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The purpose of this research is to address the fact that the changes taking place in society in the socio-economic and environmental spheres determine the need for companies to adapt to these changes in order to survive, as well as contribute to the development of the entire community. The achievement of activities by companies can contribute to the sustainable development of society, which must, first of all, be sustainable in all four aspects: economy, environment, social relations, and management. All four aspects are almost equally important, but management is a process that permeates the other three aspects, and it is impossible to achieve positive results and goals in the three previous areas without it. The national culture, organizational culture, structure, leadership, learning and progressive goals of an enterprise lead it towards sustainable management and business. Human capital within such an organization provides the basis for creativity and innovative ventures. This approach of the organization, with a set of organizational values, beliefs and ways of behavior, influences socially responsible behavior and sustainable management and business. This paper provides an analysis of factors that influence sustainable management and business, such as national culture, organizational culture, organizational learning and leadership, and proposes a model of organizational culture that supports the process of organizational learning and enables the achievement of the ultimate goal: sustainability. [ABSTRACT FROM AUTHOR]

Copyright of Biotechnologie, Agronomie, Societe et Environnement is the property of Les Presses Agronomiques de Gembloux and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Vitamin D supplementation in aging subjects manifests a positive effect on various health-related parameters. We performed a functionally-histological analysis of the adrenal cortex regarding the factors of vitamin D activity and corticosterone output after vitamin D3 application in a rat model of the andropause. Middle-aged Wistar rats were divided into sham operated (SO ; n=8), orchidectomized (Orx ; n=8) and vitamin D3-treated orchidectomized (Orx+vit. D ; n=8) groups. Vitamin D3 (5 μg/kg b.m.) was administered subcutaneously for three weeks, while the SO and Orx groups received the vehicle alone. Set objectives were achieved using histochemistry/immunohistochemistry, stereology, ultrastructural and biochemical analyses. Orchidectomy (Orx) decreased the adrenal cortex-related volume densities of vascular (p<0,0001), vitamin D receptor (VDR; p<0,0166), cytochrome P450 oxidase 2R1 (CYP 2R1; p<0,0001) and cytochrome P450 oxidase 24 (CYP 24; p<0,0001) depots, but increased the volume density of cytochrome P450 27B1 (CYP 27B1; p<0,0001) depots. In Orx+vit. D rats, increase of the adrenal cortex-related volume densities of collagen (p<0,0001), VDR (p<0,0001) and CYP 2R1 (p<0,0001) depots as well as the lipid-droplet diameter (p<0,0001) in adrenocortical outer zona fasciculata cells was observed, while a decrease of volume densities of the vascular (p<0,0001), CYP 27B1 (p<0,0001) and CYP 24 (p<0,0001) depots was registered, all versus Orx group. Plasma level of ACTH was decreased (p=0,0155) and serum concentrations of 25-hydroxyvitamin D3 and corticosterone were increased (p<0,0001 and p=0,0187, respectively), all after the same treatment. Increased corticosterone output after vitamin D3 application to andropausal rats appears not to be related to increased availability of 25-hydroxyvitamin D3 and decreased degradation of 1,25-dihydroxyvitamin D3 in adrenal tissue, but rather involves the central regulatory mechanisms. • Vitamin D3 supplementation is beneficial for maintaining health in the elderly. • Enzymes CYP 2R1 and CYP 27B1 activate vitamin D3, and CYP 24 inactivates its forms. • In the rat adrenal cortex, the active vitamin D3 form is available upon application. • The capacity for corticosterone secretion in vitamin D3 treated rats is increased. • Central effects seem to be responsible for this feedback-driven corticosterone output. [ABSTRACT FROM AUTHOR]

