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437 results on '"M. J., C"'

1. Early qualitative and quantitative amplitude-integrated electroencephalogram and raw electroencephalogram for predicting long-term neurodevelopmental outcomes in extremely preterm infants in the Netherlands: a 10-year cohort study

Author

Wang, Xiaowan, Trabatti, Chiara, Weeke, Lauren, Dudink, Jeroen, Swanenburg de Veye, Henriette, Eijsermans, Rian M J C, Koopman-Esseboom, Corine, Benders, Manon J N L, and Tataranno, Maria Luisa

Abstract

Extremely preterm infants (<28 weeks of gestation) are at great risk of long-term neurodevelopmental impairments. Early amplitude-integrated electroencephalogram (aEEG) accompanied by raw EEG traces (aEEG−EEG) has potential for predicting subsequent outcomes in preterm infants. We aimed to determine whether and which qualitative and quantitative aEEG–EEG features obtained within the first postnatal days predict neurodevelopmental outcomes in extremely preterm infants.

Published
2023
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2. Digital soil science and beyond

Author

Wadoux, Alexandre M. J.‐C. and McBratney, Alex B.

Abstract

Digital convergence is helping us to better understand and study the soil. Fixed and mobile sensors, and wireless communication systems aided by the internet produce cheap and abundant streams of digital soil data that can readily be used for modeling and information generation. Here, we explore the ways in which digital science and technology have affected soil science. We can call this digital soil science and define it as the study of the soil aided by the tools of the digital convergence. To some degree, all of our research and teaching had been enabled, enhanced, and expanded by the digital convergence. We outline how soil science has changed using illustrations of intellectual and technical developments enabled digitally. Digital soil sensors have been widely implemented, and new tools such as cell phones and applications, or metagenomics techniques are becoming available. There are also areas in soil science for which no major obstacles in the digital technologies exist, but which have not been thoroughly investigated—for example, to devise a truly digital soil field description or for building a formal digital quantitative system of soil classification. The soil science community will need to be alert to some of the dangers brought by digital convergence such as the lack of new theory and proprietary (black‐box) soil prediction. Finally, we discuss a whole set of digital tools that will, or might, gain the stage in the immediate future and take a stab in the dark on what may lie over the horizon of digital soil science. Many aspects of soil science have been strengthened by the digital convergence.We outline how soil science has changed with the digital.The dangers and immediate future of digital soil science are discussed.Scenarios on the far future of digital soil science are proposed.

Published
2021
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3. Dental caries in children with attention deficit/hyperactivity disorder: a meta-analysis.

Author

V. Z., Drumond, G. L. N., Souza, M. J. C., Pereira, R. A., Mesquita, M., Amin, and L. G., Abreu

Subjects
DENTAL caries, HYPERACTIVITY, GREY literature, PROGRAMMING languages, DATA extraction
Abstract

Objectives: The aim of the study was to evaluate whether children with attention deficit/hyperactivity disorder (ADHD) are more affected by dental caries than children without ADHD by means of a systematic review and meta-analysis. Design: Electronic searches were performed in four databases (PubMed, Embase, Scopus, and Web of Science) in July 2021. A grey literature search in OpenGrey, a search in Google Scholar, and searches in the reference list of included articles were also conducted. The eligibility criteria were observational studies in which children with ADHD were compared with children without ADHD with respect to dental caries. Study selection, data extraction, and risk of bias assessment, applying the Joanna Briggs tool, were performed by two reviewers independently. Meta-analysis and assessment of heterogeneity among studies were conducted with the meta-package of RStudio using the R programming language (R Core Team; Vienna, Austria). Results of meta-analysis were provided in mean difference (MD), odds ratio (OR), and confidence intervals (CIs). For assessment of heterogeneity, Baujat plot and influence analysis plot were obtained. Results: Thirteen studies were included and 10 were incorporated into metaanalyses. The meta-analysis showed that children with ADHD had a higher decayed, missing, and filled teeth (DMFT) index than their peers without ADHD (I2 = 42%; MD = 0.75 [0.38-1.13]). For decayed, missing, and filled surfaces (I2 = 0; MD = 0.39 [-0.02 to 0.80]) and decayed surfaces (ds) (I2 = 0%; MD = 0.35 [- 0.63 to 1.33]), no difference between groups was observed. In addition, children with ADHD had higher odds of having dental caries than their healthy peers (OR = 3.31 [1.25, 8.73]; I2 = 0%). After assessment of heterogeneity among studies, sensitivity analysis was conducted for DMFT. One study was removed and the significant difference between groups remained. Children with ADHD had a significantly higher DMFT index than their peers without ADHD (MD = 0.98 [CI = 0.75, 1.20]; I2 = 0%). Risk of bias ranged from low to high. Conclusion: The main shortcoming of the included studies is the high risk of bias regarding the strategies to deal with confounding factors. Within its limitations, this systematic review and meta-analysis demonstrated that children with ADHD were more likely to develop dental caries than their healthy counterparts. [ABSTRACT FROM AUTHOR]

Published
2024

6. The importance of Hutt Lagoon and fossil river estuaries to shorebirds in mid Western Australia.

Author

Singor, M. J. C., Giblett, Linda, and Heap, C.

Subjects
SHORE birds, ESTUARIES, LAGOONS, MIGRATORY animals, WETLAND soils, WETLANDS, RIVERS
Abstract

Little is known about the dynamics of the shorebird populations of the mid Western Australian coastline between Kalbarri and Geraldton, as this area is remote and sparsely populated. We surveyed shorebirds at several sites in this region, including fossil river estuaries from intermittent rivers (Hutt, Bowes and Greenough Rivers) and wetlands on the western shoreline of Hutt Lagoon and around Port Gregory. Totals of 21 migratory shorebird species and 9 Australian-breeding shorebird species were recorded from 64 visits in 2006–2010 and 87 visits in 2017–2018. The highest counts related to Banded Stilt Cladorhynchus leucocephalus (652), Red-capped Plover Charadrius ruficapillus (300) and Red-necked Stint Calidris ruficollis (300). The highest numbers of most species were recorded at Hutt Lagoon and associated semi-permanent wetlands near Port Gregory, with mean counts in 2017–2018 of 109 migratory shorebirds (mainly Red-necked Stints) and 227 Australian-breeding shorebirds (mainly Banded Stilts), from the accessible part of that wetland system. This shows the importance of such wetlands in providing shorebird habitat in the region. None of the wetlands met criteria for international importance. [ABSTRACT FROM AUTHOR]

Published
2019
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7. Molecular dynamics simulation and binding free energy studies of novel leads belonging to the benzofuran class inhibitors of Mycobacterium tuberculosisPolyketide Synthase 13

Author

Cruz, Jorddy N., Costa, José F. S., Khayat, André S., Kuca, Kamil, Barros, Carlos A. L., and Neto, A. M. J. C.

