNTech mRNA) in December 2020 were invited to receive immunization. Multivariate logistic regression was performed to identify predictors of acceptance. Reasons for refusal among those who never intended to be vaccinated (ie, firm refusers) and those who preferred delaying vaccination (ie, vaccine hesitants) were assessed. Among 2,761 respondents (72% female, average age, 44), 2,233 (80.9%) accepted the vaccine. Physicians, environmental services workers and healthcare managers were more likely to accept vaccination compared to nurses. Male sex, age over 50, rehabilitation center workers, and occupational COVID-19 exposure were independently associated with vaccine acceptance by multivariate analysis. Factors for refusal included vaccine novelty, wanting others to receive it first, and insufficient time for decision-making. Among those who declined, 74% reported they may accept future vaccination. Vaccine firm refusers were more likely than vaccine hesitants to distrust pharmaceutical companies and to prefer developing a natural immunity by getting COVID-19. Vaccine hesitancy exists among HCWs. Our findings provide useful information to plan future interventions and improve acceptance. [ABSTRACT FROM AUTHOR]
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- 2021
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11. Séroprévalence du SRAS-CoV-2 chez les travailleurs de la santé de 10 hôpitaux du Québec, au Canada: étude transversale
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Brousseau, Nicholas, Morin, Laurianne, Ouakki, Manale, Savard, Patrice, Quach, Caroline, Longtin, Yves, Cheng, Matthew P., Carignan, Alex, Dufresne, Simon F., Leduc, Jean-Michel, Lavallée, Christian, Gauthier, Nicolas, Bestman-Smith, Julie, Arrieta, Maria-Jesus, Ishak, Magued, Lévesque, Simon, Martin, Philippe, and De Serres, Gaston
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Contexte:La pandémie de COVID-19 a affecté de manière disproportionnée les travailleurs de la santé. Nous avons voulu mesurer la séroprévalence du SRAS-CoV-2 chez les travailleurs de la santé dans les hôpitaux du Québec, au Canada, après la première vague de la pandémie, afin d’explorer les facteurs associés à la SRAS-CoV-2-séropositivité.Méthodes:Entre le 6 juillet et le 24 septembre 2020, nous avons recruté des travailleurs de la santé de 10 hôpitaux, dont 8 d’une région où l’incidence de la COVID-19 était élevée (région de Montréal) et 2 de régions du Québec où l’incidence était faible. Les travailleurs de la santé admissibles étaient des médecins, des infirmières, des préposées aux bénéficiaires et des préposés à l’entretien ménager travaillant dans 4 types d’unité de soins (urgences, soins intensifs, unité hospitalière COVID-19 et unité hospitalière non-COVID-19). Les participants ont répondu à un questionnaire et subi un dépistage sérologique du SRAS-CoV-2. Nous avons identifié les facteurs ayant un lien indépendant avec une séroprévalence plus élevée.Résultats:Parmi les 2056 travailleurs de la santé recrutés, 241 (11,7 %) se sont révélés SRAS-CoV-2-positifs. Parmi eux, 171 (71,0 %) avaient déjà reçu un diagnostic de COVID-19. La séroprévalence a varié d’un hôpital à l’autre, de 2,4 %–3,7 % dans les régions où l’incidence était faible, à 17,9 %–32,0 % dans les hôpitaux ayant connu des éclosions touchant 5 travailleurs de la santé ou plus. La séroprévalence plus élevée a été associée au fait de travailler dans un hôpital où des éclosions sont survenues (rapport de prévalence ajusté 4,16, intervalle de confiance [IC] à 95 % 2,63–6,57), au fait d’être infirmière ou auxiliaire (rapport de prévalence ajusté 1,34, IC à 95 % 1,03–1,74), préposée aux bénéficiaires (rapport de prévalence ajusté 1,49, IC à 95 % 1,12–1,97) et d’ethnicité noire ou hispanique (rapport de prévalence ajusté 1,41, IC à 95 % 1,13–1,76). La séroprévalence moindre a été associée au fait de travailler dans une unité de soins intensifs (rapport de prévalence ajusté 0,47, IC à 95 % 0,30–0,71) ou aux urgences (rapport de prévalence ajusté 0,61, IC à 95 % 0,39–0,98).Interprétation:Les travailleurs de la santé des hôpitaux du Québec ont été exposés à un risque élevé d’infection par le SRAS-CoV-2, particulièrement lors des éclosions. Il faudra travailler à mieux comprendre la dynamique de la transmission du SRAS-CoV-2 dans les milieux de soins.
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- 2022
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12. Positive no-touch surfaces and undetectable SARS-CoV-2 aerosols in long-term care facilities: An attempt to understand the contributing factors and the importance of timing in air sampling campaigns.
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Dumont-Leblond, Nathan, Veillette, Marc, Bhérer, Luc, Boissoneault, Karine, Mubareka, Samira, Yip, Lily, Dubuis, Marie-Eve, Longtin, Yves, Jouvet, Philippe, McGeer, Alison, and Duchaine, Caroline
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• Around 32% of no-touch surfaces were positive for SARS-CoV-2 in long-term carefacilities. • Undetectable airborne SARS-CoV-2, 8-30 days after residents' symptoms onset. • Reconsideration of exposure risks in LTCFs is necessary. • Timing is crucial in air sampling campaign deployment. • Collaboration of LTCFs is key to study and have quick access to COVID-19 outbreaks. Long-term care facilities (LTCF) are environments particularly favorable to coronavirus disease (SARS-CoV-2) pandemic outbreaks, due to the at-risk population they welcome and the close proximity of residents. Yet, the transmission dynamics of the disease in these establishments remain unclear. Air and no-touch surfaces of 31 rooms from 7 LTCFs were sampled and SARS-CoV-2 was quantified by real-time reverse transcription polymerase chain reaction (RT-qPCR). Air samples were negative but viral genomes were recovered from 20 of 62 surface samples at concentrations ranging from 13 to 36,612 genomes/surface. Virus isolation (culture) from surface samples (n = 7) was negative. The presence of viral RNA on no-touch surfaces is evidence of viral dissemination through air, but the lack of airborne viral particles in air samples suggests that they were not aerosolized in a significant manner during air sampling sessions. The air samples were collected 8 to 30 days after the residents' symptom onset, which could indicate that viruses are aerosolized early in the infection process. Additional research is needed to evaluate viral viability conservation and the potential role of direct contact and aerosols in SARS-CoV-2 transmission in these institutions. [ABSTRACT FROM AUTHOR]
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- 2021
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13. Microbiological efficacy and skin tolerance of commonly used nonantiseptic inpatient bathing practices in non-ICU settings: A systematic review.
