136 results on '"P Gibson, Andrew A."'
Search Results
2. Making gifts from contracts: symbolic resources and resanctification in officers’ language
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Gibson, Andrew G.
- Abstract
AbstractOfficers of the Irish Defence Forces have studied at civilian university since 1969, with the introduction of a policy referred to as the University Service Academic Complement (USAC) scheme. In attending university through USAC, officers are obliged to sign a contract stipulating that they will repay the full costs of their time at university. This paper draws on a study of 46 retired and serving officers, to analyse how they discussed their career and the military officer’s experience of civilian higher education. While the agreement officers are obliged to sign is a legal contract, interviewees consistently characterised their experience of the USAC scheme in terms that omitted this economic reality of the financial implications of attending higher education. Instead, they favoured terms that almost exclusively excluded such a perspective, and instead made the USAC scheme appear to be a ‘gift’ in Marcel Mauss’s terms. This paper illustrates how and why this is the case, in that the use of ‘gift language’ is a type of ‘resanctification’ of the military profession by individual officers in the face of the threat to cohesion and their symbolic universe. Beyond and at the societal level, resanctification through gift language also implies a political 'double-bind' for officers in terms of their relationship with civilian military authorities and the military organisation itself. This paper concludes with an overview of some of the implications of a gift analysis for militaries and their surrounding societies.
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- 2023
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3. Utility of Repeat Endpoint Quaking-Induced Conversion Testing in Creutzfeldt–Jakob Disease
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Dawson, Benjamin K., Gibson, Andrew, Knox, J. David, Tay, Keng Yeow, Leung, Andrew, Hammond, Robert, and Budhram, Adrian
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- 2023
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4. Detection of Nonmetallic Contaminants in Lubricating Oil Using a Microwave Rectangular Cavity Resonator Sensor
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Li, Zhen, Meng, Zhaozong, and Gibson, Andrew
- Abstract
Evaluation of lubricating oil is critical to the operation and maintenance of industrial engines. Here a microwave rectangular cavity resonator sensor is developed for condition monitoring. An oil-filled quartz tube is placed at the position of maximum electric field intensity, where any impurity in the oil perturbs the resonance frequency and quality factor. This arrangement enables the detection capability of nonmetallic contaminants. Particle types are readily differentiated from the resonance parameters due to the different permittivity characteristics of the mixtures. The effect of the contamination on the permittivity is also revealed, providing an alternative analysis approach. From the measurement of standard liquids, the optimal permittivity calculation algorithm for the system developed is found, and estimation errors within ±5% are achieved. The use for oil adulteration detection is also demonstrated. The multifunctional sensor is low-cost, scalable, easy to implement, and capable of on-site and online monitoring.
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- 2023
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5. "They wash and tub and scrub": Stephen Dedalus, "Telemachus," and the English Historical Conscience.
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Gibson, Andrew
- Subjects
CONSCIENCE ,NATIONALISM ,ENGLISH idioms ,EVANGELISTS - Published
- 2022
6. Bite Injuries among Vaccination Staff Participating in a Mass Canine Rabies Vaccination Campaign, Haiti 2016–2017.
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Kirkhope, Rudy T., Gibson, Andrew D., Augustin, Pierre Dilius, Crowdis, Kelly, Fénelon, Natael, MacLeod, Ewan T., Vigilato, Marco A. N., Pieracci, Emily G., and Wallace, Ryan M.
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- 2021
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7. Backfires.
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Groenewold, Hans, Lashley, Zach, Pentecost, Bob, Lovett, Pat, Brown, Cameron, Cartwright, Tom, Thompson, Prescott, MacNevin, Lance, Zussman, Randy, Ashworth, Jim, Gibson, Andrew, Raulerson, W. W., Duryee, John M., Locwin, Ben, Calvert, John, Heldberg, Jim, Geahan, Tim, Howell, Eric, Martin, Aldo, and Terito, Jeff
- Abstract
And the best they could do is copy Ford's EcoBoost 3.5-liter engine and 10-speed, Ram's coil-spring rear suspension, and GM's "styling"? - Eric Weitze Jupiter, FL Tesla says that on a 250-kW Supercharger, its cars can gain 200 miles of range in 15 minutes - Ed. It's funny how hard Ford is working to distance itself from the white Ford Bronco of yesteryear. - Bill Robinson Oklahoma City, OK Ford is already attempting your product-planning idea with the current Escape, and while it's selling well, it's not quite ruling the segment - Ed. [Extracted from the article]
- Published
- 2022
8. HLA-B*07:02and HLA-C*07:02are associated with trimethoprim-sulfamethoxazole respiratory failure
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Goldman, Jennifer L., Miller, Jenna O., Miller, Neil, Eveleigh, Robert, Gibson, Andrew, Phillips, Elizabeth J., and Pastinen, Tomi
- Abstract
We have identified an underrecognized severe adverse drug reaction (ADR) of trimethoprim-sulfamethoxazole (TMP-SMX) associated respiratory failure in previously healthy children and young adults. We investigated potential genetic risk factors associated with TMP-SMX induced respiratory failure in a cohort of seven patients. We explored whole genome sequence among seven patients representing nearly half of all reported cases worldwide and 63 unrelated control individuals in two stages: (1) human leukocyte antigen (HLA) locus variation as several other ADRs have been associated HLA genetic variants and (2) coding variation to catalog and explore potential rare variants contributing to this devastating reaction. All cases were either heterozygous (carriers) or homozygous for the common HLA-B*07:02–HLA-C*07:02haplotype. Despite the small sample size, this observation is statistically significant both in conservative comparison to maximum reported population frequencies (binomial P= 0.00017 for HLA-B and P= 0.00028 for HLA-C) and to our control population assessed by same HLA genotyping approach (binomial P= 0.000001 for HLA-B and P= 0.000018 for HLA-C). No gene elsewhere in the genome harnessed shared rare case enriched coding variation. Our results suggests that HLA-B*07:02and HLA-C*07:02are necessary for a patient to develop respiratory failure due to TMP-SMX.
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- 2022
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9. Towards faster feedback in higher education through digitally mediated dialogic loops.