Abstract

In this work, the binding mechanism of new Polyketide Synthase 13 (Pks13) inhibitors has been studied through molecular dynamics simulation and free energy calculations. The drug Tam1 and its analogs, belonging to the benzofuran class, were submitted to 100 ns simulations, and according to the results obtained for root mean square deviation, all the simulations converged from approximately 30 ns. For the analysis of backbone flotation, the root mean square fluctuations were plotted for the Cα atoms; analysis revealed that the greatest fluctuation occurred in the residues that are part of the protein lid domain. The binding free energy value (ΔGbind) obtained for the Tam16 lead molecule was of −51.43 kcal/mol. When comparing this result with the ΔGbindvalues for the remaining analogs, the drug Tam16 was found to be the highest ranked: this result is in agreement with the experimental results obtained by Aggarwal and collaborators, where it was verified that the IC50for Tam16 is the smallest necessary to inhibit the Pks13 (IC50 = 0.19 μM). The energy decomposition analysis suggested that the residues which most interact with inhibitors are: Ser1636, Tyr1637, Asn1640, Ala1667, Phe1670, and Tyr1674, from which the greatest energy contribution to Phe1670 was particularly notable. For the lead molecule Tam16, a hydrogen bond with the hydroxyl of the phenol not observed in the other analogs induced a more stable molecular structure. Aggarwal and colleagues reported this hydrogen bonding as being responsible for the stability of the molecule, optimizing its physic-chemical, toxicological, and pharmacokinetic properties.

Published
2019
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8. Avaliação biomecânica e dimensional do fio de sutura à base de quitosana.

Author

Alves, A. P., Sá, M. J. C., Fook, M. V. L., Felipe, G. C., Henrique, F. V., Albuquerque, E. E., Medeiros, L. K. G., and Alexandre, P. R. S.

Abstract

Copyright of Arquivo Brasileiro de Medicina Veterinaria e Zootecnia is the property of Universidade Federal de Minas Gerais, Escola de Veterinaria and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2017
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10. Nomogram for 30-day morbidity after primary cytoreductive surgery for advanced stage ovarian cancer.

Author

Nieuwenhuyzen-de Boer, G. M., Gerestein, C. G., Eijkemans, M. J. C., Burger, C. W., and Kooi, G. S.

Abstract

Purpose of investigation: Extensive surgical procedures to achieve maximal cytoreduction in patients with advanced stage epithelial ovarian cancer (EOC) are inevitably associated with postoperative morbidity and mortality. This study aimed to identify preoperative predictors of 30-day morbidity after primary cytoreductive surgery for advanced stage EOC and to develop a nomogram for individual risk assessment. Materials and Methods: Patients in The Netherlands who underwent primary cytoreductive surgery for advanced stage EOC between January 2004 and December 2007. All peri- and postoperative complications within 30 days after surgery were registered and classified. To investigate predictors of 30-day morbidity, a Cox proportional hazard model with backward stepwise elimination was utilized. The identified predictors were entered into a nomogram. The main outcome was to identify parameters that predict operative risk. Results: 293 patients entered the study protocol. Optimal cytoreduction was achieved in 136 (46%) patients. Thirty-day morbidity was seen in 99 (34%) patients. Morbidity could be predicted by age (p = 0.033; OR 1.024), preoperative hemoglobin (p = 0.194; OR 0.843), and WHO performance status (p = 0.015; OR 1.821) with a optimismcorrected c-statistic of 0.62. Determinants co-morbidity status, serum CA125 level, platelet count, and presence of ascites were comparable in both groups. Conclusions: Thirty-day morbidity after primary cytoreductive surgery for advanced stage EOC could be predicted by age, hemoglobin, and WHO performance status. The generated nomogram could be valuable for predicting operative risk in the individual patient. [ABSTRACT FROM AUTHOR]

Published
2016
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11. Neurodevelopmental Outcomes at Five Years After Early-Onset Fetal Growth Restriction: Analyses in a Dutch Subgroup Participating in a European Management Trial

Author

Pels, A., Knaven, O. C., Wijnberg-Williams, B. J., Eijsermans, M. J. C., Mulder-de Tollenaer, S. M., Aarnoudse-Moens, C. S. H., Koopman-Esseboom, C., van Eyck, J., Derks, J. B., Ganzevoort, W., and van Wassenaer-Leemhuis, A. G.

Abstract

(Abstracted from Eur J Obstet Gynecol Reprod Biol2019;234:63–70)Uteroplacental insufficiency is the most common cause of fetal growth restriction (FGR), with potentially critical consequences for both the mother and fetus. Definitions of uteroplacental insufficiency vary between an antenatal diagnosis reflecting the placental dysfunction and a postnatal diagnosis based on birth weight.

Published
2019
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12. High Order Finite Volume Methods Applied to Sediment Transport and Submarine Avalanches.

Author

Benzoni-Gavage, Sylvie, Serre, Denis, Bresch, D., Díaz, M. J. C., Fernández-Nieto, E. D., Ferreiro, A. M., and Mangeney, A.

Abstract

In this work different numerical models related with the sediment transport process are presented. Two kinds of models are presented: the first one uses a continuity equation for the sediment layer in order to study bed-load sediment transport phenomena. The second one is a model for submarine avalanches. [ABSTRACT FROM AUTHOR]

Published
2008
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13. Activity of cycloartane-type triterpenes and sterols isolated from Musa paradisiaca fruit peel against Leishmania infantum chagasi.

Author

Silva, A. A. S., Morais, S. M., Falcão, M. J. C., Vieira, I. G. P., Ribeiro, L. M., Viana, S. M., Teixeira, M. J., Barreto, F. S., Carvalho, C. A., Cardoso, R. P. A., and Andrade-Junior, H. F.

Abstract

The aim of the study was to evaluate in vitro the antileishmanial activity of triterpenes and sterols isolated from Musa paradisiaca (banana) fruit peel used traditionally to treat leishmaniasis. The compounds were isolated from the ethanolic extract of the peel of the banana fruit by column chromatography. The chemical structure of compounds was determined by ¹H and 13C - nuclear magnetic resonance spectroscopy. The cytotoxicity was measured in RAW 264.7 cells and LLC-MK2. Leishmanicidal activity against L. infantum chagasi promastigotes was performed by the MTT colorimetric method and activity against amastigotes was assayed in mammalian cells using in situ ELISA method. Five compounds were identified, consisting of three triterpenes: cycloeucalenone, 31-norcyclolaudenone and 24-methylene-cicloartanol and a mixture of two sterols: beta-sitosterol and stigmasterol. With the exception of cycloeucalenone, all compounds showed statistically similar activity against promastigote to pentamidine. While, acting against amastigotes, excluding 31-norcyclolaudenone, other compounds showed activity similar to amphotericin B. All compounds showed low cytotoxicity in mammalian cells. Conclusion: This study partially confirms the use of Musa paradisiaca in folk medicine against leishmaniasis. Further in vivo studies are necessary to evaluate the efficacy. [ABSTRACT FROM AUTHOR]

Published
2014
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16. Teaching Fourier Series Expansions in Undergraduate Education with the Help of the FouSE Android Application.

Author

Reis, M. J. C. S., Soares, S., Cardeal, S., Morais, R., Peres, E., and Ferreira, P. J. S. G.