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Zanichelli, Veronica, Pavoni, Carolyn, Eastmond, Jennifer, and Longtin, Yves
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• Patient bathing with nonantiseptic products was not found to reduce health care-associated infections. • Patient bathing with nonantiseptic products does not reduce skin colonization. • No-rinse washcloths may be preferable in bed-bound patients to decrease skin lesions. • Showers may reduce C difficile skin contamination more effectively than baths. Nonantiseptic bathing practices among inpatients and residents of nursing homes vary in terms of frequency, bathing type and product. We performed a systematic review to compare the efficacy of different bathing practices in reducing skin colonization, health care-associated infections (HAI) or their impact on skin integrity. We searched Medline and Embase up until February 2018 testing a combination of terms for 3 concepts: (1) personal hygiene, (2) inpatients, (3) skin colonization, integrity or HAIs. Studies set in ICUs or including children were excluded. This review was registered in PROSPERO: CRD42018091639. Seven studies were included. No statistically significant impact in terms of reduced skin colonization was described irrespective of bathing product, type or frequency except for a reduced burden of C difficile on the skin of infected patients after showering compared to bathing. One study addressing impact on HAI did not detect a significant difference when a waterless no-rinse product was used. Integrity of the skin was better preserved by no-rinse products. No study described a statistically significant reduction of bacterial skin colonization or incidence of HAI after bathing hospitalized patients with nonantiseptic products. However, waterless no-rinse products were associated with less skin damage in most studies. [ABSTRACT FROM AUTHOR]
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- 2021
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14. Impact of extended use and decontamination with vaporized hydrogen peroxide on N95 respirator fit.
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Lieu, Anthony, Mah, Jordan, Zanichelli, Veronica, Exantus, Rose Carmel, and Longtin, Yves
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• We evaluated the impact of extended use and H 2 O 2 decontamination on N95 respirators. • Extended N95 use and decontamination was associated with a rapid loss of fit test. • User seal check overestimated user fit test. • Single-use N95 respirator longevity may be shorter than previously reported. To address the shortage of N95 respirators in the wake of the COVID-19 pandemic, some organizations have recommended the decontamination of respirators using vaporized hydrogen peroxide (VHP) sterilizer for up to 10 times. However, these recommendations are based on studies that did not take into account the extended use of respirators, which can degrade respirator fit. We investigated the impact of extended use and decontamination with VHP on N95 Respirator Fit. We performed a prospective cohort study to determine the number of times respirators can be decontaminated before respirator fit test failure. The primary outcome was the overall number of cycles required for half of the respirators to fail (either mechanical failure or fit test failure). Thirty-six participants completed 360 hours of respirator usage across 90 cycles. The median number of cycles completed by participants before respirator failure was 2. The overall number of cycles required for half of respirators to fail was 1, 3, 5, and 4 for the 3M 1860(S), 3M 1870+, Moldex 151X and ProGear 88020 respirators, respectively. The combination of prolonged usage and VHP decontamination was associated with early failure. Decontamination and prolonged usage of respirators must be done cautiously. [ABSTRACT FROM AUTHOR]
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- 2020
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15. The Conscientious Use of Images Illustrating Diversity in Medical Education Marketing.
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Hernandez, Rachael, Hoffmann-Longtin, Krista, Patrick, Shawn, Tucker-Edmonds, Brownsyne, Rucker, Sydney, and Livingston, Nikki
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- 2020
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16. Trends in the use of laboratory tests for the diagnosis of Clostridium difficile infection and association with incidence rates in Quebec, Canada, 2010-2014.
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Bogaty, C., Lévesque, S., Garenc, C., Frenette, C., Bolduc, D., Galarneau, L.-A., Lalancette, C., Loo, V., Tremblay, C., Trudeau, M., Vachon, J., Dionne, M., Villeneuve, J., Longtin, J., and Longtin, Y.
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Background Several Clostridium difficile infection (CDI) surveillance programs do not specify laboratory strategies to use. We investigated the evolution in testing strategies used across Quebec, Canada, and its association with incidence rates. Methods Cross-sectional study of 95 hospitals by surveys conducted in 2010 and in 2013-2014. The association between testing strategies and institutional CDI incidence rates was analyzed via multivariate Poisson regressions. Results The most common assays in 2014 were toxin A/B enzyme immunoassays (EIAs) (61 institutions, 64%), glutamate dehydrogenase (GDH) EIAs (51 institutions, 53.7%), and nucleic acid amplification tests (NAATs) (34 institutions, 35.8%). The most frequent algorithm was a single-step NAAT (20 institutions, 21%). Between 2010 and 2014, 35 institutions (37%) modified their algorithm. Institutions detecting toxigenic C difficile instead of C difficile toxin increased from 14 to 37 ( P < .001). Institutions detecting toxigenic C difficile had higher CDI rates (7.9 vs 6.6 per 10,000 patient days; P = .01). Institutions using single-step NAATs, GDH plus toxigenic cultures, and GDH plus cytotoxicity assays had higher CDI rates than those using an EIA-based algorithm ( P < .05). Conclusions Laboratory detection of CDI has changed since 2010. There is an association between diagnostic algorithms and CDI incidence. Mitigation strategies are warranted. [ABSTRACT FROM AUTHOR]
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- 2017
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17. Creating Choice and Building Consensus: Invitational Rhetoric as a Strategy to Promote Vasectomies in the United States
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Longtin, Krista and Binion, Kelsey
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Abstract:According to a recent study by the Brookings Institution (Reeves & Krause, 2016), vasectomies are safer, more effective, and less expensive than most other voluntary sterilization methods. While the procedure has grown in popularity in recent years, particularly in the United Kingdom and Canada, it is much less common in the United States. This discrepancy can be attributed to both social (a perception that contraception is “women’s work”) and policy-based factors (lack of coverage under the Affordable Care Act). This paper examines the role and extent to which invitational rhetoric could be a useful communicative lens for both partners and providers considering vasectomies, thus increasing access to and utilization of the safe, effective, and affordable procedure. In this policy brief, we suggest strategies for incorporating invitational rhetoric into health professions education curricula, patient counseling literature, and policy language in order to address some of the social stigma around the procedure.
