7 results on '"P. J. McCann"'
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2. Discovery of Dapagliflozin: A Potent, Selective Renal Sodium-Dependent Glucose Cotransporter 2 (SGLT2) Inhibitor for the Treatment of Type 2 Diabetes.
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Wei Meng, William N. Washburn, Bruce A. Ellsworth, Alexandra A. Nirschl, Peggy J. McCann, Manorama Patel, Ravindar N. Girotra, Gang Wu, Philip M. Sher, Eamonn P. Morrison, Scott A. Biller, Robert Zahler, Prashant P. Deshpande, Annie Pullockaran, Deborah L. Hagan, Nathan Morgan, Joseph R. Taylor, Mary T. Obermeier, William G. Humphreys, and Ashish Khanna
- Published
- 2008
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3. Quaternary ammonium-linked glucuronidation of 1-substituted imidazoles by liver microsomes: interspecies differences and structure-metabolism relationships.
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C, Vashishtha Sarvesh, M, Hawes Edward, J, McCann Denis, Omar, Ghosheh, and Lawrence, Hogg
- Abstract
N-Glucuronidation at an aromatic tertiary amine of 5-membered polyaza ring systems was investigated for a model series of eight 1-substituted imidazoles in liver microsomes from five species. The major objectives were to investigate substrate specificities of the series in human microsomes and interspecies variation for the prototype molecule, 1-phenylimidazole. The formed quaternary ammonium-linked metabolites were characterized by positive ion electrospray mass spectrometry. The incubation conditions for the N-glucuronidation of 1-substituted imidazoles were optimized; where for membrane disrupting agents, alamethicin was more effective than the detergents examined. The need to optimize alamethicin concentration was indicated by 4-fold interspecies variation in optimal concentration and by a change in effect from removal of glucuronidation latency to inhibition on increasing concentration. For the four species with quantifiable N-glucuronidation of 1-phenylimidazole, there were 8- and 18-fold variations in the determined apparent K(m) (range, 0.63 to 4.8 mM) and V(max) (range, 0.08 to 1.4 nmol/min/mg of protein) values, respectively. The apparent clearance values (V(max)/K(m)) were in the following order: human congruent with guinea pig congruent with rabbit > rat congruent with dog (no metabolite detected). Monophasic kinetics were observed for the N-glucuronidation of seven substrates by human liver microsomes, which suggests that one enzyme is involved in each metabolic catalysis. No N-glucuronidation was observed for the substrate containing the para-phenyl substituent with the largest electron withdrawing effect, 1-(4-nitrophenyl)imidazole. Linear correlation analyses between apparent microsomal kinetics and substrate physicochemical parameters revealed significant correlations between K(m) and lipophilicity (pi(para) or log P values) and between V(max)/K(m) and both electronic properties (sigma(para) value) and pKa.
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- 2002
4. Quaternary ammonium-linked glucuronidation of 1-substituted imidazoles: studies of human UDP-glucuronosyltransferases involved and substrate specificities.
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C, Vashishtha S, M, Hawes E, G, McKay, and J, McCann D
- Abstract
A series of eight 1-substituted imidazoles was investigated as model substrates for glucuronidation at an aromatic tertiary amine of polyaza heterocyclic ring systems. The human UDP-glucuronosyltransferases (UGTs) involved and substrate specificities were investigated. Nine expressed enzymes (UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A9, UGT1A10, UGT2B7, and UGT2B15) were examined, but only UGT1A4 catalyzed the formation of a quaternary ammonium-linked glucuronide metabolite for six of the substrates. UGT1A3 also catalyzed the glucuronidation of the previously investigated 1-phenylimidazole but none of the newly investigated compounds. No glucuronidation was observed with 1-(4-nitrophenyl)imidazole, the compound with the 4-phenyl substituent with the largest electron withdrawing effect. The incubation conditions for the determination of the kinetic constants for UGT1A4 catalysis of six substrates were optimized and included incubation at pH 7.4 with alamethicin at 10 microg/mg of protein. Latency disrupting agents, including alamethicin and sonication, enhanced glucuronidation 1.25-fold at most. There were 17.5- and 2.2-fold variations in the apparent K(m) (range, 0.18-3.15 mM) and V(max) values (range, 0.16-0.35 nmol/min/mg of protein). Linear correlation analyses between UGT1A4 kinetics and substrate physicochemical parameters showed significant correlation between V(max) and both the partition coefficient (log P, n-octanol/water) and pK(a) and between K(m) and pK(a), thereby indicating that the lipophilicity and the ease of availability of the tertiary amine lone pair of electrons of the substrate are important with respect to enzyme catalysis.