Subjects
FOURIER series, UNDERGRADUATE education, ELECTRICAL engineering education, COMPUTER interfaces, SIGNALS & signaling, APPROXIMATION error, ELECTRICAL harmonics
Abstract

This paper discusses the teaching of Fourier Series concepts in undergraduate Electrical Engineering education with the help of an Android application, especially developed to that end. In order to better understand the links and implications, some of the basic Fourier series theory is briefly reviewed. The Android application has an easy-to-use, friendly interface, conceived to help undergraduate students test and assess the Fourier series expansions on a typical set of signals. The application also allows the students to control the total approximation error and the number of terms/harmonics used in the expansions. It has been found a very useful learning resource in the Fourier series context. [ABSTRACT FROM AUTHOR]

Published
2014
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18. Implementation of PATHS through Dutch Municipal Health Services: A Quasi-Experiment.

Author

Goossens, Ferry X., Gooren, Evelien M. J. C., de Castro, Bram Orobio, van Overveld, Kees W., Buijs, Goof J., Monshouwer, Karin, Onrust, Simone A., and Paulussen, Theo G. W. M.

Subjects
EDUCATIONAL programs, VIOLENCE prevention, HEALTH promotion, MENTAL health services
Abstract

The article presents a study which evaluates the effectiveness of a school-based Providing Alternative Thinking Strategies (PATHS) prevention program in the Netherlands. The PATHS program was implemented by health promotion professionals through municipal health services. The authors recommend to conduct further study about the implementation of effective violence prevention programs.

Published
2012

22. SPIRULINA DOES NOT DECREASE MUSCLE DAMAGE NOR OXDIDATIVE STRESS IN CYCLING ATHLETES WITH ADEQUATE NUTRITIONAL STATUS.

Author

Franca, G. A. M., Silva, A. S., Costa, M. J. C., Junior, J. S. Moura, Nébrega, T. K. S., Gonçalves, M. C. R., and Asciutti, I. S. R.

Abstract

The objective of this study was to assess the effect of Spirulina maxima on oxidative stress and muscle damage in cycling athletes subjected to high volume and intensity of training. Eighteen male athletes were randomly divided into an experimental group (n=11) with age 27.8±3.5 and placebo (n=7) with age 34.3±2.3 in a double-blind fashion. They carried out a protocol of Spirulina dietary supplementation (7.5 g/day) of placebo for four weeks and maintained their trainings during this period. A nutritional anamnesis was performed and blood tests were done to determine pre and post levels of creatine kinase (CK), lactic dehydrogenase (LHD), superoxide dismutase (SOD) and malondialdehyde (MDA). The supplemented and placebo groups performed the same volume training, has adequate macronutrients and antioxidant vitamins ingestion before study, as well as initial CK, LDH, SOD and MDA levels. Supplementation did not promote a significant alteration in CK levels on supplemented group (158.4±16.3 for 140.0±16.6 U/l, p>0.05), LDH (420±13.2 for 394.9±27.9 UI/l, p>0.05), MDA (2.8±0.2 for 2.9±0.4 nmol/ml, p>0.05), nor an increase in the SOD (7.3±0.6 for 7.0±0.6 U/mg Hb, p>0.05). We conclude that administration of Spirulina does not interfere in the magnitude of muscle damage nor in antioxidant status of cycling athletes that practice intense training. [ABSTRACT FROM AUTHOR]

Published
2010
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23. Grafting is not feasible for propagating jarrah (Eucalyptus marginata) selected for resistance to Phytophthora Dieback caused by Phytophthora cinnamomi.

Author

STUKELY, M. J. C. and BARBOUR, L.

Abstract

Lines of jarrah, possessing a high level of genetically-controlled resistance to Phytophthora cinnamomi, have been selected for use in rehabilitation plantings of diseased forest sites. Some Dieback Resistant Jarrah (DRJ) lines cannot easily be propagated by the standard tissue culture procedure. Grafting was assessed as an alternative propagation method to enable these DRJ lines to be included in seed production orchards. Two trials were carried out at separate locations, each using a range of different combinations of DRJ rootstock and scions. Only six grafts finally survived from a total of over 900 across the trials. It was concluded that the cleft graft method, as applied here to one-year-old rootstock, is not a successful cloning method for jarrah. [ABSTRACT FROM AUTHOR]

Published
2009

24. Acoustic performance of a noise barrier coated with an absorptive material.

Author

Palma, M. J. C. and Samagaio, A.

Subjects
NOISE control, CIVIL engineering, ABSORPTION, COMPUTER software, ACOUSTICAL engineering
Abstract

A noise barrier design of the absorptive type, incorporating LECA®, a well know material used in civil engineering because of its above-average sound absorption characteristics, as a coating material, is presented. The performance of the barrier was tested experimentally, using in situ measurements at Highway A2 in Portugal, and theoretically with MicroBruit, a computer program for traffic noise prediction. In general, results indicate that absorptive noise barriers made from concrete and coated with LECA® yield results similar to those obtained with uncoated reflective barriers. [ABSTRACT FROM AUTHOR]

Published
2006
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26. Efficacy and safety of fluoxetine in the treatment of patients with major depression after first myocardial infarction: findings from a double-blind, placebo-controlled trial.

Author

Strik, Jacqueline J. M. H., Honig, Adriaan, Lousberg, Richel, Lousberg, Aimee H. P., Cheriex, Emile C., Tuynman-Qua, Hanneke G., Kuijpers, Petra M. J. C., Wellens, H. J. J., Van Praag, H. M., Strik, J J, Honig, A, Lousberg, R, Lousberg, A H, Cheriex, E C, Tuynman-Qua, H G, Kuijpers, P M, and Wellens, H J

Abstract

Objective: Depression and hostility are significant risk factors for mortality and morbidity after myocardial infarction (MI). Much research is still needed to identify effective ways to reduce emotional distress in patients with cardiovascular disease. This double-blind, placebo-controlled study investigated the efficacy and safety of the antidepressant fluoxetine in patients with depression after their first MI.Methods: Fifty-four patients with major depression after MI were randomly assigned to receive a flexible-dose regimen of fluoxetine or placebo for the first 9 weeks of a double-blind, placebo-controlled trial. Patients without serious adverse effects who wished to continue participating in the study were given fluoxetine or placebo for an additional 16 weeks. To evaluate the efficacy of fluoxetine, the 17-item Hamilton Depression Rating Scale (HAMD-17) and the Hostility Scale of the 90-item Symptom Check List (SCL-90) were used as primary measures of outcome. To evaluate the safety of fluoxetine, cardiac function was measured before and after treatment with echocardiography and electrocardiography.Results: The a priori difference in antidepressive efficacy (4-point difference in HAMD-17 scores between the fluoxetine and placebo groups) was not met. However, the response rate among patients receiving fluoxetine was significantly greater than that among patients receiving placebo at week 25 (48 vs. 26%, p = .05). Among patients with mild depression (HAMD-17 score < or =21), HAMD-17 scores were significantly different (p < .05) between the fluoxetine and placebo groups at weeks 9 (by 5.4 points) and 25 (by 5.8 points). Also, hostility scores at week 25 were significantly reduced among patients receiving fluoxetine (p = .02). Analysis of electrocardiographic and echocardiographic parameters revealed no decrease in cardiac function as a result of treatment with fluoxetine.Conclusions: Although the overall difference between the fluoxetine and placebo groups was not significant, there was a trend favoring fluoxetine in this relatively small sample. The response rate in the group receiving fluoxetine was comparable with that observed in other studies of patients with cardiovascular disease. In addition, fluoxetine seemed to be particularly effective in patients with mild depression and was associated with a statistically significant reduction in hostility. The results of this study suggest that fluoxetine can be safely used to treat patients with post-MI depression beginning 3 months after the event. [ABSTRACT FROM AUTHOR]

Published
2000
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28. The term ‘Anthropocene’ in the context of formal geological classification

Author

Gibbard, P. L. and Walker, M. J. C.