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- 2021
18. SARS-CoV-2 seroprevalence in health care workers from 10 hospitals in Quebec, Canada: a cross-sectional study
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Brousseau, Nicholas, Morin, Laurianne, Ouakki, Manale, Savard, Patrice, Quach, Caroline, Longtin, Yves, Cheng, Matthew P., Carignan, Alex, Dufresne, Simon F., Leduc, Jean-Michel, Lavallée, Christian, Gauthier, Nicolas, Bestman-Smith, Julie, Arrieta, Maria-Jesus, Ishak, Magued, Lévesque, Simon, Martin, Philippe, and De Serres, Gaston
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Background:The COVID-19 pandemic has disproportionately affected health care workers. We sought to estimate SARS-CoV-2 seroprevalence among hospital health care workers in Quebec, Canada, after the first wave of the pandemic and to explore factors associated with SARS-CoV-2 seropositivity.Methods:Between July 6 and Sept. 24, 2020, we enrolled health care workers from 10 hospitals, including 8 from a region with a high incidence of COVID-19 (the Montréal area) and 2 from low-incidence regions of Quebec. Eligible health care workers were physicians, nurses, orderlies and cleaning staff working in 4 types of care units (emergency department, intensive care unit, COVID-19 inpatient unit and non-COVID-19 inpatient unit). Participants completed a questionnaire and underwent SARS-CoV-2 serology testing. We identified factors independently associated with higher seroprevalence.Results:Among 2056 enrolled health care workers, 241 (11.7%) had positive SARS-CoV-2 serology. Of these, 171 (71.0%) had been previously diagnosed with COVID-19. Seroprevalence varied among hospitals, from 2.4% to 3.7% in low-incidence regions to 17.9% to 32.0% in hospitals with outbreaks involving 5 or more health care workers. Higher seroprevalence was associated with working in a hospital where outbreaks occurred (adjusted prevalence ratio 4.16, 95% confidence interval [CI] 2.63–6.57), being a nurse or nursing assistant (adjusted prevalence ratio 1.34, 95% CI 1.03–1.74) or an orderly (adjusted prevalence ratio 1.49, 95% CI 1.12–1.97), and Black or Hispanic ethnicity (adjusted prevalence ratio 1.41, 95% CI 1.13–1.76). Lower seroprevalence was associated with working in the intensive care unit (adjusted prevalence ratio 0.47, 95% CI 0.30–0.71) or the emergency department (adjusted prevalence ratio 0.61, 95% CI 0.39–0.98).Interpretation:Health care workers in Quebec hospitals were at high risk of SARS-CoV-2 infection, particularly in outbreak settings. More work is needed to better understand SARS-CoV-2 transmission dynamics in health care settings.
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- 2021
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19. The Conscientious Use of Images Illustrating Diversity in Medical Education Marketing
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Hernandez, Rachael, Hoffmann-Longtin, Krista, Patrick, Shawn, Tucker-Edmonds, Brownsyne, Rucker, Sydney, and Livingston, Nikki
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An institution’s marketing materials are an important part of presenting its culture. In 2018, communication professionals in the Office of Faculty Affairs, Professional Development, and Diversity at the Indiana University School of Medicine recognized after reviewing the literature that using images illustrating diversity in marketing materials may have unintended negative consequences and could potentially reflect poorly on the institution. Representations of diversity that are discordant with the actual demographics of an institution can create distrust among faculty, students, and staff who discover an institution is not as diverse or supportive of diversity as their marketing materials suggest. If institutions adopt an aspirational approach to images and depict more diversity than actual demographics reflect, the authors of this Perspective recommend that they both develop marketing materials that present a widely diverse selection of images and demonstrate transparency in their communication strategies.To improve their promotional materials, the authors conducted an analysis of their institution’s strategy for selecting images for these materials, identified institutional goals related to the strategic use of images, created training materials for staff, and drafted a public-facing statement about diversity in images. These measures are a significant step forward in cultivating the ethical use of images illustrating diversity. In the future, institutions should highlight their approaches to using images to portray diversity, as well as photograph and document a wide range of events that represent diverse topics and individuals. When these images are used for marketing purposes, it is also important to ensure that they are used in an appropriate context and not selected with the single goal of presenting diversity. Future research should focus on how underrepresented students and faculty interpret the use of diverse images in marketing, as well as their preferences for the use of their own images in marketing materials portraying diversity.
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- 2020
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20. Computational modeling of through-thickness flow and pressure drop characteristics in woven matrix porous media
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Zhi, Z., Chen, H., Longtin, J. P., Alkhader, M., and Venkatesh, T. A.
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ABSTRACTA hybrid finite element/volume model that captures the flow and pressure drop characteristics in highly porous woven matrix media is developed. It is demonstrated that the characteristics of flow through a woven matrix composed of fibers with circular cross-section can be modeled using the finite element method with an equivalent woven matrix system composed of fibers with square cross-section. From simulations of fluid flow in a range of models with varying sizes, it is demonstrated that changes in the thickness of the finite element model in the fluid flow direction and defects in the lay-up of the woven matrix layers have significant effects on the pressure drops. Higher defect densities result in greater pressure drops as they disrupt the steady flow of fluid in the through-thickness direction. The pressure drops obtained in the finite element model simulations of thick models that contained some defective layers match well with experimental observations.
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- 2020
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21. Development and validation of a clinical risk calculator for mortality after colectomy for fulminant Clostridium difficile colitis.
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Abou Khalil, Maria, Bhatnagar, Sahir Rai, Feldman, Liane, Longtin, Yves, Vasilevsky, Carol-Ann, Carignan, Alex, Morin, Nancy, and Boutros, Marylise
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- 2019
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22. Infectivity of healthcare workers diagnosed with coronavirus disease 2019 (COVID-19) approximately 2 weeks after onset of symptoms: A cross-sectional study
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Longtin, Yves, Charest, Hugues, Quach, Caroline, Savard, Patrice, Baz, Mariana, Boivin, Guy, Farfard, Judith, Villeneuve, Jasmin, Roger, Michel, and De Serres, Gaston
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AbstractWe performed viral culture of respiratory specimens in 118 severe acute respiratory coronavirus virus 2 (SARS-CoV-2)–infected healthcare workers (HCWs), ∼2 weeks after symptom onset. Only 1 HCW (0.8%) had a positive culture. No factors for prolonged viral shedding were identified. Infectivity is resolved in nearly all HCWs ∼2 weeks after symptom onset.
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- 2022
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23. It's in our hands: a rapid, international initiative to translate a hand hygiene song during the COVID-19 pandemic.
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Thampi, N., Longtin, Y., Peters, A., Pittet, D., and Overy, K.
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- 2020
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24. Development and validation of a clinical risk calculator for mortality after colectomy for fulminant Clostridium difficilecolitis
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Abou Khalil, Maria, Bhatnagar, Sahir Rai, Feldman, Liane, Longtin, Yves, Vasilevsky, Carol-Ann, Carignan, Alex, Morin, Nancy, and Boutros, Marylise
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Supplemental digital content is available in the text.
