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11 results on '"NGUYEN, JULIE K."'

1. Racial and ethnic underrepresentation in dermatology clinical trials.

Author

Mineroff, Jessica, Nguyen, Julie K., and Jagdeo, Jared

Abstract

Including participants of diverse racial and ethnic populations in clinical trials is important to reduce disparities and promote health care equity. To evaluate racial and ethnic representation in dermatology clinical trials. Participant data from dermatology trials completed in the United States from 2017 to 2021 from ClinicalTrials.gov were compared to census data to determine if minority groups were represented at rates that reflect population demographics. Participation was compared with prevalence rates for the most underrepresented racial group. Of 246 trials that met inclusion criteria, 87.4% (215) reported racial data. Compared to census data, Black/African American, American Indian/Alaskan Native, and 2 or more races were underrepresented. Hispanic or Latinos were an underrepresented ethnic group. The search was limited to ClinicalTrials.gov registered studies that fell within search parameters. Race reporting methods were not specified. Detailed analysis was only performed for the most underrepresented racial group. Certain minority groups were underrepresented in dermatology trials. Black/African Americans were most underrepresented and underrepresented even when accounting for prevalence rates. Trial representation that accurately reflects population demographics and subgroup prevalence rates can help reduce health inequity, improve clinical understanding, and enhance treatment access for the growing diverse population. [ABSTRACT FROM AUTHOR]

Published
2023
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2. Achieving Equity in Child and Adolescent Mental Health by Addressing Racism Through Prevention Science

Author

Goodrum, Nada M., Cooper, Daniel K., Edmunds, Sarah, Wippold, Guillermo M., Bradshaw, Jessica, Nguyen, Julie K., Milburn, Norweeta, and Are, Funlola

Abstract

Prevention science is a multidisciplinary field dedicated to promoting public health and reducing early risk factors that lead to negative health outcomes. It has been used to successfully improve child and family mental health and well-being, including for families affected by adversity. Despite advances in prevention efforts, major public health inequities remain for Black, Indigenous, and other People of Color (BIPOC) children and families, in part because of equity-implicit “one-size-fits-all” approaches that do not directly address racism which in part underlies the very health concerns these efforts aim to prevent. Structural racism not only introduces additional risk for negative health outcomes for BIPOC families but also it reduces access to prevention-focused programs and policies, thus perpetuating inequities across generations. Adopting an equity-explicit, antiracist lens that attends to the effects of structural racism can strengthen the impact of prevention efforts by more effectively improving child and family health, reducing access barriers, and effecting multigenerational change for BIPOC families experiencing various levels of adversity. Evidence-informed recommendations for applying antiracist prevention science include the following: explicitly incorporating an understanding of structural racism within prevention science methods and theory (e.g., risk and resilience frameworks); establishing and fostering truly equitable community partnerships; diversifying the field through mentorship of BIPOC scholars and clinicians focused on child and family well-being; assembling diverse transdisciplinary research teams to address child health inequities in a family-centered manner; attending to intersectionality; and using implementation science to promote access and sustainability for all families.

Published
2023
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4. Continuous gradient temperature Raman spectroscopy from −100 to 40 °C yields new molecular models of arachidonic acid and 2-Arachidonoyl-1-stearoyl-sn-glycero-3-phosphocholine.

Author

Broadhurst, C. Leigh, Schmidt, Walter F., Nguyen, Julie K., Qin, Jianwei, Chao, Kuanglin, and Kim, Moon S.