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- 2001
5. Synthesis and identification of the quaternary ammonium-linked glucuronide of 1-phenylimidazole in human liver microsomes and investigation of the human UDP-glucuronosyltransferases involved.
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C, Vashishtha S, M, Hawes E, G, McKay, and J, McCann D
- Abstract
1-Phenylimidazole was investigated as a potential model substrate with respect to formation of a quaternary ammonium-linked glucuronide (N(+)-glucuronide) at an aromatic type tertiary amine. A reference sample of the potential N(+)-glucuronide metabolite of 1-phenylimidazole was obtained by organic synthesis. The structural identity of the metabolite formed by incubation of 1-phenylimidazole with human liver microsomes was proven to be the N(+)-glucuronide by exhibiting the same HPLC retention time and electrospray ionization mass spectrum as the reference sample. The screening of 1-phenylimidazole against a panel of nine expressed human UDP-glucuronosyltransferases indicated the involvement of UGT1A3 and UGT1A4 in the formation of the N(+)-glucuronide metabolite.
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- 2000
6. Retrospective study of reasons for improved survival in patients with breast cancer in east Anglia: earlier diagnosis or better treatment.
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D, Stockton, T, Davies, N, Day, and J, McCann
- Abstract
OBJECTIVES: To investigate the recent fall in mortality from breast cancer in England and Wales, and to determine the relative contributions of improvements in treatment and earlier detection of tumours. DESIGN: Retrospective study of all women with breast cancer registered by the East Anglian cancer registry and diagnosed between 1982 and 1989. SUBJECTS: 3965 patients diagnosed 1982-5 compared with 4665 patients diagnosed 1986-9, in three age groups 0-49, 50-64, > or = 65 years, with information on stage at diagnosis and survival. MAIN OUTCOME MEASURES: Three year relative survival rates by time period, age group, and stage; relative hazard ratios for each time period and age group derived from Cox's proportional hazards model, adjusted for single year of age and stage. RESULTS: Survival improved in the later time period, although there was little stage specific improvement. The proportion of early stage tumours increased especially in the 50-64 year age group, and adjustment for stage accounted for over half of the improvement in survival in women aged under 65 years. CONCLUSION: Over half of the drop in mortality in women aged under 65 years seems to be attributable to earlier detection of tumours, which has been observed since the mid-1980s. This could have resulted from an increase in breast awareness predating the start of the breast screening programme.
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- 1997
7. Open data from the first and second observing runs of Advanced LIGO and Advanced Virgo
