11 results on '"Murray, Micah M."'
Search Results
2. Mitochondrial, exosomal miR137-COX6A2 and gamma synchrony as biomarkers of parvalbumin interneurons, psychopathology, and neurocognition in schizophrenia
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Khadimallah, Ines, Jenni, Raoul, Cabungcal, Jan-Harry, Cleusix, Martine, Fournier, Margot, Beard, Elidie, Klauser, Paul, Knebel, Jean-François, Murray, Micah M., Retsa, Chrysa, Siciliano, Milena, Spencer, Kevin M., Steullet, Pascal, Cuenod, Michel, Conus, Philippe, and Do, Kim Q.
- Abstract
Early detection and intervention in schizophrenia requires mechanism-based biomarkers that capture neural circuitry dysfunction, allowing better patient stratification, monitoring of disease progression and treatment. In prefrontal cortex and blood of redox dysregulated mice (Gclm-KO ± GBR), oxidative stress induces miR-137 upregulation, leading to decreased COX6A2 and mitophagy markers (NIX, Fundc1, and LC3B) and to accumulation of damaged mitochondria, further exacerbating oxidative stress and parvalbumin interneurons (PVI) impairment. MitoQ, a mitochondria-targeted antioxidant, rescued all these processes. Translating to early psychosis patients (EPP), blood exosomal miR-137 increases and COX6A2 decreases, combined with mitophagy markers alterations, suggest that observations made centrally and peripherally in animal model were reflected in patients’ blood. Higher exosomal miR-137 and lower COX6A2 levels were associated with a reduction of ASSR gamma oscillations in EEG. As ASSR requires proper PVI-related networks, alterations in miR-137/COX6A2 plasma exosome levels may represent a proxy marker of PVI cortical microcircuit impairment. EPP can be stratified in two subgroups: (a) a patients’ group with mitochondrial dysfunction “Psy-D”, having high miR-137 and low COX6A2 levels in exosomes, and (b) a “Psy-ND” subgroup with no/low mitochondrial impairment, including patients having miR-137 and COX6A2 levels in the range of controls. Psy-D patients exhibited more impaired ASSR responses in association with worse psychopathological status, neurocognitive performance, and global and social functioning, suggesting that impairment of PVI mitochondria leads to more severe disease profiles. This stratification would allow, with high selectivity and specificity, the selection of patients for treatments targeting brain mitochondria dysregulation and capture the clinical and functional efficacy of future clinical trials.
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- 2022
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3. The physics of higher-order interactions in complex systems
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Battiston, Federico, Amico, Enrico, Barrat, Alain, Bianconi, Ginestra, Ferraz de Arruda, Guilherme, Franceschiello, Benedetta, Iacopini, Iacopo, Kéfi, Sonia, Latora, Vito, Moreno, Yamir, Murray, Micah M., Peixoto, Tiago P., Vaccarino, Francesco, and Petri, Giovanni
- Abstract
Complex networks have become the main paradigm for modelling the dynamics of interacting systems. However, networks are intrinsically limited to describing pairwise interactions, whereas real-world systems are often characterized by higher-order interactions involving groups of three or more units. Higher-order structures, such as hypergraphs and simplicial complexes, are therefore a better tool to map the real organization of many social, biological and man-made systems. Here, we highlight recent evidence of collective behaviours induced by higher-order interactions, and we outline three key challenges for the physics of higher-order systems.
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- 2021
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4. Are musical activities associated with enhanced speech perception in noise in adults? A systematic review and meta-analysis
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Maillard, Elisabeth, Joyal, Marilyne, Murray, Micah M., and Tremblay, Pascale
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The ability to process speech in noise (SPiN) declines with age, with a detrimental impact on life quality. Music-making activities such as singing and playing a musical instrument have raised interest as potential prevention strategies for SPiN perception decline because of their positive impact on several brain system, especially the auditory system, which is critical for SPiN. However, the literature on the effect of musicianship on SPiN performance has yielded mixed results. By critically assessing the existing literature with a systematic review and a meta-analysis, we aim to provide a comprehensive portrait of the relationship between music-making activities and SPiN in different experimental conditions. 38/49 articles, most focusing on young adults, were included in the quantitative analysis. The results show a positive relationship between music-making activities and SPiN, with the strongest effects found in the most challenging listening conditions, and little to no effect in less challenging situations. This pattern of results supports the notion of a relative advantage for musicians on SPiN performance and clarify the scope of this effect. However, further studies, especially with older adults, using adequate randomization methods, are needed to extend the present conclusions and assess the potential for musical activities to be used to mitigate SPiN decline in seniors.