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Willis, Jill, Gibson, Andrew, Kelly, Nick, Spina, Nerida, Azordegan, Jennifer M., and Crosswell, Leanne
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PSYCHOLOGICAL feedback ,HIGHER education ,WEB-based user interfaces ,DIGITAL technology ,FOCUS groups ,PRAGMATICS ,STUDENT teaching - Abstract
How feedback is understood and enacted has shifted from the traditional practice of providing individual feedback on summative tasks at key points to a more ongoing series of dialogues between the teacher and students during the teaching period. This paper reports on the experiences of designing faster feedback through weekly dialogic feedback loops to enhance students' personal connection to their learning while providing teachers with faster, actionable feedback data to inform learning design. A pragmatic inquiry considered how benefits might potentially be amplified through the use of digital technologies. Data included student reflections collected via the GoingOK web application, interviews and focus groups. The findings identify and theorise four types of digitally mediated feedback loops: students in computer-mediated dialogue with themselves; students and teachers in dialogue with each other; the reflection on how feedback informed learning; and the sociotechnical dialogue informing ongoing technical design. Three design dilemmas that were experienced by teachers as they enacted digitally mediated dialogic feedback loops are articulated, alongside the principles that enabled responsive design. Understanding these design elements is fundamental if automation of some parts of the feedback loop through reflective writing analytics is to be considered both feasible and desirable. [ABSTRACT FROM AUTHOR]
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- 2021
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10. Comparative Effectiveness of Sodium-Glucose Cotransporter 2 Inhibitors vs Sulfonylureas in Patients With Type 2 Diabetes
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Xie, Yan, Bowe, Benjamin, Gibson, Andrew K., McGill, Janet B., Maddukuri, Geetha, and Al-Aly, Ziyad
- Abstract
IMPORTANCE: In the treatment of type 2 diabetes, evidence of the comparative effectiveness of sodium-glucose cotransporter 2 (SGLT2) inhibitors vs sulfonylureas—the second most widely used antihyperglycemic class after metformin—is lacking. OBJECTIVE: To evaluate the comparative effectiveness of SGLT2 inhibitors and sulfonylureas associated with the risk of all-cause mortality among patients with type 2 diabetes using metformin. DESIGN, SETTING, AND PARTICIPANTS: A cohort study used data from the US Department of Veterans Affairs compared the use of SGLT2 inhibitors vs sulfonylureas in individuals receiving metformin for treatment of type 2 diabetes. A total of 23 870 individuals with new use of SGLT2 inhibitors and 104 423 individuals with new use of sulfonylureas were enrolled between October 1, 2016, and February 29, 2020, and followed up until January 31, 2021. EXPOSURES: New use of SGLT2 inhibitors or sulfonylureas. MAIN OUTCOMES AND MEASURES: This study examined the outcome of all-cause mortality. Predefined variables and covariates identified by a high-dimensional variable selection algorithm were used to build propensity scores. The overlap weighting method based on the propensity scores was used to estimate the intention-to-treat effect sizes of SGLT2 inhibitor compared with sulfonylurea therapy. The inverse probability of the treatment adherence weighting method was used to estimate the per-protocol effect sizes. RESULTS: Among the 128 293 participants (mean [SD] age, 64.60 [9.84] years; 122 096 [95.17%] men), 23 870 received an SGLT2 inhibitor and 104 423 received a sulfonylurea. Compared with sulfonylureas, SGLT2 inhibitors were associated with reduced risk of all-cause mortality (hazard ratio [HR], 0.81; 95% CI, 0.75-0.87), yielding an event rate difference of −5.15 (95% CI, −7.16 to −3.02) deaths per 1000 person-years. Compared with sulfonylureas, SGLT2 inhibitors were associated with a reduced risk of death, regardless of cardiovascular disease status, in several categories of estimated glomerular filtration rate (including rates from >90 to ≤30 mL/min/1.73 m2) and in participants with no albuminuria (albumin to creatinine ratio [ACR] ≤30 mg/g), microalbuminuria (ACR >30 to ≤300 mg/g), and macroalbuminuria (ACR >300 mg/g). In per-protocol analyses, continued use of SGLT2 inhibitors was associated with a reduced risk of death compared with continued use of sulfonylureas (HR, 0.66; 95% CI, 0.60-0.74; event rate difference, −10.10; 95% CI, −12.97 to −7.24 deaths per 1000 person-years). In additional per-protocol analyses, continued use of SGLT2 inhibitors with metformin was associated with a reduced risk of death compared with SGLT2 inhibitor treatment without metformin (HR, 0.70; 95% CI, 0.50-0.97; event rate difference, −7.62; 95% CI, −17.12 to −0.48 deaths per 1000 person-years). CONCLUSIONS AND RELEVANCE: In this comparative effectiveness study analyzing data from the US Department of Veterans Affairs, among patients with type 2 diabetes receiving metformin therapy, SGLT2 inhibitor treatment was associated with a reduced risk of all-cause mortality compared with sulfonylureas. The results provide data from a real-world setting that might help guide the choice of antihyperglycemic therapy.
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- 2021
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11. Tolvaptan- and Tolvaptan-Metabolite-Responsive T Cells in Patients with Drug-Induced Liver Injury.
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Gibson, Andrew, Hammond, Sean, Jaruthamsophon, Kanoot, Roth, Sharin, Mosedale, Merrie, and Naisbitt, Dean J.
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- 2020
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12. Process Development and Large-Scale Synthesis of a c-Met Kinase Inhibitor
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Stewart, Gavin W., Brands, Karel M. J., Brewer, Sarah E., Cowden, Cameron J., Davies, Antony J., Edwards, John S., Gibson, Andrew W., Hamilton, Simon E., Katz, Jason D., Keen, Stephen P., Mullens, Peter R., Scott, Jeremy P., Wallace, Debra J., and Wise, Christopher S.
- Abstract
A highly convergent synthesis of c-Met kinase inhibitor 1has been demonstrated on a multikilogram scale using three key fragments: dihalotricyclic core 2, chiral sulfamide side chain 3, and pyrazole boronic ester 4. The chirality in sulfamide side chain 3was installed using the cheap and readily available starting material (S)-epichlorohydrin. A total of 2.71 kg of 1were isolated in seven steps (the longest linear sequence).
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- 2024
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13. In Situ Investigation of the Electrodeposition Mechanism of Manganese Dioxide from a Citrate Electrolyte: The Effect of Intermediate Stabilization on Material Morphology.
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Dupont, Madeleine F., Gibson, Andrew J., Elbourne, Aaron, Forghani, Marveh, Cross, Andrew D., and Donne, Scott W.