BACKGROUND: Miliary sarcoidosis is a rare form of sarcoidosis characterized by numerous miliary-like micronodules dispersed throughout the lungs. It has been documented in less than 1% of all sarcoidosis cases. We first described a rare case of miliary sarcoidosis and then conducted a literature review on the subject. CASE PRESENTATION: A 51-year-old male complained about a progressive loss of appetite, significant weight loss, occasional night sweats, and fatigue. After a thorough clinical exploration, a differential diagnosis of miliary lung disease was suspected - miliary tuberculosis, fungal infection, metastatic pulmonary carcinoma, or sarcoidosis. High-resolution chest computed tomography revealed bilateral diffuse micronodules with mediastinal lymphadenopathy. Histopathological analysis of transbronchial bioptic tissue identified non-caseating epithelioid granulomas, while no malignant cells were found. Lung tuberculosis and fungal infections were excluded. The levels of angiotensin-converting enzyme in the blood, as well as serum's and 24-hour urine calcium levels, were elevated. After a multidisciplinary discussion, the diagnosis of miliary pulmonary sarcoidosis was established. The patient was treated with prednisone for a total of 9 months, with full clinical and radiological recovery. Using PubMed, we also conducted a review of the literature on this topic and discovered only a few case reports of patients with miliary sarcoidosis, with just one systematic review accessible. The key findings of studies investigating patients diagnosed with miliary sarcoidosis are tabularly displayed. CONCLUSIONS: Miliary sarcoidosis is an uncommon type of pulmonary sarcoidosis that can mimic several entities that manifest as miliary nodules. Most patients require treatment since it can have a significant impact on lung function. [ABSTRACT FROM AUTHOR]

Purpose Investigation of the influence of different conditioning contraction protocols on the eccentric variables in terms depth of descent of body centre of mass at countermovement jump as well as capacity of muscle force, power, and velocity at countermovement jump, and depth jump, i.e., velocity at time of rebound both mentioned jumps. Methods In a sample of 29-students (age: 19.6 ± 0.8), 1 repetition maximum was determined by estimating 10 repetition maximum, to be stratified in a six-week workout. Static group practiced hold back squat at 120° for 12 seconds, dynamic group practiced back squat at 120° (x8) for 12 seconds, and combined group practiced 2 back squat at 120° and 2 seconds endurance (x2) for 12 seconds. Control group had a 6 to 8 hours of activity per week. After the pre-contractions, they continuously performed shock-plyometrics (50 cm box), triple jump and 5-meter sprint. Training load was 80% of 1 repetition maximum. Results A statistically significant increase (13.3, and 9.3%) was found in spontaneous descent of body centre of mass at static and dynamic group, unlike in combined and control group (4.4, and 5.5%). In variables force, power, and velocity eccentric phases of countermovement jumps, significant performance ranges of experimental groups from 5.9 to 13.3% were found, unlike in depth jump variables for which there was no significance. Concentric variable in terms velocity time of rebound countermovement jump exhibits significance for dynamic and combined groups in values (3.4, and 4.3%), i.e., same variable of depth jump for static, dynamic, and combined groups in values (2.0, 2.9, 4.1%, respectively; p=0.05). Conclusion The most indicated increases in variable, velocity at time of rebound at both jumps, were observed after the dynamic loads, referring to sublimated eccentric and concentric manifestations of muscular effects. [ABSTRACT FROM AUTHOR]

OBJECTIVE: The current COVID-19 pandemic has increased occupational stress for all healthcare providers, making job burnout one of the most common and largely unrecognized mental health issues among healthcare professionals. Besides physicians and nurses, pharmacy practitioners were "front-line" healthcare professionals with a critical and unique role in the public health crisis. Considering this, the aim of this study was to examine distress levels and the prevalence of job burnout among Serbian pharmacy practitioners in relation to the COVID-19 pandemic. SUBJECTS AND METHODS: This cross-sectional online study was conducted in April and May of 2020. A total of 176 pharmacy practitioners anonymously and voluntarily completed the two-section questionnaire, consisting of Copenhagen burnout inventory, CBI and 4DSQ Distress subscale. The two-section questionnaire was distributed online, among various social-media groups of pharmacy practitioners, as well as by personal contacts following the "snowball" sampling method. RESULTS: Results revealed moderately high burnout scores in our sample. The majority of the participants showed signs of personal-related job burnout, followed by work-related and client-related burnout. A strongly elevated distress level was obtained in almost two-thirds of study respondents. In addition, a significant and high correlation of all CBI subscales with distress was found, as well as medium correlations with sleep duration shortening as a mediator between distress and job burnout. CONCLUSIONS: Results of our study showed that job burnout significantly increased among pharmacy practitioners during the COVID-19 pandemic. Furthermore, we discovered that stress has an indirect impact on study participants' burnout via insufficient sleep. [ABSTRACT FROM AUTHOR]

