Search

[Display omitted] • Therapeutic strategies for both neuropathic pain and fibromyalgia have been extensively elaborated. • Numerous types of dietary supplements, including phytochemicals, minerals, and vitamins have been thoroughly covered. • Insights into the pathophysiological mechanisms implicated in neuropathic pain as well as fibromyalgia. • Illustration of mechanistic approaches of nutraceuticals in neuropathic pain and fibromyalgia. • Clinical studies performed on some molecules against painful conditions have also been incorporated. Though both neuropathy and fibromyalgia are serious complications that cause widespread pain, distinguishing between the two in order to provide adequate care is difficult. Metabolic disorders, chemotherapy, and neurotoxic exposure are frequently reported with neuropathic pain, whereas inflammatory and musculoskeletal diseases are associated with fibromyalgia. In recent years, these pain syndromes have become a significant challenge for healthcare experts due to their complex etiology, limited drug availability, and effectiveness. Notably, pharmaceutical drugs (antidepressants, anticonvulsants) available today have adverse effects, including physical dependence and tolerance. Therefore, a plethora of nutraceuticals has drawn considerable attention from patients seeking relief from chronic pain conditions. Nonetheless, only a few preclinical and clinical studies have been conducted to establish the safety and efficacy of these supplements. The current review concentrates on the role of a variety of nutraceuticals in the treatment of neuropathic pain and fibromyalgia, as well as their potential mechanisms and clinical trials. [ABSTRACT FROM AUTHOR]

[Display omitted] • The structures, bioactivities and mechanisms of phytoconstituents for the management of Huntington's disease were mentioned. • Clinical trials conducted on some phytoconstituents and vitamins against Huntington's disease were included. • Other medicinal properties of phytoconstituents in concern were mentioned in the form of figure. • Pathophysiological mechanisms implicated in Huntington's disease were elaborated. Among several neurodegenerative diseases, Huntington disease has posed a major threat across the world, particularly in the aged population. The disease is caused due to expansion of cytosine-adenine-guanine repeats which further triggers the formation of a mutant huntingtin protein responsible for neuronal death. Numerous pathophysiologic mechanisms have been implicated in Huntington's disease. Striatum and cortex represent the most affected parts of the brain. Even though a wide range of medicines are available but they possess serious side effects. Therefore, the emergence of nutraceuticals derived from natural sources has received great attention in the pharmaceutical domain. Nutraceuticals are health-promoting supplements and enhance immunity in human beings. Currently, oxidative stress is the leading factor for chronic diseases that occur due to low intake of antioxidants. Herbal nutraceuticals are said to be enriched with a massive number of antioxidants. Therefore, this article throws light on various herbal nutraceuticals and their noteworthy effects on Huntington's disease. [ABSTRACT FROM AUTHOR]