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Rich Abbott, Thomas D. Abbott, Sheelu Abraham, Fausto Acernese, Kendall Ackley, Carl Adams, Rana X. Adhikari, Vaishali B. Adya, Christoph Affeldt, Michalis Agathos, Kazuhiro Agatsuma, Nancy Aggarwal, Odylio D. Aguiar, Amit Aich, Lorenzo Aiello, Anirban Ain, Ajith Parameswaran, Gabrielle Allen, Annalisa Allocca, Paul A. Altin, Alex Amato, Shreya Anand, Alena Ananyeva, Stuart B. Anderson, Warren G. Anderson, Svetoslava V. Angelova, Stefano Ansoldi, Sarah Antier, Stephen Appert, Koji Arai, Melody C. Araya, Joseph S. Areeda, Marc Arène, Nicolas Arnaud, Scott M. Aronson, Kg G. Arun, Stefano Ascenzi, Gregory Ashton, Stuart M. Aston, Pia Astone, Florian Aubin, Peter Aufmuth, Kellie AultONeal, Corey Austin, Valerie Avendano, Stanislav Babak, Philippe Bacon, Francesca Badaracco, Maria K.M. Bader, Sangwook Bae, Anne M. Baer, Jonathon Baird, Francesca Baldaccini, Giulio Ballardin, Stefan W. Ballmer, Anna-marie Bals, Alexander Balsamo, Gregory Baltus, Sharan Banagiri, Deepak Bankar, Rameshwar S. Bankar, Juan C. Barayoga, Claudio Barbieri, Barry C. Barish, David Barker, Kevin Barkett, Pablo Barneo, Fabrizio Barone, Bryan Barr, Lisa Barsotti, Matteo Barsuglia, Daniel Barta, Jeffrey Bartlett, Imre Bartos, Riccardo Bassiri, Andrea Basti, Mateusz Bawaj, Joseph C. Bayley, Marco Bazzan, Bence Bécsy, Michal Bejger, Imene Belahcene, Angus S. Bell, Deeksha Beniwal, Michael G. Benjamin, Joe D. Bentley, Fabio Bergamin, Beverly K. Berger, Gerald Bergmann, Sebastiano Bernuzzi, Christopher P.L. Berry, Diego Bersanetti, Alessandro Bertolini, Joseph Betzwieser, Rohan Bhandare, Ankit V. Bhandari, Jeffrey Bidler, Edward Biggs, Igor A. Bilenko, Garilynn Billingsley, Ross Birney, Ofek Birnholtz, Sebastien Biscans, Matteo Bischi, Sylvia Biscoveanu, Aparna Bisht, Guldauren Bissenbayeva, Massimiliano Bitossi, Marieanne A. Bizouard, Kent K. Blackburn, Jonathan Blackman, Carl D. Blair, David G. Blair, Ryan M. Blair, Fabrizio Bobba, Nina Bode, Michel Boer, Yannick Boetzel, Gilles Bogaert, Francois Bondu, Edgard Bonilla, Romain Bonnand, Phillip Booker, Boris A. Boom, Rolf Bork, Valerio Boschi, Sukanta Bose, Vladimir Bossilkov, Joel Bosveld, Yann Bouffanais, Antonella Bozzi, Carlo Bradaschia, Patrick R. Brady, Alyssa Bramley, Marica Branchesi, Jim E. Brau, Matteo Breschi, Tristan Briant, Joseph H. Briggs, Francesco Brighenti, Alain Brillet, Marc Brinkmann, Patrick Brockill, Aidan F. Brooks, Jonathan Brooks, Daniel D. Brown, Sharon Brunett, Giacomo Bruno, Robert Bruntz, Aaron Buikema, Tomasz Bulik, Henk J. Bulten, Alessandra Buonanno, Damir Buskulic, Robert L. Byer, Miriam Cabero, Laura Cadonati, Giampietro Cagnoli, Craig Cahillane, Juan Calderón Bustillo, Jack D. Callaghan, Thomas A. Callister, Enrico Calloni, Jordan B. Camp, Maurizio Canepa, Kipp C. Cannon, Huy-tuong Cao, Junwei Cao, Giovanni Carapella, Franco Carbognani, Santiago Caride, Matthew F. Carney, Gregorio Carullo, Julia Casanueva Diaz, Claudio Casentini, Javier Castañeda, Sarah Caudill, Marco Cavaglià, Fabien Cavalier, Roberto Cavalieri, Giancarlo Cella, Pablo Cerdá-Durán, Elisabetta Cesarini, Oualid Chaibi, Kabir Chakravarti, Chiwai Chan, Manleong Chan, Shiuh Chao, Philip Charlton, Eve A. Chase, Eric Chassande-Mottin, Deep Chatterjee, Mayank Chaturvedi, Hsin-yu Y. Chen, Xu Chen, Yanbei Chen, Hai-ping Cheng, Chi-kit K. Cheong, Hanyu Y. Chia, Francesco Chiadini, Roberto Chierici, Andrea Chincarini, Antonino Chiummo, Gihyuk Cho, Heesuk S. Cho, Min-a Cho, Nelson Christensen, Qi Chu, Sheon Chua, Ka-wai W. Chung, Shinkee Chung, Giacomo Ciani, Pawel Ciecielag, Marek Cieślar, Alexei A. Ciobanu, Riccardo Ciolfi, Francesco Cipriano, Alessio Cirone, Filiberto Clara, James A. Clark, Patrick Clearwater, Sebastien Clesse, Frederic