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- 2023
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5. Contributions of pitch and bandwidth to sound-induced enhancement of visual cortex excitability in humans
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Spierer, Lucas, Manuel, Aurelie L., Bueti, Domenica, and Murray, Micah M.
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Multisensory interactions have been documented within low-level, even primary, cortices and at early post-stimulus latencies. These effects are in turn linked to behavioral and perceptual modulations. In humans, visual cortex excitability, as measured by transcranial magnetic stimulation (TMS) induced phosphenes, can be reliably enhanced by the co-presentation of sounds. This enhancement occurs at pre-perceptual stages and is selective for different types of complex sounds. However, the source(s) of auditory inputs effectuating these excitability changes in primary visual cortex remain disputed. The present study sought to determine if direct connections between low-level auditory cortices and primary visual cortex are mediating these kinds of effects by varying the pitch and bandwidth of the sounds co-presented with single-pulse TMS over the occipital pole. Our results from 10 healthy young adults indicate that both the central frequency and bandwidth of a sound independently affect the excitability of visual cortex during processing stages as early as 30 msec post-sound onset. Such findings are consistent with direct connections mediating early-latency, low-level multisensory interactions within visual cortices.
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- 2013
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6. Electrophysiological differences and similarities in audiovisual speech processing in CI users with unilateral and bilateral hearing loss
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Layer, Natalie, Weglage, Anna, Müller, Verena, Meister, Hartmut, Lang-Roth, Ruth, Walger, Martin, Murray, Micah M., and Sandmann, Pascale
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Hearing with a cochlear implant (CI) is limited compared to natural hearing. Although CI users may develop compensatory strategies, it is currently unknown whether these extend from auditory to visual functions, and whether compensatory strategies vary between different CI user groups. To better understand the experience-dependent contributions to multisensory plasticity in audiovisual speech perception, the current event-related potential (ERP) study presented syllables in auditory, visual, and audiovisual conditions to CI users with unilateral or bilateral hearing loss, as well as to normal-hearing (NH) controls. Behavioural results revealed shorter audiovisual response times compared to unisensory conditions for all groups. Multisensory integration was confirmed by electrical neuroimaging, including topographic and ERP source analysis, showing a visual modulation of the auditory-cortex response at N1 and P2 latency. However, CI users with bilateral hearing loss showed a distinct pattern of N1 topography, indicating a stronger visual impact on auditory speech processing compared to CI users with unilateral hearing loss and NH listeners. Furthermore, both CI user groups showed a delayed auditory-cortex activation and an additional recruitment of the visual cortex, and a better lip-reading ability compared to NH listeners. In sum, these results extend previous findings by showing distinct multisensory processes not only between NH listeners and CI users in general, but even between CI users with unilateral and bilateral hearing loss. However, the comparably enhanced lip-reading ability and visual-cortex activation in both CI user groups suggest that these visual improvements are evident regardless of the hearing status of the contralateral ear.
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- 2022
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7. Auditory-Somatosensory Multisensory Processing in Auditory Association Cortex: An fMRI Study
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Foxe, John J., Wylie, Glenn R., Martinez, Antigona, Schroeder, Charles E., Javitt, Daniel C., Guilfoyle, David, Ritter, Walter, and Murray, Micah M.
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Using high-field (3 Tesla) functional magnetic resonance imaging (fMRI), we demonstrate that auditory and somatosensory inputs converge in a subregion of human auditory cortex along the superior temporal gyrus. Further, simultaneous stimulation in both sensory modalities resulted in activity exceeding that predicted by summing the responses to the unisensory inputs, thereby showing multisensory integration in this convergence region. Recently, intracranial recordings in macaque monkeys have shown similar auditory-somatosensory convergence in a subregion of auditory cortex directly caudomedial to primary auditory cortex (area CM). The multisensory region identified in the present investigation may be the human homologue of CM. Our finding of auditory-somatosensory convergence in early auditory cortices contributes to mounting evidence for multisensory integration early in the cortical processing hierarchy, in brain regions that were previously assumed to be unisensory.
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- 2002
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8. Neural processing of illusory and real contours revealed by highdensity ERP mapping
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Pegna, Alan J., Khateb, Asaid, Murray, Micah M., Landis, Theodor, and Michel, Christoph M.
