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1. Vitamin K-dependent carboxylation: inhibition by a peptide containing 4-methylene glutamic acid

Author

Guibé, Eryka, Maréchal, Paulette Decottignies-Le, Le Maréchal, Pierre, and Azerad, Robert

Abstract

The peptide Boc-4-methylene Glu-Glu-Val has been synthesized and shown to be a strong inhibitor of the vitamin K-dependent carboxylation catalyzed by a detergent solubilized rat liver microsome preparation. The inhibition is apparently competitive with respect to the substrate peptide and non-competitive with respect to HCO 3−

Published
1984
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