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Understanding the impact of green spaces on public health is crucial for urban planning and mental well-being enhancement in small and medium-sized cities (SMSCs). This study compares the influence of green spaces on mental well-being and psychological distress in Córdoba and Nitra. Using a cross-sectional survey, responses from 632 participants were collected and evenly distributed between the two cities. Mental well-being and psychological distress were assessed using the WHO-5 and K6 scales, while also considering sociodemographic factors and green space usage frequency. The findings indicate that green space perception positively correlates with mental well-being in both cities. However, the extent and nature of engagement with these spaces, and their associated health benefits, significantly differ between Córdoba and Nitra. In Nitra, more time spent in green spaces was strongly linked to higher mental well-being scores. In contrast, in Córdoba, this association was significant only for those spending over three hours in green spaces. The impacts on psychological distress varied, with notable negative associations tied to the frequency of green exercise in Nitra. These results suggest that while green spaces generally support mental well-being and reduce psychological distress, the benefits are not uniformly experienced across different urban settings. Variations could be due to distinct urban characteristics like size and weather. This study highlights the need for a nuanced understanding of how green spaces influence public health, tailored to each city's specific characteristics. It emphasizes the importance for urban planners to consider these factors to maximize the health benefits of green spaces. • Objective: A study on green spaces' impact on mental health in Córdoba, Spain and Nitra, Slovakia. • Methodology: Six hundred thirty-two surveys analyzed on green space perception and metal health outcomes. • Findings: • Green Space Perception and Mental Well-being: Green space perception linked to better well-being in both cities. • Implications: Green spaces shown as vital for public health and mental well-being. • Conclusion: Findings highlight the importance of green space design for health benefits. [ABSTRACT FROM AUTHOR]