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Eventrelated potential ERP studies have shown that responses to illusory IC, as compared to no contours NC, may differ within 200 ms following stimulus presentation. However, whether these responses reflect the modulation of similar, or the activation ofdistinct brain regions has never been assessed. Using ERP map series and source localisation analyses, we compared early responses 0200ms to IC and NC, as well as to real contours RC. Although IC displayed higher field strength during the NI component, topographical analyses showed a similar sequence of stable field configurations in all conditions. Source localisation applied to the NI map revealed bilateral activation of lateraloccipital regions. These results suggest that both IC and RC processing modulate a common network associated with fillingin processes and figureground segregation. Neuro Report13965968
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- 2002
9. Visual Perceptual Learning in Human Object Recognition Areas: A Repetition Priming Study Using High-Density Electrical Mapping
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Doniger, Glen M., Foxe, John J., Schroeder, Charles E., Murray, Micah M., Higgins, Beth A., and Javitt, Daniel C.
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It is often the case that only partial or degraded views of an object are available to an observer, and yet in many of these cases, object recognition is accomplished with surprising ease. The perceptual filling-in or “closure” that makes this possible has been linked to a group of object recognition areas in the human brain, the lateral occipital (LO) complex, and has been shown to have a specific electrophysiological correlate, the Nclcomponent of the event related potential. Perceptual closure presumably occurs because repeated and varied exposure to different classes of objects has caused the brain to undergo “perceptual learning,” which promotes a robust mnemonic representation, accessible under partial information circumstances. The present study examined the impact of perceptual learning on closure-related brain processes. Fragmented pictures of common objects were presented, such that information content was incrementally increased until just enough information was present to permit closure and object recognition. Periodic repetition of a subset of these picture sequences was used to induce repetition priming due to perceptual learning. This priming has an electrophysiological signature that is putatively generated in the LO complex, but significantly precedes the electrophysiological correlate of closure. The temporal progression of priming- and closure-related activity in the LO complex supports the view that sensory processing entails multiple reentrant stages of activity within processing modules of the visual hierarchy. That the earliest priming-related activity occurs over LO complex, sug-gests that the sensory trace itself may reside in these object recognition areas.
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- 2001
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10. Electrically Assisted Movement Therapy in Chronic Stroke Patients With Severe Upper Limb Paresis: A Pilot, Single-Blind, Randomized Crossover Study.
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Carda, Stefano, Biasiucci, Andrea, Maesani, Andrea, Ionta, Silvio, Moncharmont, Julien, Clarke, Stephanie, Murray, Micah M., and Millán, José del R.
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Objective To evaluate the effects of electrically assisted movement therapy (EAMT) in which patients use functional electrical stimulation, modulated by a custom device controlled through the patient's unaffected hand, to produce or assist task-specific upper limb movements, which enables them to engage in intensive goal-oriented training. Design Randomized, crossover, assessor-blinded, 5-week trial with follow-up at 18 weeks. Setting Rehabilitation university hospital. Participants Patients with chronic, severe stroke (N=11; mean age, 47.9y) more than 6 months poststroke (mean time since event, 46.3mo). Interventions Both EAMT and the control intervention (dose-matched, goal-oriented standard care) consisted of 10 sessions of 90 minutes per day, 5 sessions per week, for 2 weeks. After the first 10 sessions, group allocation was crossed over, and patients received a 1-week therapy break before receiving the new treatment. Main Outcome Measures Fugl-Meyer Motor Assessment for the Upper Extremity, Wolf Motor Function Test, spasticity, and 28-item Motor Activity Log. Results Forty-four individuals were recruited, of whom 11 were eligible and participated. Five patients received the experimental treatment before standard care, and 6 received standard care before the experimental treatment. EAMT produced higher improvements in the Fugl-Meyer scale than standard care ( P <.05). Median improvements were 6.5 Fugl-Meyer points and 1 Fugl-Meyer point after the experimental treatment and standard care, respectively. The improvement was also significant in subjective reports of quality of movement and amount of use of the affected limb during activities of daily living ( P <.05). Conclusions EAMT produces a clinically important impairment reduction in stroke patients with chronic, severe upper limb paresis. [ABSTRACT FROM AUTHOR]
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- 2017
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11. On-line Morpho-Syntactic Processing in the Healthy and Aphasic Brain
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Schneider, Laurence, Toepel, Ulrike, Murray, Micah M., and Clarke, Stephanie
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- 2010
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