Abstract

In recent years, ‘Anthropocene’ has been proposed as an informal stratigraphic term to denote the current interval of anthropogenic global environmental change. A case has also been made to formalize it as a series/epoch, based on the recognition of a suitable marker event, such as the start of the Industrial Revolution in northern Europe. For the Anthropocene to merit formal definition, a global signature distinct from that of the Holocene is required that is marked by novel biotic, sedimentary and geochemical change. Although there is clear evidence of anthropogenic effects in geological sequences, it is uncertain whether these trends are sufficiently distinct, consistent and dated for the proposal for a Holocene/Anthropocene boundary to be substantiated. The current view of the Earth-Science community is that it should remain informal. For formal definition a Global Stratigraphic Section and Point (GSSP) is required. Adoption of the term ‘Anthropocene’ will ultimately depend on recognition of a global event horizon. Without this, there is no justification for decoupling the Anthropocene from the Holocene. If the Anthropocene is deemed to have utility, it should be as an informal historical designation rather than a formally defined stratigraphic unit (of whatever status) within the geological timescale.

Published
2014
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30. Abstracts

Author

Derlon, J. M., Petit-taboué, M. C., Dauphin, F., Courtheoux, P., Chapon, F., Creissard, P., Darcel, F., Houtteville, J. P., Kaschten, B., Sadzot, B., Stevenaert, A., Tjuvajev, Juri G., Macapinlac, Homer A., Daghighian, Farhad, Ginos, James Z., Finn, Ronald D., Jiaju Zhang, M. S., Beattie, Bradley, Graham, Martin, Larson, Steven M., Blasberg, Ronald G., Levivier, M., Goldman, S., Pirotte, B., Brucher, J. M., Balériaux, D., Luxen, A., Hildebrand, J., Brotchi, J., Go, K. G., Kamman, R. L., Mooyaart, E. L., Heesters, M. A. A. M., Sijens, P. E., Oudksrk, M., van Dijk, P., Levendag, P. C., Vecht, Ch. J., Metz, R. J., Kennedy, D. N., Rosen, B. R., Hochberg, F. H., Fishman, A. J., Filipek, P. A., Caviness, V. S., Gross, M. W., Weinzierl, F. X., Trappe, A. E., Goebel, W. E., Frank, A. M., Becker, Georg, Krone, Andreas, Schmidt, Karsten, Hofmann, Erich, Bogdahn, Ulrich, Bencsch, H., Fclber, S., Finkenstedt, G., Kremser, C., Sfockhammer, G., Aichner, F., Bogdahn, U., Fröhlich, T., Becker, G., Krone, A., Schlief, R., Schürmann, J., Jachimczak, P., Hofmann, E., Roggendorf, W., Roosen, K., Carapella, C. M., Carpinelli, G., Passalacqua, R., Raus, L., Giannini, M., Mastrostefano, R., Podo, F., Tofani, A., Maslrostefano, R., Mottoles, M., Ferraironi, A., Scelsa, M. G., Oppido, P., Riccio, A., Maini, C. L., Collombier, L., Taillandier, L., Dcbouverie, M., Laurens, M. H., Thouvenot, P., Weber, M., Bertrand, A., Cruickshank, G. S., Patterson, J., Hadley, D., De Witte, Olivier, Hildebrand, Jerzy, Luxen, André, Goldman, Serge, Ernestus, R. -I., Bockhorst, K., Eis, M., Els, T., Hoehn-Berlage, M., Gliese, M., Fründ, R., Geissler, A., Woertgen, C., Holzschuh, M., Goldman, Serge, Levivier, M., Pirotte, B., Brucher, J. M., Luxen, A., Brotchi, J., Hildebrand, J., Hausmann, O., Merlo, A., Jerrnann, E., Uirich, J., Chiquet-Ehrismann, R., Müller, J., Mäcke, H., Gratzl, O., Herholz, K., Ghaemi, M., Würker, M., Pietrzyk, U., Heiss, W. -D., Kotitschke, K., Brandl, M., Tonn, J. C., Haase, A., Bogdahn, U., Kotitschke, K., Muigg, S., Felber, S., Aichner, F., Haase, A., Bogdahn, U., Krone, A., Becker, G., Woydt, M., Roggendorf, W., Hofmann, E., Bogdahn, U., Roosen, K., Lanfermann, Heinrich, Heindel, Walter, Kugel, Harald, Erneslus, Ralf -Ingo, Röhn, Gabricle, Lackner, Klaus, Metz, R. J., Kennedy, D. N., Pardo, F. S., Kutke, S., Sorensen, A. G., Hochberg, F. H., Fishman, A. J., Filipek, P. A., Rosen, B. R., Caviness, V. S., Mechtler, L. L., Withiam-Lench, S., Shin, K., Klnkel, W. R., Patel, M., Truax, B., Kinkel, P., Shin, K., Mechtler, L., Ricci, M., Pantano, P., Maleci, A., Pierallini, S., Di Stefano, D., Bozzao, L., Cantore, G. P., Röhn, Gabriele, Els, T., Schröder, R., Hoehn-Berlage, M., Ernestus, R. -I., Ruda, R., Mocellini, C., Soffietti, R., Campana, M., Ropolo, R., Riva, A., de Filippi, P. G., Schiffer, D., Salgado, D., Rodrigues, M., Salgado, L., Fonseca, A. T., Vieira, M. R., Bravo Marques, J. M., Satoh, H., Uozumi, T., Kiya, K., Kurisu, K., Arita, K., Sumida, M., Ikawa, F., Tzuk-Shina, Tz., Gomori, J. M., Rubinstein, R., Lossos, A., Siegal, T., Vaalburg, W., Paans, A. M. J., Willemsen, A. T. M., van Waarde, A., Pruim, J., Visser, G. M., Go, K. G., Valentini, S., Ting, Y. L. T., De Rose, R., Chidichimo, G., Corricro, G., van Lcycn-Pilgram, Karin, Erncslus, Ralf -Ingo, Klug, Norfried, van Leyen-Pilgram, K., Ernestus, R. -I., Schröder, R., Klug, N., Woydt, M., Krone, A., Tonn, J. C., Becker, G., Neumann, U., Roggendorf, W., Roosen, K., Plate, Karl H., Breier, Georg, Millaucr, Birgit, Weich, Herbert A., Ullrich, Axel, Risau, Werner, Roosen, N., Chopra, R. K., Mikkelsen, T., Rosenblum, S. D., Yan, P. 