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- 2019
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25. Entre vie nue et projets de mort: l’imaginaire de la violence dans le discours du Conseil civique des organisations populaires et indigènes du Honduras (2009–2015)
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Longtin, David
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RÉSUMÉCet article présente une analyse du discours du Conseil civique des organisations populaires et indigènes du Honduras (COPINH), une fédération lenca du Honduras mobilisée autour de conflits socioenvi-ronnementaux liés à l’extraction minière, l’exploitation forestière, l’accès aux terres communales et la privatisation de l’eau et dont les membres font face à la répression et la criminalisation de leurs actions. En mettant en scène la défense du territoire, le discours du COPINH oppose le caractère sacré, inviolable et digne de la vie humaine et naturelle à la condition de la vie nue, c’est-à-dire à l’abandon à la mort en toute impunité. Ce faisant, à travers les significations associées à la vie et à la mort, ce discours participe à la mise en circulation d’un imaginaire qui déplace le sens attribué aux projets de barrages hydroélectriques et d’extraction minière affectant des communautés, qualifiés de « projets de mort » détruisant les espaces naturels sacrés.
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- 2019
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26. Effect of Detecting and Isolating Clostridium difficile Carriers at Hospital Admission on the Incidence of C difficile Infections: A Quasi-Experimental Controlled Study
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Longtin, Yves, Paquet-Bolduc, Bianka, Gilca, Rodica, Garenc, Christophe, Fortin, Elise, Longtin, Jean, Trottier, Sylvie, Gervais, Philippe, Roussy, Jean-François, Lévesque, Simon, Ben-David, Debby, Cloutier, Isabelle, and Loo, Vivian G.
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IMPORTANCE: Clostridium difficile infection (CDI) is a major cause of health care–associated infection worldwide, and new preventive strategies are urgently needed. Current control measures do not target asymptomatic carriers, despite evidence that they can contaminate the hospital environment and health care workers’ hands and potentially transmit C difficile to other patients. OBJECTIVE: To investigate the effect of detecting and isolating C difficile asymptomatic carriers at hospital admission on the incidence of health care–associated CDI (HA-CDI). DESIGN, SETTING, AND PARTICIPANTS: We performed a controlled quasi-experimental study between November 19, 2013, and March 7, 2015, in a Canadian acute care facility. Admission screening was conducted by detecting the tcdB gene by polymerase chain reaction on a rectal swab. Carriers were placed under contact isolation precautions during their hospitalization. MAIN OUTCOMES AND MEASURES: Changes in HA-CDI incidence level and trend during the intervention period (17 periods of 4 weeks each) were compared with the preintervention control period (120 periods of 4 weeks each) by segmented regression analysis and autoregressive integrated moving average (ARIMA) modeling. Concomitant changes in the aggregated HA-CDI incidence at other institutions in Québec City, Québec (n = 6) and the province of Québec (n = 94) were also examined. RESULTS: Overall, 7599 of 8218 (92.5%) eligible patients were screened, among whom 368 (4.8%) were identified as C difficile carriers. During the intervention, 38 patients (3.0 per 10 000 patient-days) developed an HA-CDI compared with 416 patients (6.9 per 10 000 patient-days) during the preintervention control period (P < .001). There was no immediate change in the level of HA-CDIs on implementation (P = .92), but there was a significant decrease in trend over time of 7% per 4-week period (rate ratio, 0.93; 95% CI, 0.87-0.99 per period; P = .02). ARIMA modeling also detected a significant effect of the intervention, represented by a gradual progressive decrease in the HA-CDI time series by an overall magnitude of 7.2 HA-CDIs per 10 000 patient-days. We estimated that the intervention had prevented 63 of the 101 (62.4%) expected cases. By contrast, no significant decrease in HA-CDI rates occurred in the control groups. CONCLUSIONS AND RELEVANCE: Detecting and isolating C difficile carriers was associated with a significant decrease in the incidence of HA-CDI. If confirmed in subsequent studies, this strategy could help prevent HA-CDI.
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- 2016
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27. European tattoo ingredient ban: Implications for North America.
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DeBiasio, Celina, Li, Heidi Oi-Yee, Brandts-Longtin, Olivier, and Kirchhof, Mark G.
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- 2022
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28. Rectal swab screening assays of public health importance in molecular diagnostics: Sample adequacy control.
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Glisovic, Sanja, Eintracht, Shaun, Longtin, Yves, Oughton, Matthew, and Brukner, Ivan
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Rectal swabs are routinely used by public health authorities to screen for multi-drug resistant enteric bacteria including vancomycin-resistant enterococci (VRE) and carbapenem-resistant enterobacteriaceae (CRE). Screening sensitivity can be influenced by the quality of the swabbing, whether performed by the patient (self-swabbing) or a healthcare practitioner. One common exclusion criterion for rectal swabs is absence of “visible soiling” from fecal matter. In our institution, this criterion excludes almost 10% of rectal swabs received in the microbiology laboratory. Furthermore, over 30% of patients in whom rectal swabs are cancelled will not be re-screened within the next 48 h, resulting in delays in removing infection prevention measures. We describe two quantitative polymerase chain reaction (qPCR)-based assays, human RNAse P and eubacterial 16S rDNA, which might serve as suitable controls for sampling adequacy. However, lower amounts of amplifiable human DNA make the 16s rDNA assay a better candidate for sample adequacy control. [ABSTRACT FROM AUTHOR]
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- 2018
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29. Efficacy of the World Health Organization–recommended handwashing technique and a modified washing technique to remove Clostridium difficile from hands.
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Deschênes, Philippe, Chano, Frédéric, Dionne, Léa-Laurence, Pittet, Didier, and Longtin, Yves
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Background The efficacy of the World Health Organization (WHO)–recommended handwashing technique against Clostridium difficile is uncertain, and whether it could be improved remains unknown. Also, the benefit of using a structured technique instead of an unstructured technique remains unclear. Methods This study was a prospective comparison of 3 techniques (unstructured, WHO, and a novel technique dubbed WHO shortened repeated [WHO-SR] technique) to remove C difficile . Ten participants were enrolled and performed each technique. Hands were contaminated with 3 × 10 6 colony forming units (CFU) of a nontoxigenic strain containing 90% spores. Efficacy was assessed using the whole-hand method. The relative efficacy of each technique and of a structured (either WHO or WHO-SR) vs an unstructured technique were assessed by Mann-Whitney U test and Wilcoxon signed-rank test. Results The median effectiveness of the unstructured, WHO, and WHO-SR techniques in log 10 CFU reduction was 1.30 (interquartile range [IQR], 1.27-1.43), 1.71 (IQR, 1.34-1.91), and 1.70 (IQR, 1.54-2.42), respectively. The WHO-SR technique was significantly more efficacious than the unstructured technique ( P = .01). Washing hands with a structured technique was more effective than washing with an unstructured technique (median, 1.70 vs 1.30 log 10 CFU reduction, respectively; P = .007). Conclusions A structured washing technique is more effective than an unstructured technique against C difficile . [ABSTRACT FROM AUTHOR]
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- 2017
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30. Porcine reproductive and respiratory syndrome virus (PRRSV) in pig meat.