Abstract

Despite its biochemical importance, a complete Raman analysis of arachidonic acid (AA, 20:4n-6) has never been reported. Gradient temperature Raman spectroscopy (GTRS) applies the temperature gradients utilized in differential scanning calorimetry (DSC) to Raman spectroscopy, providing a straightforward technique to identify molecular rearrangements that occur near and at phase transitions. Herein we utilize the GTRS technique for AA and 1 -18:0, 2 -20:4n-6 phosphatidyl choline (AAPC) from cryogenic to mammalian body temperatures. 20 Mb three-dimensional data arrays with 0.2 °C increments and first/second derivatives allowed complete assignment of solid, liquid and transition state vibrational modes. The AA DSC shows a large exothermic peak at −60 °C indicating crystallization or a similar major structural change. No exothermic peak of this magnitude was observed in six other unsaturated lipids (DHA, n-3DPA, n-6DPA, LA, ALA, OA). Melting in AA occurs over a large range: (−60 to −35 °C): very large frequency offsets and intensity changes correlate with premelting initiating circa −60 °C, followed by melting (−37 °C). Novel, unique 3D structures for both molecules reveal that AA is not symmetric as a free fatty acid, and it changes significantly when in the sn-2 phospholipid position. Further, different CH and CH 2 sites are unequally elastic and nonequivalent. [ABSTRACT FROM AUTHOR]

Published
2017
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5. Allele-defined genome of the autopolyploid sugarcane Saccharum spontaneumL.

Author

Zhang, Jisen, Zhang, Xingtan, Tang, Haibao, Zhang, Qing, Hua, Xiuting, Ma, Xiaokai, Zhu, Fan, Jones, Tyler, Zhu, Xinguang, Bowers, John, Wai, Ching Man, Zheng, Chunfang, Shi, Yan, Chen, Shuai, Xu, Xiuming, Yue, Jingjing, Nelson, David R., Huang, Lixian, Li, Zhen, Xu, Huimin, Zhou, Dong, Wang, Yongjun, Hu, Weichang, Lin, Jishan, Deng, Youjin, Pandey, Neha, Mancini, Melina, Zerpa, Dessireé, Nguyen, Julie K., Wang, Liming, Yu, Liang, Xin, Yinghui, Ge, Liangfa, Arro, Jie, Han, Jennifer O., Chakrabarty, Setu, Pushko, Marija, Zhang, Wenping, Ma, Yanhong, Ma, Panpan, Lv, Mingju, Chen, Faming, Zheng, Guangyong, Xu, Jingsheng, Yang, Zhenhui, Deng, Fang, Chen, Xuequn, Liao, Zhenyang, Zhang, Xunxiao, Lin, Zhicong, Lin, Hai, Yan, Hansong, Kuang, Zheng, Zhong, Weimin, Liang, Pingping, Wang, Guofeng, Yuan, Yuan, Shi, Jiaxian, Hou, Jinxiang, Lin, Jingxian, Jin, Jingjing, Cao, Peijian, Shen, Qiaochu, Jiang, Qing, Zhou, Ping, Ma, Yaying, Zhang, Xiaodan, Xu, Rongrong, Liu, Juan, Zhou, Yongmei, Jia, Haifeng, Ma, Qing, Qi, Rui, Zhang, Zhiliang, Fang, Jingping, Fang, Hongkun, Song, Jinjin, Wang, Mengjuan, Dong, Guangrui, Wang, Gang, Chen, Zheng, Ma, Teng, Liu, Hong, Dhungana, Singha R., Huss, Sarah E., Yang, Xiping, Sharma, Anupma, Trujillo, Jhon H., Martinez, Maria C., Hudson, Matthew, Riascos, John J., Schuler, Mary, Chen, Li-Qing, Braun, David M., Li, Lei, Yu, Qingyi, Wang, Jianping, Wang, Kai, Schatz, Michael C., Heckerman, David, Van Sluys, Marie-Anne, Souza, Glaucia Mendes, Moore, Paul H., Sankoff, David, VanBuren, Robert, Paterson, Andrew H., Nagai, Chifumi, and Ming, Ray

