14 results on '"Miró, Jose M"'
Search Results
2. Mycobacterium Wolinskyi: A New Non-Tuberculous Mycobacterium Associated with Cardiovascular Infections?
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Hernández-Meneses, Marta, González-Martin, Julian, Agüero, Daiana, Tolosana, Jose M., Sandoval, Elena, Falces, Carles, San Antonio, Rodolfo, Vidal, Bárbara, Moreno, Asunción, Ambrosioni, Juan, Miró, Jose M., Hospital Clínic of Barcelona Infectious Endocarditis Team, Miró, José M., de la Mària, Cristina Garcia, Cañas, María Alexandra, Garcia, Javier, Almela, Manel, Vila, Jordi, Quintana, Eduard, and Falces, Carlos more...
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- 2021
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Catalog
3. Mycobacterium Wolinskyi:A New Non-Tuberculous Mycobacterium Associated with Cardiovascular Infections?
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Hernández-Meneses, Marta, González-Martin, Julian, Agüero, Daiana, Tolosana, Jose M., Sandoval, Elena, Falces, Carles, San Antonio, Rodolfo, Vidal, Bárbara, Moreno, Asunción, Ambrosioni, Juan, and Miró, Jose M. more...
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Mycobacterium wolinskyiis a rapid-growth non-tuberculous mycobacterium. Twenty-one cases of M. wolinskyiinfection have been described so far, more than half as cardiovascular or postoperative cardiothoracic infections. We report the case of a patient with a cardiovascular implantable electronic device infected by M. wolinskyi, successfully treated with device removal and antimicrobials. more...
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- 2021
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4. Community-Acquired Pneumococcal Pneumonia in Virologically Suppressed HIV-Infected Adult Patients
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Cillóniz, Catia, Torres, Antoni, Manzardo, Christian, Gabarrús, Albert, Ambrosioni, Juan, Salazar, Adriana, García, Felipe, Ceccato, Adrián, Mensa, Josep, de la Bella Casa, Jorge Puig, Moreno, Asunción, and Miró, Jose M. more...
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The study aimed to investigate whether the clinical presentations and outcomes (length of stay, ICU admission, and 30-day mortality) of pneumococcal pneumonia in virologically suppressed patients who were HIV-infected on ART with a CD4+ T-cell count > 350 cells/mm3are comparable to those seen in patients with HIV, using a case-control design. more...
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- 2017
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5. Left-sided infective endocarditis in patients with liver cirrhosis.
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Ruiz-Morales, J., Ivanova-Georgieva, R., Fernández-Hidalgo, N., García-Cabrera, E., Miró, Jose M., Muñoz, P., Almirante, B., Plata-Ciézar, A., González-Ramallo, V., Gálvez-Acebal, J., Fariñas, M.C., Bravo-Ferrer, J.M., Goenaga-Sánchez, M.A., Hidalgo-Tenorio, C., Goikoetxea-Agirre, J., de Alarcón-González, A., Spanish Collaboration on Endocarditis Group-Grupo de Apoyo al Manejo de la Endocarditis en España (GAMES), and Spanish Network for Research in Infectious Diseases (REIPI) more...