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Raymond, Philippe, Bellehumeur, Christian, Nagarajan, Malliga, Longtin, Diane, Ferland, Alexandra, Müller, Peter, Bissonnette, Rachel, and Simard, Carole
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Copyright of Canadian Journal of Veterinary Research / Revue Canadienne de Recherche Vétérinaire is the property of Canadian Veterinary Medical Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2017
31. Opening Doors for New Graduate Nurses in Perianesthesia.
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Bies, Team Leader: Jessica, Longtin, Team Members: Jamie, and Smith, Kristine
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The Nursing Practice and Education Team identified the need to develop a perianesthesia evidence-based new graduate program across a large healthcare system. Historically, perianesthesia nursing positions required previous critical care nursing experience. Due to the ongoing nursing shortage, organizations face challenges in hiring experienced nurses. The goal was to develop and implement a structured, new graduate perianesthesia nursing orientation program, using a tiered approach to learning in a critical care environment while providing the foundations of perianesthesia nursing. The team reviewed evidence and literature of new graduate orientation programs. Seventeen nurses, who graduated within the previous 2 years were interviewed to identify the specific needs of nurses transitioning from academia to clinical practice. A 9-month program was developed that combines The American Society of PeriAnesthesia Nurses Competency-based orientation program and American Association of Critical Care Nurses Essentials to Critical Care Orientation Course, which provides the foundation of critical care knowledge. The program consists of prelearning, didactic, skills training, case studies, shadow experiences, and targeted clinical components with a preceptor. There are three stages that target specific goals and learning objectives. The program expands their hands-on clinical practice while allowing them to gain valuable experience, enhance their decision-making, and develop critical thinking skills while building a foundation of nursing excellence. The first cohort of nurses were surveyed at the beginning and end of the program. The average in confidence in nursing skills on a 1 to 10 scale improved from 3.5 to 9 and all nurses responded they were "very likely" to recommend the program. In addition, the request for a second cohort was received from the Operational Leadership Team. The program supports a large healthcare organization in creating innovative pathways and utilizing various, diverse approaches to successfully train new graduate nurses in the perianesthesia environment. This allows an organization to break down the traditional barriers, opening doors for new graduate nurses to develop into competent perianesthesia nurses, while providing them with a pipeline of support and mentorship. [ABSTRACT FROM AUTHOR]
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- 2023
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32. Driving the Musculoskeletal Diagnosis Train on the High-Value Track.
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DÉCARY, SIMON, LONGTIN, CHRISTIAN, NAYE, FLORIAN, and TOUSIGNANT-LAFLAMME, YANNICK
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The article presents the clinicians who provide high-value musculoskeletal care offer evidence-based management that can improve pain, function, and quality of life. Topics include the outcomes emphasizes treatment strategies at the expense of accurate diagnosis, the guidelines rarely provide quality information on differential diagnosis and prognosis, and the disconnect is worrying, because accurate diagnosis can lead to more appropriate care and improved patient outcomes.
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- 2020
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33. Management of a hospital outbreak of extensively drug-resistant Acinetobacter baumannii using a multimodal intervention including daily chlorhexidine baths.
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Gray, A.P., Allard, R., Paré, R., Tannenbaum, T., Lefebvre, B., Lévesque, S., Mulvey, M., Maalouf, L., Perna, S., and Longtin, Y.
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Background: Extensively drug-resistant Acinetobacter baumannii (XDR-Ab) is an increasingly important cause of healthcare-associated infection. Uncertainties remain concerning optimal control measures for healthcare-associated outbreaks.Aim: To describe the epidemiology and control of an XDR-Ab outbreak that involved multiple units of a large hospital from March 2012 to January 2014.Methods: Case-finding included screening of rectum, groin, throat, nose, wounds, iatrogenic portals of entry, and catheterized sites. Antimicrobial susceptibility was evaluated by disc diffusion and E-test. Resistance genes were detected by polymerase chain reaction. Clonality was assessed by pulsed-field gel electrophoresis. Charts of cases were reviewed to identify risk factors for invasive infection. Control measures included isolation and cohorting of cases, hand hygiene reinforcement, environmental decontamination, and source control with daily baths using wipes pre-impregnated with chlorhexidine gluconate.Findings: A single clonal strain of XDR-Ab colonized or infected 29 patients. Five patients died of XDR-Ab bacteraemia. Transmission occurred primarily on two wards. Colonization was detected at all anatomical screening sites; only 57% (16/28) of cases were rectal carriers. Advanced malignancy was a risk factor for bacteraemia (relative risk: 5.8; 95% confidence interval: 1.2-27.0). Transmission ended following implementation of the multimodal control strategy. No additional nosocomial cases occurred during the following 20 months.Conclusion: Our study highlights the need to screen multiple anatomic sites to diagnose carriage and identifies risk factors for XDR-Ab bacteraemia. A multimodal intervention that included daily chlorhexidine baths for cases was rapidly followed by the termination of the outbreak. Hospitals should consider similar interventions when managing future XDR-Ab outbreaks. [ABSTRACT FROM AUTHOR]- Published
- 2016
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34. The evolving epidemiology of Clostridium difficileinfection in Canadian hospitals during a postepidemic period (2009–2015)
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Katz, Kevin C., Golding, George R., Choi, Kelly Baekyung, Pelude, Linda, Amaratunga, Kanchana R., Taljaard, Monica, Alexandre, Stephanie, Collet, Jun Chen, Davis, Ian, Du, Tim, Evans, Gerald A., Frenette, Charles, Gravel, Denise, Hota, Susy, Kibsey, Pamela, Langley, Joanne M., Lee, Bonita E., Lemieux, Camille, Longtin, Yves, Mertz, Dominik, Mieusement, Lorraine Maze Dit, Minion, Jessica, Moore, Dorothy L., Mulvey, Michael R., Richardson, Susan, Science, Michelle, Simor, Andrew E., Stagg, Paula, Suh, Kathryn N., Taylor, Geoffrey, Wong, Alice, and Thampi, Nisha
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Background:The clinical and molecular epidemiology of health care–associated Clostridium difficileinfection in nonepidemic settings across Canada has evolved since the first report of the virulent North American pulsed-field gel electrophoresis type 1 (NAP1) strain more than 15 years ago. The objective of this national, multicentre study was to describe the evolving epidemiology and molecular characteristics of health care–associated C. difficileinfection in Canada during a post-NAP1-epidemic period, particularly patient outcomes associated with the NAP1 strain.Methods:Adult inpatients with C. difficileinfection were prospectively identified, using a standard definition, between 2009 and 2015 through the Canadian Nosocomial Infection Surveillance Program (CNISP), a network of 64 acute care hospitals. Patient demographic characteristics, severity of infection and outcomes were reviewed. Molecular testing was performed on isolates, and strain types were analyzed against outcomes and epidemiologic trends.Results:Over a 7-year period, 20 623 adult patients admitted to hospital with health care–associated C. difficileinfection were reported to CNISP, and microbiological data were available for 2690 patients. From 2009 to 2015, the national rate of health care–associated C. difficileinfection decreased from 5.9 to 4.3 per 10 000 patient-days. NAP1 remained the dominant strain type, but infection with this strain has significantly decreased over time, followed by an increasing trend of infection with NAP4 and NAP11 strains. The NAP1 strain was significantly associated with a higher rate of death attributable to C. difficileinfection compared with non-NAP1 strains (odds ratio 1.91, 95% confidence interval [CI] 1.29–2.82). Isolates were universally susceptible to metronidazole; one was nonsusceptible to vancomycin. The proportion of NAP1 strains within individual centres predicted their rates of health care–associated C. difficileinfection; for every 10% increase in the proportion of NAP1 strains, the rate of health care–associated C. difficileinfection increased by 3.3% (95% CI 1.7%–4.9%).Interpretation:Rates of health care–associated C. difficileinfection have decreased across Canada. In nonepidemic settings, NAP4 has emerged as a common strain type, but NAP1, although decreasing, continues to be the predominant circulating strain and remains significantly associated with higher attributable mortality.