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R., Davegna, C., Pezzotta, S., Paoletti, R., Fumagalli, R., Infuso, L., Sankar, A. A., Darling, J. L., Thomas, D. G. T., Defer, G. -L., Brugières, P., Gray, F., Chomienne, C., Poirier, J., Degos, L., Degos, J. D., Colombo, Bruno M., DiDonato, Stefano, Finocchiaro, Gaetano, Hebeda, K. M., Sterenborg, H. J. C. M., Saarnak, A. E., Wolbers, J. G., van Gemert, M. J. C., Kaaijk, P., Troost, D., Leenstra, S., Das, P. K., Bosch, D. A., Kostron, H., Hochleitner, B. W., Obwegeser, A., Ortler, M., Seiwald, M., Vooys, W., Krouwer, H. G. J., de Gast, G. C., Marx, J. J. M., Osman, Farah J., Lunardi, P., Puzzilli, F., Menovsky, T., Beek, J. F., Wolbers, J. G., van Gemert, M. J. C., Naujocks, G., Wiestler, O. D., Schirrmacher, V., Schramm, J., Schmitz, A., Eis-Hübinger, A. M., Piepmeier, p. h., Pedersen, Patricia, Greer, Charles, Quigley, Matthew R., Shih, Tommy, Elrifal, Amr, Rothfus, William, Maroon, Joseph C., Rohertson, L., Rampling, R., Whoteley, T. L., Piumb, J. A., Kerr, D. J., Falina, P. A., Crossan, I. M., Roosen, N., Rock, J. P., Feng, J., Zeng, H., Ho, K. L., Fenstermacher, J. D., Rosenblum, M. L., Ruchoux, M. M., Vincent, S., Jonca, F., Plouet, J., Lecomte, M., Samid, D., Thibault, A., Ram, Z., Oldfield, E. H., Myers, C. E., Reed, E., Schabet, M., Herrlinger, U., Buchholz, R., Shoshan, Y., Siegal, T., Siegal, T., Shezen, E., Siegal, Tz., Stockhammer, G., Rosenblum, M., Samid, D., Lieberman, F., Terzis, A. J. A., Bjerkvig, R., Laerum, O. D., Arnold, H., Thibault, A., Samid, D., Figg, W. D., Myers, C. E., Reed, E., Thomas, R., Flux, G., Chittenden, S., Doshi, P., Brazil, L., Thomas, D. G. T., Bignor, D., Zalutsky, M., Brada, M., Tjuvajev, Juri, Kaplitt, Michael, Desai, Revathi, Bradley, M. S., Bettie, B. S., Gansbacher, Bernd, Blasberg, Ronald, Haugland, H. K., Saraste, J., Rooseni, K., Laerum, O. D., Vincent, A. J. P. E., Avezaat, C. J. J., Bout, A., Noteboom, J. L., Vecht, C. h., Valerio, D., Hoogerbrugge, P. M., Weber, F., Reszka, R., Zhu, J., Walther, W., List, J., Schulz, W., Wolbers, J. G., Sterenborg, I. I. J. C. M., Kamphorst, W., van Gemert, M. J. C., van Alplien, H. A. M., Salander, P., Bergenheim, T., Henriksson, R., Grant, R., Brazil, L., Thomas, R., Guerrero, D., Laing, R., Ashley, S., Brada, M., Schmidt, B., Bauer, B., Grau, G., Bohnstedt, T., Frydrych, A., Franz, K., Lorenz, R., Brandes, A., Amanzo, P. D'., Zampieri, P., Rigon, A., Scelzi, E., Rotilio, A., Berti, F., Paccagnella, A., Fiorentino, M. V., Müller, B., Krauseneck, P., van Deventer, P. L., Dellemijn, P. L. I., van den Bent, M. J., Vecht, Ch. J., Kansen, P. J., Tredici, G., Petruccioli, N. G., Cavaletti, G., Cavalletti, E., Kiburg, B., Müller, L. J., Moorer-van Delft, C. M., Heimans, J. J., Boer, H. H., Pace, A., Bove, L., Pietrangeli, A., Innocenti, P., Aloe, A., Nardi, M., Jandolo, B., Kellie, S. J., De Graaf, S. S. N., Bloemhof, H., Roebuck, D., Dalla, Pozza L., Uges, D. D. R., Johnston, I., Besser, M., Chaseling, R. A., Koeppen, S., Gründemann, S., Lossos, A., Siegal, T., Nitschke, M., Vieregge, P., Reusche, E., Rob, P., Kömpf, D., Postma, T. J., Vermorken, J. B., Heimans, J. J., Rampling, R. P., Dunlop, D. J., Steward, M. S., Campbell, S. M., Roy, S., Hilkens, P. H. E., Verweij, J., van Putten, W. L. J., Vecht, Ch. J., van den Bent, M. J., Hilkens, P. H. E., Moll, J. W. B., van der Burg, M. E. L., Planting, A. S. T., van Putten, W. L. J., Vecht, Ch. J., van den Bent, M. J., Wondrusch, E., Zifko, U., Drlicek, M., Liszka, U., Grisold, W., Zifko, U., Fazeny, B., Dittrich, Ch., Wondrusch, E., Grisold, W., Verschuuren, Jan J., Meneses, Patricio I., Rosenfeld, Myrna R., Kaplitt, Michael G., Posner, Jerome B., Dalmau, Josep, Sillevis Smitt, P. A. E., Manley, G., Posner, J. B., Cavaletti, G., Bogliun, G., Margorati, L., Bianchi, G., Drlicek, M., Liska, U., Casati, B., Kolig, C., Grisold, H., Graus, F., Reñe, R., Uchuya, M., Valldeoriola, F., Delattre, J. Y., Benedetti de Cosentiro, C., Ortale, D., Martinez, R., Lambre, J., Cagnolati, S., Vinai, C., Salmaggi, A., Nemni, R., Silvani, A., Forno, M. G., Luksch, R., Confalonieri, P., Boiardi, A., Nitschke, M., Scholz, J., Vieregge, P., Kömpf, D., Hochberg, F. H., Pfeiffer, G., Netzer, J., Hansen, Ch., Eggers, Ch., Hagel, Ch., Kunze, K., Verschuuren, Jan J., Rosenblum, Marc K., Lieberman, Frank S., Posner, Jerome B., and Dalmau, Josep

Published
1994
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31. Effect of Secondary Prehospital Risk Factors on Outcome in Severe Traumatic Brain Injury in the Context of Fast Access to Trauma Care

Author

Franschman, Gaby, Peerdeman, Saskia M., Andriessen, Teuntje M. J. C., Greuters, Sjoerd, Toor, Annelies E., Vos, Pieter E., Bakker, Fred C., Loer, Stephan A., and Boer, Christa

Abstract

Prevention of secondary prehospital risk factors such as hypoxia and hypotension is likely to improve patient prognosis in severe traumatic brain injury (TBI). Because the Dutch trauma care organization is characterized by fast access to specialized trauma care due to the geographical situation, we investigated whether and to what extend secondary risk factors, such as hypoxia and hypotension, and measures, such as endotracheal intubation, affect outcome in severe TBI in the context of a region with fast access to trauma care.