- Abstract
In this work, the electrodeposition of manganese dioxide in the presence of citrate anions is characterized using a combination of in situ electrochemical quartz crystal microbalance (EQCM), small angle X-ray scattering (SAXS), quasi-in situ atomic force microscopy (AFM) and ex situ transmission electron spectroscopy (TEM). Manganese dioxide was deposited onto a platinum substrate at 1.3 V (vs SCE) from solutions containing 0.01 mM MnSO
4 , 0.1 M Na2 SO4 and manganese citrate concentrations of 0, 0.5, 2 or 4 mM. It was found that varying the citrate concentration changed the deposition mechanism by stabilising the Mn3+ intermediate formed by the oxidation of Mn2+ . The different stability of the Mn3+ ion affects the rate of nucleation on the surface and subsequent growth of the film. This in turn, affects the morphology of the deposited material. Understanding the effects of the deposition mechanism on the resultant film morphology is necessary to optimise the properties of electrodeposited films for their various applications. [ABSTRACT FROM AUTHOR]- Published
- 2020
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14. Prophylactic biological mesh reinforcement versus standard closure of stoma site (ROCSS): a multicentre, randomised controlled trial
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Bhangu, Aneel, Nepogodiev, Dmitri, Ives, Natalie, Magill, Laura, Glasbey, James, Forde, Colm, Bisgaard, Thue, Handley, Kelly, Mehta, Samir, Morton, Dion, Pinkney, Thomas, Mehta, Samir, Handley, Kelly, Ives, Natalie, Bhangu, Aneel, Brown, James, Forde, Colm, Futaba, Kaori, Glasbey, James, Handley, Kelly, Ives, Natalie, Khan, Sarah, Magill, Laura, Mehta, Samir, Morton, Dion, Nepogodiev, Dmitri, Pallan, Arvind, Patel, Abhilasha, Ashdown-Phillips, Steve, Roberts, Tracy, Jowett, Susan, Munetsi, Lorraine, Pinkney, Thomas, Torrance, Andrew, Brown, James, Handley, Kelly, Hilken, Nicholas, Hill, Matt, Hunter, Mark, Ives, Natalie, Khan, Sarah, Leek, Susan, Lilly, Helen, Magill, Laura, Mehta, Samir, Sawant, Amruta, Vince, Alexandra, Walters, Michael, Bemelman, Willem, Blussé, Marjolein, Borstlap, Wernard, Busch, Olivier RC, Buskens, Christianne, Klaver, Charlotte, Marsman, Hendrik, van Ruler, Oddeke, Tanis, Pieter, Westerduin, Emma, Wicherts, Dennis, Das, Parthasarathi, Essapen, Sharadah, Frost, Victoria, Glennon, Ana, Gray, Catherine, Hussain, Anwar, McNichol, Lisa, Nisar, Pasha, Scott, Humphrey, Trickett, Jonathan, Trivedi, Prateesh, White, Daniel, Amarnath, Talakalukoppa, Ardley, Rohan, Gupta, Robin, Hall, Emily, Hodgkins, Kathryn, Narula, Harjeet, Sewell, Terri-Ann, Simms, John M, Toms, Julie, White, Tim, Atkinson, Angela, Beral, Dan, Lancaster, Nicola, Mackenzie, Felicity, Wilson, Tim, Cruttenden-Wood, David, Gibbins, Jackie, Halls, Mark, Hill, Dennise, Hogben, Karen, Jones, Stephanie, Lamparelli, Michael J, Lewis, Mark, Moreton, Sarah, Ng, Paul, Oglesby, Arabis, Orbell, James, Stubbs, Benjamin, Subramanian, Krishnan, Talwar, Anjay, Wilsher, Simon, Al-Rashedy, Mohammed, Fensom, Catherine, Gok, Muhammed, Hardstaff, Lisa, Malik, Kamran, Sadat, Mohammed, Townley, Barbara, Wilkinson, Lesley, Cosier, Tracey, Mangam, Sudhakar, Rabie, Mohamed, Broadley, Graham, Canny, John, Fallis, Simon, Green, Nikki, Hawash, Ahmed, Karandikar, Sharad, Mirza, Mehboob, Rawstorne, Edward, Reddan, Julie, Richardson, Jonathan, Thompson, Chris, Waite, Kathryn, Youssef, Haney, Bisgaard, Thue, De Nes, Lindsey, Rosenstock, Steffen, Strandfelt, Pernille, Westen, Mikkel, Aryal, Kamal, Kshatriya, Kirosh Shankar, Lal, Roshan, Velchuru, Vamsi, Wilhelmsen, Elva, Akbar, Ayesha, Antoniou, Anthony, Clark, Sue, Datt, Pooja, Goh, Jason, Jenkins, Ian, Kennedy, Robin, Maeda, Yasuko, Nastro, Piero, Owen, Harriet, Phillips, Robin KS, Warusavitarne, Janindra, Bradley-Potts, Joanne, Charleston, Peter, Clouston, Hamish, Duff, Sarah, Fatayer, Taher, Gipson, Anna, Heywood, Nick, Junejo, Muneer, Kennedy, James, Lalor, Helen, Manning, Chris, McCormick, Richard, Parmar, Kathryn, Preston, Stephen, Ramesh, Aswatha, Sharma, Abhiram, Telford, Karen, Adeosun, Abidemi, Hammond, Toby, Smolen, Susan, Topliffe, Joanne, Docherty, James G, Lim, Michael, Lim, Michael, Macleod, Kathleen, Monaghan, Eimar, Patience, Lesley, Thomas, Ian, Walker, Kenneth G, Walker, Michael, Watson, Angus JM, Burgess, Amanda, Ghanem, Yasser, Glister, Georgina, Kapur, Sandeep, Paily, Abhilash, Pal, Atanu, Ravikumar, Rathinam, Rosbergen, Melissa, Sargen, Kevin, Speakman, Christopher, Agarwal, Anil K, Banerjee, Amlan, Borowski, David, Garg, Dharmendra, Gill, Talvinder, Johnston, Tracey, Kelsey, Susan, Munipalle, Phanibhushana Chakravarthy, Tabaqchali, Mohamed, Wilson, Deborah, Acheson, Austin, Cripps, Heather, El-Sharkawy, Ahmed, Ng, Oliver, Sharma, Parveen, Ward, Kym, Chandler, Dawne, Courtney, Edward, Bunni, John, Butcher, Katrina, Dalton, Stephen, Flindall, Ian, Katebe, Joyce, Roy, Pratik, Tate, Jeremy, Vincent, Tracy, Williamson, Michael