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- 2018
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35. Do experienced physiotherapists and final year physiotherapy trainees apply similar force during posterior-to-anterior lumbar mobilization techniques?
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Gagnon, Dany H., Longtin, Christian, Berbiche, Djamal, and Gaudreault, Nathaly
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This study aims to quantify the force applied during posterior-to-anterior lumbar vertebrae mobilizations of different grades (I to IV) and compare that force between experienced physiotherapists and final year physiotherapy students. Four experienced physiotherapists and four final year physiotherapy students participated in this study along with five healthy asymptomatic individuals. A manual therapy table positioned over three force plates allowed for measurements of the force oscillation frequency and intensity applied during grade I, II, III and IV posterior-to-anterior (PA) mobilizations at two lumbar vertebral levels (L2 and L4). Mixed model ANOVAs were used to compare the force applied between the experienced physiotherapists and students, and between the various grades. The results showed that the mean oscillation frequency was similar between the groups for all grades. Grade I and grade IV PA mobilizations showed similar mean oscillation frequency as did grade II and III PA mobilizations. The minimum and maximum force applied was higher for the physiotherapists than for the students for all mobilization grades ( p values < 0.05). Similar mean maximum force values were recorded for PA mobilizations between grade I and II and between grade III and grade IV. Grade III and IV PA mobilizations yielded higher mean maximum force values than those recorded during grade I and grade II PA mobilizations. The method used in this study allowed for quantification of the force applied during lumbar PA mobilizations. Experienced physiotherapists apply greater force than physiotherapy students across all grades, despite similar oscillation frequency. [ABSTRACT FROM AUTHOR]
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- 2016
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36. A Competency-Based Approach to Recruiting, Developing, and Giving Feedback to Department Chairs.
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Palmer, Megan, Hoffmann-Longtin, Krista, Walvoord, Emily, Bogdewic, Stephen P., and Dankoski, Mary E.
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- 2015
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37. Correlation between Clostridium difficileBacterial Load, Commercial Real-Time PCR Cycle Thresholds, and Results of Diagnostic Tests Based on Enzyme Immunoassay and Cell Culture Cytotoxicity Assay
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Dionne, Léa-Laurence, Raymond, Frédéric, Corbeil, Jacques, Longtin, Jean, Gervais, Philippe, and Longtin, Yves
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ABSTRACTThe impact of Clostridium difficilefecal loads on diagnostic test results is poorly understood, but it may have clinical importance. In this study, we investigated the relationship between C. difficilefecal load and the results of four assays: a glutamate dehydrogenase (GDH) enzyme immunoassay (EIA), a toxin A/B antigen EIA (ToxAB), a cell culture cytotoxicity assay (CCA), and PCR targeting the tcdBgene. We also compared the PCR cycle threshold (CT) with the results of quantitative culture using Spearman's rank correlation coefficient. Finally, we sequenced the genomes of 24 strains with different detection profiles. A total of 203 clinical samples harboring toxigenic C. difficilewere analyzed and sorted into one of four groups: 17 PCR+(group 1), 37 PCR+GDH+(group 2), 24 PCR+GDH+CCA+(group 3), and 125 PCR+GDH+ToxAB+(group 4). The overall median fecal load in log10CFU/g was 6.67 (interquartile range [IQR], 5.57 to 7.54). The median fecal bacterial load of groups 1, 2, 3, and 4 were 4.15 (IQR, 3.00 to 4.98), 5.74 (IQR, 4.75 to 6.16), 6.20 (IQR, 5.23 to 6.80), and 7.08 (IQR, 6.35 to 7.83), respectively. Group 1 samples had lower fecal loads than those from each of the other groups (P< 0.001). Group 2 samples had lower fecal loads than those from groups 3 and 4 (P< 0.001). There was a significant correlation between PCR CTand fecal loads (? = -0.697; P< 0.001). NAP1 strains were associated with the detection of toxins by EIA or CCA (P= 0.041). This study demonstrates an association between C. difficilefecal load and the results of routinely used diagnostic tests.
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- 2013
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38. Laser assisted hybrid additive manufacturing of thermoelectric modules
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Neuenschwander, Beat, Grigoropoulos, Costas P., Makimura, Tetsuya, Račiukaitis, Gediminas, Zhang, Tao, Tewolde, Mahder, Longtin, Jon P., and Hwang, David J.