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COMPARATIVE studies ,CARDIAC surgery ,INFECTIVE endocarditis ,CIRRHOSIS of the liver ,LONGITUDINAL method ,RESEARCH methodology ,MEDICAL cooperation ,PROGNOSIS ,RESEARCH ,EVALUATION research ,DISEASE complications - Abstract
Objective: To evaluate the course of left-sided infective endocarditis (LsIE) in patients with liver cirrhosis (LC) analyzing its influence on mortality and the impact of surgery.Methods: Prospective cohort study, conducted from 1984 to 2013 in 26 Spanish hospitals.Results: A total of 3.136 patients with LsIE were enrolled and 308 had LC: 151 Child-Pugh A, 103 B, 34 C and 20 were excluded because of unknown stage. Mortality was significantly higher in the patients with LsIE and LC (42.5% vs. 28.4%; p < 0.01) and this condition was in general an independent worse factor for outcome (HR 1.51, 95% CI: 1.23-1.85; p < 0.001). However, patients in stage A had similar mortality to patients without cirrhosis (31.8% vs. 28.4% p = NS) and in this stage heart surgery had a protective effect (28% in operated patients vs. 60% in non-operated when it was indicated). Mortality was significantly higher in stages B (52.4%) and C (52.9%) and the prognosis was better for patients in stage B who underwent surgery immediately (mortality 50%) compared to those where surgery was delayed (58%) or not performed (74%). Only one patient in stage C underwent surgery.Conclusions: Patients with liver cirrhosis and infective endocarditis have a poorer prognosis only in stages B and C. Early surgery must be performed in stages A and although in selected patients in stage B when indicated. [ABSTRACT FROM AUTHOR] more...- Published
- 2015
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6. Guía ESC 2015 sobre el tratamiento de la endocarditis infecciosa
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Habib, Gilbert, Lancellotti, Patrizio, Antunes, Manuel J., Bongiorni, Maria Grazia, Casalta, Jean-Paul, Zotti, Francesco del, Dulgheru, Raluca, Khoury, Gebrine El, Erba, Paola Anna, Iung, Bernard, Miró, Jose M., Mulder, Barbara J., Plonska-Gosciniak, Edyta, Price, Susanna, Roos-Hesselink, Jolien, Snygg-Martin, Ulrika, Thuny, Franck, Mas, Pilar Tornos, Vilacosta, Isidre, Zamorano, José Luis, Erol, Çetin, Nihoyannopoulos, Petros, Aboyans, Victor, Agewall, Stefan, Athanassopoulos, George, Aytekin, Saide, Benzer, Werner, Bueno, Héctor, Broekhuizen, Lidewij, Carerj, Scipione, Cosyns, Bernard, de Backer, Julie, de Bonis, Michele, Dimopoulos, Konstantinos, Donal, Erwan, Drexel, Heinz, Flachskampf, Frank Arnold, Hall, Roger, Halvorsen, Sigrun, Hoen, Bruno, Kirchhof, Paulus, Lainscak, Mitja, Leite-Moreira, Adelino F., Lip, Gregory Y.H., Mestres, Carlos A., Piepoli, Massimo F., Punjabi, Prakash P., Rapezzi, Claudio, Rosenhek, Raphael, Siebens, Kaat, Tamargo, Juan, and Walker, David M. more...
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Se puede consultar en el apéndice las filiaciones de los coordinadores de sección.
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- 2016
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7. Interacciones graves o potencialmente letales entre antirretrovirales y otros medicamentos
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Manzardo, Christian, Tuset, Montserrat, Miró, Jose M., and Gatell, Jose M.
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El tratamiento antirretroviral de gran actividad (TARGA) ha permitido un buen control de la infección por VIH, y por lo tanto la población afectada envejece progresivamente y la esperanza de vida va siendo parecida a la de la población general. Por otro lado, se sabe que la infección por VIH predispone, incluso en pacientes con TARGA efectivo, a un mayor riesgo cardiovascular y a una mayor incidencia de algunas neoplasias. Por todo ello, la mayor parte de pacientes infectados por el VIH reciben diversos medicamentos (pautados por el facultativo o autoadministrados) además de los antirretrovirales. Este artículo revisa las interacciones que pueden provocar daños importantes o incluso poner en peligro la vida de los pacientes y que los clínicos —sobre todo los que no manejan directamente pacientes infectados por el VIH— tendrían que conocer. También se revisan las implicaciones de las interacciones entre antirretrovirales y otros fármacos en situaciones especiales, como la administración concomitante de citostáticos, inmunosupresores utilizados en el trasplante de órganos sólidos o pacientes que reciben los nuevos tratamientos para el virus de la hepatitisC. En general, las pautas con 2 inhibidores nucleós(t)idos de la transcriptasa inversa con raltegravir o dolutegravir son las que tienen menos potencial de interacciones clínicamente significativas. more...
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- 2015
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8. Early In Vitroand In VivoDevelopment of High-Level Daptomycin Resistance Is Common in Mitis Group Streptococci after Exposure to Daptomycin
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García-de-la-Mària, Cristina, Pericas, Juan M., del Río, Ana, Castañeda, Ximena, Vila-Farrés, Xavier, Armero, Yolanda, Espinal, Paula A., Cervera, Carlos, Soy, Dolors, Falces, Carlos, Ninot, Salvador, Almela, Manel, Mestres, Carlos A., Gatell, Jose M., Vila, Jordi, Moreno, Asuncion, Marco, Francesc, and Miró, Jose M. more...