Cleva, Eugenio Coccia, Pierre-francois Cohadon, David Cohen, Marta Colleoni, Christophe G. Collette, Christopher Collins, Monica Colpi, Marcio Constancio Jr., Livia Conti, Sam J. Cooper, Paul Corban, Thomas R. Corbitt, Isabel Cordero-Carrión, Silvia Corezzi, Kenneth R. Corley, Neil Cornish, David Corre, Alessandra Corsi, Stefano Cortese, Cesar A. Costa, Roberto Cotesta, Michael W. Coughlin, Scott B. Coughlin, Jeanpierre Coulon, Stefan T. Countryman, Peter Couvares, Pep B. Covas, David M. Coward, Matthew J. Cowart, Dennis C. Coyne, Robert Coyne, Jolien D. E. Creighton, Teviet D. Creighton, Jonathan Cripe, Michael Croquette, Sgwynne G. Crowder, Jean-rene Cudell, Torrey J. Cullen, Alan Cumming, Rebecca Cummings, Liam Cunningham, Elena Cuoco, Malgorzata Curylo, Tito Dal Canton, Gergely Dálya, Aykutlu Dana, Lara M. Daneshgaran-Bajastani, Beatrice D’Angelo, Stefan L. Danilishin, Sabrina D’Antonio, Karsten Danzmann, Christian Darsow-Fromm, Arnab Dasgupta, Laurence E. H. Datrier, Vincenzo Dattilo, Ishant Dave, Michel Davier, Gareth S. Davies, Derek Davis, Edward J. Daw, Dan DeBra, Malathi Deenadayalan, Jerome Degallaix, Martina De Laurentis, Samuel Deléglise, Matthew Delfavero, Nicola De Lillo, Walter Del Pozzo, Lindsay M. DeMarchi, Virginia D’Emilio, Nicholas Demos, Thomas Dent, Roberto De Pietri, Rosario De Rosa, Camilla De Rossi, Riccardo DeSalvo, Omar de Varona, Sanjeev Dhurandhar, Mario C. Díaz, Mauricio Diaz-Ortiz Jr., Tim Dietrich, Luciano Di Fiore, Chiara Di Fronzo, Cinzia Di Giorgio, Fabrizio Di Giovanni, Matteo Di Giovanni, Tristano Di Girolamo, Alberto Di Lieto, Binlei Ding, Sibilla Di Pace, Irene Di Palma, Francesco Di Renzo, Atul K. Divakarla, Artemiy Dmitriev, Zoheyr Doctor, Fred Donovan, Katherine L. Dooley, Suresh Doravari, Iain Dorrington, Thomas P. Downes, Marco Drago, Jenne C. Driggers, Zhihui Du, Jean-gregoire Ducoin, Peter Dupej, Ofelia Durante, Domenico D’Urso, Sheila E. Dwyer, Paul J. Easter, Graeme Eddolls, Bruce Edelman, Tega B. Edo, Oliver Edy, Anamaria Effler, Phil Ehrens, Johannes Eichholz, Stephen S. Eikenberry, Marc Eisenmann, Robert A. Eisenstein, Aldo Ejlli, Lucianolucianikerrico Errico, Reed C. Essick, Hector Estelles, Dimitri Estevez, Zachariah B. Etienne, Todd Etzel, Matthew Evans, Tom M. Evans, Rebecca E. Ewing, Viviana Fafone, Stephen Fairhurst, Xilong Fan, Stefania Farinon, Benjamin Farr, Will M. Farr, Edward J. Fauchon-Jones, Marc Favata, Maxime Fays, Mariana Fazio, Jon Feicht, Martin M. Fejer, Fangchen Feng, Edit Fenyvesi, Deborah L. Ferguson, Alvaro Fernandez-Galiana, Isidoro Ferrante, Elvis C. Ferreira, Tabata A. Ferreira, Francesco Fidecaro, Irene Fiori, Donatella Fiorucci, Maya Fishbach, Ryan P. Fisher, Rosalba Fittipaldi, Margot Fitz-Axen, Vincenzo Fiumara, Raffaele Flaminio, Erik Floden, Eric Flynn, Heather Fong, Antonio A. Font, Perry Forsyth, Jean-daniel Fournier, Sergio Frasca, Franco Frasconi, Zsolt Frei, Andreas Freise, Raymond Frey, Valentin Frey, Peter Fritschel, Valery V. Frolov, Gabriele Fronzè, Paul Fulda, Michael Fyffe, Hunter A. Gabbard, Bhooshan U. Gadre, Sebastian M. Gaebel, Jonathan R. Gair, Shanika Galaudage, Dhruva Ganapathy, Sharad G. Gaonkar, Cecilio García-Quirós, Fabio Garufi, Bubba Gateley, Sergio Gaudio, Gayathri Gayathri, Gianluca Gemme, Eric Genin, Alberto Gennai, Daniel George, Jogy George, Laszlo Gergely, Sudarshan Ghonge, Abhirup Ghosh, Archisman