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1. Impact of asymptomatic Herpes simplex virus-2 infection on T cell phenotype and function in the foreskin

Author

Prodger, Jessica L., Gray, Ronald, Kigozi, Godfrey, Nalugoda, Fred, Galiwango, Ronald, Nehemiah, Kighoma, Kakanga, Moses, Hirbod, Taha, Wawer, Maria J., Sewankambo, Nelson, Serwadda, David, and Kaul, Rupert

Abstract

Herpes simplex virus type 2 (HSV-2) increases the risk of HIV acquisition in men and overall CD4T cell density in the foreskin. Using tissues obtained during routine male circumcision, we examined the impact of HSV-2 on the function and phenotype of foreskin T cells in Ugandan men. HSV-2 infection was predominantly associated with a compartmentalized increase in CCR5 expression by foreskin CD4T cells, which may contribute to HIV susceptibility.

Published
2012
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