ER, Wood, James, Bignell, Mark, Branagan, Graham, Broardhurst, Jack, Chave, Helen, Dean, Hilary, D'Souza, Nigel, Foster, Gemma, Sleight, Simon, Sutaria, Rupesh, Ahmed, Ishmail, Budhoo, Misra Rai, Colley, Julie, Cruickshank, Neil, Gill, Kathryn, Hayes, Anne, Joy, Howard, Kamabjha, Carrington, Plowright, James, Radley, Simon, Rea, Mr, Thumbe, Vijay, Torrance, Andrew, Varghese, Philip, Wilkin, Richard, Zulueta, Elzbieta, Allsop, Lynne, Atkari, Bence, Badrinath, Krishnamurthy, Daliya, Prita, Dube, Mukul, Heeley, Cheryl, Hind, Richard, Nash, Dominic, Palfreman, Andrea, Peacock, Oliver, Watson, Nicholas, Blodwell, Michelle, Javaid, Ali, Mohamad, Ashiq, Muhammad, Karim, Qureshi, Nafees, Ridgway, Stephanie, Siddiqui, Kamran, Solkar, Mamoon, Vere, Joanne, Wordie, Alexander, Chang, Jessica, Elgaddal, Sanaa, Green, Marie, Hollyman, Marianne, Mirza, Nazzia, Rankin, Jayne, Williams, Graham, Ali, Wadah, Hardwick, Anne, Mohamed, Zakir, Navid, Ahmad, Netherton, Kimberley, Obreja, Mugurel, Rao, Milind, Stringer, Joanna, Tennakoon, Athula, Bullen, Timothy, Butt, Mansoor, Dawson, Robin, Dawson, Sarah, Farmer, Martin, Garimella, Veerabhadram, Gates, Zoe, Wilkings, Lisa, Yeomans, Neil, Adedeji, Olufunso, Alalawi, Rashid, Al Araimi, Aamed, Ashraf, Shazad, Bach, Simon, Beggs, Andrew, Cagigas, Carmen, Dattani, Mit, Dimitriou, Nikolletta, Futaba, Kaori, Ghods-Ghorbani, Manijeh, Glasbey, James, Gourevitch, David, Haydon, Geoffrey, Ismail, Tariq, Keh, Christopher, Morton, Dion G, Narewal, Mandip, Nepogodiev, Dmitri, Papettas, Trifonas, Pinkney, Tom, Poh, Aaron, Ranstorne, Edward, Royle, Timothy J, Shah, Tahir, Singh, Jagdeep, Smart, Chris, Suggett, Nigel, Tayyab, Muhammad, Vijayan, Deepak, Vohra, Ravinder, Wairaich, Naseem, Yeung, Denise, Bamford, Richard, Chambers, Joanne, Cotton, David, Houlihan, Rebecca, Kynaston, James, Longman, Rob, Lowe, Amelia, Messenger, David, Owais, Anwar, Phillpott, Catherine, Shabbir, Jamshed, Baragwanath, Phil, El-Sayed, Charlotte, Gaunt, Anne, Khatri, Chetan, McCullough, Peter, Patel, Abhilasha, Ward, Stephen, Wilkin, Richard, Obukofe, Ross, Stroud, Robert, Mason, David, Williams, Nigel, Wong, Ling S, Chaudhri, Sanjay, Cooke, Jill, Cunha, Melissa, Fairey, Howard, Norwood, Michael, Singh, Baljit, Thomasset, Sarah, Abbott, Sian, Addison, Sarah, Archer, James, Bhangu, Aneel, Church, Robert, Holford, Erika, Lenehan, Fionnaula, Odogwu, Steve, Richardson, Lisa, Sidebotham, Jane, Swan, Elaine, Tilley, Alison, Wagstaff, Lynda, Amey, Isobel, Baird, Yolanda, Cripps, Neil, Greenslade, Susanna, Harris, Guy, Levy, Bruce, Mckenzie, Paul, Misselbrook, Alison, Moore, Sally, Skull, Angela, Nicol, Deborah, Reddy, Bala, Thrush, Jessica, Iglesias Vecchio, Miriam, Dunn, Yvonne, Williams, Claire, Furtado, Sanjay, Gill, Michael, Gilmore, Lydia, Goldsmith, Paul, Kocialkowski, Cezary, Loganathan, Sadasivam, Nath, Rabindra, Paraoan, Marius, Taylor, Tracey, Allison, Andrew, Allison, Joanna, Curtis, Nathan, Dalton, Richard, D'Costa, Conrad, Dennison, Godwin, Foster, Jake, Francis, Nader, Gibbons, James, Hamdan, Mohammed, Lewis, Alison, Ockrim, Jonathan, Sharma, Rishabha, Spurdle, Katie, Varadharajan, Saseendran, Aghahoseini, Assad, Alexander, David J, Bandyopadhyay, Dibyendu, Bradford, Ian, Chitsabesan, Praminthra, Coleman, Zoe, Gibson, Andrew, Lasithiotakis, Kostas, Panagiotou, Dimitrios, Polyzois, Konstantinos, Stojkovic, Stevan, Woodcock, Nicholas, Wright, Monica, Hargest, Rachel, Jackson, Richard, Rajesh, Arumugam, Ogunbiyi, Olagunju, Slater, Andrew, and Yu, Ly-Mee
- Abstract
Closure of an abdominal stoma, a common elective operation, is associated with frequent complications; one of the commonest and impactful is incisional hernia formation. We aimed to investigate whether biological mesh (collagen tissue matrix) can safely reduce the incidence of incisional hernias at the stoma closure site.
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- 2020
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15. Tolvaptan- and Tolvaptan-Metabolite-Responsive T Cells in Patients with Drug-Induced Liver Injury
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Gibson, Andrew, Hammond, Sean, Jaruthamsophon, Kanoot, Roth, Sharin, Mosedale, Merrie, and Naisbitt, Dean J.
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Tolvaptan is an effective drug for the treatment of autosomal dominant polycystic kidney disease, but its use is associated with a significant risk of liver injury in a small number of patients. Herein we describe the presence of tolvaptan- and tolvaptan-metabolite-responsive T cell clones within the peripheral circulation of patients with liver injury. Drug treatment of the clones resulted in a proliferative response and secretion of IFN-γ, IL-13, and the cytolytic molecule granzyme B. Future work should explore pathways of tolvaptan driven T cell activation and the role of T cells in the disease pathogenesis.