Ghosh, Shaon Ghosh, Bruno Giacomazzo, Joe A. Giaime, Dwayne D. Giardina, Des R. Gibson, Chalisa Gier, Kiranjyot Gill, Jane Glanzer, Jan Gniesmer, Patrick Godwin, Evan Goetz, Ryan Goetz, Niklas Gohlke, Boris Goncharov, Gabriela González, Gopakumar Gopakumar, Sarah E. Gossan, Matthieu Gosselin, Romain Gouaty, Benjamin Grace, Aniello Grado, Massimo Granata, Alastair Grant, Slawomir Gras, Philippe Grassia, Corey Gray, Rachel Gray, Giuseppe Greco, Anna C. Green, Rhys Green, Elizabeth M. Gretarsson, Hannah L. Griggs, G. Grignani, Andrea Grimaldi, Stefan J. Grimm, Hartmut Grote, Steffen Grunewald, Pierre Gruning, Gianluca M. Guidi, Andre R. Guimaraes, Gerard Guixé, Hitesh K. Gulati, Yuefan Guo, Anuradha Gupta, Anchal Gupta, Pawan Gupta, Eric K. Gustafson, Dick Gustafson, Leila Haegel, Odysse Halim, Evan D. Hall, Eleanor Z. Hamilton, Giles Hammond, Maria Haney, Manuela M. Hanke, Jonathan Hanks, Chad Hanna, Mark D. Hannam, Otto A. Hannuksela, Travis J. Hansen, Joe Hanson, Thomas Harder, Terra Hardwick, Haris Haris, Jan Harms, Gregg M. Harry, Ian W. Harry, Raine K. Hasskew, Carl-johan Haster, Karen Haughian, Fergus J. Hayes, James Healy, Antoine Heidmann, Matthew C. Heintze, Joscha Heinze, Henrich Heitmann, Frances Hellman, Patrice Hello, Gary Hemming, Martin Hendry, Siong S. Heng, Eric Hennes, Jan-simon Hennig, Michele Heurs, Stefan Hild, Tanja Hinderer, Sarah Y. Hoback, Sven Hochheim, Elyssa Hofgard, David Hofman, Aaron M. Holgado, Nathan A. Holland, Kathy Holt, Daniel E. Holz, Paul Hopkins, Christian Horst, James Hough, Eric J. Howell, Charlie G. Hoy, Yiwen Huang, Moritz T. Hübner, Eliu A. Huerta, Dominique Huet, Brennan Hughey, Victor Hui, Sascha Husa, Sabina H. Huttner, Rachael Huxford, Tien Huynh-Dinh, Bartosz Idzkowski, Alberto Iess, Henri Inchauspe, Craig Ingram, Giuseppe Intini, Isac, Jean M., Max Isi, Bala R. Iyer, Thibaut Jacqmin, Sameer J. Jadhav, Shreejit P. Jadhav, Alasdair L. James, Karan Jani, Nagaraj N. Janthalur, Piotr Jaranowski, Deep Jariwala, Rafel Jaume, Alex C. Jenkins, Jun Jiang, Grace R. Johns, Aaron W. Jones, Ian I. Jones, Jeff D. Jones, Philip Jones, Russell Jones, Reinier J. G. Jonker, Ju Ju, Jonas Junker, Chinmay V. Kalaghatgi, Vassiliki Kalogera, Brittany Kamai, Shivaraj Kandhasamy, Gungwon Kang, Jonah B. Kanner, Shasvath J. Kapadia, Sudarshan Karki, Rahul Kashyap, Marie Kasprzack, Wolfgang Kastaun, Stavros Katsanevas, Erik Katsavounidis, William Katzman, Steffen Kaufer, Keita Kawabe, Fabien Kéfélian, David Keitel, Azadeh Keivani, Ross Kennedy, Joey S. Key, Sudiksha Khadka, Farit Y. Khalili, Imran Khan, Sebastian Khan, Zaki A. Khan, Efim A. Khazanov, Nandita Khetan, Mohammad Khursheed, Nutsinee Kijbunchoo, Chunglee Kim, Grace J. Kim, Jeongcho C. Kim, Kyungmin Kim, Won Kim, Whansun S. Kim, Young-min Kim, Charles Kimball, Peter J. King, Maya Kinley-Hanlon, Robin Kirchhoff, Jeffrey S. Kissel, Lisa Kleybolte, Sergei Klimenko, Tyler D. Knowles, Philip Koch, Sina M. Koehlenbeck, Gideon Koekoek, Soumen Koley, Veronica Kondrashov, Antonios Kontos, Nico Koper, Mikhail Korobko, William Z. Korth, Manoj Kovalam, Dan B. Kozak, Volker Kringel, Nv V. Krishnendu, Andrzej Królak, Natalie Krupinski, Gerrit Kuehn, Anil Kumar, Prayush Kumar, Rahul Kumar, Rakesh Kumar, Sumit Kumar, Ling-chi Kuo, Adam Kutynia, Benjamin D. Lackey, Danny Laghi, Emile Lalande, Lam L. Lam, Astrid Lamberts, Michael Landry, Benjamin B. Lane, Ryan