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- 2017
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39. Clostridium difficileInfections in Children: Impact of the Diagnostic Method on Infection Rates
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AlGhounaim, Mohammad, Longtin, Yves, Gonzales, Milagros, Merckx, Joanna, Winters, Nicholas, and Quach, Caroline
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BACKGROUNDPolymerase chain reaction (PCR) assays based on the detection of the toxin B gene are replacing enzyme-linked immunosorbent assay (ELISA)–based toxin production detection or cell cytotoxicity assay in most laboratories.OBJECTIVETo determine the proportion of pediatric patients diagnosed withClostridium difficileinfection by PCR who would have also been diagnosed by ELISA and to compare the clinical characteristics of PCR+/ELISA+ vs PCR+/ELISA− patients.METHODSUsing the microbiology laboratory information system, stool samples positive for C. difficileby PCR between October 2010 and July 2014 were identified. Using frozen stool specimens, an ELISA for toxin A and B was performed. A retrospective medical chart review was conducted to obtain demographic and clinical data. Duplicate samples were excluded.RESULTSA total of 136 PCR-positive samples underwent ELISA testing: 54 (40%) were positive for toxin A or B. The mean (SD) age of the entire cohort was 8.5 (6.2) years. There was no difference in age, gender, clinical manifestation, previous medical problems, and management between patients positive or negative by ELISA. However, patients positive by ELISA were more likely to have had a recent exposure to antibiotics (67.9% vs 50%; crude odds ratio, 2.1 [95% CI, 1.03–4.28]).CONCLUSIONIn our pediatric population, 60% of patients with C. difficilediagnosed by PCR had no toxin detectable by ELISA. ELISA-negative patients were less likely to have received an antibiotic recently compared with ELISA-positive patients. These results highlight the need to standardize laboratory criteria for the diagnosis of C. difficileinfections in children.Infect Control Hosp Epidemiol2016;37:1087–1093
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- 2016
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40. Predictors of Heavy Stethoscope Contamination Following a Physical Examination
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Tschopp, Clément, Schneider, Alexis, Longtin, Yves, Renzi, Gesuele, Schrenzel, Jacques, and Pittet, Didier
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BACKGROUNDThe degree of bacterial contamination of stethoscopes can vary significantly following a physical examination.OBJECTIVETo conduct a prospective study to investigate the impact of various environmental and patient characteristics on stethoscope contamination.METHODSFollowing a standardized examination, the levels of bacterial contamination of 4 regions of the physicians’ hands and 2 sections of the stethoscopes, and the presence of different pathogenic bacteria, were assessed. Predictors of heavy stethoscope contamination were identified through multivariate logistic regression.RESULTSIn total, 392 surfaces were sampled following examination of 56 patients. The microorganisms most frequently recovered from hands and stethoscopes were Enterococcusspp. (29% and 20%, respectively) and Enterobacteriaceae (16% and 7%, respectively). Staphylococcus aureus(either methicillin susceptible or resistant), extended-spectrum β-lactamase–producing Enterobacteriaceae, and Acinetobacter baumanniiwere recovered from 4%-9% of the samples from either hands or stethoscopes. There was a correlation between the likelihood of recovering these pathogens from the stethoscopes vs from the physicians’ hands (ρ=0.79; P=.04). The level of patient’s skin contamination was an independent predictor of contamination of the stethoscope diaphragm (adjusted odds ratio [aOR], 1.001; P=.007) and tube (aOR, 1.001; P=.003). Male sex (aOR, 28.24; P=.01) and reception of a bed bath (aOR, 7.52; P=.048) were also independently associated with heavy tube contamination.CONCLUSIONSStethoscope contamination following a single physical examination is not negligible and is associated with the level of contamination of the patient’s skin. Prevention of pathogen dissemination is needed.Infect Control Hosp Epidemiol2016;37:673–679
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- 2016
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41. Growth Assisted by Glancing Angle Deposition: A New Technique to Fabricate Highly Porous Anisotropic Thin Films
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Sanchez-Valencia, Juan Ramon, Longtin, Remi, Rossell, Marta D., and Gröning, Pierangelo
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We report a new methodology based on glancing angle deposition (GLAD) of an organic molecule in combination with perpendicular growth of a second inorganic material. The resulting thin films retain a very well-defined tilted columnar microstructure characteristic of GLAD with the inorganic material embedded inside the columns. We refer to this new methodology as growth assisted by glancing angle deposition or GAGLAD, since the material of interest (here, the inorganic) grows in the form of tilted columns, though it is deposited under a nonglancing configuration. As a “proof of concept”, we have used silver and zinc oxide as the perpendicularly deposited material since they usually form ill-defined columnar microstructures at room temperature by GLAD. By means of our GAGLAD methodology, the typical tilted columnar microstructure can be developed for materials that otherwise do not form ordered structures under conventional GLAD. This simple methodology broadens significantly the range of materials where control of the microstructure can be achieved by tuning the geometrical deposition parameters. The two examples presented here, Ag/Alq3 and ZnO/Alq3, have been deposited by physical vapor deposition (PVD) and plasma enhanced chemical vapor deposition (PECVD), respectively: two different vacuum techniques that illustrate the generality of the proposed technique. The two type of hybrid samples present very interesting properties that demonstrate the potentiality of GAGLAD. On one hand, the Ag/Alq3 samples present highly optical anisotropic properties when they are analyzed with linearly polarized light. To our knowledge, these Ag/Alq3 samples present the highest angular selectivity reported in the visible range. On the other hand, ZnO/Alq3 samples are used to develop highly porous ZnO thin films by using Alq3 as sacrificial material. In this way, antireflective ZnO samples with very low refractive index and extinction coefficient have been obtained.
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- 2016
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42. Interdisciplinary Support Services for Students with Autism Spectrum Disorders.
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Longtin, Susan
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PILOT projects ,PUBLIC universities & colleges ,COLLEGE students with disabilities ,AUTISM spectrum disorders ,ACADEMIC achievement ,PATIENTS ,SERVICES for students - Abstract
This Practice Brief describes a grant-funded pilot program at an urban four-year public college, developed to address the needs of students with Autism Spectrum Disorders (ASD). This Interdisciplinary Collaborative Support Services program provided (1) more clinical assistance for students with ASD to promote their academic and social success; (2) education, training, and supervision for graduate student mentors; (3) in-service training for faculty, staff, students, and administrators; and (4) a resource library related to the target population. This article describes the work among the different program partners to offer interdisciplinary, collaborative services for the students who elected to participate in the initiative and reports both the positive outcomes and challenges of the program. This article concludes with suggestions for expansion of the practice and research opportunities on the efficacy of the model. [ABSTRACT FROM AUTHOR]
- Published
- 2014
43. On the utility of mucilage ducts as a taxonomic character in Laminariaand Saccharina(Phaeophyceae) – the conundrum of S. groenlandica
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Longtin, Caroline M. and Saunders, Gary W.
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Abstract:We used a combination of molecular and morphological tools to determine whether mucilage ducts are a useful taxonomic character for species differentiation in the genera Laminariaand Saccharinain the North Atlantic and to verify the taxonomic status of Saccharina groenlandicaand the genetic species currently attributed to it in North America (NAGenSp). Microscopic examination of genetically verified Laminaria digitata, Laminaria hyperborea, Saccharina latissimaand the NAGenSp determined that the presence/absence of mucilage ducts in the blade is not a useful taxonomic character. However, the presence/absence and location of mucilage ducts in the stipe were useful for species differentiation. Laminaria digitataand S. latissimalacked mucilage ducts in the stipe, while the NAGenSp had mucilage ducts in the cortex, and L. hyperboreahad mucilage ducts in the medulla. Microscopic examination of the type material of S. groenlandicadetermined that S. groenlandicais synonymous with S. latissimaand that the reportedly diagnostic appearance of mucilage ducts in the stipe and blade of type material were the result of pseudo-mucilage ducts (putative infections). Microscopic examination of the type material of Laminaria nigripesrevealed a combination of mislabelled L. digitataand a single specimen that matched the type description, as well as northern individuals of the NAGenSp necessitating the combination Saccharina nigripes(J. Agardh) Longtin et G.W. Saunders comb. nov. Saccharina nigripesis distributed throughout the Northeast Pacific, Canadian Arctic, Northwest Atlantic, and Northern Europe (Greenland, Iceland, and Scandinavia).