Price changes on all international financial and commodity markets have shown a significant correlation. The correlation dependence increased due to macroeconomic changes that led to cyclical economic trends caused by the COVID-19 pandemic. In the new economic circumstances, there has been a change in investment strategy of individual and institutional investors. The investment portfolios have increased in demand related to the purchase of gold, seen as a safe-haven asset, which has led to significant growth in aggregate demand on the international precious metals market. This paper deals with a dynamic conditional correlation (DCC) between the investment in gold as an asset and the movement of major world market indices. We used cryptocurrency (bitcoin) volatility as an independent variable in the model. We tested its correlation to the other major market indices and gold as a safe-haven asset. Related to a proposed model based on GARCH DCC and the Generalised Reduced Gradient (GDR) algorithm, we set up the Hedging Effectiveness (HE) index and an optimally weighted investment portfolio. [ABSTRACT FROM AUTHOR]

OBJECTIVE: Pharmacovigilance education and reporting of adverse drug reactions (ADRs) are important competencies that healthcare sciences students should develop before completing their studies and entering clinical practice. Since students frequently lack adequate knowledge in this area and fail to recognize the importance of ADRs monitoring and reporting, the aim of this study was to develop and validate a unique and reliable instrument for assessing health sciences students' knowledge and attitudes toward pharmacovigilance and ADRs reporting. SUBJECTS AND METHODS: A cross-sectional observational study was conducted from February to July 2021 to examine students' knowledge and attitudes toward pharmacovigilance activities. Students of medicine, dentistry, pharmacy, and nursing science of three faculties in the Autonomous Province of Vojvodina, Serbia were examined. A total of 211 of them completed the specially designed, three-section questionnaire (Demographic data section, Pharmacovigilance Knowledge test, PVKT, and Pharmacovigilance Attitude Questionnaire, PVAQ). The questionnaire was posted on the Google Forms platform, and the link was distributed to respondents via the official websites and social networks of all three faculties. RESULTS: Findings demonstrated good psychometric properties and reliability of the ques-tionnaire. Six questions were removed from the PVKT after item analyses. After excluding these items, the calculated ordinal alpha of the final version of the PVKT, which included 14 items, was good (aord = 0.83), as were other statistical indicators. PVAQ reliability testing also revealed great performance of this questionnaire-calculated ordinal alpha for two PVAQ subscales was excellent (aord = 0.91, for both scales). CONCLUSIONS: This questionnaire has favorable validity and reliability in assessing healthcare sciences students' knowledge and attitudes toward pharmacovigilance and ADRs reporting. [ABSTRACT FROM AUTHOR]

OBJECTIVE: COVID-19 is associated with an increased incidence of pulmonary embolism (PE). Elevated D-dimer levels are linked to an increased risk of PE and poor clinical outcome. We reported a case of PE in a COVID-19 patient with normal D-dimer levels and conducted a review of the literature on the subject. CASE REPORT: A 38-year-old man with no prior comorbidities returned to the COVID-19 outpatient clinic 36 hours after being discharged from the hospital, where he had been treated for COVID-19 pneumonia. He reported a sudden feeling of dyspnea and chest pain. The physical examination was unremarkable. No new changes were detected on the chest X-ray. D-dimer and cardiac-specific markers values were within the referent range. The patient underwent an urgent computerized tomography pulmonary angiography which revealed signs of bilateral arterial thrombosis. He was treated with a therapeutic dose of low molecular weight heparin and discharged after 15 days, with a recommendation to use a direct oral anticoagulant. CONCLUSIONS: Healthcare professionals should be aware that PE can occur as a late complication of COVID-19. Clinical suspicion of PE should lead physicians to use additional diagnostic methods to confirm or rule out PE, even if D-dimer levels are within the referent range. [ABSTRACT FROM AUTHOR]