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- 2020
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16. Near infrared spectroscopic measurement of strain in rocks
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Butcher, Emily, Gibson, Andrew, Benson, Philip M, Koor, Nick, and Swift, Gareth
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The measurement of strain is a fundamental and widely studied parameter in engineering, rock mechanics, construction and materials testing. Contact sensors often used in these fields require contact with the target surface throughout the duration of a strain event. Non-contact methods typically require that that the measurement surface is prepared and often coated prior to testing. This paper considers the potential application of near infrared spectroscopy as a non-contact technique for the measurement of strain on natural surfaces. Excellent correlation was found between surface measurements of visible-NIR spectra and longitudinal strain taken during indirect Brazilian Disc Test for samples of sandstone, marble and basalt.
- Published
- 2019
17. Near infrared spectroscopic measurement of strain in rocks
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Butcher, Emily, Gibson, Andrew, Benson, Philip M, Koor, Nick, and Swift, Gareth
- Abstract
The measurement of strain is a fundamental and widely studied parameter in engineering, rock mechanics, construction and materials testing. Contact sensors often used in these fields require contact with the target surface throughout the duration of a strain event. Non-contact methods typically require that that the measurement surface is prepared and often coated prior to testing. This paper considers the potential application of near infrared spectroscopy as a non-contact technique for the measurement of strain on natural surfaces. Excellent correlation was found between surface measurements of visible-NIR spectra and longitudinal strain taken during indirect Brazilian Disc Test for samples of sandstone, marble and basalt.
- Published
- 2019
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18. Cross-reactivity between vancomycin, teicoplanin, and telavancin in patients with HLA-A∗32:01–positive vancomycin-induced DRESS sharing an HLA class II haplotype.
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Nakkam, Nontaya, Gibson, Andrew, Mouhtouris, Effie, Konvinse, Katherine C., Holmes, Natasha E., Chua, Kyra Y., Deshpande, Pooja, Li, Danmeng, Ostrov, David A., Trubiano, Jason, and Phillips, Elizabeth J.
- Published
- 2021
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19. What does wellness look like for multi-use developments?
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Gibson, Andrew
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ABSTRACTThe work from home regime has created a shift in the thinking of how to operate multiuse buildings in city environments. One of the thoughts apply to the future of these spaces and the function of many cities.
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- 2019
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20. The PROTROPIC feasibility study: prognostic value of elevated troponins in critical illness
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Belley-Cote, Emilie P., Whitlock, Richard P., Ulic, Diana V., Honarmand, Kimia, Khalifa, Abubaker, McClure, Graham R., Gibson, Andrew, Alshamsi, Fayez, D’Aragon, Frederick, Rochwerg, Bram, Duan, Erick, Savija, Nevena, Karachi, Tim, Lamontagne, François, Kavsak, Peter, and Cook, Deborah J.
- Abstract
Purpose: Elevated cardiac troponin concentrations in people with critical illness are associated with an increased risk of death. We aimed to assess the feasibility of a larger study to ascertain the utility of cardiac troponin as a prognostic tool for mortality in critically ill patients. Methods: Patients admitted to participating intensive care units during the one-month enrolment period were eligible. We excluded cardiac surgical patients and patients who were admitted and either died or were discharged within 12 hr. In enrolled patients, we measured high-sensitivity cardiac troponin I (hs-cTnI) and obtained electrocardiograms to ascertain the incidence of myocardial infarction (MI) and isolated troponin elevation. Our feasibility objectives were to measure recruitment rate, the proportion of patients who consented under a deferred consent model, and time required for data collection and study procedures. Results: Over a four-week enrolment period, 280 patients were enrolled using a deferred consent model. We obtained subsequent consent from 81% of patients. Study procedures and data collection required 1.7 hr per participant. Overall, 86 (38%) suffered a MI, 23 (10%) had an isolated hs-cTnI elevation, and 117 (52%) had no hs-cTnI elevation. The crude hospital mortality rate was 10% without an hs-cTnI elevation, 29% with an isolated hs-cTnl elevation (relative risk [RR]) 2.2; 95% confidence interval [CI], 1.0 to 6.0) and 29% with an MI (RR, 2.6; 95% CI, 1.4 to 5.1). Conclusion: Myocardial injury with elevated hs-cTnI concentrations and MIs occur frequently during critical illness. This pilot study has established the feasibility of conducting a large-scale investigation addressing this issue.
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- 2019
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21. Enantioselective Synthesis of 4′-Ethynyl-2-fluoro-2′-deoxyadenosine (EFdA) via Enzymatic Desymmetrization.
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McLaughlin, Mark, Kong, Jongrock, Belyk, Kevin M., Chen, Billy, Gibson, Andrew W., Keen, Stephen P., Lieberman, David R., Milczek, Erika M., Moore, Jeffrey C., Murray, David, Feng Peng, Ji Qi, Reamer, Robert A., Song, Zhiguo J., Lushi Tan, Lin Wang, and Williams, Michael J.
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- 2017
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22. New Approaches to Investigate Drug-Induced Hypersensitivity.
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Ogese, Monday O., Ahmed, Shaheda, Alferivic, Ana, Betts, Catherine J., Dickinson, Anne, Faulkner, Lee, French, Neil, Gibson, Andrew, Hirschfield, Gideon M., Kammüller, Michael, Xiaoli Meng, Martin, Stefan F., Musette, Philippe, Norris, Alan, Pirmohamed, Munir, Kevin Park, B., Purcell, Anthony W., Spraggs, Colin F., Whritenour, Jessica, and Naisbitt, Dean J.
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- 2017
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23. Drug reaction with eosinophilia and systemic symptoms (DRESS) with dual sensitization to both vancomycin and ceftriaxone.
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Krantz, Matthew, Gibson, Andrew, Ram, Ramesh, Gangula, Rama, James, Fiona, Holmes, Natasha, Mouhtouris, Effie, Pakala, Suman, Fernandez, Edward, Deshpande, Pooja, Trubiano, Jason, and Phillips, Elizabeth
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- 2023
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24. Updates on the immunopathology and genomics of severe cutaneous adverse drug reactions.