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- 2015
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44. A Competency-Based Approach to Recruiting, Developing, and Giving Feedback to Department Chairs
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Palmer, Megan, Hoffmann-Longtin, Krista, Walvoord, Emily, Bogdewic, Stephen P., and Dankoski, Mary E.
- Abstract
Academic health centers (AHCs) are under unprecedented pressure, making strong leadership during these challenging times critical. Department chairs have tremendous influence in their AHCs, yet data indicate that—despite outstanding academic credentials—they are often underprepared to take on these important leadership roles. The authors sought to improve the approach to recruiting, developing, and giving feedback to department chairs at their institution, the Indiana University School of Medicine (IUSM), by reorganizing these processes around six key leadership competencies: leadership and team development, performance and talent management, vision and strategic planning, emotional intelligence, communication skills, and commitment to the tripartite mission. Over a two-year period (2009–2011), IUSM faculty and administrators developed standardized recruitment procedures to assess potential chairs based on the six leadership domains, and searches are now streamlined through centralized staff support in the dean’s office. Additionally, IUSM offers a chair development series to support learning around these leadership competencies and to meet the stated professional development needs of the chairs. Finally, chairs receive structured feedback regarding their leadership (among other considerations) through two different assessment instruments, IUSM’s Department Chair 360° Leadership Survey and IUSM’s Faculty Vitality Survey—both of which the dean reviews annually. Strategically attending to the way that chairs are selected, developed, and given feedback has tremendous potential to increase the success of chairs and, in turn, to constructively shape the culture of AHCs.
- Published
- 2015
- Full Text
- View/download PDF
45. Multifunctional magneto-plasmonic nanotransducers for advanced theranostics: synthesis, modeling and experiment
- Author
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Liao, Wei-Hsin, Masoumi, Masoud, Wang, Ya, Liu, Mingzhao, Tewolde, Mahder, and Longtin, Jon
- Published
- 2015
- Full Text
- View/download PDF
46. Et si le patient vous demandait de vous laver les mains...
- Author
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Des Rosiers, Natacha, Laplante, Pauline, Longtin, Yves, and Michaud, Cécile
- Published
- 2014
47. Using the College Infrastructure to Support Students on the Autism Spectrum.
- Author
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Longtin, Susan E.
- Subjects
COLLEGE students with disabilities ,AUTISM spectrum disorders ,HIGHER education ,ASPERGER'S syndrome ,UNIVERSITIES & colleges - Abstract
College students with high functioning autism (HFA) and Asperger syndrome (AS) are participating in postsecondary education in increasing numbers. Institutions of higher education (IHE) that admit these students should support their individual and unique needs. The challenges these students face in the domains of social interaction and executive function are often not addressed adequately. Traditional accommodations for students with disabilities are often insufficient to impact these students' academic success and broader educational experience. Currently, only a handful of colleges and universities have developed specialized programs to support students on the autism spectrum. Often costly, such programs add thousands of dollars in fees above and beyond escalating tuition costs. Consequently, it is not surprising that most of the specialized autism support programs reside in private rather than public institutions. This article will discuss the notion that postsecondary institutions that do not have autism specialty support programs can utilize the resources that already exist in their infrastructure to support these students. This article describes the contributions of the various resources, facilities, and centers present on many college campuses that can be better utilized to support this endeavor. A key element of this approach is the coordination and collaboration among the different divisions in order to best serve this growing student population. [ABSTRACT FROM AUTHOR]
- Published
- 2014
48. Stepping Stones: Nine Lessons from Women Leaders in Academic Medicine.
- Author
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Palmer, Megan M., Hoffmann-Longtin, Krista J., Walvoord, Emily C., and Dankoski, Mary E.
- Subjects
MEDICAL schools ,STUDY & teaching of medicine ,ACADEMIC medical centers ,LEADERSHIP ,EMPLOYEE empowerment ,COMMUNICATION - Abstract
Women now make up half of all medical school matriculates; yet few women hold leadership positions in academic health centers. The reasons for this gender gap are complex and have been the subject of much discussion. However, the experiences of women who successfully ascend to positions of senior leadership are rarely examined. It is critical to develop a greater understanding of women's paths to leadership positions in order to inspire and enable more women to seek such opportunities. Using a semi-structured protocol, we interviewed 16 women leaders who were willing to share their career journeys in a public forum. These leaders were asked to share pivotal moments or milestones, referred to as "stepping stones," in their careers. The interviews were taped, transcribed and analysed for significant patterns and consistent themes. Nine themes were identified and included: hold fast to your values; be open to unexpected opportunities; surround yourself with people who believe in you and people you believe in; be assertive in your communication and actions; continually refine your leadership skills; don't take things personally; stay organized; build positive relationships and welcoming environments; and when and if necessary, prove them wrong. The women leaders had strikingly similar lessons to share. This study develops a deeper understanding of the career paths of women in leadership positions, setting the stage for future study as well as encouraging and empowering more women to climb the leadership ladder. [ABSTRACT FROM AUTHOR]
- Published
- 2013
49. Academic Writing: Supporting Faculty in a Critical Competency for Success.
- Author
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Dankoski, Mary E., Palmer, Megan M., Banks, Julianna, Brutkiewicz, Randy R., Walvoord, Emily, Hoffmann-Longtin, Krista, Bogdewic, Stephen P., and Gopen, George D.
- Subjects
ACADEMIC discourse ,UNIVERSITY faculty ,OUTCOME-based education ,PROFESSIONAL education ,WRITTEN communication - Abstract
All faculty regardless of discipline or school need to be highly competent at writing for an academic audience. The "publish or perish" pressure is alive and well for academic advancement, publications, and external grant finding. Yet feiv faculty, particularly in the health professions and sciences, receive formal training on the craft of writing. Faculty developers have offered a variety of programs designed to enhance the writing skills of faculty using a various formats and with varying success. Since 2006, the Indiana University School of Medicine's (1USM) Office of Facult}/ Affairs and Professional Development has offered an in-depth two-day workshop plus individual tutorials designed to enhance faculty academic writing skills. This paper presents the results of an evaluation of faculty perceptions of the impact of their participation in this program. [ABSTRACT FROM AUTHOR]
- Published
- 2012
50. Chevaux et Mystères.
- Author
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LONGTIN, Mario and SALATKO-PETRYSZCZE, Camille
- Published
- 2011
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