Published
2011
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32. THE MARTIN-BELL SYNDROME: A PSYCHOLOGICAL, LOGOPAEDIC AND CYTOGENETIC STUDY OF TWO AFFECTED BROTHERS.

Author

Renier, W. O., Smeets, D. F. C. M., Scheres, J. M. J. C., Hustinx, T. W. J., Hulsmans, C. F. C., Ophey, C. P. M. O., Bomers, A. J. A. M., and Gabreëls, F. J. M.

Subjects
SYNDROMES, DISEASES, PEOPLE with intellectual disabilities, DEVELOPMENTAL disabilities, GENETICS, PATIENTS
Abstract

The article focuses on the Martin-Bell syndrome. Recently the authors had the opportunity to observe two brothers with Martin-Bell syndrome who had a different degree of mental retardation and verbal disabilities, and who also showed a remarkably different expression of the X-fragility. In this article they report and discuss their investigations. Chromosomes were studied in cultured peripheral lymphocytes from the two patients and their mother. The X-fragility can only be found if appropriate media are used, and A great difference between the two brothers in clinical, psychological, logopaedic and cytogenetic expression of the syndrome is found and discussed.

Published
1983
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33. Normal compartment pressures of the lower leg in children

Author

Staudt, J. M., Smeulders, M. J. C., and van der Horst, C. M. A. M.

Abstract

Compartment pressures have not previously been studied in healthy children. We compared the pressures in the four lower leg compartments of healthy children with those of healthy adults.We included patients aged between two months and six years, and measured the pressures in 80 compartments of 20 healthy children using simple needle manometry. Measurements were repeated in a control group of 20 healthy adults.The mean compartment pressure in the lower leg in children was significantly higher than in adults (p < 0.001). On average, pressures in the four compartments varied between 13.3 mmHg and 16.6 mmHg in the children and between 5.2 mmHg and 9.7 mmHg in the adults. The latter is in accordance with those recorded in the literature. The mean arterial pressure did not relate to age or to pressure in the compartment.The findings of this study that the normal compartment pressure of the lower leg in healthy children is significantly higher than that in adults may be of considerable significance in clinical decision-making in children of this age.

Published
2008
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34. Treatment of Post-Myocardial Infarction Depressive Disorder A Randomized, Placebo-Controlled Trial With Mirtazapine

Author

Honig, Adriaan, Kuyper, Astrid M. G., Schene, Aart H., Melle, Joost P. van, de Jonge, Peter, Tulner, Dorien M., Schins, Annique, Crijns, Harry J. G. M., Kuijpers, Petra M. J. C., Vossen, Helen, Lousberg, Richel, and Ormel, Johan

Abstract

To examine the antidepressant efficacy of a dual-acting antidepressant (mirtazapine) in patients with post-myocardial infarction (MI) depressive disorder. Antidepressants used in post MI trials with a randomized, double-blind, placebo-controlled design have been restricted to selective serotonin reuptake inhibitors (SSRIs). Antidepressant effects have been limited.

Published
2007
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35. Successful Control of Widespread Methicillin-Resistant Staphylococcus aureusColonization and Infection in a Large Teaching Hospital in The Netherlands

Author

van Trijp, M. J. C. A., Melles, D. C., Hendriks, W. D. H., Parlevliet, G. A., Gommans, M., and Ott, A.

Abstract

Objective.The low prevalence of infection and colonization with methicillin-resistant Staphylococcus aureus(MRSA) in The Netherlands is ascribed to a national “search-and-destroy” policy. We describe the measures that were implemented to control widespread MRSA colonization and infection in a Dutch hospital.Design.Descriptive intervention study.Setting.Teaching medical center with a capacity of 679 beds, including 16 intensive care beds.Interventions.MRSA colonization and infection were identified using conventional culture with a selective broth. Isolates were typed using pulsed-field gel electrophoresis. Measures to control the epidemic included screening of contacts (patients and hospital staff), screening of patients at readmission or discharge, strict isolation of MRSA-positive patients, decolonization of colonized staff and patients, the development of an electronic signal identifying MRSA-positive patients, and the development of a culture information-system for hospital personnel.Results.Awareness of uncontrolled dissemination of MRSA began in November 2001. Because the clone involved had a low minimum inhibitory concentration for oxacillin, at first it was not recognized as MRSA. In February 2002, when major screening efforts started, it appeared that MRSA had spread all over the hospital and that many staff members were colonized. By the end of December 2005, a total of 600 patients and 135 staff members were found to be newly colonized. The yearly incidence of cases of MRSA colonization and infection decreased from 351 in 2002 to 56 in 2005. Typing of the isolates showed that 3 MRSA clones were predominant. Outbreaks of colonization involving these clones did not occur after 2003.Conclusion.Our observations show that strict application of “search-and-destroy” measures can effectively control a huge epidemic of MRSA colonization and infection.

Published
2007
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36. Differential corporate reporting: Registered accountants’ and auditors’ views in South Africa

Author

Stainbank, L J and Wells, M J C

Abstract

This paper reports the results of a postal survey of South African Registered Accountants’ and Auditors’ views on the suitability of selected South African Statements of Generally Accepted Accounting Practice to a range of South African entities varied by size, structure and user base. The paper provides evidence of (1) the need for differential corporate reporting in South Africa, (2) that a single threshold for differential corporate reporting may not adequately address the South African differential corporate reporting needs, and (3) the need for both the presentation and disclosure and the recognition and measurement requirements of specific statements of South African Generally Accepted Accounting Practice to be dealt with in differential corporate reporting standards.

Published
2007
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37. Lack of immunological cross-reactivity between parasite-derived and recombinant forms of ES-62, a secreted protein of Acanthocheilonema viteae

Author

EGAN, C. A., HOUSTON, K. M., ALCOCER, M. J. C., SOLOVYOVA, A., TATE, R., LOCHNIT, G., McINNES, I. B., HARNETT, M. M., GEYER, R., BYRON, O., and HARNETT, W.

Abstract

The longevity of filarial nematodes is dependent on secreted immunomodulatory products. Previous investigation of one such product, ES-62, has suggested a critical role for post-translationally attached phosphorylcholine (PC) moieties. In order to further investigate this, ES-62 lacking PC was produced, using the Pichia pastoris recombinant gene expression system. Unlike parasite-derived ES-62, which is tetrameric the recombinant material was found to consist of a mixture of apparently stable tetramers, dimers and monomers. Nevertheless, the recombinant protein was considered to be an adequate PC-free ES-62 as it was recognized by existing antisera against the parasite-derived protein. However, subsequent to this, recognition of parasite-derived ES-62 by antibodies produced against the recombinant protein was found to be absent. In an attempt to explain this, recombinant ES-62 was subjected to structural analysis and was found to (i) contain 3 changes in amino acid composition; (ii) demonstrate significant alterations in glycosylation; (iii) show major differences in protein secondary structure. The effects of these alterations in relation to the observed change in immunogenicity were investigated and are discussed. The data presented clearly show that recognition by existing antibodies is insufficient proof that recombinant proteins can be used to mimic parasite-derived material in studies on nematode immunology and vaccination.