• Impact of the measurement conditions was evaluated on mammography dosimeters. • Measurement condition might have a significant > 5 % impact on the response of a semiconductor-based X-ray multimeter. • X-ray multimeter should be calibrated with the correct settings and representative beams. The effect of mammography measurement conditions was investigated to evaluate their impact on measurement uncertainties in clinical practice. The most prominent physical X-ray beam quantities i.e., − air kerma, half-value layer, and X-ray tube voltage − were examined by measuring the response of two ionization chambers and six X-ray multimeters (XMMs) of different models. Measurements were performed using several anode/filter combinations and both with and without the compression paddle in the X-ray beam. Maximum differences of higher than 6 % were found for all quantities when the dosimeter displayed value was compared with the reference value or the variation within the clinical anode/filter combinations Mo/Mo and Mo/Rh were considered. The study showed that the calibration procedure with the W/Al anode/filter combination was reliable only for ionization chambers, and the response of XMMs varies in such a way that the calibration coefficient cannot be predicted between various measurement conditions used in calibration and clinical practices. XMM calibrations are typically performed without a compression paddle in the beam, and the response of the XMM changes when radiation quality is slightly altered. If XMM specific data is not available, based on this study, an additional uncertainty of 2 % (k = 1) could be used as a typical estimate, at least for air kerma measurements. XMMs should be used for clinical measurements in mammography only with correct settings. If the correct settings are not available, the XMMs should not be used or used only with extreme caution. [ABSTRACT FROM AUTHOR]

Copyright of Croatian Journal of Education / Hrvatski Časopis za Odgoj i Obrazovanje is the property of Uciteljski Fakultet u Zagrebu and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

INTRODUCTION: PerOssal® is biologically degradable and osteoconductive bone substitute consisting of nanocrystalline hydroxyapatite (51.5 %) and calcium sulfate (48.5 %). It is used for bone defect treatments as a synthetic carrier for antibiotics suitable for infected areas. Since the effect of PerOssal® has not been investigated so far in combination with mesenchymal stem cells (MSC) for bone tissue regeneration, we aimed to explore in vitro whether this material can support growth and osteogenesis of MSC from bone marrow (BM-MSC). Materials and Methods: BM-MSC were isolated from BM mononuclear cell fraction of human healthy donors and cultivated in standard conditions. One pellet of PerOssal® was dissolved in 10 ml of Phosphate Buffered Saline and added to cells in different ratios. Viability of BM-MSC was assessed by MTT test after one, five and seven days. Migration capacity of BM-MSC was followed by both scratch assay and transwell system, while osteogenic potential was investigated by histochemical staining after induced osteogenic differentiation. RESULTS AND DISCUSSION: Initial experiments showed that BM-MSC adhere to PerOssal® surface. Considering that culture media induced decomposition of PerOssal® which aggravated functional evaluation of attached BM-MSC, our further in vitro studies were directed on testing the effects of different PerOssal® dilutions on BM-MSC functional properties. Our results demonstrated that at all dilutions tested PerOssal® didn’t affect viability of BM-MSC in a shortterm treatment, while in higher doses it decreased cell viability at day 7. At the same time point, morphology of BMMSC was changed with high dose of PerOssal®. On the other side, at lower doses PerOssal® stimulated migration of BMMSC as demonstrated by both scratch and transwell assays. As for the analyses of BM-MSC osteogenic differentiation, stimulatory effect on early osteogenesis was noticed for lower PerOssal® doses, opposite to decreased BM-MSC osteogenesis observed when higher doses were applied. CONCLUSIONS: These data imply that osteoinductive effect of PerOssal® related to BM-MSC recruitment likely considers later phases of material resorption corresponding to its lower concentrations. For potential use as a biomaterial for cell therapy in tissue engineering, PerOssal® should be applied in lower doses. [ABSTRACT FROM AUTHOR]