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Gibson, Andrew, Deshpande, Pooja, Campbell, Chelsea N., Krantz, Matthew S., Mukherjee, Eric, Mockenhaupt, Maja, Pirmohamed, Munir, Palubinsky, Amy M., and Phillips, Elizabeth J.
- Abstract
Severe cutaneous adverse reactions (SCARs) such as Stevens-Johnson syndrome, toxic epidermal necrolysis (SJS/TEN), and drug reaction with eosinophilia and systemic symptoms (DRESS)/drug-induced hypersensitivity syndrome (DIHS) cause significant morbidity and mortality and impede new drug development. HLA class I associations with SJS/TEN and drug reaction with eosinophilia and systemic symptoms/drug-induced hypersensitivity syndrome have aided preventive efforts and provided insights into immunopathogenesis. In SJS/TEN, HLA class I–restricted oligoclonal CD8
+ T-cell responses occur at the tissue level. However, specific HLA risk allele(s) and antigens driving this response have not been identified for most drugs. HLA risk alleles also have incomplete positive and negative predictive values, making truly comprehensive screening currently challenging. Although, there have been key paradigm shifts in knowledge regarding drug hypersensitivity, there are still many open and unanswered questions about SCAR immunopathogenesis, as well as genetic and environmental risk. In addition to understanding the cellular and molecular basis of SCAR at the single-cell level, identification of the MHC-restricted drug-reactive self- or viral peptides driving the hypersensitivity reaction will also be critical to advancing premarketing strategies to predict risk at an individual and drug level. This will also enable identification of biologic markers for earlier diagnosis and accurate prognosis, as well as drug causality and targeted therapeutics. [ABSTRACT FROM AUTHOR]- Published
- 2023
- Full Text
- View/download PDF
25. Self-tattooing of eyeball with inadvertent corneoscleral perforation: the implication of social media
- Author
-
Ng, Jia Yu, Ting, Darren Shu Jeng, Vaideanu-Collins, Daniela, Mudhar, Hardeep Singh, Wagner, Bart, Goggin, Patricia, Gibson, Andrew, and Patel, Trushar
- Published
- 2019
- Full Text
- View/download PDF
26. Genetic and nongenetic factors that may predispose individuals to allergic drug reactions
- Author
-
Gibson, Andrew, Ogese, Monday, and Pirmohamed, Munir
- Published
- 2018
- Full Text
- View/download PDF
27. Proof of concept of faecal egg nematode counting as a practical means of veterinary engagement with planned livestock health management in a lower income country
- Author
-
Leahy, Eithne, Bronsvoort, Barend, Gamble, Luke, Gibson, Andrew, Kaponda, Henderson, Mayer, Dagmar, Mazeri, Stella, Shervell, Kate, and Sargison, Neil
- Abstract
The wellbeing and livelihood of farmers in impoverished regions of the world is intrinsically linked to the health and welfare of their livestock; hence improved animal health is a pragmatic component of poverty alleviation. Prerequisite knowledge and understanding of the animal health challenges facing cattle keepers in Malawi is constrained by the lack of veterinary infrastructure, which inevitably accompanies under-resourced rural development in a poor country. We collaborated with public and private paraveterinary services to locate 62 village Zebu calves and 60 dairy co-operative calves dispersed over a wide geographical area. All calves were visited twice about 2 to 3 weeks apart, when they were clinically examined and faecal samples were collected. The calves were treated with 7.5 mg/kg of a locally-available albendazole drench on the first visit, and pre- and post- treatment trichostrongyle and Toxocarafaecal egg counts were performed using a modified McMaster method. Our clinical findings point towards a generally poor level of animal health, implying a role of ticks and tick-transmitted diseases in village calves and need for improvement in neonatal calf husbandry in the dairy co-operative holdings. High faecal trichostrongyle egg counts were not intuitive, based on our interpretation of the animal management information that was provided. This shows the need for better understanding of nematode parasite epidemiology within the context of local husbandry and environmental conditions. The albendazole anthelmintic was effective against Toxocara, while efficacy against trichostrongyle nematodes was poor in both village and dairy co-operative calves, demonstrating the need for further research to inform sustainable drug use. Here we describe the potential value of faecal nematode egg counting as a platform for communicating with and gaining access to cattle keepers and their animals, respectively, in southern Malawi, with the aim of providing informative background knowledge and understanding that may aid in the establishment of effective veterinary services in an under-resourced community.
- Published
- 2017
- Full Text
- View/download PDF
28. Palliative Epineurotomy for Focal Radial Malignant Peripheral Nerve Sheath Tumor in a Dog.
- Author
-
Gibson, Andrew David, Davies, Emma, Lara-Garcia, Ana, and Lafuente, Pilar
- Subjects
PERIPHERAL nerve tumors ,CANCER in dogs ,CANCER histopathology ,CANCER relapse ,LEG amputation ,DIAGNOSIS - Abstract
This case report describes the diagnosis of a peripheral nerve sheath tumor of the deep branch of the radial nerve distal to the elbow in a dog. The lesion was identified using computed tomography and ultrasonography and confirmed as sarcoma on histopathological analysis of incisional biopsies. Clinical signs dramatically improved following surgical biopsy before recurring three months later. Repeat epineurotomy of the deep branch of the radial nerve resulted in clinical improvement for a further month before signs once again returned. Epineurotomy as a palliative treatment for peripheral nerve sheath tumors has not been previously described, but may have a place in palliation of clinical signs in specific cases of peripheral nerve sheath tumors in which limb amputation is not an option. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
29. Data poverty: A global evaluation for 2009 to 2013 - implications for sustainable development and disaster risk reduction.
- Author
-
Leidig, Mathias, Teeuw, Richard M., and Gibson, Andrew D.