Published
2006
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38. Cytotoxic Flavonoids from Platymiscium floribundum

Author

Falcao, M. J. C., Pouliquem, Y. B. M., Lima, M. A. S., Gramosa, N. V., Costa-Lotufo, L. V., Militao, G. C. G., Pessoa, C., Moraes, M. Odorico de, and Silveira, E. R.

Abstract

Two new isoflavonoids, 7-hydroxy-6,4‘-dimethoxy-isoflavonequinone (1) and 2‘-hydroxy-6,4‘,6‘ ‘,4‘ ‘‘-tetramethoxy-[7-O-7‘ ‘]-bisisoflavone (2), and seven other known flavonoids, 3-hydroxy-9-methoxypterocarpan (medicarpin), 3,10-dihydroxy-9-methoxypterocarpan, 3,9-dimethoxypterocarpan (homopterocarpin) (3), 2,3,9-trimethoxypterocarpan (4), 3,4-dihydroxy-9-methoxypterocarpan (vesticarpan) (5), 2‘,4,4‘-trihydroxychalcone (isoliquiritigenin), and 7,4‘-dihydroxyflavanone (liquiritigenin) (6), were isolated from the heartwood of Platymiscium floribundum. The structures of compounds 1 and 2 were established by spectroscopic methods. Compounds 3−6 showed cytotoxic activity when evaluated against five human cancer cell lines in vitro.

Published
2005

39. Dynamic Viscosities of KI or NH<INF>4</INF>I in Methanol and NH<INF>4</INF>I in Ethanol at Several Temperatures and 0.1 MPa

Author

Gonzalez, B., Dominguez, A., Tojo, J., Esteves, M. J. C., Cardoso, M. J. E. d. M., and Barcia, O. E.

Abstract

Viscosities and densities have been determined for some binary strong electrolyte solutions&sbd;KI + methanol, NH4I + methanol and NH4I + ethanol&sbd;at (298.15, 303.15, 308.15, and 313.15) K and 0.1 MPa. The viscosity data have been analyzed using the three-parameter Jones−Dole equation (Kaminsky, M. Ion−solvent interaction and the viscosity of strong electrolyte solutions. Discuss. Faraday Soc. 1957, 24, 171−179), and the A, B, and D parameters have been calculated. A Debye−Hückel model for calculating the viscosity proposed by Esteves et al. (Esteves, M.; Cardoso, M.; Barcia, O. A Debye−Hückel model for calculating the viscosity of binary strong electrolyte solutions. Ind. Eng. Chem. Res. 2001, 40, 5021−5028. Esteves, M.; Cardoso, M.; Barcia, O. A Debye−Hückel Model for Calculating the Viscosity of Binary Strong Electrolyte Solutions at Different Temperatures. Ind. Eng. Chem. Res. 2002, 41, 5109−5113) has been used to correlate the experimental data.

Published
2005

41. Mechanical Evaluation of the Pronator Teres Rerouting Tendon Transfer

Author

VEEGER, H. E. J., KREULEN, M., and SMEULDERS, M. J. C.

Abstract

We simulated pronator teres rerouting using a three-dimensional biomechanical model of the arm. Simulations comprised the evaluation of changes in muscle length and the moment arm of pronator teres with changes in forearm axial rotation and elbow flexion. The rerouting of Pronator Teres was simulated by defining a path for it through the interosseous membrane with re-attachment to its original insertion. However the effect of moving the insertion to new positions, 2 cm below and above, the original position was also assessed. The effect on total internal rotation and external rotation capacity was determined by calculating the potential moments for pronator teres, supinator, pronator quadratus, biceps brachii and brachioradialis. Pronator teres was found to be a weak internal rotator in extreme pronation, but a strong internal rotator in neutral rotation and in supination. After rerouting pronator teres was only a strong external rotator in full pronation and not at other forearm positions, where the effect of rerouting was comparable to a release procedure.

Published
2004
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42. Three-Dimensional Video Analysis of Forearm Rotation before and After Combined Pronator Teres Rerouting and Flexor Carpi Ulnaris Tendon Transfer Surgery in Patients with Cerebral Palsy

Author

KREULEN, M., SMEULDERS, M. J. C., VEEGER, H. E. J., HAGE, J. J., and VAN DER HORST, C. M. A. M.

Abstract

The effect of combined pronator teres rerouting and flexor carpi ulnaris transfer on forearm rotation was prospectively studied by comparison of pre- and postoperative three-dimensional analysis of forearm range of motion in ten patients with cerebral palsy. One year postoperatively, surgery had improved maximal supination of the forearm in all patients by an average of 63°, but there was also a mean loss of 40° pronation. Forearm range of motion increased by a mean of 23°. The centre of the range of motion on average shifted 52° in the direction of supination. Based on these results of objective forearm range of motion analysis, we conclude that the common combination of pronator teres rerouting and flexor carpi ulnaris transfer in patients with cerebral palsy effectively facilitates active supination but impairs active pronation.

Published
2004
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43. Biomechanical effects of dissecting flexor carpi ulnaris

Author

Kreulen, M., Smeulders, M. J. C., Hage, J. J., and Huijing, P. A.

Abstract

Our aim was to determine whether the length and function of the flexor carpi ulnaris muscle were affected by separating it from its soft tissue connections. We measured the length of flexor carpi ulnaris before and after its dissection in ten patients with cerebral palsy. After tenotomy, tetanic contraction shortened the muscle by a mean of 8 mm. Subsequent dissection to separate it from all soft tissue connections, resulted in a further mean shortening of 17 mm (p < 0.001). This indicated that the dissected connective tissue had been strong enough to maintain the length of the contracting muscle. Passive extension of the wrist still lengthened the muscle after tenotomy, whereas this excursion significantly decreased after subsequent dissection.We conclude that the connective tissue envelope, which may be dissected during tendon transfer of flexor carpi ulnaris may act as a myofascial pathway for the transmission of force. This may have clinical implications for the outcome after tendon transfer.

Published
2003
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44. The evaluation of rhizomania resistant sugar beet for the UK

Author

ASHER, M J C, CHWARSZCZYNSKA, D M, and LEAMAN, M

Abstract

Sugar beet rhizomania disease, caused by Beet necrotic yellow vein virusand transmitted by the soil-borne parasite Polymyxa betae, was first recorded in the UK in 1987. Recently, breeding lines and cultivars with partial resistance to the virus derived from the 'Holly' source of resistance have been developed and their suitability for use under UK conditions is explored in this paper. Virus multiplication in the roots of resistant lines exposed to severe disease pressure in glasshouse tests, when quantified by ELISA, was less than one third of that in susceptible controls. More recently developed resistant lines had a lower virus content, on average, largely due to a reduced frequency of susceptible individuals. There was no evidence for resistance to the vector, P. betae, in virus resistant lines. However, the proportion of viruliferous P. betaeresting spores in the roots, estimated using the most probable number (MPN) technique, was reduced by at least one third in resistant lines compared with the most susceptible control. A novel line, containing an additional gene to that in 'Holly', was the most effective, reducing the infection level to 3 of that in the susceptible control.