INTRODUCTION: Nanosized synthetic hydroxyapatite (HAp), closely resembling biological apatite found in human bones and teeth, is extensively studied for its potential in hard tissue repair. Ion-doping of HAp with therapeutic ions is emerging as a promising strategy to mimic biological apatite, promoting specific biological responses such as osteogenesis, angiogenesis, increased cell proliferation, and antimicrobial activity. The aim of our study was to explore and compare the effects of Sr,Cu co-doped α tricalcium phosphate (αTCP) with/without Mg doped HAP on healing of critical size rat calvaria defects in vivo. MATERIALS AND METHODS: Nanosized HAp powders, both single-ion doped with 5 mol.% Mg and co-doped with 3 mol.% Sr and 0.4 mol.% Cu ions, were synthesized using a modified hydrothermal method and α-TCP powder was obtained by calcination of the doped HAp at 1500°C for 2 h. Six male Wistar Albino rats, 8 weeks old, were used to surgically induce two 5 mm bone defects on calvaria. The defects were augmented with either Sr,Cu αTCP with/without Mg HAp material or with “gold standard” material, Bio-OSS (Geistlich Pharma, Wolhusen, Switzerland). Animals were sacrificed 8 weeks after augmentation. Collected tissues were further analyzed using CBCT, histology and qRT-PCR. Collected data were analyzed statistically. RESULTS AND DISCUSSION: Results of CBCT analysis presented high defect closure using Bio-OSS and Sr,Cu αTCP, and median level of closure when using Sr,Cu αTCP/Mg HAp (p<0.05). This difference could be due to high levels of endothelial cell stimulation by magnesium ions contributing to higher closure by fibrous tissue as presented in our histological analysis. However, using both Sr,Cu αTCP or Sr,Cu αTCP/Mg HAp resulted in stimulating mineralized tissue deposition. In our qRT-PCR analysis, Sr,Cu αTCP and Bio-OSS similarly (p>0.05) increased the expression of proinflammatory cytokine TNF-α, unlike using Sr,Cu αTCP/Mg HAp which showed lower levels (p<0.05). This could again be appointed to the aforementioned effect of magnesium ions. Interestingly, both Sr,Cu αTCP and Sr,Cu αTCP/Mg HAp presented higher expression of TGFβ, a growth factor connected with better bone regeneration, compared to BioOSS. Additionally, all tested materials presented similarly high expression of ALP, known marker of osteogenic differentiation. However, Bio-OSS presented significantly higher RANKL/OPG ratio, a marker indicating osteoclastic activity, compared to Sr,Cu αTCP, while Sr,Cu αTCP/Mg HAp showed the lowest values. CONCLUSIONS: This study demonstrates that Sr,Cu αTCP and Sr,Cu αTCP/Mg HAp exhibit promising bone healing outcomes of critical size calvaria defects, comparable to that of Bio-OSS. [ABSTRACT FROM AUTHOR]

Armillaria ostoyae is an edible mushroom, appreciated in human nutrition, with several medicinal properties already proven. However, its phenolic composition and effects on cancer have never been investigated so far, especially regarding specific signaling pathways included in first steps of cancer metastatic process, epithelial-mesenchymal transition (EMT) and migration. We report phenolic profile of two Armillaria ostoyae extracts, ethanol and diethyl ether (E and DE) and their effects on colorectal carcinoma (HCT-116) and cervical adenocarcinoma (HeLa) cells. Phenolics were detected using HPLC, while effects on cancer cells were investigated using MTT test; expression of markers related to EMT on gene and protein level by flow cytometry, immunofluorescence and qRT-PCR method. Antimigratory potential was assessed on collective and individual type of migration by Wound healing assay and RTCA technique. Sinapic acid was detected as the main phenolic component in E , while rutin and naringin were dominant in DE type of extract. Extracts notably suppressed pro-EMT markers: vimentin, N-cadherin, β-catenin, Snail, Smad2 and MMP-9, and elevated anti-EMT marker E-cadherin. Consequently, collective and single cell migration were significantly inhibited via regulation of TGF-β and Wnt/β-catenin signaling components. DE extract was more efficient in suppression of EMT and migration of colorectal and cervical cancer cells. [Display omitted] • First report on A. ostoyae mushroom extracts on cancer cells. • Diethyl ether and ethanolic extracts had anti-EMT effect on cancer cells. • Molecular mechanism of action via regulation of TGF-β and Wnt signaling pathways. • Colorectal cancer HCT-116 cells were more sensitive to applied extracts. • A. ostoyae , novel, promising and noteworthy natural source of biological activity. [ABSTRACT FROM AUTHOR]