- Subjects
SUSTAINABLE development ,DIGITAL divide ,GEOINFORMATICS ,CLIMATE change ,TIME series analysis ,FREEWARE (Computer software) - Abstract
The article presents a time series (2009–2013) analysis for a new version of the “Digital Divide” concept that developed in the 1990s. Digital information technologies, such as the Internet, mobile phones and social media, provide vast amounts of data for decision-making and resource management. The Data Poverty Index (DPI) provides an open-source means of annually evaluating global access to data and information. The DPI can be used to monitor aspects of data and information availability at global and national levels, with potential application at local (district) levels. Access to data and information is a major factor in disaster risk reduction, increased resilience to disaster and improved adaptation to climate change. In that context, the DPI could be a useful tool for monitoring the Sustainable Development Goals of the Sendai Framework for Disaster Risk Reduction (2015–2030). The effects of severe data poverty, particularly limited access to geoinformatic data, free software and online training materials, are discussed in the context of sustainable development and disaster risk reduction. Unlike many other indices, the DPI is underpinned by datasets that are consistently provided annually for almost all the countries of the world and can be downloaded without restriction or cost. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
30. Process Development of the HCV NS5B Site D Inhibitor MK-8876.
- Author
-
Williams, Michael J., Qinghao Chen, Codan, Lorenzo, Dermenjian, Renee K., Dreher, Spencer, Gibson, Andrew W., Xianliang He, Yan Jin, Keen, Stephen P., Lee, Alfred Y., Lieberman, David R., Wei Lin, Guiquan Liu, McLaughlin, Mark, Reibarkh, Mikhail, Scott, Jeremy P., Strickfuss, Sophie, Lushi Tan, Varsolona, Richard J., and Feng Wen
- Published
- 2016
- Full Text
- View/download PDF
31. Backfires:.
- Author
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Thomas, Tyler, Gibson, Andrew, Cope, Tom, Pudumjee, Viraf, Morrow, Bob, Vogel, Lyn, Hari, Sunil, Sheatsley, David, Schiller, Carl, Michael, Aaron, Estey, Don, Ryan R., Rubin, William, Lee, John, Garlick, Philip, Smith, Henry, Messina, Vince, Beachy, Keith, Ron, and Ron, Grelsamer
- Published
- 2017
32. Regulation of FcR? function by site-specific serine phosphorylation
- Author
-
Shah, Spandan, Gibson, Andrew W., Ji, Chuanyi, Darrington, Eric, Mobley, James, Kojima, Kyoko, Edberg, Jeffrey C., and Kimberly, Robert P.
- Abstract
The common FcR?, an immunoreceptor tyrosine-based activation motif (ITAM)- containing adaptor protein, associates with multiple leukocyte receptor complexes and mediates signal transduction through the ITAM in the cytoplasmic domain. The presence of multiple serine and threonine residues within this motif suggests the potential for serine/threonine phosphorylation in modulating signaling events. Single-site mutational analysis of these residues in RBL-2H3 cells indicates that each may contribute to net FcR?-mediated signaling, and mass spectrometry of WT human FcR? from receptor-stimulated cells shows consistent preferential phosphorylation of the serine residue at position 51. Immunoblot analysis, mass spectrometry, and mutational analyses showed that phosphorylation of serine 51 in the 7-residue spacer between the 2 YxxL sequences regulates FcR? signaling by inhibiting tyrosine phosphorylation at the membrane proximal Y47 position of the ITAM, but not phosphorylation at position Y58. This inhibition results in reduced Syk recruitment and activation. With in vitro kinase assays, PKC-d and PKA show preferential phosphorylation of S51. Serine/threonine phosphorylation of the FcR? ITAM, which functions as an integrator of multiple signaling elements, may explain in part the contribution of variants in PKC-d and other PKC isoforms to some autoimmune phenotypes.
- Published
- 2017
- Full Text
- View/download PDF
33. Outpatient Chronic Anticoagulation Improves Outcomes in Patients With Coronavirus Disease 2019 and Cardiovascular Risk Factors.
- Author
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Gibson, Andrew K., Yan, Yan, Chadwick-Mansker, Kelley, and Zayed, Mohamed A.
- Published
- 2021
- Full Text
- View/download PDF
34. Select Bibliography.
- Author
-
Gibson, Andrew
- Subjects
BIBLIOGRAPHY - Abstract
The sources cited within this issue are presented including "Occasional, Critical and Political Writing," edited by Kevin Barry, "The Cambridge Companion to Joyce," by Derek Attridge, and "The Language of James Joyce," by Katie Wales.
- Published
- 2006
35. References.
- Author
-
Gibson, Andrew
- Subjects
BIBLIOGRAPHICAL citations - Abstract
References for the book "James Joyce" are presented including "The Life of Charles Stewart Parnell," with a preface by John E. Redmond, "The Kiltartan History Book," by Lady Augusta Gregory, and "The Eighteenth Brumaire of Louis Bonaparte.
- Published
- 2006
36. Chronology.
- Author
-
Gibson, Andrew
- Subjects
IRISH authors -- 20th century -- Biography - Abstract
A chapter from of the book "James Joyce" is presented. This chapter offers a chronology of events in the life of Irish author James Joyce. He was born James Augustine Joyce to John Stanislaus and Mary Jane in Rathgar, Dublin, Ireland on February 2, 1882 and enrolled at Clongowes Wood College in County Kildare in 1888. In 1931, Joyce married Nora Barnacle in London, England.
- Published
- 2006
37. Chapter 19: The Megalith.
- Author
-
Gibson, Andrew
- Subjects
IRISH authors -- 20th century -- Biography ,FICTION - Abstract
Chapter 19 of the book "James Joyce" is presented. This chapter focuses on the novel "Finnegans Wake" as a unique achievement of Irish author James Joyce. It compares the novel to Irish megaliths due to its massive, strange, cryptic construction with embellishments that are impossible to interpret. Also noted is the function of the literary work as not just a historical memory in light of its responsiveness to contemporary culture and prophetic quality.
- Published
- 2006
38. Chapter 18: A Wild, Blind, Aged Bard.
- Author
-
Gibson, Andrew
- Subjects
IRISH authors -- 20th century -- Biography ,AGING ,EYE diseases - Abstract
Chapter 18 of the book "James Joyce" is presented. The chapter looks at the indications of aging and the bardic attributes of Irish author James Joyce. His constant weakness has been his eyes as demonstrated by his eye attack in Zurich, Switzerland and threat of glaucoma in 1922. The belief of Joyce that Ireland should listen to him reportedly show his bardic conviction and his refusal to surrender an ancient Irish version of the idea of the Irish artist as legislator.
- Published
- 2006
39. Chapter 17: Joyce Enterprises.
- Author
-
Gibson, Andrew
- Subjects
IRISH authors -- 20th century -- Biography ,FRIENDSHIP - Abstract
Chapter 17 of the book "James Joyce" is presented. This chapter discusses the development of Irish author James Joyce as the executive director and sole inspiration of his companions. One of his indispensable followers was Russian émigré Paul Léon. Also noted is the friendship between Joyce and another Irish writer, James Stephens.