N. Lang, Jacob Lange, Brian Lantz, Robert K. Lanza, Iuri La Rosa, Angelique Lartaux-Vollard, Paul D. Lasky, Michael Laxen, Albert Lazzarini, Claudia Lazzaro, Paola Leaci, Sean Leavey, Yannick K. Lecoeuche, Chang-hwan H. Lee, Hyung-mok M. Lee, Hyungwon W. Lee, Joongoo Lee, Kyung-ha Lee, Johannes Lehmann, Nicolas Leroy, Nicolas Letendre, Yuri Levin, Alvin K. Y. Li, Jin Li, Kaye li, Tjonnie G. F. Li, Xiang Li, Frank Linde, Seth D. Linker, Jethro N. Linley, Tyson B. Littenberg, Liu Liu, Xiaoshu Liu, Miquel Llorens-Monteagudo, Ka-lok Lo, Alexandra Lockwood, Lionel T. London, Alessandro Longo, Matteo Lorenzini, Vincent Loriette, Marc Lormand, Giovanni Losurdo, James D. Lough, Carlos O. Lousto, Geoffrey Lovelace, Harald Lück, Diana Lumaca, Andrew P. Lundgren, Ma Yiqiu, Ronaldas Macas, Sean Macfoy, Myron MacInnis, Duncan M. Macleod, Ian O. MacMillan, Adrian Macquet, Ignacio Magaña Hernandez, Fabian Magaña-Sandoval, Ryan M. Magee, Ettore Majorana, Ivan Maksimovic, Asmita Malik, Catherine Man, Vuk Mandic, Valentina Mangano, Georgia L. Mansell, Michael Manske, Maddalena Mantovani, Michela Mapelli, Fabio Marchesoni, Frederique Marion, Szabolcs Márka, Zsuzsanna Márka, Charalampos Markakis, Ashot S. Markosyan, Aaron Markowitz, Ed Maros, Antonio Marquina, Sylvain Marsat, Filippo Martelli, Ian W. Martin, Rodica M. Martin, Valerie Martinez, Denis V. Martynov, Hossein Masalehdan, Ken Mason, Elena Massera, Alain Masserot, Thomas J. Massinger, Mariela Masso-Reid, Simone Mastrogiovanni, Andrew Matas, Fabrice Matichard, Nergis Mavalvala, Emily Maynard, Joshua J. McCann, Richard McCarthy, David E. McClelland, Scott McCormick, Lee McCuller, Stephen C. McGuire, Connor McIsaac, Jessica McIver, David J. McManus, Terry McRae, Sean T. McWilliams, Duncan Meacher, Grant D. Meadors, Moritz Mehmet, Ajit K. Mehta, Elena Mejuto Villa, Andrew Melatos, Gregory Mendell, Adam A. Mercer, Lorenzo Mereni, Kara Merfeld, Edmond L. Merilh, Jonathan D. Merritt, Mourad Merzougui, Syd Meshkov, Chris Messenger, Cody Messick, Remi Metzdorff, Patrick M. Meyers, Fabian Meylahn, Ashish Mhaske, Andrea Miani, Haixing Miao, Ioannis Michaloliakos, Christophe Michel, Hannah Middleton, Leopoldo Milano, Andrewlawrence L. Miller, Meg Millhouse, Joseph C. Mills, Edoardo Milotti, Michael C. Milovich-Goff, Olivier Minazzoli, Yuri Minenkov, Alec Mishkin, Chandra Mishra, Timesh Mistry, Sanjit Mitra, Valery P. Mitrofanov, Guenakh Mitselmakher, Richard Mittleman, Geoffrey Mo, Kentaro Mogushi, Satyanarayan R. P. Mohapatra, Siddharth R. Mohite, Manel Molina-Ruiz, Marina Mondin, Matteo Montani, Christopher J. Moore, Dan Moraru, Filip Morawski, Gerardo Moreno, Soichiro Morisaki, Benoit Mours, Conor M. Mow-Lowry, Simone Mozzon, Federico Muciaccia, Arunava Mukherjee, Debnandini Mukherjee, Soma Mukherjee, Subroto Mukherjee, Nikhil Mukund, Adam Mullavey, Jesper Munch, Erik A. Muñiz, Peter G. Murray, Alessandro Nagar, Ilaria Nardecchia, Luca Naticchioni, Rajesh K. Nayak, Benjamin F. Neil, Joshua Neilson, Gijs Nelemans, Timothy J. N. Nelson, Marina Nery, Ansel Neunzert, Kwan-yeung Y. Ng, Sebastian Ng, Catherine Nguyen, Philippe Nguyen, David Nichols, Shania A. Nichols, Samaya Nissanke, Flavio Nocera, Minkyun Noh, Chris North, Devon Nothard, Laura K. Nuttall, Jason Oberling, Brendan D. O’Brien, Gor Oganesyan, Greg H. Ogin, John J. Oh, Sanghoon H. Oh, Frank Ohme, Hiroaki Ohta, Marcos A. Okada, Miquel