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An efficient nickel‐catalyzed sequential one‐pot strategy for the synthesis of coumarin‐appended quinolines and bis‐quinolines has been developed under mild reaction conditions in moderate to good yields (up to 84 %) viadehydrogenative Friedlander annulation followed by C(sp3)−H functionalization. The use of a cost‐effective Ni catalyst, environmentally friendly solvents and simple operating procedures are the attractive attributes of this method. Additionally, the photophysical properties of the synthesized derivatives were explored utilizing UV‐vis absorption and fluorescence emission studies. Furthermore, the large‐scale synthesis and the synthetic utility of the derivatives highlight the potential applicability of this strategy in synthetic organic chemistry. Moreover, A plausible reaction mechanism is supported by the control experiments and reaction monitoring by 1H NMR analysis. An efficient Ni‐catalyzed one‐pot sequential method has been proposed for the synthesis of coumarin‐containing quinolines and bis‐quinolines. The three‐step sequence, starting with 2‐amino 5‐chloro benzhydrol, yields up to 87 % of coumarin‐containing quinolines and 89 % of bis‐quinolines. This method offers operational simplicity and scalability, facilitating the synthesis of desired products in a short reaction time (8–10 h).

Over the past few decades, thienoquinolines have gained considerable attention due to their biological and synthetic applications. Few reports have been disclosed on Thienoquinoline synthesis. Hence, in the present review, we provided a comprehensive update on the synthesis of Thienoquinolines. A brief description of the preparation procedure, reactivity, and mechanisms are included, where as possible. Respectively, the thienoquinoline synthesis is classified and summarized based on its reactivity, so it will help the researchers to obtain knowledge over the previous literature reports to overcome their problems in designing a new process. Thienoquinoline a fused quinoline heterocycle with a sulfur atom, known to have several bioactivities in medicinal chemistry. Its synthetic utility over organic transformations to produce varied molecules with biological importance. In this review, we discussed about the synthesis of Thienoquinolines from the beginning, and a brief description of the preparation procedure and reactivity are enclosed.

An efficient, solvent-free synthesis of 2-acylthieno[2,3-b]quinolines is reported from 2-halo-quinolinyl ketones through Cu-TEMPO catalyzed dehydrogenation, sp2-C–H functionalization using elemental sulfur as thiol surrogate (sulfur source) and tetrabutylammonium acetate as an ionic reaction medium. The optimized reaction conditions give excellent product yields under mild reaction conditions with chemoselectivity and broad functional group tolerance. The synthetic importance of the synthesized molecules is showcased further by Friedländer annulation, reduction, and alkene functionalization reactions.