The article presents the discussion on immunization being the key factor for prevention and suppression of SARS CoV-2 infection. Topics include pharmacovigilance being the crucial and most reliable source of all drug safety information, for patients, and healthcare professionals; and pain, swelling and redness, followed by systemic reactions such as fever, muscle pain, joint pain, tremor, weakness, headache, and nausea.

Copyright of Serbian Dental Journal / Stomatološki Glasnik Srbije is the property of National Library of Serbia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

For hundreds of years honey and bee products have been used in diets and as a home remedies. In order to assess the prevalence of bee products usage in pediatric pulmonary patients, an anonymous survey of parents/guardians was conducted. A cross-sectional study was performed in the pediatric pulmonology outpatients clinic using a questionnaire which contained 20 open-ended and closed questions. Of 138 questionnaires distributed, 120 were fully completed and included in the analysis. 79% of the respondents had given their child some form of bee product to alleviate health problems (e.g. asthma and bronchitis), which most frequently included meadow honey, propolis and royal jelly. Living in the city and older age of parents/guardians significantly increased the probability of using bee products. Products were usually purchased in pharmacies or beekeepers shops. Bee product blends, used by ≈74%, were often produced at home, and they contained a variety of plant ingredients (pine needles, black radish, dandelions, onions, ginger, thyme, St Johns' Wort, yarrow, etc.). More than a half reported better improvements combining bee products and prescribed medicines. A few very mild side-effects were reported by 5% and one case of an allergic reaction to propolis. Medicinal usage of bee products among pediatric pulmonology patients in South- East Serbia is widespread. Almost all interviewed parents/guardians would like to learn more about bee products and the possibilities for their safe and effective application. [ABSTRACT FROM AUTHOR]

Abstract In a rat model of the andropause we aimed to examine the influence of daidzein, soy isoflavone, on the structure and function of parathyroid glands (PTG) and the expression levels of some of the crucial regulators of Ca2+ and Pi homeostasis in the kidney, and to compare these effects with the effects of estradiol, serving as a positive control. Middle-aged (16-month-old) male Wistar rats were divided into the following groups: sham-operated (SO), orchidectomized (Orx), orchidectomized and estradiol-treated (Orx + E; 0.625 mg/kg b.w./day, s.c.) as well as orchidectomized and daidzein-treated (Orx + D; 30 mg/kg b.w./day, s.c.) group. Every treated group had a corresponding control group. PTH serum concentration was decreased in Orx + E and Orx + D groups by 10% and 21% (p < 0.05) respectively, in comparison with the Orx. PTG volume was decreased in Orx + E group by 16% (p < 0.05), when compared to the Orx. In Orx + E group expression of NaPi 2a was lower (p < 0.05), while NaPi 2a abundance in Orx + D animals was increased (p < 0.05), when compared to Orx. Expression of PTH1R was increased (p < 0.05) in Orx + E group, while in Orx + D animals the same parameter was decreased (p < 0.05), in comparison with Orx. Klotho expression was elevated (p < 0.05) in Orx + D rats, in regard to Orx. Orx + D induced reduction in Ca2+/creatinine and Pi/creatinine ratio in urine by 32% and 16% (p < 0.05) respectively, in comparison with Orx. In conclusion, presented results indicate the more coherent beneficial effects of daidzein compared to estradiol, on disturbed Ca2+ and Pi homeostasis, and presumably on bone health, in the aging male rats. [ABSTRACT FROM AUTHOR]

Copyright of Facta Universitatis: Series Physical Education & Sport is the property of Facta Universitatis, Series Physical Education & Sport and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Facta Universitatis: Series Physical Education & Sport is the property of Facta Universitatis, Series Physical Education & Sport and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)