- Published
- 2006
40. Chapter 15: Monsieur Joyce in Paris.
- Author
-
Gibson, Andrew
- Subjects
IRISH authors -- 20th century -- Biography - Abstract
Chapter 15 of the book "James Joyce" is presented. This chapter recalls the stay of Irish author James Joyce in Paris, France starting July 20, 1920. The Joyces were financially supported by English feminist, communist and avant-garde supporter Harriet Shaw Weaver. It is noted that Joyce believed French criticism would play a key role in his way to the English-speaking world.
- Published
- 2006
41. Chapter 16: Joyce and Free Statehood.
- Author
-
Gibson, Andrew
- Subjects
IRISH authors -- 20th century -- Biography ,SOVEREIGNTY - Abstract
Chapter 16 of the book "James Joyce" is presented. The chapter focuses on the emergence of Ireland as a free state and the perspectives on the issue by Irish author James Joyce. The reluctance of the author to return to Ireland is partly attributed to the development of the Irish Free State. Joyce reportedly recognized the oppressive features of the new culture and repressions as indication of persistent weakness by 1932.
- Published
- 2006
42. Chapter 14: The National Epic.
- Author
-
Gibson, Andrew
- Subjects
IRISH authors -- 20th century -- Biography ,ADVERTISING ,BLOOM, Leopold (Fictional character) - Abstract
Chapter 14 of the book "James Joyce" is presented. The chapter looks at the themes and styles in the novel "Ulysses," by Irish author James Joyce. It mentions that Joyce considers advertising canvasser Leopold Bloom as paradigmatic modern Irishman who represents a direction in which Ireland needed to take. The tenth chapter of the novel provided a conspectus while the eleventh one is said to be musical in style.
- Published
- 2006
43. Chapter 13: Writing Ulysses.
- Author
-
Gibson, Andrew
- Subjects
IRISH authors -- 20th century -- Biography - Abstract
Chapter 13 of the book "James Joyce" is presented. This chapter provides information on the creation of the novel "Ulysses," by Irish author James Joyce. He began planning the short story called "Ulysses" in 1907, wrote chapters 13 and 14 when he returned to Trieste, Italy and the last four chapters in Paris, France. He used the Homerian epic "Odyssey" as a structural basis of his novel.
- Published
- 2006
44. Chapter 12: Joyce, Ireland and the War.
- Author
-
Gibson, Andrew
- Subjects
IRISH authors -- 20th century -- Biography - Abstract
Chapter 12 of the book "James Joyce" is presented. The chapter examines the experience of Irish author James Joyce and his mistress Nora Barnacle during the British war in Zurich, Switzerland in 1915. Also noted are the reasons behind the decision of Joyce to join Claud Sykes in establishing the English Players theatre company to perform plays in English. His book "Ulysses" reportedly made caustic jokes about British representatives abroad.
- Published
- 2006
45. Chapter 11: Ireland Made Me: A Portrait of the Artist.
- Author
-
Gibson, Andrew
- Subjects
IRISH authors -- 20th century -- Biography ,FICTION - Abstract
Chapter 11 of the book "James Joyce" is presented. This chapter cites the significance of the novel "A Portrait of the Artist As a Young Man," by Irish author James Joyce. The role of Joyce as the vivisectionist of his own soul in the novel is explained. The sentimental education of the hero is cited as a key obscure development at work in the literature.
- Published
- 2006
46. Chapter 10: The Battle of the Book.
- Author
-
Gibson, Andrew
- Subjects
IRISH authors -- 20th century -- Biography - Abstract
Chapter 10 of the book "James Joyce" is presented. The chapter recalls the struggle of Irish author James Joyce to get his short story collection "Dubliners" published in Trieste, Italy. It points out that Joyce has been humiliated by Ulsterman George Roberts of the publisher Maunsel and Co. when he demanded concessions. The beginning of Joyce's friendship with American intellectual Ezra Pound in December 1913 reportedly marked the turning point in his life and career.
- Published
- 2006
47. Chapter 9: A Second Outpost of Empire.
- Author
-
Gibson, Andrew
- Subjects
IRISH authors -- 20th century -- Biography - Abstract
Chapter 9 of the book "James Joyce" is presented. This chapter assesses the role of the Italian city of Trieste as an outpost of the Austro-Hungarian Empire in the reversed perspective of Ireland by author James Joyce. A comparison of the geography and politics of Trieste and Dublin, Ireland is offered. He left the Italian in the summer of 1920 after its freedom was granted because a new Trieste has little appeal to him.
- Published
- 2006
48. Chapter 8: Looking Back: Dubliners.
- Author
-
Gibson, Andrew
- Subjects
IRISH authors -- 20th century -- Biography - Abstract
Chapter 8 of the book "James Joyce" is presented. The chapter examines the significance of "Dubliners," a collection of short stories penned by Irish author James Joyce. The collection focuses on the condition of Dublin at the turn of the 20th century and explains his reason for living the country following the death of his mother. His story "The Dead" reportedly served as Joyce's homage to a history of suffering due to the famine.
- Published
- 2006
49. Chapter 7: Continental Exile.
- Author
-
Gibson, Andrew
- Subjects
IRISH authors -- 20th century -- Biography ,EXILES - Abstract
Chapter 7 of the book "James Joyce" is presented. This chapter considers the continental exile of Irish author James Joyce. He and his mistress Nora Barnacle left Ireland on October 8, 1904 for London, England and traveled to Paris, France, Zurich, Switzerland, and Trieste, Italy. The travel of Joyce to Europe reportedly show that he identified with the tradition of Irish saints and scholars during the dark ages. Also noted is his identification with the tradition of Gaelic emigration as political exile in Europe.
- Published
- 2006
50. Chapter 6: 16 June 1904.
- Author
-
Gibson, Andrew
- Subjects
IRISH authors -- 20th century -- Biography - Abstract
Chapter 6 of the book "James Joyce" is presented. The chapter looks at the significance of the setting of the book "Ulysses," by James Joyce in Dublin, Ireland on June 16, 1904. It mentions that Joyce has identified the contemporary Irish Catholic Church with English petit bourgeois culture and its economic fetish in his book "Stephen Hero." The real-life dilemma and symbolic predicament of Joyce in 1904 were said to be evoked in the first three chapters of "Ulysses."
- Published
- 2006
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