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ABSTRACTThe development of high-level daptomycin resistance (HLDR; MIC of ≥256 mg/liter) after exposure to daptomycin has recently been reported in viridans group streptococcus (VGS) isolates. Our study objectives were as follows: to know whether in vitrodevelopment of HLDR after exposure to daptomycin was common among clinical isolates of VGS and Streptococcus bovis; to determine whether HLDR also developed during the administration of daptomycin to treat experimental endocarditis caused by the daptomycin-susceptible, penicillin-resistant Streptococcus mitisstrain S. mitis351; and to establish whether combination with gentamicin prevented the development of HLDR in vitroand in vivo. In vitrostudies were performed with 114 VGS strains (mitis group, 92; anginosus group, 10; mutans group, 8; and salivarius group, 4) and 54 Streptococcus bovisstrains isolated from 168 consecutive patients with infective endocarditis diagnosed between 1995 and 2010. HLDR was only observed after 24 h of exposure to daptomycin in 27% of the mitis group, including 27% of S. mitisisolates, 47% of S. oralisisolates, and 13% of S. sanguisisolates. In our experimental model, HLDR was detected in 7/11 (63%) and 8/12 (67%) isolates recovered from vegetations after 48 h of daptomycin administered at 6 mg/kg of body weight/24 h and 10 mg/kg/24 h, respectively. In vitro, time-kill experiments showed that daptomycin plus gentamicin was bactericidal against S. mitis351 at tested concentrations of 0.5 and 1 times the MIC and prevented the development of HLDR. In vivo, the addition of gentamicin at 1 mg/kg/8 h to both daptomycin arms prevented HLDR in 21 out of 23 (91%) rabbits. Daptomycin plus gentamicin was at least as effective as vancomycin plus gentamicin. In conclusion, HLDR develops rapidly and frequently in vitroand in vivoamong mitis group streptococci. Combining daptomycin with gentamicin enhanced its activity and prevented the development of HLDR in most cases. more...
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- 2013
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9. Associations between integrase strand-transfer inhibitors and cardiovascular disease in people living with HIV: a multicentre prospective study from the RESPOND cohort consortium
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Neesgaard, Bastian, Greenberg, Lauren, Miró, Jose M, Grabmeier-Pfistershammer, Katharina, Wandeler, Gilles, Smith, Colette, De Wit, Stéphane, Wit, Ferdinand, Pelchen-Matthews, Annegret, Mussini, Cristina, Castagna, Antonella, Pradier, Christian, d'Arminio Monforte, Antonella, Vehreschild, Jörg J, Sönnerborg, Anders, Anne, Alain V, Carr, Andrew, Bansi-Matharu, Loveleen, Lundgren, Jens D, Garges, Harmony, Rogatto, Felipe, Zangerle, Robert, Günthard, Huldrych F, Rasmussen, Line D, Necsoi, Coca, van der Valk, Marc, Menozzi, Marianna, Muccini, Camilla, Peters, Lars, Mocroft, Amanda, and Ryom, Lene more...
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Although associations between older antiretroviral drug classes and cardiovascular disease in people living with HIV are well described, there is a paucity of data regarding a possible association with integrase strand-transfer inhibitors (INSTIs). We investigated whether exposure to INSTIs was associated with an increased incidence of cardiovascular disease. more...
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- 2022
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10. Efficacy and Safety of Once-Daily Combination Therapy with Didanosine, Lamivudine and Nevirapine in Antiretroviral-Naive HIV-Infected Patients
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Ribera, Esteban, Rodríguez-Pardo, Dolors, Rubio, Manuel, Soler, Anna, Pedrol, Enric, Blanco, José L, González, Alicia, Crespo, Manel, Falcó, Vicenç, Ocaña, Imma, Deig, Elisabeth, Miró, Jose M, and Pahissa, Albert more...