Published
2002
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45. A prospective randomized comparison of sequential versus monoculture systems for in-vitro human blastocyst development.

Author

Macklon, N S, Pieters, M H E C, Hassan, M A, Jeucken, P H M, Eijkemans, M J C, and Fauser, B C J M

Abstract

Extending the period of in-vitro culture to the blastocyst stage may improve implantation rates in IVF treatment. Recognition of the dynamic nature of early embryo metabolism has led to the development of commercially available sequential culture systems. However, their improved efficacy over monoculture systems remains to be demonstrated in prospective studies.

Published
2002
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46. Debye−Hückel Model for Calculating the Viscosity of Binary Strong Electrolyte Solutions at Different Temperatures

Author

Esteves, M. J. C., Cardoso, M. J. E. de M., and Barcia, O. E.

Abstract

In the present article, a recently published model (Esteves, M. J. C.; Cardoso, M. J. E. de M.; Barcia, O. E. Ind. Eng. Chem. Res. 2001, 40, 5021) for calculating the viscosity of binary strong electrolyte solutions, at 25 °C and 0.1 MPa, has been extended for calculating the viscosity of binary strong electrolyte solutions at different temperatures. A temperature dependence has been introduced into the two adjustable parameters of the original model. The empirical expression originally proposed by Silvester and Pitzer (J. Phys. Chem. 1977, 81, 1822) to take into account the temperature dependence of thermodynamic properties of aqueous electrolyte solutions has been adopted. The proposed model contains a total of five adjustable parameters that have been fitted by means of experimental viscosity data in the literature. The total number of 20 binary electrolyte systems (at 0.1 MPa and in the temperature range of −35 to 55 °C) with two different solvents (water and methanol) have been studied. The overall average mean relative standard deviation is 0.98%

Published
2002

47. Oxynitride Perovskites:  Synthesis and Structures of LaZrO<INF>2</INF>N, NdTiO<INF>2</INF>N, and LaTiO<INF>2</INF>N and Comparison with Oxide Perovskites

Author

Clarke, S. J., Guinot, B. P., Michie, C. W., Calmont, M. J. C., and Rosseinsky, M. J.

Abstract

A new oxynitride, LaZrO2N, has been synthesized by the reaction of a highly reactive X-ray amorphous La2Zr2O7 precursor with flowing ammonia at between 900 and 1000 °C. The white insulating material crystallizes in the GdFeO3 distorted perovskite structure type with orthorhombic space group Pnma and with a = 5.875 25(5) Å, b = 8.250 31(7) Å, c = 5.810 08(5) Å, and Z = 4, as determined by neutron powder diffraction. A detailed structural analysis of the isostructural NdTiO2N is also reported:  Pnma, a = 5.5492(1) Å, b = 7.8017(1) Å, c = 5.529 01(9) Å, and Z = 4. LaTiO2N crystallizes in a different distorted perovskite structure, which is triclinic, and consequently has two distinct Ti(O4N2) octahedra (LaTiO2N:  I&onemacr;, a = 5.6097(1) Å, b = 7.8719(2) Å, c = 5.5752(1) Å, α = 90.199(2)°, β = 90.154(3)°, γ = 89.988(8)°, Z = 4). Oxide and nitride ions are completely disordered in all three phases. The M(O,N)6 octahedra (M = Ti, Zr) in these phases and a number of perovskite titanates and zirconates become more regular as the tilting distortion of the octahedral framework becomes more pronounced, as a result of quenching of the second-order Jahn−Teller distortion of the octahedra.

Published
2002

48. A Debye−Hückel Model for Calculating the Viscosity of Binary Strong Electrolyte Solutions

Author

Esteves, M. J. C., Cardoso, M. J. E. de M., and Barcia, O. E.

Abstract

In this article we present a new model for correlating dynamic viscosity of binary strong electrolyte solutions. The proposed model is based on Eyring's absolute rate theory and the Debye−Hückel model for calculating the excess (electrostatic) free energy of activation of the viscous flow. In the present model we consider that the free energy of activation of the viscous flow as being the same as the appropriate thermodynamic free energy used for calculating equilibrium properties of the electrolyte solution. Modifications of Eyring's absolute rate theory must be performed to take into account the solvent as a continuous medium, as considered in the Debye−Hückel theory. This is accomplished by means of the osmotic-pressure framework for solutions. In this framework one adopts a thermodynamic free energy, which is considered as a function of the absolute temperature, pressure, number of moles of the solute species, and chemical potential of the solvent. The proposed model contains two adjustable parameters that have been fitted by means of experimental viscosity data of the literature. The total number of 21 binary electrolyte systems (at 0.1 MPa and 25 °C) with different solvents (water, methanol, ethanol, and 1-butanol) have been studied. The calculated viscosity values are in good agreement with the experimental ones. The overall average mean relative standard deviation is 0.52%.

Published
2001

49. Prognostic models based on literature and individual patient data in logistic regression analysis

Author

Steyerberg, E. W., Eijkemans, M. J. C., Van Houwelingen, J. C., Lee, K. L., and Habbema, J. D. F.

Abstract

Prognostic models can be developed with multiple regression analysis of a data set containing individual patient data. Often this data set is relatively small, while previously published studies present results for larger numbers of patients. We describe a method to combine univariable regression results from the medical literature with univariable and multivariable results from the data set containing individual patient data. This ‘adaptation method’ exploits the generally strong correlation between univariable and multivariable regression coefficients. The method is illustrated with several logistic regression models to predict 30‐day mortality in patients with acute myocardial infarction. The regression coefficients showed considerably less variability when estimated with the adaptation method, compared to standard maximum likelihood estimates. Also, model performance, as distinguished in calibration and discrimination, improved clearly when compared to models including shrunk or penalized estimates. We conclude that prognostic models may benefit substantially from explicit incorporation of literature data. Copyright © 2000 John Wiley & Sons, Ltd.

Published
2000
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50. Prognostic models based on literature and individual patient data in logistic regression analysis

Author

Steyerberg, E. W., Eijkemans, M. J. C., Houwelingen, J. C. Van, Lee, K. L., and Habbema, J. D. F.

Abstract

Prognostic models can be developed with multiple regression analysis of a data set containing individual patient data. Often this data set is relatively small, while previously published studies present results for larger numbers of patients. We describe a method to combine univariable regression results from the medical literature with univariable and multivariable results from the data set containing individual patient data. This ‘adaptation method’ exploits the generally strong correlation between univariable and multivariable regression coefficients. The method is illustrated with several logistic regression models to predict 30-day mortality in patients with acute myocardial infarction. The regression coefficients showed considerably less variability when estimated with the adaptation method, compared to standard maximum likelihood estimates. Also, model performance, as distinguished in calibration and discrimination, improved clearly when compared to models including shrunk or penalized estimates. We conclude that prognostic models may benefit substantially from explicit incorporation of literature data. Copyright © 2000 John Wiley & Sons, Ltd.

Published
2000

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