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To evaluate the dosimetry, clinical outcomes, and toxicity of patients treated with stereotactic body radiotherapy (SBRT) for adrenal metastases.

To present clinical outcomes, early toxicity, and dosimetric constraints for patients undergoing stereotactic body radiation therapy (SBRT) for abdominal or pelvic tumors.

Malignant phyllodes tumor is a rare and potentially aggressive breast neoplasm. Little information is available regarding the optimal management of these lesions and rarer still are data regarding survival. The current study used a large population database to determine prognostic factors that predict cause‐specific survival (CSS).Data were obtained from the Surveillance, Epidemiology, and End Results Program (SEER) for the years 1983–2002. Women receiving resection for primary nonmetastatic malignant phyllodes tumor of the breast were included (n = 821). Analyses of patient, pathologic, and treatment characteristics were performed using univariate and multivariate Cox regression analyses for the CSS endpoint.With a median follow‐up of 5.7 years, CSS was 91%, 89%, and 89%, at 5, 10, and 15 years, respectively. Mastectomy was performed in 428 women (52%) and wide excision or lumpectomy in 393 (48%). Women undergoing mastectomy were significantly older (P = .004) and had larger tumors (P = .009). Wide excision was associated with equivalent or improved CSS relative to mastectomy on univariate and multivariate analyses. Older age predicted for cause‐specific mortality on multivariate analysis. Adjuvant radiotherapy (RT) predicted for worse CSS when implemented compared with surgery alone.Mastectomy was not found to provide a benefit in CSS compared with wide excision in malignant phyllodes tumor of the breast. Women undergoing wide excision had at the minimum similar cancer‐specific mortality compared with those who received mastectomy. The role of adjuvant RT is uncertain and requires further investigation. Cancer 2006. © 2006 American Cancer Society.

In this retrospective study we determined the results of salvage external beam radiation therapy (RT) to the prostate bed for isolated increase of serum prostate specific antigen (PSA) after radical prostatectomy.

Although endometrial cancer continues to be the most prevalent gynecologic malignancy in the United States, optimal adjuvant treatment for stage I adenocarcinoma remains uncertain. Five-year survival rates as high as 90% are reported in women given adjuvant radiation therapy (RT) in conjunction with surgical removal. Poorer outcomes are recorded for those having stage IC disease (more than 50% myometrial invasion) or grade 3 or 4 adenocarcinoma. This retrospective analysis is based on data from the Surveillance, Epidemiology, and End Results (SEER) program of the U.S. National Cancer Institute for the years 1988 through 2001. The study population included 21,249 women with an average age of 63 years who had American Joint Committee on Cancer stage IA–C node-negative endometrial adenocarcinoma. All participants underwent total abdominal hysterectomy and bilateral salpingooophorectomy.