Oliver, Christian Olivetto, Patrick Oppermann, Richard Oram, Brian O’Reilly, Rich G. Ormiston, Luis F. Ortega, Richard O’Shaughnessy, Serguei Ossokine, Charles Osthelder, David J. Ottaway, Harry Overmier, Ben J. Owen, Alexander E. Pace, Giulia Pagano, Michael A. Page, Giulia Pagliaroli, Archana Pai, Siddhesh A. Pai, Jordan R. Palamos, Oleg Palashov, Cristiano Palomba, Howard Pan, Pratap K. Panda, Tsun-ho Pang, Chris Pankow, Francesco Pannarale, Brijesh C. Pant, Federico Paoletti, Andrea Paoli, Abhishek Parida, William Parker, Daniela Pascucci, Antonio Pasqualetti, Roberto Passaquieti, Diego Passuello, Barbara Patricelli, Ethan Payne, Brynley L. Pearlstone, Thida C. Pechsiri, Ari J. Pedersen, Mike Pedraza, Arnaud Pele, Steven Penn, Albino Perego, Carlos J. Perez, Perigois Périgois, Antonio Perreca, Stephane Perriès, Jan Petermann, Harald P. Pfeiffer, Margot Phelps, Khun S. Phukon, Ornella J. Piccinni, Mikhael Pichot, Marco Piendibene, Francesco Piergiovanni, Vincenzo Pierro, Gabriel Pillant, Laurent Pinard, Innocenzo M. Pinto, Krzysztof Piotrzkowski, Marc Pirello, Matthew Pitkin, Wolfango Plastino, Rosa Poggiani, Yat-tung T. Pong, Sarah Ponrathnam, Pasquale Popolizio, Ed K. Porter, Jade Powell, Atul K. Prajapati, Kiran Prasai, Raghurama Prasanna, Geraint Pratten, Tanner Prestegard, Maria Principe, Giovanni A. Prodi, Leonid Prokhorov, Michele Punturo, Paola Puppo, Michael Pürrer, Hong Qi, Volker Quetschke, Pedro J. Quinonez, Fred J. Raab, Geert Raaijmakers, Hugh Radkins, Nicholas Radulesco, Peter Raffai, Hanna Rafferty, Sendhil Raja, Rajan Rajan, Binod Rajbhandari, Malik Rakhmanov, Karla E. Ramirez, Antoni Ramos-Buades, Javed Rana, Kaushik Rao, Piero Rapagnani, Vivien Raymond, Massimiliano Razzano, Jocelyn Read, Tania Regimbau, Luca Rei, Stuart Reid, David H. Reitze, Piero Rettegno, Fulvio Ricci, Colter J. Richardson, Jonathan W. Richardson, Paul M. Ricker, Gunnar Riemenschneider, Keith Riles, Monica Rizzo, Norna A. Robertson, Florent Robinet, Alessio Rocchi, Ramon D. Rodriguez-Soto, Loic Rolland, Jameson G. Rollins, Vincent J. Roma, M. Romanelli, Rocco Romano, Chandra L. Romel, Isobel M. Romero-Shaw, Janeen H. Romie, Caitlin A. Rose, Dakota Rose, Kyle Rose, Dorota Rosińska, Shawn G. Rosofsky, Michael P. Ross, Sheila Rowan, Samuel J. Rowlinson, Palash K. Roy, Santosh Roy, Soumen Roy, Paolo Ruggi, Guntis Rutins, Kyle Ryan, Surabhi Sachdev, Travis Sadecki, Mairi Sakellariadou, Om S. Salafia, Livio Salconi, Muhammed Saleem, Anuradha Samajdar, Eduardo J. Sanchez, Luis E. Sanchez, Nicolas Sanchis-Gual, Jaclyn R. Sanders, Kevin A. Santiago, Edison Santos, Nikhil Sarin, Benoit Sassolas, B S. Sathyaprakash, Orion Sauter, Richard L. Savage, Vaibhav Savant, Disha Sawant, Sihem Sayah, Dean Schaetzl, Paul Schale, Mark Scheel, Jacob Scheuer, Patricia Schmidt, Roman Schnabel, Robert M. S. Schofield, Axel Schönbeck, Emil Schreiber, Bernd W. Schulte, Bernard F. Schutz, Otto Schwarm, Eyal Schwartz, Jamie Scott, Susan M. Scott, Ed Seidel, Danny Sellers, Anand S. Sengupta, Noah Sennett, Daniel Sentenac, Valeria Sequino, Alexander Sergeev, Yoshinta Setyawati, Daniel A. Shaddock, Thomas Shaffer, Selim S. Shahriar, A. Sharma, Priyanka Sharma, Peter Shawhan, Hongyu Shen, Minori Shikauchi, Rosalie Shink, David H. Shoemaker, Deirdre M. Shoemaker, Keerti Shukla, Shyamsundar ShyamSundar, Karelle Siellez, Magdalena Sieniawska, Daniel Sigg, Leo P. Singer, Divya Singh, Neha Singh, Ayatri Singha, Akshat Singhal, Alicia M. Sintes, Valeria Sipala, Vasileios Skliris, Bram J. J. Slagmolen, Teresa J. Slaven-Blair, Jiri Smetana, Joshua R. 