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Background Simplified antiretroviral regimens are needed to improve patient adherence and quality of life. The purpose of this study was to evaluate the efficacy and safety of a once-daily regimen consisting of didanosine (ddI), lamivudine (3TC) and nevirapine (NVP) for adult antiretroviral-naive patients with HIV-1 infection.Methods This was a prospective, one-arm, multicentre pilot study. Daily drug dosage was 250 or 400 mg didanosine, 300 mg lamivudine and 400 mg nevirapine. The primary outcome measure was the percentage of patients with a plasma HIV-RNA level <50 copies/ml at 12 months on an intention-to-treat (ITT) basis.Results Seventy patients were enrolled in the study. At baseline, mean plasma HIV-1 RNA was 5.10 log10copies/ml, and mean CD4 cell count was 262 cells/µl. At month 12, 67% (95% CI: 56–78) of patients maintained a viral load of <50 copies/ml in the ITT analysis and CD4 counts increased a median of 201 cells/µl. The treatment was more effective in patients with baseline CD4 counts >100 cells/µl than in those with a poorer immunological status at baseline, although the number of patients with CD4 counts <100 was low. Four patients died during the study period. Therapy was discontinued in 18 patients due to virological failure in 11, adverse events in seven, loss to follow-up or withdrawal of consent in four and death in one. Eight out of nine patients with available genotype after virological failure showed resistance mutations to NVP (Y181C and others) and 3TC (M184V/I), and four of them also had ddI resistance (L74V). The lipid profile was favourable, with a decrease in the ratio of total-to-high density lipoprotein cholesterol.Conclusion A once-daily combination of ddI, 3TC and NVP seems to be an effective, safe and easy-to-take regimen in antiretroviral-naive patients, at least in those who do not have severe immunodepression at baseline. more...
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- 2005
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11. Depressive Symptoms after Initiation of Interferon Therapy in Human Immunodeficiency Virus-Infected Patients with Chronic Hepatitis C
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Laguno, Montserrat, Blanch, Jordi, Murillas, Javier, Blanco, Jose Luis, León, Agathe, Lonca, Montserrat, Larrousse, Maria, Biglia, Alejandra, Martinez, Esteban, García, Felipe, Miró, Jose M, de Pablo, Joan, Gatell, Josep M, and Mallolas, Josep more...
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Background Interferon alpha (IFN-a) therapy for chronic hepatitis C (CHC) infection is commonly associated with neuropsychiatric side effects including depressive symptomatology. In this study, we evaluated the incidence and management of depressive symptoms during IFN-a therapy in HIV-infected patients with CHC.Methods HIV-infected patients with CHC who began IFN-a and ribavirin therapy during the recruitment period April 2001 to April 2003 were included in the study. Patients with a history of major depressive disorder were excluded.Results Of 113 co-infected patients who started IFN-a therapy during the recruitment period, 45 (40%) developed symptoms of depression (sadness, tiredness and apathy). Twenty of them (44%) were treated with citalopram, a selective serotonin re-uptake inhibitor, resulting in a significant improvement in their symptoms. Most of the patients (60%) showed depressive side effects in the first 3 months after initiation of IFN-a. In addition, during the study, three patients developed psychotic symptoms and one committed suicide.Conclusions The incidence of depressive symptoms in patients with HIV/HCV co-infection treated with IFN-a is high. Most of the depressive symptoms were not severe and improved with antidepressant therapy, without reduction or cessation of IFN-a therapy. During the first weeks after initiating IFN-a therapy for HIV/HCV co-infection, close assessment of psychiatric symptoms is recommended. Early treatment of these side effects with antidepressants would help avoid early dropouts from interferon therapy. more...
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- 2004
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12. Short Communication: Reversible Mitochondrial Respiratory Chain Impairment During Symptomatic Hyperlactatemia Associated with Antiretroviral Therapy
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Miró, Òscar, López, Sònia, Martínez, Esteban, Rodríguez-Santiago, Benjamín, Blanco, José L., Milinkovic, Ana, Miró, Jose M., Nunes, Virginia, Casademont, Jordi, Gatell, Josep M., and Cardellach, Francesc more...
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Direct evidence confirming the hypothesis that a dysfunction of the mitochondrial respiratory chain (MRC) underlies the pathogenesis of hyperlactatemia associated with highly active antiretroviral therapy (HAART) is scarce. We studied mitochondrial DNA (mtDNA) content and MRC function in the skeletal muscle of an HIV-infected patient during an episode of symptomatic hyperlactatemia. Skeletal muscle biopsy was performed during the episode when the patient was symptomatic and 3 months later when the patient was clinically recovered. Assessment of mitochondria was performed using histological, polarographic, spectrophotometrical, and Southern blot and real time PCR DNA quantification methods. The histological study disclosed extensive mitochondrial impairment in the form of ragged-red fibers or equivalents on oxidative reactions. These findings were associated with an increase in mitochondrial content and a decrease in both mitochondrial respiratory capacity and MRC enzyme activities. Mitochondrial DNA content declined to 53% of control values. Mitochondrial abnormalities had almost disappeared later when the patient became asymptomatic. Our findings support the hypothesis that MRC dysfunction stands at the basis of HAART-related hyperlactatemia. more...