Abstract

Modern sugarcanes are polyploid interspecific hybrids, combining high sugar content from Saccharum officinarumwith hardiness, disease resistance and ratooning of Saccharum spontaneum. Sequencing of a haploid S. spontaneum, AP85-441, facilitated the assembly of 32 pseudo-chromosomes comprising 8 homologous groups of 4 members each, bearing 35,525 genes with alleles defined. The reduction of basic chromosome number from 10 to 8 in S. spontaneumwas caused by fissions of 2 ancestral chromosomes followed by translocations to 4 chromosomes. Surprisingly, 80% of nucleotide binding site-encoding genes associated with disease resistance are located in 4 rearranged chromosomes and 51% of those in rearranged regions. Resequencing of 64 S. spontaneumgenomes identified balancing selection in rearranged regions, maintaining their diversity. Introgressed S. spontaneumchromosomes in modern sugarcanes are randomly distributed in AP85-441 genome, indicating random recombination among homologs in different S. spontaneumaccessions. The allele-defined Saccharumgenome offers new knowledge and resources to accelerate sugarcane improvement.

Published
2018
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9. Publisher Correction: Allele-defined genome of the autopolyploid sugarcane Saccharum spontaneumL

Author

Zhang, Jisen, Zhang, Xingtan, Tang, Haibao, Zhang, Qing, Hua, Xiuting, Ma, Xiaokai, Zhu, Fan, Jones, Tyler, Zhu, Xinguang, Bowers, John, Wai, Ching Man, Zheng, Chunfang, Shi, Yan, Chen, Shuai, Xu, Xiuming, Yue, Jingjing, Nelson, David R., Huang, Lixian, Li, Zhen, Xu, Huimin, Zhou, Dong, Wang, Yongjun, Hu, Weichang, Lin, Jishan, Deng, Youjin, Pandey, Neha, Mancini, Melina, Zerpa, Dessireé, Nguyen, Julie K., Wang, Liming, Yu, Liang, Xin, Yinghui, Ge, Liangfa, Arro, Jie, Han, Jennifer O., Chakrabarty, Setu, Pushko, Marija, Zhang, Wenping, Ma, Yanhong, Ma, Panpan, Lv, Mingju, Chen, Faming, Zheng, Guangyong, Xu, Jingsheng, Yang, Zhenhui, Deng, Fang, Chen, Xuequn, Liao, Zhenyang, Zhang, Xunxiao, Lin, Zhicong, Lin, Hai, Yan, Hansong, Kuang, Zheng, Zhong, Weimin, Liang, Pingping, Wang, Guofeng, Yuan, Yuan, Shi, Jiaxian, Hou, Jinxiang, Lin, Jingxian, Jin, Jingjing, Cao, Peijian, Shen, Qiaochu, Jiang, Qing, Zhou, Ping, Ma, Yaying, Zhang, Xiaodan, Xu, Rongrong, Liu, Juan, Zhou, Yongmei, Jia, Haifeng, Ma, Qing, Qi, Rui, Zhang, Zhiliang, Fang, Jingping, Fang, Hongkun, Song, Jinjin, Wang, Mengjuan, Dong, Guangrui, Wang, Gang, Chen, Zheng, Ma, Teng, Liu, Hong, Dhungana, Singha R., Huss, Sarah E., Yang, Xiping, Sharma, Anupma, Trujillo, Jhon H., Martinez, Maria C., Hudson, Matthew, Riascos, John J., Schuler, Mary, Chen, Li-Qing, Braun, David M., Li, Lei, Yu, Qingyi, Wang, Jianping, Wang, Kai, Schatz, Michael C., Heckerman, David, Van Sluys, Marie-Anne, Souza, Glaucia Mendes, Moore, Paul H., Sankoff, David, VanBuren, Robert, Paterson, Andrew H., Nagai, Chifumi, and Ming, Ray

Abstract

In the version of this article originally published, the accession codes listed in the data availability section were incorrect and the section was incomplete. The text for this section should have read “The genome assembly and gene annotation have been deposited in the NCBI database under accession number QVOL00000000, BioProject number PRJNA483885 and BioSample number SAMN09753102. The data can also be downloaded from the following link: http://www.life.illinois.edu/ming/downloads/Spontaneum_genome/.” The errors have been corrected in the HTML and PDF versions of the article.

Published
2018
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