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Thorne, Eric Thrane, Calley L. Tinsman, Saravanan R. Saravanan, Shubhanshu Tiwari, Srishti Tiwari, Vaibhav Tiwari, Karl Toland, Mauro Tonelli, Zeno Tornasi, Alejandro Torres-Forné, Calum I. Torrie, I. Tosta e Melo, Daniel Töyrä, Emily A. Trail, Flavio Travasso, Gary Traylor, Maria C. Tringali, Aashish Tripathee, Agata Trovato, Randy J. Trudeau, Ka-wa W. Tsang, Maggie Tse, Rhondale Tso, Leo Tsukada, Daichi Tsuna, Takuya Tsutsui, Margherita Turconi, Amit S. Ubhi, Koh Ueno, Dennis Ugolini, Cs S. Unnikrishnan, Alexander L. Urban, Samantha A. Usman, Andrei C. Utina, Henning Vahlbruch, Gabriele Vajente, Guillermo Valdes, Michele Valentini, M. Vallisneri, Niels van Bakel, Martin van Beuzekom, Jo F. J. van den Brand, Chris Van Den Broeck, Daniel C. Vander-Hyde, Laura van der Schaaf, Joris V. Van Heijningen, Marielle A. van Veggel, Marco Vardaro, Vijay Varma, Steve Vass, Matyas Vasúth, Alberto Vecchio, Gabriele Vedovato, John Veitch, Peter J. Veitch, Krishna Venkateswara, Gautam Venugopalan, Didier Verkindt, Doga Veske, Flavio Vetrano, Andrea Viceré, Aaron D. Viets, Serena Vinciguerra, David J. Vine, Jeanyves Vinet, Salvatore Vitale, Francisco Hernandez Vivanco, Thomas Vo, Helios Vocca, Cheryl Vorvick, Sergey P. Vyatchanin, Andrew R. Wade, Leslie E. Wade, Madeline Wade, Rob Walet, Marissa Walker, Gavin S. Wallace, Larry Wallace, Sinead Walsh, Jonathan Z. Wang, Sibo Wang, Wenhui H. Wang, Yifan F. Wang, Robert L. Ward, Zane A. Warden, Jim Warner, Michal Was, Jennifer Watchi, Betsy Weaver, Li-wei Wei, Michael Weinert, Alan J. Weinstein, Rainer Weiss, Felix Wellmann, Linqing Wen, Peter Weßels, Jonathan W. Westhouse, Karl Wette, John T. Whelan, Bernard F. Whiting, Chris Whittle, Dennis M. Wilken, Daniel Williams, Williams, Roy D., Andrew R. Williamson, Joshua L. Willis, Benno Willke, Walter Winkler, Christopher C. Wipf, Holger Wittel, Graham Woan, Janis Woehler, Jared K. Wofford, Chun-fung Wong, Jennifer L. Wright, David S. Wu, Daniel M. Wysocki, Liting Xiao, Hiro Yamamoto, Le Yang, Yang Yang, Ziyan Yang, Min-jet J. Yap, Maher Yazback, David W. Yeeles, Hang Yu, Haocun Yu, Shingheirobin Yuen, Adam K. Zadrożny, Adam Zadrożny, Michele Zanolin, Tatiana Zelenova, Jean-pierre Zendri, Michael Zevin, Jue Zhang, Liyuan Zhang, Teng Zhang, Chunnong Zhao, Guoying Zhao, Minchuan Zhou, Zifan Zhou, Xingjiang J. Zhu, Aaron B. Zimmerman, Michael E. Zucker, and John Zweizig
- Abstract
Advanced LIGO and Advanced Virgo are monitoring the sky and collecting gravitational-wave strain data with sufficient sensitivity to detect signals routinely. In this paper we describe the data recorded by these instruments during their first and second observing runs. The main data products are gravitational-wave strain time series sampled at 16384 Hz. The datasets that include this strain measurement can be freely accessed through the Gravitational Wave Open Science Center at http://gw-openscience.org, together with data-quality information essential for the analysis of LIGO and Virgo data, documentation, tutorials, and supporting software.
- Published
- 2021
- Full Text
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