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1. Efficacy of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine against cervical infection and precancer caused by oncogenic HPV types (PATRICIA): final analysis of a double-blind, randomised study in young women

Author

Paavonen, J, Naud, P, Salmerón, J, Wheeler, CM, Chow, S-N, Apter, D, Kitchener, H, Castellsague, X, Teixeira, JC, Skinner, SR, Hedrick, J, Jaisamrarn, U, Limson, G, Garland, S, Szarewski, A, Romanowski, B, Aoki, FY, Schwarz, TF, Poppe, WAJ, Bosch, FX, Jenkins, D, Hardt, K, Zahaf, T, Descamps, D, Struyf, F, Lehtinen, M, and Dubin, G

Abstract

The human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine was immunogenic, generally well tolerated, and effective against HPV-16 or HPV-18 infections, and associated precancerous lesions in an event-triggered interim analysis of the phase III randomised, double-blind, controlled PApilloma TRIal against Cancer In young Adults (PATRICIA). We now assess the vaccine efficacy in the final event-driven analysis.

Published
2009
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