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- 2003
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13. The Combination of Daptomycin and Fosfomycin Has Synergistic, Potent, and Rapid Bactericidal Activity against Methicillin-Resistant Staphylococcus aureusin a Rabbit Model of Experimental Endocarditis
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García-de-la-Mària, Cristina, Gasch, Oriol, García-Gonzalez, Javier, Soy, Dolors, Shaw, Evelyn, Ambrosioni, Juan, Almela, Manel, Pericàs, Juan M., Tellez, Adrián, Falces, Carlos, Hernandez-Meneses, Marta, Sandoval, Elena, Quintana, Eduard, Vidal, Barbara, Tolosana, Jose M., Fuster, David, Llopis, Jaume, Pujol, Miquel, Moreno, Asuncion, Marco, Francesc, and Miró, Jose M. more...
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ABSTRACTWe investigated whether the addition of fosfomycin or cloxacillin to daptomycin provides better outcomes in the treatment of methicillin-resistant Staphylococcus aureus(MRSA) experimental aortic endocarditis in rabbits. Five MRSA strains were used to perform in vitrotime-kill studies using standard (106) and high (108) inocula. Combined therapy was compared to daptomycin monotherapy treatment in the MRSA experimental endocarditis model. A human-like pharmacokinetics model was applied, and the equivalents of cloxacillin at 2 g/4 h, fosfomycin at 2 g/6 h, and daptomycin at 6 to 10 mg/kg/day were administered intravenously. A combination of daptomycin and either fosfomycin or cloxacillin was synergistic in the five strains tested at both inocula. A bactericidal effect was detected in four of five strains tested with both combinations. The MRSA-277 strain (vancomycin MIC, 2 μg/ml) was used for the experimental endocarditis model. Daptomycin plus fosfomycin significantly improved the efficacy of daptomycin monotherapy at 6 mg/kg/day in terms of both the proportion of sterile vegetations (100% versus 72%, P= 0.046) and the decrease in the density of bacteria within the vegetations (P= 0.025). Daptomycin plus fosfomycin was as effective as daptomycin monotherapy at 10 mg/kg/day (100% versus 93%, P= 1.00) and had activity similar to that of daptomycin plus cloxacillin when daptomycin was administered at 6 mg/kg/day (100% versus 88%, P= 0.48). Daptomycin nonsusceptibility was not detected in any of the isolates recovered from vegetations. In conclusion, for the treatment of MRSA experimental endocarditis, the combination of daptomycin plus fosfomycin showed synergistic and bactericidal activity. more...
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- 2018
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14. AUC/MIC Pharmacodynamic Target Is Not a Good Predictor of Vancomycin Efficacy in Methicillin-Resistant Staphylococcus aureusExperimental Endocarditis
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Castañeda, Ximena, García-de-la-Mària, Cristina, Gasch, Oriol, Pericas, Juan M., Armero, Yolanda, Soy, Dolors, García-González, Javier, Falces, Carlos, Ninot, Salvador, Almela, Manel, Ambrosioni, Juan, Quintana, Eduardo, Vidal, Barbara, Fuster, David, Llopis, Jaume, Soto, Sara, Moreno, Asuncion, Marco, Francesc, and Miró, Jose M. more...
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ABSTRACTThe aim of this in vivostudy was to compare the efficacy of vancomycin at standard doses (VAN-SD) to that of VAN at adjusted doses (VAN-AD) in achieving a VAN area under the curve/MIC ratio (AUC/MIC) of ≥400 against three methicillin-resistant Staphylococcus aureus(MRSA) strains with different microdilution VAN MICs in an experimental endocarditis model. The valve vegetation bacterial counts after 48 h of VAN therapy were compared, and no differences were observed between the two treatment groups for any of the three strains tested. Overall, for VAN-SD and VAN-AD, the rates of sterile vegetations were 15/45 (33.3%) and 21/49 (42.8%) (P= 0.343), while the medians (interquartile ranges [IQRs]) for log10CFU/g of vegetation were 2 (0 to 6.9) and 2 (0 to 4.5) (P= 0.384), respectively. In conclusion, this VAN AUC/MIC pharmacodynamic target was not a good predictor of vancomycin efficacy in MRSA experimental endocarditis. more...
- Published
- 2017
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