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Background: The validity of clinical complete response (cCR) in predicting the pathological complete response of esophageal cancer patients who underwent chemoradiotherapy (CRT) is still debatable. Moreover, using different tools and criteria for diagnosing treatment response can cause an effect on the correlation between cCR and oncologic outcomes. This study aims to assess the outcome of post CRT patients with cCR using available combined tools as endoscopy with biopsy and CT scan. Materials and Methods: Locally advanced esophageal cancer patients who received CRT for preoperative and definitive settings at our institution were retrospectively reviewed. After completion of CRT, combined endoscopy and CT scan findings were used to defined cCR, and correlated with treatment outcomes. Results: A total of 79 patients were identified. cCR was observed in 13 of 41 (32%), and 10 of 38 (26%) patients treated with tri-modality and definitive CRT (DCRT) group, respectively. The sensitivity, specificity, positive predictive value, and negative predictive value of cCR for predicting pCR were 75%, 96%, 85%, and 92%, respectively. In tri-modality group, there were trends toward better overall survival (OS) (p = 0.056) and disease-free survival (DFS) (p = 0.130) in patients with cCR. The esophageal cancer specific survival was significantly better in cCR patients (p < 0.05). In DCRT group, the OS and DFS of patients with cCR were significantly greater than those with non-cCR (p < 0.01). Patients with non-cCR in both groups had more rate of disease recurrence than those with cCR (p < 0.05). Conclusion: cCR applied in this study correlates well with the PCR and survival outcomes in esophageal cancer patients undergoing CRT. However, it still cannot represent the absence of residual cancer cells. Further studies with a greater number of patients and proper methodology are required to validate the results. [ABSTRACT FROM AUTHOR]